Gs - κ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 275 6x36 G.H5 L 393 G.H5.25
Hydrophobic C-term R 361 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term R 361 - G.h4s6 R 356 G.h4s6.12
Polar ICL2 R 170 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 170 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 170 34x57 G.H5 H 387 G.H5.19
Van-der-waals TM5 R 252 5x64 G.H5 Q 384 G.H5.16
Aromatic TM6 K 265 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 K 265 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 K 265 6x26 G.h4s6 Y 358 G.h4s6.20
Polar TM3 D 155 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 155 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 155 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 256 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 V 256 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL2 P 163 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 163 34x50 G.H5 H 387 G.H5.19
Polar ICL2 R 170 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 170 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 170 34x57 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 272 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 272 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 167 34x54 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 163 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 164 34x51 G.H5 R 380 G.H5.12
Polar TM3 A 159 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 159 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 159 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 V 276 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 166 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 A 166 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 163 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM6 K 265 6x26 G.H5 L 394 G.H5.26
Hydrophobic TM3 A 159 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 159 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 167 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM6 K 265 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 K 265 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 N 268 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 N 268 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 167 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 167 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 V 256 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 256 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM3 R 156 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM6 I 272 6x33 G.H5 L 388 G.H5.20
Polar H8 D 334 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 D 334 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 D 334 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 163 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 163 34x50 G.H5 Q 384 G.H5.16
Ionic C-term R 361 - G.h4s6 D 354 G.h4s6.10
Polar C-term R 361 - G.h4s6 D 354 G.h4s6.10
Van-der-waals C-term R 361 - G.h4s6 D 354 G.h4s6.10
Van-der-waals TM7 L 333 7x56 G.H5 E 392 G.H5.24
Polar ICL3 S 260 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 S 260 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 260 - G.H5 R 385 G.H5.17
Hydrophobic TM3 V 160 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 160 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 253 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 253 5x65 G.H5 L 388 G.H5.20
Polar H8 N 336 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM2 T 94 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 94 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 164 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 164 34x51 G.S3 V 217 G.S3.01
Polar H8 E 335 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 E 335 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 E 335 8x48 G.H5 E 392 G.H5.24
Polar TM3 V 160 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 160 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 160 3x54 G.H5 Q 384 G.H5.16
Polar TM3 R 156 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 156 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 156 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 272 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 269 6x30 G.H5 L 388 G.H5.20