Gq - Olfactory receptor 51D1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 246 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 A 246 6x29 G.H5 Q 350 G.H5.17
Polar TM3 D 134 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 134 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 134 3x49 G.H5 Y 356 G.H5.23
Polar TM3 A 138 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 138 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 138 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 A 146 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 A 146 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM7 K 307 7x56 G.H5 L 358 G.H5.25
Van-der-waals TM7 K 307 7x56 G.H5 L 358 G.H5.25
Polar ICL2 R 144 34x52 G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL2 R 144 34x52 G.s2s3 Q 197 G.s2s3.01
Hydrophobic TM6 K 249 6x32 G.H5 K 354 G.H5.21
Van-der-waals TM6 K 249 6x32 G.H5 K 354 G.H5.21
Polar TM6 T 253 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 T 253 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 T 253 6x36 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 142 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 142 34x50 G.H5 K 345 G.H5.12
Hydrophobic ICL2 L 143 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 143 34x51 G.H5 F 341 G.H5.08
Polar H8 K 309 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 K 309 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 K 309 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM3 I 139 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 139 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 L 143 34x51 G.S3 V 199 G.S3.01
Hydrophobic ICL2 L 143 34x51 G.H5 K 345 G.H5.12
Polar ICL2 S 147 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 S 147 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 S 147 34x55 G.hns1 R 38 G.hns1.03
Polar ICL2 P 142 34x50 G.H5 N 352 G.H5.19
Polar TM3 R 135 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM4 G 151 4x39 G.HN R 34 G.HN.52
Van-der-waals TM4 G 151 4x39 G.HN R 34 G.HN.52
Polar ICL2 R 144 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 R 144 34x52 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 R 144 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM2 E 70 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM4 C 152 4x40 G.HN R 34 G.HN.52
Van-der-waals TM4 C 152 4x40 G.HN R 34 G.HN.52
Hydrophobic TM2 M 72 2x39 G.H5 L 358 G.H5.25
Van-der-waals TM2 M 72 2x39 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 246 6x29 G.H5 L 353 G.H5.20
Hydrophobic TM6 S 256 6x39 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 143 34x51 G.H5 V 344 G.H5.11
Polar TM6 T 253 6x36 G.H5 Y 356 G.H5.23
Hydrophobic TM6 T 253 6x36 G.H5 Y 356 G.H5.23
Van-der-waals TM6 T 253 6x36 G.H5 Y 356 G.H5.23
Hydrophobic TM4 T 150 4x38 G.HN R 34 G.HN.52
Polar TM6 K 249 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 249 6x32 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 249 6x32 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 143 34x51 G.H5 I 348 G.H5.15
Polar TM2 Y 73 2x40 G.H5 E 355 G.H5.22
Polar H8 T 308 8x47 G.H5 L 358 G.H5.25
Hydrophobic H8 T 308 8x47 G.H5 L 358 G.H5.25
Van-der-waals H8 T 308 8x47 G.H5 L 358 G.H5.25
Hydrophobic TM2 Y 73 2x40 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 143 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 143 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM3 I 139 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM6 A 250 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM6 A 250 6x33 G.H5 L 353 G.H5.20
Polar TM6 K 249 6x32 G.H5 L 353 G.H5.20
Hydrophobic TM6 K 249 6x32 G.H5 L 353 G.H5.20
Polar H8 K 309 8x48 G.H5 L 358 G.H5.25
Hydrophobic H8 K 309 8x48 G.H5 L 358 G.H5.25
Van-der-waals H8 K 309 8x48 G.H5 L 358 G.H5.25
Hydrophobic TM2 M 72 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 M 72 2x39 G.H5 Y 356 G.H5.23
Ionic ICL1 R 66 12x48 G.HN E 26 G.HN.44
Polar ICL1 R 66 12x48 G.HN E 26 G.HN.44
Hydrophobic ICL1 R 66 12x48 G.HN E 26 G.HN.44
Van-der-waals ICL1 R 66 12x48 G.HN E 26 G.HN.44
Hydrophobic TM3 A 138 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 138 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 144 34x52 G.S3 V 199 G.S3.01
Hydrophobic ICL3 L 241 - G.H5 L 349 G.H5.16
Van-der-waals ICL3 L 241 - G.H5 L 349 G.H5.16
Hydrophobic ICL2 P 142 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM7 Y 304 7x53 G.H5 L 358 G.H5.25
Van-der-waals TM7 Y 304 7x53 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 142 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 142 34x50 G.H5 I 348 G.H5.15
Polar TM7 K 307 7x56 G.H5 V 359 G.H5.26
Van-der-waals TM7 K 307 7x56 G.H5 V 359 G.H5.26
Ionic TM2 E 70 2x37 G.hns1 R 37 G.hns1.02
Polar TM2 E 70 2x37 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 E 70 2x37 G.hns1 R 37 G.hns1.02
Van-der-waals TM2 E 70 2x37 G.hns1 R 37 G.hns1.02
Polar ICL2 H 145 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 H 145 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 H 145 34x53 G.H5 Y 356 G.H5.23