Gi1 - δ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 L 245 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 245 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 153 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 153 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 M 262 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 154 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 154 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 V 243 5x68 G.H5 D 341 G.H5.13
Polar TM2 T 84 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 84 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL3 R 244 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 244 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 V 154 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 L 240 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 R 239 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 239 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 153 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 343 G.H5.15
Polar TM2 T 84 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 84 2x39 G.H5 C 351 G.H5.23
Hydrophobic C-term E 355 - G.H3 W 258 G.H3.17
Van-der-waals C-term E 355 - G.H3 W 258 G.H3.17
Hydrophobic TM6 I 259 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 246 - G.H5 F 354 G.H5.26
Hydrophobic TM6 V 263 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 240 5x65 G.H5 L 348 G.H5.20
Polar ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Polar TM6 R 258 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 245 - G.H5 K 345 G.H5.17
Hydrophobic TM5 V 243 5x68 G.H5 I 344 G.H5.16
Aromatic TM6 R 258 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 258 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 258 6x32 G.H5 F 354 G.H5.26
Ionic ICL2 R 160 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 160 34x57 G.H5 D 350 G.H5.22
Polar TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 146 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 150 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 157 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL3 R 244 - G.S6 Y 320 G.S6.02
Hydrophobic TM2 T 82 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 82 2x37 G.H5 D 350 G.H5.22
Polar ICL3 R 244 - G.H5 D 341 G.H5.13
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 160 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 160 34x57 G.H5 N 347 G.H5.19
Ionic TM6 K 252 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 252 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 252 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 252 6x26 G.h4s6 E 318 G.h4s6.12
Polar ICL3 L 245 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 245 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 245 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 246 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 157 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 157 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM6 M 262 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 262 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 149 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 154 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 I 259 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 E 251 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 E 251 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 V 150 3x54 G.H5 I 344 G.H5.16
Ionic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 I 259 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 259 6x33 G.H5 L 353 G.H5.25