Gi1 - NK1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 134 3x54 G.H5 L 353 G.H5.25
Ionic TM6 K 243 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 243 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 243 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 243 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM5 P 229 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 223 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 134 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 134 3x54 G.H5 L 348 G.H5.20
Ionic TM5 D 231 5x73 G.S6 H 322 G.S6.04
Polar TM5 D 231 5x73 G.S6 H 322 G.S6.04
Hydrophobic TM5 D 231 5x73 G.S6 H 322 G.S6.04
Van-der-waals TM5 D 231 5x73 G.S6 H 322 G.S6.04
Hydrophobic ICL2 L 138 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 138 - G.H5 I 343 G.H5.15
Hydrophobic TM3 A 133 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 137 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 137 - G.H5 I 344 G.H5.16
Polar TM2 T 65 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 137 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 137 - G.H5 I 343 G.H5.15
Hydrophobic TM5 I 228 5x70 G.S6 Y 320 G.S6.02
Polar TM4 S 143 4x38 G.HN R 24 G.HN.48
Hydrophobic TM4 S 143 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 S 143 4x38 G.HN R 24 G.HN.48
Hydrophobic TM5 P 229 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 P 229 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 G 230 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 G 230 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM3 R 130 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 353 G.H5.25
Polar ICL2 R 141 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 141 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 141 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 140 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 242 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 242 6x29 G.H5 F 354 G.H5.26
Hydrophobic C-term T 356 - G.S2 V 185 G.S2.02
Hydrophobic ICL2 L 138 - G.H5 T 340 G.H5.12
Hydrophobic TM6 M 250 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 250 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 137 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 P 140 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 P 229 5x71 G.H5 F 334 G.H5.06
Van-der-waals TM5 P 229 5x71 G.H5 F 334 G.H5.06
Hydrophobic ICL2 L 138 - G.S3 L 194 G.S3.01
Hydrophobic H8 N 309 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 309 8x47 G.H5 G 352 G.H5.24
Polar C-term K 337 - G.h3s5 T 260 G.h3s5.01
Van-der-waals C-term K 337 - G.h3s5 T 260 G.h3s5.01
Polar TM3 A 133 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 133 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 223 5x65 G.H5 I 344 G.H5.16
Polar TM4 S 143 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 S 143 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 143 4x38 G.HN E 28 G.HN.52
Ionic C-term K 337 - G.h3s5 D 261 G.h3s5.02
Polar C-term K 337 - G.h3s5 D 261 G.h3s5.02
Polar ICL2 P 137 - G.H5 N 347 G.H5.19
Polar ICL2 R 141 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 141 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 141 - G.H5 C 351 G.H5.23
Polar H8 N 309 8x47 G.H5 K 349 G.H5.21
Aromatic C-term Y 349 - G.H2 H 213 G.H2.09
Hydrophobic C-term Y 349 - G.H2 H 213 G.H2.09
Van-der-waals C-term Y 349 - G.H2 H 213 G.H2.09
Polar TM6 R 235 6x22 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 R 235 6x22 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 R 235 6x22 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 V 246 6x33 G.H5 F 354 G.H5.26
Hydrophobic C-term L 342 - G.H3 W 258 G.H3.17
Van-der-waals C-term L 342 - G.H3 W 258 G.H3.17
Polar TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 M 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 249 6x36 G.H5 L 353 G.H5.25
Polar TM4 T 145 4x40 G.HN R 24 G.HN.48
Hydrophobic TM4 T 145 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 T 145 4x40 G.HN R 24 G.HN.48
Polar TM6 Q 239 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 Q 239 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 239 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 P 229 5x71 G.S6 Y 320 G.S6.02
Van-der-waals TM5 P 229 5x71 G.S6 Y 320 G.S6.02
Polar TM2 T 67 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 67 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 67 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 138 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 138 - G.H5 F 336 G.H5.08
Hydrophobic TM5 P 229 5x71 G.H5 A 338 G.H5.10
Van-der-waals ICL3 S 232 - G.H4 Q 304 G.H4.12
Hydrophobic TM5 G 230 5x72 G.S6 T 321 G.S6.03
Van-der-waals TM5 G 230 5x72 G.S6 T 321 G.S6.03
Hydrophobic TM3 I 134 3x54 G.H5 I 344 G.H5.16
Ionic ICL1 R 62 12x49 G.h3s5 D 261 G.h3s5.02
Hydrophobic ICL3 S 232 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 S 232 - G.H4 E 308 G.H4.16
Hydrophobic TM6 V 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 246 6x33 G.H5 L 353 G.H5.25
Hydrophobic C-term L 342 - G.h2s4 E 216 G.h2s4.02
Polar TM5 D 231 5x73 G.H4 Q 304 G.H4.12
Hydrophobic TM5 D 231 5x73 G.H4 Q 304 G.H4.12
Van-der-waals TM5 D 231 5x73 G.H4 Q 304 G.H4.12
Polar TM5 D 231 5x73 G.S6 F 323 G.S6.05
Hydrophobic TM5 D 231 5x73 G.S6 F 323 G.S6.05
Van-der-waals TM5 D 231 5x73 G.S6 F 323 G.S6.05
Ionic TM6 R 235 6x22 G.H4 E 308 G.H4.16
Polar TM6 R 235 6x22 G.H4 E 308 G.H4.16
Van-der-waals TM6 R 235 6x22 G.H4 E 308 G.H4.16
Ionic H8 R 311 8x49 G.H5 D 350 G.H5.22
Polar H8 R 311 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 311 8x49 G.H5 D 350 G.H5.22
Ionic ICL2 R 141 - G.H5 D 350 G.H5.22
Polar ICL2 R 141 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 141 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 141 - G.H5 D 350 G.H5.22
Polar C-term T 357 - G.hfs2 T 182 G.hfs2.06
Hydrophobic TM6 V 246 6x33 G.H5 L 348 G.H5.20
Polar TM5 D 231 5x73 G.S6 T 321 G.S6.03
Van-der-waals TM5 D 231 5x73 G.S6 T 321 G.S6.03
Hydrophobic ICL2 P 140 - G.HN E 28 G.HN.52