Gz - NTS2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 V 361 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 V 361 7x56 G.H5 G 353 G.H5.24
Polar C-term G 403 - G.H3 W 259 G.H3.17
Van-der-waals C-term G 403 - G.H3 W 259 G.H3.17
Hydrophobic ICL2 P 140 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM6 L 292 6x30 G.H5 L 349 G.H5.20
Hydrophobic C-term F 402 - G.H3 I 254 G.H3.12
Van-der-waals C-term F 402 - G.H3 I 254 G.H3.12
Ionic TM6 R 288 6x26 G.H5 D 342 G.H5.13
Polar TM6 R 288 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 288 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 288 6x26 G.H5 D 342 G.H5.13
Polar ICL2 P 140 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 140 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 141 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 L 141 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term P 405 - G.H3 W 259 G.H3.17
Van-der-waals C-term P 405 - G.H3 W 259 G.H3.17
Hydrophobic TM5 L 233 5x65 G.H5 L 354 G.H5.25
Hydrophobic ICL3 V 281 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 V 281 - G.H4 Q 305 G.H4.12
Hydrophobic TM3 R 133 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 299 6x37 G.H5 L 354 G.H5.25
Hydrophobic C-term F 402 - G.H2 I 213 G.H2.08
Ionic TM6 R 287 6x25 G.h4s6 E 316 G.h4s6.09
Polar TM6 R 287 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 R 287 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 R 287 6x25 G.h4s6 E 316 G.h4s6.09
Polar ICL2 R 144 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic ICL2 R 144 34x54 G.h2s4 T 220 G.h2s4.05
Van-der-waals ICL2 R 144 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic C-term D 404 - G.H3 W 259 G.H3.17
Hydrophobic ICL2 L 141 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 141 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM4 T 148 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 148 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic C-term F 402 - G.H2 W 212 G.H2.07
Van-der-waals C-term F 402 - G.H2 W 212 G.H2.07
Polar TM2 R 69 2x40 G.H5 I 352 G.H5.23
Hydrophobic TM2 R 69 2x40 G.H5 I 352 G.H5.23
Van-der-waals TM2 R 69 2x40 G.H5 I 352 G.H5.23
Hydrophobic TM3 V 137 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 137 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 137 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL3 L 280 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 L 280 - G.H4 R 306 G.H4.13
Hydrophobic C-term F 402 - G.H3 W 259 G.H3.17
Ionic TM6 R 288 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 288 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 P 140 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 140 34x50 G.H5 I 345 G.H5.16
Aromatic C-term F 402 - G.h2s4 F 216 G.h2s4.01
Hydrophobic C-term F 402 - G.h2s4 F 216 G.h2s4.01
Van-der-waals C-term F 402 - G.h2s4 F 216 G.h2s4.01
Hydrophobic ICL2 L 141 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 141 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM7 V 361 7x56 G.H5 L 354 G.H5.25
Van-der-waals TM7 V 361 7x56 G.H5 L 354 G.H5.25
Hydrophobic ICL3 S 248 - G.H4 V 302 G.H4.08
Van-der-waals ICL3 S 248 - G.H4 V 302 G.H4.08
Polar TM4 P 149 4x39 G.H5 Y 351 G.H5.22
Hydrophobic TM4 P 149 4x39 G.H5 Y 351 G.H5.22
Van-der-waals TM4 P 149 4x39 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 R 144 34x54 G.S1 I 34 G.S1.02
Van-der-waals ICL2 R 144 34x54 G.S1 I 34 G.S1.02
Van-der-waals C-term F 402 - G.H2 R 209 G.H2.04
Hydrophobic TM5 L 236 5x68 G.H5 I 345 G.H5.16
Polar ICL3 S 279 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 S 279 - G.H4 R 306 G.H4.13
Polar TM2 R 67 2x38 G.H5 N 347 G.H5.18
Van-der-waals TM2 R 67 2x38 G.H5 N 347 G.H5.18
Ionic ICL2 R 142 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 142 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 142 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 142 34x52 G.s2s3 E 194 G.s2s3.02
Polar C-term D 404 - G.H3 N 258 G.H3.16
Van-der-waals C-term D 404 - G.H3 N 258 G.H3.16
Polar ICL2 L 147 34x57 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 147 34x57 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 S 145 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 R 288 6x26 G.H5 Q 346 G.H5.17
Polar H8 S 362 8x47 G.H5 C 355 G.H5.26
Polar TM3 R 133 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM2 R 67 2x38 G.H5 Y 351 G.H5.22
Van-der-waals TM2 R 67 2x38 G.H5 Y 351 G.H5.22
Polar ICL2 R 144 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 144 34x54 G.S1 E 33 G.S1.01
Ionic ICL3 K 284 - G.H4 E 309 G.H4.16
Polar ICL3 K 284 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 K 284 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 K 284 - G.H4 E 309 G.H4.16
Hydrophobic TM2 R 69 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 R 69 2x40 G.H5 Y 351 G.H5.22
Polar TM6 S 295 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 295 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 295 6x33 G.H5 L 354 G.H5.25
Polar ICL2 R 144 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 144 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 L 233 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM4 P 149 4x39 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 P 149 4x39 G.hns1 R 31 G.hns1.02
Polar TM6 R 287 6x25 G.h4s6 K 315 G.h4s6.08
Hydrophobic C-term P 405 - G.H3 N 258 G.H3.16
Hydrophobic TM4 R 150 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 R 150 4x40 G.HN R 24 G.HN.48
Polar TM3 A 136 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 N 348 G.H5.19
Polar H8 S 362 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 S 362 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 S 362 8x47 G.H5 G 353 G.H5.24
Polar H8 S 363 8x48 G.H5 C 355 G.H5.26
Hydrophobic H8 S 363 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 S 363 8x48 G.H5 C 355 G.H5.26
Hydrophobic C-term P 406 - G.H3 W 259 G.H3.17
Van-der-waals C-term P 406 - G.H3 W 259 G.H3.17
Hydrophobic ICL2 L 141 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 L 147 34x57 G.H5 I 352 G.H5.23
Polar ICL3 K 284 - G.S6 I 320 G.S6.01
Hydrophobic TM3 A 136 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 136 3x53 G.H5 I 352 G.H5.23