G13 - μ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 K 102 12x51 G.HN F 4 G.HN.04
Hydrophobic ICL2 L 178 34x54 G.hns1 R 47 G.hns1.03
Polar TM2 T 105 2x39 G.H5 Q 373 G.H5.22
Hydrophobic ICL3 M 266 - G.H5 D 364 G.H5.13
Polar ICL2 P 174 34x50 G.H5 N 370 G.H5.19
Van-der-waals TM6 R 279 6x32 G.H5 Q 377 G.H5.26
Hydrophobic TM2 I 109 2x43 G.H5 M 375 G.H5.24
Van-der-waals TM2 I 109 2x43 G.H5 M 375 G.H5.24
Hydrophobic TM5 M 257 5x61 G.H5 L 376 G.H5.25
Van-der-waals TM5 M 257 5x61 G.H5 L 376 G.H5.25
Hydrophobic ICL3 M 266 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 M 266 - G.H5 H 368 G.H5.17
Hydrophobic TM5 R 260 5x64 G.H5 L 367 G.H5.16
Hydrophobic ICL3 M 266 - G.h4s6 P 341 G.h4s6.20
Van-der-waals ICL3 M 266 - G.h4s6 P 341 G.h4s6.20
Hydrophobic TM6 M 283 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 M 283 6x36 G.H5 M 375 G.H5.24
Hydrophobic H8 D 342 8x47 G.H5 M 375 G.H5.24
Van-der-waals H8 D 342 8x47 G.H5 M 375 G.H5.24
Polar ICL2 R 181 34x57 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 R 181 34x57 G.H5 Q 373 G.H5.22
Van-der-waals ICL2 R 181 34x57 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 P 174 34x50 G.H5 I 366 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 366 G.H5.15
Hydrophobic ICL2 V 175 34x51 G.H5 K 363 G.H5.12
Ionic ICL2 D 179 34x55 G.hns1 R 47 G.hns1.03
Polar ICL2 D 179 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 D 179 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 D 179 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM4 T 182 4x38 G.hns1 K 46 G.hns1.02
Hydrophobic TM3 A 170 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 170 3x53 G.H5 L 374 G.H5.23
Ionic TM5 R 260 5x64 G.H5 D 364 G.H5.13
Polar TM5 R 260 5x64 G.H5 D 364 G.H5.13
Van-der-waals TM5 R 260 5x64 G.H5 D 364 G.H5.13
Polar H8 N 344 8x49 G.H5 K 372 G.H5.21
Hydrophobic ICL3 L 267 - G.H5 L 371 G.H5.20
Hydrophobic ICL1 K 100 12x49 G.HN F 4 G.HN.04
Van-der-waals ICL1 K 100 12x49 G.HN F 4 G.HN.04
Hydrophobic TM5 V 264 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 V 264 5x68 G.H5 L 367 G.H5.16
Hydrophobic TM2 N 106 2x40 G.H5 M 375 G.H5.24
Van-der-waals TM2 N 106 2x40 G.H5 M 375 G.H5.24
Hydrophobic ICL3 M 266 - G.S6 Y 343 G.S6.02
Van-der-waals ICL3 M 266 - G.S6 Y 343 G.S6.02
Hydrophobic TM6 I 280 6x33 G.H5 L 376 G.H5.25
Van-der-waals TM6 I 280 6x33 G.H5 L 376 G.H5.25
Hydrophobic H8 E 343 8x48 G.H5 Q 377 G.H5.26
Hydrophobic C-term H 387 - G.s4h3 L 261 G.s4h3.13
Van-der-waals C-term H 387 - G.s4h3 L 261 G.s4h3.13
Hydrophobic TM6 I 280 6x33 G.H5 Q 377 G.H5.26
Hydrophobic TM3 V 171 3x54 G.H5 L 371 G.H5.20
Hydrophobic ICL2 V 175 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 V 175 34x51 G.S3 V 216 G.S3.01
Hydrophobic TM3 V 171 3x54 G.H5 L 374 G.H5.23
Hydrophobic ICL2 R 181 34x57 G.H5 L 374 G.H5.23
Hydrophobic ICL2 P 174 34x50 G.H5 L 367 G.H5.16
Ionic C-term D 374 - G.H3 R 279 G.H3.16
Polar C-term D 374 - G.H3 R 279 G.H3.16
Hydrophobic C-term D 374 - G.H3 R 279 G.H3.16
Van-der-waals C-term D 374 - G.H3 R 279 G.H3.16
Polar ICL2 R 181 34x57 G.H5 N 370 G.H5.19
Van-der-waals ICL2 R 181 34x57 G.H5 N 370 G.H5.19
Polar C-term Q 370 - G.H3 R 279 G.H3.16
Hydrophobic C-term Q 370 - G.H3 R 279 G.H3.16
Van-der-waals C-term Q 370 - G.H3 R 279 G.H3.16
Hydrophobic TM3 V 171 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 171 3x54 G.H5 L 367 G.H5.16
Hydrophobic TM6 M 283 6x36 G.H5 L 376 G.H5.25
Van-der-waals TM6 M 283 6x36 G.H5 L 376 G.H5.25
Polar TM3 A 170 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM1 Y 98 1x60 G.HN M 1 G.HN.01
Hydrophobic TM1 R 97 1x59 G.HN M 1 G.HN.01
Van-der-waals TM1 R 97 1x59 G.HN M 1 G.HN.01
Hydrophobic TM2 T 105 2x39 G.H5 M 375 G.H5.24
Hydrophobic TM5 L 261 5x65 G.H5 L 371 G.H5.20
Polar C-term N 371 - G.H3 R 279 G.H3.16
Hydrophobic C-term N 371 - G.H3 R 279 G.H3.16
Van-der-waals C-term N 371 - G.H3 R 279 G.H3.16
Hydrophobic ICL2 A 177 34x53 G.H5 N 370 G.H5.19
Hydrophobic TM5 V 264 5x68 G.H5 D 364 G.H5.13
Polar TM3 R 167 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 L 374 G.H5.23
Hydrophobic ICL2 L 178 34x54 G.H5 I 366 G.H5.15
Polar ICL1 K 100 12x49 G.HN M 1 G.HN.01
Van-der-waals ICL1 K 100 12x49 G.HN M 1 G.HN.01