Gq - OPN1SW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 240 6x29 G.H5 Q 350 G.H5.17
Hydrophobic TM5 L 224 5x65 G.H5 L 353 G.H5.20
Polar TM6 V 244 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 244 6x33 G.H5 L 358 G.H5.25
Polar TM5 Q 231 5x72 G.H5 A 342 G.H5.09
Van-der-waals TM5 Q 231 5x72 G.H5 A 342 G.H5.09
Hydrophobic TM6 A 240 6x29 G.H5 L 353 G.H5.20
Polar TM3 E 128 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 128 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 128 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 V 227 5x68 G.H5 K 345 G.H5.12
Hydrophobic TM6 A 240 6x29 G.H5 V 359 G.H5.26
Polar TM6 T 236 6x25 G.H5 Q 350 G.H5.17
Hydrophobic TM3 I 133 3x54 G.H5 L 349 G.H5.16
Polar TM6 T 237 6x26 G.H5 Q 350 G.H5.17
Polar TM3 V 132 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 V 132 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM6 E 243 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM3 V 132 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 V 132 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM5 L 220 5x61 G.H5 L 358 G.H5.25
Polar H8 N 304 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 304 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 304 8x47 G.H5 N 357 G.H5.24
Polar H8 K 305 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 K 305 8x48 G.H5 N 357 G.H5.24
Hydrophobic TM2 L 66 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 L 66 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM5 L 224 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM3 R 129 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 244 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 M 251 6x40 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 133 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 133 3x54 G.H5 L 358 G.H5.25
Polar TM6 T 237 6x26 G.H5 D 346 G.H5.13
Hydrophobic TM6 T 237 6x26 G.H5 D 346 G.H5.13
Van-der-waals TM6 T 237 6x26 G.H5 D 346 G.H5.13
Hydrophobic TM2 L 66 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 L 66 2x39 G.H5 Y 356 G.H5.23
Polar TM3 R 129 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 133 3x54 G.H5 N 352 G.H5.19
Hydrophobic TM5 Q 231 5x72 G.H5 D 346 G.H5.13
Van-der-waals TM5 Q 231 5x72 G.H5 D 346 G.H5.13
Polar TM6 S 234 6x23 G.H5 D 346 G.H5.13
Hydrophobic TM6 T 236 6x25 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM5 V 227 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM6 V 244 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM3 I 133 3x54 G.H5 L 353 G.H5.20
Polar H8 K 305 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 K 305 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 K 305 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM3 I 133 3x54 G.H5 Y 356 G.H5.23
Hydrophobic TM3 K 135 3x56 G.H5 I 348 G.H5.15