Gt1 - OPN5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 78.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 Q 317 8x54 G.h4s6 D 311 G.h4s6.09
Hydrophobic H8 Q 317 8x54 G.h4s6 D 311 G.h4s6.09
Van-der-waals H8 Q 317 8x54 G.h4s6 D 311 G.h4s6.09
Polar TM6 S 243 6x26 G.H5 K 341 G.H5.17
Hydrophobic TM6 S 243 6x26 G.H5 K 341 G.H5.17
Van-der-waals TM6 S 243 6x26 G.H5 K 341 G.H5.17
Polar TM6 S 242 6x25 G.S6 Y 316 G.S6.02
Hydrophobic TM6 S 242 6x25 G.S6 Y 316 G.S6.02
Van-der-waals TM6 S 242 6x25 G.S6 Y 316 G.S6.02
Hydrophobic ICL2 G 141 34x53 G.H5 I 340 G.H5.16
Hydrophobic TM6 R 239 6x22 G.S5 V 261 G.S5.03
Van-der-waals TM6 R 239 6x22 G.S5 V 261 G.S5.03
Hydrophobic TM6 L 246 6x29 G.H5 E 342 G.H5.18
Hydrophobic TM6 L 246 6x29 G.H5 K 341 G.H5.17
Hydrophobic TM6 L 250 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 L 250 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM6 T 251 6x34 G.H5 F 350 G.H5.26
Van-der-waals TM6 T 251 6x34 G.H5 F 350 G.H5.26
Polar ICL2 L 144 34x56 G.H5 C 347 G.H5.23
Polar ICL2 S 139 34x51 G.s2s3 K 188 G.s2s3.01
Hydrophobic ICL2 S 139 34x51 G.s2s3 K 188 G.s2s3.01
Van-der-waals ICL2 S 139 34x51 G.s2s3 K 188 G.s2s3.01
Hydrophobic TM6 R 239 6x22 G.H5 I 338 G.H5.14
Polar TM6 H 244 6x27 G.H5 K 341 G.H5.17
Hydrophobic TM6 H 244 6x27 G.H5 K 341 G.H5.17
Van-der-waals TM6 H 244 6x27 G.H5 K 341 G.H5.17
Hydrophobic TM2 P 67 2x38 G.H5 L 349 G.H5.25
Ionic ICL1 R 66 12x51 G.H5 E 342 G.H5.18
Polar ICL1 R 66 12x51 G.H5 E 342 G.H5.18
Hydrophobic TM3 D 130 3x49 G.H5 L 349 G.H5.25
Van-der-waals TM3 D 130 3x49 G.H5 L 349 G.H5.25
Hydrophobic TM3 R 131 3x50 G.H5 L 344 G.H5.20
Van-der-waals TM3 R 131 3x50 G.H5 L 344 G.H5.20
Polar TM2 A 68 2x39 G.H5 C 347 G.H5.23
Van-der-waals TM2 A 68 2x39 G.H5 C 347 G.H5.23
Polar ICL3 S 238 - G.S6 S 317 G.S6.03
Van-der-waals ICL3 S 238 - G.S6 S 317 G.S6.03
Hydrophobic TM6 I 240 6x23 G.H5 A 334 G.H5.10
Van-der-waals TM6 I 240 6x23 G.H5 A 334 G.H5.10
Hydrophobic ICL2 V 142 34x54 G.S3 L 190 G.S3.01
Van-der-waals ICL2 V 142 34x54 G.S3 L 190 G.S3.01
Hydrophobic TM6 L 246 6x29 G.H5 K 345 G.H5.21
Van-der-waals TM6 L 246 6x29 G.H5 K 345 G.H5.21
Hydrophobic H8 Q 317 8x54 G.h4s6 V 312 G.h4s6.10
Van-der-waals H8 Q 317 8x54 G.h4s6 V 312 G.h4s6.10
Polar TM6 R 239 6x22 G.S6 Y 316 G.S6.02
Hydrophobic TM6 R 239 6x22 G.S6 Y 316 G.S6.02
Van-der-waals TM6 R 239 6x22 G.S6 Y 316 G.S6.02
Hydrophobic TM6 E 247 6x30 G.H5 F 350 G.H5.26
Van-der-waals TM6 E 247 6x30 G.H5 F 350 G.H5.26
Hydrophobic TM6 M 248 6x31 G.H5 F 350 G.H5.26
Hydrophobic ICL2 G 141 34x53 G.H5 L 344 G.H5.20
