Golf - Olfactory receptor 51M1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 Y 72 2x40 G.H5 Q 377 G.H5.22
Polar H8 E 310 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 E 310 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 E 310 8x49 G.H5 E 379 G.H5.24
Hydrophobic TM6 R 248 6x32 G.H5 L 381 G.H5.26
Van-der-waals TM6 R 248 6x32 G.H5 L 381 G.H5.26
Van-der-waals TM6 E 245 6x29 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 248 6x32 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 248 6x32 G.H5 L 380 G.H5.25
Polar ICL2 S 145 34x54 G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 S 145 34x54 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 S 145 34x54 G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 V 146 34x55 G.hns1 A 41 G.hns1.03
Van-der-waals ICL2 V 146 34x55 G.hns1 A 41 G.hns1.03
Hydrophobic TM4 T 149 4x38 G.HN L 37 G.HN.52
Van-der-waals TM4 T 149 4x38 G.HN L 37 G.HN.52
Polar TM6 R 248 6x32 G.h4s6 Y 345 G.h4s6.20
Ionic TM6 E 245 6x29 G.H5 R 372 G.H5.17
Polar TM6 E 245 6x29 G.H5 R 372 G.H5.17
Hydrophobic TM6 E 245 6x29 G.H5 R 372 G.H5.17
Van-der-waals TM6 E 245 6x29 G.H5 R 372 G.H5.17
Aromatic ICL2 Y 144 34x53 G.H5 H 374 G.H5.19
Hydrophobic ICL2 Y 144 34x53 G.H5 H 374 G.H5.19
Van-der-waals ICL2 Y 144 34x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 A 137 3x53 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 P 141 34x50 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 P 141 34x50 G.H5 H 374 G.H5.19
Hydrophobic ICL2 L 142 34x51 G.S3 F 206 G.S3.03
Hydrophobic TM7 K 307 7x56 G.H5 E 379 G.H5.24
Van-der-waals TM7 K 307 7x56 G.H5 E 379 G.H5.24
Polar ICL2 L 142 34x51 G.S1 H 43 G.S1.02
Hydrophobic ICL2 L 142 34x51 G.S1 H 43 G.S1.02
Van-der-waals ICL2 L 142 34x51 G.S1 H 43 G.S1.02
Hydrophobic ICL2 L 142 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM2 M 71 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 M 71 2x39 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 R 143 34x52 G.s2s3 K 203 G.s2s3.02
Hydrophobic H8 T 308 8x47 G.H5 E 379 G.H5.24
Ionic H8 K 309 8x48 G.H5 E 379 G.H5.24
Polar H8 K 309 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 K 309 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 K 309 8x48 G.H5 E 379 G.H5.24
Hydrophobic ICL2 P 141 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 141 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 T 252 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 252 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 252 6x36 G.H5 L 375 G.H5.20
Van-der-waals TM6 T 252 6x36 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 142 34x51 G.H5 R 367 G.H5.12
Hydrophobic ICL2 L 142 34x51 G.S3 V 204 G.S3.01
Van-der-waals ICL2 L 142 34x51 G.S3 V 204 G.S3.01
Hydrophobic ICL2 P 141 34x50 G.H5 R 367 G.H5.12
Van-der-waals ICL2 P 141 34x50 G.H5 R 367 G.H5.12
Hydrophobic ICL2 L 142 34x51 G.H5 C 366 G.H5.11
Hydrophobic TM3 R 134 3x50 G.H5 L 380 G.H5.25
Polar TM3 D 133 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 D 133 3x49 G.H5 Y 378 G.H5.23
Polar TM3 I 138 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 I 138 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 Q 371 G.H5.16
Polar TM3 A 137 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 A 137 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 A 137 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM6 A 249 6x33 G.H5 L 375 G.H5.20
Polar ICL2 Y 144 34x53 G.H5 Y 378 G.H5.23
Van-der-waals ICL2 Y 144 34x53 G.H5 Y 378 G.H5.23
Hydrophobic H8 E 310 8x49 G.H5 Q 377 G.H5.22
Van-der-waals H8 E 310 8x49 G.H5 Q 377 G.H5.22
Polar ICL2 S 145 34x54 G.hns1 A 41 G.hns1.03
Hydrophobic TM3 I 138 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 142 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 142 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 R 143 34x52 G.S3 V 204 G.S3.01
Van-der-waals ICL2 R 143 34x52 G.S3 V 204 G.S3.01
Polar H8 K 309 8x48 G.H5 L 381 G.H5.26
Hydrophobic TM5 L 240 5x68 G.H5 Q 371 G.H5.16
Van-der-waals TM5 L 240 5x68 G.H5 Q 371 G.H5.16