Golf - Olfactory receptor 51B6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 S 126 3x56 G.H5 Q 371 G.H5.16
Van-der-waals TM3 S 126 3x56 G.H5 Q 371 G.H5.16
Polar ICL2 T 131 34x54 G.H5 H 374 G.H5.19
Hydrophobic ICL2 T 131 34x54 G.H5 H 374 G.H5.19
Van-der-waals ICL2 T 131 34x54 G.H5 H 374 G.H5.19
Hydrophobic TM2 Y 58 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 234 6x32 G.H5 L 381 G.H5.26
Van-der-waals TM6 K 234 6x32 G.H5 L 381 G.H5.26
Polar ICL2 T 131 34x54 G.S1 H 43 G.S1.02
Polar ICL2 P 127 34x50 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 P 127 34x50 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 Q 371 G.H5.16
Hydrophobic TM6 E 231 6x29 G.S6 Y 347 G.S6.02
Van-der-waals TM6 E 231 6x29 G.S6 Y 347 G.S6.02
Hydrophobic TM2 M 57 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 57 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 L 375 G.H5.20
Van-der-waals ICL2 P 127 34x50 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 128 34x51 G.S3 F 206 G.S3.03
Van-der-waals ICL2 L 128 34x51 G.S3 F 206 G.S3.03
Polar ICL2 L 128 34x51 G.S1 H 43 G.S1.02
Hydrophobic ICL2 L 128 34x51 G.S1 H 43 G.S1.02
Van-der-waals ICL2 L 128 34x51 G.S1 H 43 G.S1.02
Hydrophobic ICL2 L 128 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 128 34x51 G.H5 I 370 G.H5.15
Polar H8 Q 296 8x49 G.H5 Y 378 G.H5.23
Hydrophobic H8 Q 296 8x49 G.H5 Y 378 G.H5.23
Van-der-waals H8 Q 296 8x49 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 T 131 34x54 G.H5 Y 378 G.H5.23
Polar TM6 T 238 6x36 G.H5 L 381 G.H5.26
Hydrophobic TM6 T 238 6x36 G.H5 L 381 G.H5.26
Van-der-waals TM6 T 238 6x36 G.H5 L 381 G.H5.26
Polar ICL2 L 128 34x51 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 L 128 34x51 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 L 128 34x51 G.H5 Q 371 G.H5.16
Hydrophobic TM5 I 226 5x68 G.H5 R 372 G.H5.17
Van-der-waals TM5 I 226 5x68 G.H5 R 372 G.H5.17
Polar ICL2 R 129 34x52 G.s2s3 D 202 G.s2s3.01
Hydrophobic ICL2 R 129 34x52 G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 R 129 34x52 G.s2s3 D 202 G.s2s3.01
Hydrophobic ICL2 L 128 34x51 G.H5 R 367 G.H5.12
Van-der-waals ICL2 L 128 34x51 G.H5 R 367 G.H5.12
Hydrophobic TM6 K 234 6x32 G.H5 K 376 G.H5.21
Van-der-waals TM6 K 234 6x32 G.H5 K 376 G.H5.21
Hydrophobic ICL2 L 128 34x51 G.S3 V 204 G.S3.01
Hydrophobic ICL2 Y 130 34x53 G.H5 L 375 G.H5.20
Van-der-waals TM2 E 55 2x37 G.H5 L 380 G.H5.25
Polar TM2 Y 58 2x40 G.H5 E 379 G.H5.24
Polar ICL2 T 131 34x54 G.hns1 K 40 G.hns1.02
Ionic TM6 E 231 6x29 G.H5 R 372 G.H5.17
Polar TM6 E 231 6x29 G.H5 R 372 G.H5.17
Van-der-waals TM6 E 231 6x29 G.H5 R 372 G.H5.17
Hydrophobic TM6 A 235 6x33 G.H5 L 381 G.H5.26
Hydrophobic TM2 E 55 2x37 G.H5 Y 378 G.H5.23
Van-der-waals TM2 E 55 2x37 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 Y 130 34x53 G.H5 L 380 G.H5.25
Van-der-waals ICL2 Y 130 34x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 T 131 34x54 G.hns1 A 41 G.hns1.03
Polar TM6 T 238 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 238 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 238 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 129 34x52 G.S3 V 204 G.S3.01
Van-der-waals ICL2 R 129 34x52 G.S3 V 204 G.S3.01
Polar TM6 K 234 6x32 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 K 234 6x32 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 K 234 6x32 G.h4s6 Y 345 G.h4s6.20
Polar H8 Q 296 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 Q 296 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 Q 296 8x49 G.H5 E 379 G.H5.24
Hydrophobic TM3 T 123 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 T 123 3x53 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 127 34x50 G.H5 R 372 G.H5.17