G15 - Olfactory receptor 51J1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 D 140 - G.hns1 R 40 G.hns1.02
Polar ICL2 D 140 - G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 D 140 - G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 D 140 - G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 P 139 34x57 G.HN K 37 G.HN.52
Van-der-waals ICL2 P 139 34x57 G.HN K 37 G.HN.52
Polar ICL2 S 137 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 S 137 34x55 G.hns1 R 40 G.hns1.02
Polar TM7 K 297 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM7 K 297 7x56 G.H5 N 372 G.H5.24
Hydrophobic TM3 P 125 3x50 G.H5 Y 367 G.H5.19
Hydrophobic H8 E 311 8x60 G.HN W 7 G.HN.07
Van-der-waals H8 E 311 8x60 G.HN W 7 G.HN.07
Polar C-term R 314 - G.HN R 8 G.HN.08
Hydrophobic C-term R 314 - G.HN R 8 G.HN.08
Van-der-waals C-term R 314 - G.HN R 8 G.HN.08
Hydrophobic TM6 G 235 6x29 G.H5 L 374 G.H5.26
Hydrophobic TM5 T 226 5x64 G.H5 L 364 G.H5.16
Van-der-waals TM5 T 226 5x64 G.H5 L 364 G.H5.16
Polar ICL2 D 140 - G.HN K 37 G.HN.52
Hydrophobic ICL2 D 140 - G.HN K 37 G.HN.52
Van-der-waals ICL2 D 140 - G.HN K 37 G.HN.52
Polar TM5 I 230 5x68 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 I 230 5x68 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 I 230 5x68 G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL2 T 133 34x51 G.H5 R 360 G.H5.12
Hydrophobic TM5 V 227 5x65 G.H5 L 374 G.H5.26
Hydrophobic TM5 V 227 5x65 G.H5 L 368 G.H5.20
Van-der-waals TM5 V 227 5x65 G.H5 L 368 G.H5.20
Hydrophobic ICL2 P 132 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 132 34x50 G.H5 R 360 G.H5.12
Hydrophobic TM5 I 223 5x61 G.H5 L 373 G.H5.25
Polar TM6 K 238 6x32 G.H5 N 372 G.H5.24
Hydrophobic TM6 K 238 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 K 238 6x32 G.H5 N 372 G.H5.24
Polar TM6 T 242 6x36 G.H5 N 372 G.H5.24
Hydrophobic TM6 T 242 6x36 G.H5 N 372 G.H5.24
Van-der-waals TM6 T 242 6x36 G.H5 N 372 G.H5.24
Hydrophobic TM6 C 243 6x37 G.H5 L 373 G.H5.25
Van-der-waals TM6 C 243 6x37 G.H5 L 373 G.H5.25
Hydrophobic ICL2 H 136 34x54 G.H5 V 363 G.H5.15
Van-der-waals ICL2 H 136 34x54 G.H5 V 363 G.H5.15
Polar C-term R 315 - G.HN W 7 G.HN.07
Van-der-waals C-term R 315 - G.HN W 7 G.HN.07
Van-der-waals TM2 Q 60 2x37 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 P 132 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 132 34x50 G.H5 V 363 G.H5.15
Hydrophobic ICL2 L 135 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL3 A 231 - G.H5 L 374 G.H5.26
Van-der-waals ICL3 A 231 - G.H5 L 374 G.H5.26
Hydrophobic ICL2 P 132 34x50 G.H5 L 364 G.H5.16
Hydrophobic TM6 T 242 6x36 G.H5 L 373 G.H5.25
Van-der-waals TM6 T 242 6x36 G.H5 L 373 G.H5.25
Hydrophobic TM3 S 128 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 S 128 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM6 K 238 6x32 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 K 238 6x32 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM2 M 62 2x39 G.H5 I 371 G.H5.23
Van-der-waals TM2 M 62 2x39 G.H5 I 371 G.H5.23
Hydrophobic ICL3 A 231 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 A 231 - G.h4s6 R 338 G.h4s6.20
Hydrophobic TM3 H 129 3x54 G.H5 L 368 G.H5.20
Van-der-waals TM3 H 129 3x54 G.H5 L 368 G.H5.20
Hydrophobic TM5 I 230 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 I 230 5x68 G.H5 D 361 G.H5.13
Hydrophobic ICL1 I 56 12x48 G.HN L 33 G.HN.48
Van-der-waals ICL1 I 56 12x48 G.HN L 33 G.HN.48
Ionic TM6 E 234 6x28 G.h4s6 K 331 G.h4s6.13
Polar TM6 E 234 6x28 G.h4s6 K 331 G.h4s6.13
Hydrophobic TM6 E 234 6x28 G.h4s6 K 331 G.h4s6.13
Van-der-waals TM6 E 234 6x28 G.h4s6 K 331 G.h4s6.13
Hydrophobic TM5 I 230 5x68 G.H5 A 365 G.H5.17
Polar TM6 K 238 6x32 G.H5 L 374 G.H5.26
Hydrophobic TM6 K 238 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 238 6x32 G.H5 L 374 G.H5.26
Polar ICL2 H 136 34x54 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 H 136 34x54 G.hns1 G 41 G.hns1.03
Hydrophobic TM5 I 223 5x61 G.H5 L 368 G.H5.20
Hydrophobic TM3 H 129 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 H 129 3x54 G.H5 L 364 G.H5.16
Polar TM6 A 239 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 A 239 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 A 239 6x33 G.H5 L 373 G.H5.25
Hydrophobic ICL2 T 141 - G.HN K 37 G.HN.52
Van-der-waals ICL2 T 141 - G.HN K 37 G.HN.52
Polar ICL2 T 133 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL2 T 133 34x51 G.S3 T 202 G.S3.01
Van-der-waals ICL2 T 133 34x51 G.S3 T 202 G.S3.01
Hydrophobic TM5 I 230 5x68 G.H5 L 364 G.H5.16
Hydrophobic TM3 S 128 3x53 G.H5 L 364 G.H5.16
Van-der-waals TM3 S 128 3x53 G.H5 L 364 G.H5.16
Polar ICL2 H 136 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 H 136 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 H 136 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 H 136 34x54 G.S1 L 43 G.S1.02
Van-der-waals ICL2 H 136 34x54 G.S1 L 43 G.S1.02
Hydrophobic TM1 T 54 1x59 G.HN W 7 G.HN.07
Van-der-waals TM1 T 54 1x59 G.HN W 7 G.HN.07
Hydrophobic ICL2 T 133 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 T 133 34x51 G.S1 L 43 G.S1.02
Hydrophobic ICL2 H 136 34x54 G.h2s4 I 227 G.h2s4.05
Polar C-term R 315 - G.HN R 8 G.HN.08
Hydrophobic C-term R 315 - G.HN R 8 G.HN.08
Van-der-waals C-term R 315 - G.HN R 8 G.HN.08
Hydrophobic ICL2 T 133 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 T 133 34x51 G.H5 F 356 G.H5.08
Hydrophobic ICL2 S 137 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 S 137 34x55 G.hns1 G 41 G.hns1.03
Ionic ICL2 E 134 34x52 G.s2s3 K 201 G.s2s3.02
Polar ICL2 E 134 34x52 G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 E 134 34x52 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 E 134 34x52 G.s2s3 K 201 G.s2s3.02