Van-der-waals ICL2 G 141 34x53 G.H5 L 344 G.H5.20
Polar ICL1 R 66 12x51 G.H5 G 348 G.H5.24
Hydrophobic ICL1 R 66 12x51 G.H5 G 348 G.H5.24
Van-der-waals ICL1 R 66 12x51 G.H5 G 348 G.H5.24
Polar TM6 R 239 6x22 G.S6 S 317 G.S6.03
Hydrophobic TM6 R 239 6x22 G.S6 S 317 G.S6.03
Van-der-waals TM6 R 239 6x22 G.S6 S 317 G.S6.03
Hydrophobic TM4 K 145 4x38 G.hns1 R 28 G.hns1.03
Van-der-waals TM4 K 145 4x38 G.hns1 R 28 G.hns1.03
Polar TM4 K 145 4x38 G.hns1 A 27 G.hns1.02
Hydrophobic TM4 K 145 4x38 G.hns1 A 27 G.hns1.02
Van-der-waals TM4 K 145 4x38 G.hns1 A 27 G.hns1.02
Polar ICL3 D 237 - G.S6 M 319 G.S6.05
Hydrophobic TM3 K 134 3x53 G.H5 L 349 G.H5.25
Van-der-waals TM3 K 134 3x53 G.H5 L 349 G.H5.25
Ionic TM6 E 247 6x30 G.H5 K 341 G.H5.17
Hydrophobic TM6 E 247 6x30 G.H5 K 341 G.H5.17
Van-der-waals TM6 E 247 6x30 G.H5 K 341 G.H5.17
Polar ICL1 R 66 12x51 G.H5 K 345 G.H5.21
Hydrophobic ICL1 R 66 12x51 G.H5 K 345 G.H5.21
Van-der-waals ICL1 R 66 12x51 G.H5 K 345 G.H5.21
Hydrophobic ICL2 V 142 34x54 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 V 142 34x54 G.hns1 R 28 G.hns1.03
Hydrophobic TM2 A 68 2x39 G.H5 L 349 G.H5.25
Van-der-waals TM2 A 68 2x39 G.H5 L 349 G.H5.25
Ionic ICL3 D 237 - G.H4 K 300 G.H4.12
Hydrophobic TM4 K 147 4x40 G.HN K 20 G.HN.48
Van-der-waals TM4 K 147 4x40 G.HN K 20 G.HN.48
Hydrophobic ICL2 L 138 34x50 G.H5 I 340 G.H5.16
Van-der-waals ICL2 L 138 34x50 G.H5 I 340 G.H5.16
Hydrophobic ICL1 R 66 12x51 G.H5 C 347 G.H5.23
Van-der-waals ICL1 R 66 12x51 G.H5 C 347 G.H5.23
Polar TM2 E 69 2x40 G.H5 G 348 G.H5.24
Hydrophobic TM2 E 69 2x40 G.H5 G 348 G.H5.24
Van-der-waals TM2 E 69 2x40 G.H5 G 348 G.H5.24
Polar TM6 S 242 6x25 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 S 242 6x25 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 S 242 6x25 G.h4s6 E 314 G.h4s6.12
Aromatic ICL3 F 236 - G.H5 F 330 G.H5.06
Hydrophobic ICL3 F 236 - G.H5 F 330 G.H5.06
Van-der-waals ICL3 F 236 - G.H5 F 330 G.H5.06
Hydrophobic ICL2 W 143 34x55 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 W 143 34x55 G.hns1 R 28 G.hns1.03
Ionic TM4 H 148 4x41 G.HN E 24 G.HN.52
Hydrophobic TM4 H 148 4x41 G.HN E 24 G.HN.52
Hydrophobic ICL2 L 138 34x50 G.H5 D 337 G.H5.13
Van-der-waals ICL2 L 138 34x50 G.H5 D 337 G.H5.13
Polar TM3 R 131 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM3 R 131 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 349 G.H5.25
Polar TM2 P 67 2x38 G.H5 C 347 G.H5.23
Hydrophobic TM2 P 67 2x38 G.H5 C 347 G.H5.23
Van-der-waals TM2 P 67 2x38 G.H5 C 347 G.H5.23
Hydrophobic TM6 I 240 6x23 G.S6 H 318 G.S6.04
Polar TM6 S 243 6x26 G.S6 Y 316 G.S6.02
Hydrophobic TM6 S 243 6x26 G.S6 Y 316 G.S6.02
Van-der-waals TM6 S 243 6x26 G.S6 Y 316 G.S6.02
Hydrophobic TM6 R 239 6x22 G.S5 F 263 G.S5.05
Van-der-waals TM6 R 239 6x22 G.S5 F 263 G.S5.05
Hydrophobic ICL2 V 142 34x54 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 V 142 34x54 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 V 142 34x54 G.s2s3 K 188 G.s2s3.01
Hydrophobic H8 F 313 8x50 G.h4s6 D 311 G.h4s6.09
Van-der-waals H8 F 313 8x50 G.h4s6 D 311 G.h4s6.09
Polar TM4 K 145 4x38 G.HN E 24 G.HN.52
Hydrophobic TM4 K 145 4x38 G.HN E 24 G.HN.52
Van-der-waals TM4 K 145 4x38 G.HN E 24 G.HN.52
Polar TM6 R 239 6x22 G.S6 H 318 G.S6.04
Hydrophobic TM6 R 239 6x22 G.S6 H 318 G.S6.04
Van-der-waals TM6 R 239 6x22 G.S6 H 318 G.S6.04
Polar TM4 K 145 4x38 G.HN A 23 G.HN.51
Hydrophobic TM4 K 145 4x38 G.HN A 23 G.HN.51
Van-der-waals TM4 K 145 4x38 G.HN A 23 G.HN.51
Hydrophobic ICL2 L 138 34x50 G.H5 T 336 G.H5.12
Polar TM4 K 145 4x38 G.HN K 25 G.HN.53
Polar ICL2 S 139 34x51 G.s2s3 D 189 G.s2s3.02
Hydrophobic ICL2 S 139 34x51 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 S 139 34x51 G.s2s3 D 189 G.s2s3.02
Hydrophobic TM6 L 246 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 L 246 6x29 G.H5 F 350 G.H5.26
Hydrophobic TM3 K 134 3x53 G.H5 L 344 G.H5.20
Van-der-waals TM3 K 134 3x53 G.H5 L 344 G.H5.20
Hydrophobic TM6 I 240 6x23 G.H5 F 330 G.H5.06
Polar ICL3 D 237 - G.S6 H 318 G.S6.04
Hydrophobic ICL2 L 138 34x50 G.s2s3 K 188 G.s2s3.01
Van-der-waals ICL2 L 138 34x50 G.s2s3 K 188 G.s2s3.01
Ionic ICL1 R 66 12x51 G.H5 D 346 G.H5.22
Polar ICL1 R 66 12x51 G.H5 D 346 G.H5.22
Hydrophobic ICL1 R 66 12x51 G.H5 D 346 G.H5.22
Van-der-waals ICL1 R 66 12x51 G.H5 D 346 G.H5.22
Polar TM2 A 68 2x39 G.H5 G 348 G.H5.24
Hydrophobic TM2 A 68 2x39 G.H5 G 348 G.H5.24
Van-der-waals TM2 A 68 2x39 G.H5 G 348 G.H5.24
Hydrophobic TM3 V 127 3x46 G.H5 L 349 G.H5.25
Hydrophobic TM6 L 250 6x33 G.H5 F 350 G.H5.26
Van-der-waals TM6 L 250 6x33 G.H5 F 350 G.H5.26
Hydrophobic TM6 E 247 6x30 G.H5 L 344 G.H5.20
Van-der-waals TM6 E 247 6x30 G.H5 L 344 G.H5.20
Polar TM6 S 243 6x26 G.H5 I 338 G.H5.14
Hydrophobic TM6 S 243 6x26 G.H5 I 338 G.H5.14
Van-der-waals TM6 S 243 6x26 G.H5 I 338 G.H5.14
Hydrophobic TM6 K 249 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 I 240 6x23 G.H5 I 338 G.H5.14
Polar TM6 R 239 6x22 G.S5 L 262 G.S5.04
Hydrophobic TM6 R 239 6x22 G.S5 L 262 G.S5.04
Van-der-waals TM6 R 239 6x22 G.S5 L 262 G.S5.04
Hydrophobic TM3 R 131 3x50 G.H5 F 350 G.H5.26
Van-der-waals TM3 R 131 3x50 G.H5 F 350 G.H5.26