Gt1 - Olfactory receptor 1G1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM6 T 240 6x36 G.H5 F 350 G.H5.26
Polar ICL2 H 131 34x52 G.hns1 D 26 G.hns1.01
Hydrophobic ICL2 H 131 34x52 G.hns1 D 26 G.hns1.01
Van-der-waals ICL2 H 131 34x52 G.hns1 D 26 G.hns1.01
Polar H8 N 294 8x47 G.H5 G 348 G.H5.24
Hydrophobic TM2 M 59 2x39 G.H5 L 349 G.H5.25
Hydrophobic TM3 I 126 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 I 126 3x54 G.H5 L 344 G.H5.20
Hydrophobic TM6 K 236 6x32 G.H5 K 341 G.H5.17
Van-der-waals TM6 K 236 6x32 G.H5 K 341 G.H5.17
Polar ICL2 H 131 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 H 131 34x52 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 H 131 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic TM3 A 125 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 A 125 3x53 G.H5 C 347 G.H5.23
Polar TM2 Y 60 2x40 G.H5 G 348 G.H5.24
Hydrophobic TM2 Y 60 2x40 G.H5 G 348 G.H5.24
Hydrophobic ICL2 L 130 34x51 G.H5 I 339 G.H5.15
Van-der-waals ICL2 L 130 34x51 G.H5 I 339 G.H5.15
Hydrophobic ICL2 H 131 34x52 G.S3 L 190 G.S3.01
Van-der-waals ICL2 H 131 34x52 G.S3 L 190 G.S3.01
Hydrophobic ICL2 Y 132 34x53 G.H5 C 347 G.H5.23
Van-der-waals ICL2 Y 132 34x53 G.H5 C 347 G.H5.23
Aromatic TM6 K 236 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 K 236 6x32 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 F 350 G.H5.26
Hydrophobic ICL2 L 130 34x51 G.H5 N 343 G.H5.19
Van-der-waals ICL2 L 130 34x51 G.H5 N 343 G.H5.19
Hydrophobic ICL2 L 130 34x51 G.h2s4 T 215 G.h2s4.05
Hydrophobic ICL2 P 129 34x50 G.H5 L 344 G.H5.20
Hydrophobic ICL2 L 130 34x51 G.S1 V 30 G.S1.02
Van-der-waals ICL2 L 130 34x51 G.S1 V 30 G.S1.02
Hydrophobic TM3 C 122 3x50 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 130 34x51 G.H5 I 340 G.H5.16
Van-der-waals ICL2 L 130 34x51 G.H5 I 340 G.H5.16
Hydrophobic TM3 H 128 3x56 G.hns1 R 28 G.hns1.03
Hydrophobic H8 E 296 8x49 G.H5 F 350 G.H5.26
Van-der-waals H8 E 296 8x49 G.H5 F 350 G.H5.26
Polar ICL2 H 131 34x52 G.S1 V 30 G.S1.02
Hydrophobic ICL2 H 131 34x52 G.S1 V 30 G.S1.02
Polar ICL1 Q 54 12x49 G.h4s6 D 311 G.h4s6.09
Van-der-waals ICL1 Q 54 12x49 G.h4s6 D 311 G.h4s6.09
Hydrophobic TM2 M 59 2x39 G.H5 C 347 G.H5.23
Van-der-waals TM2 M 59 2x39 G.H5 C 347 G.H5.23
Hydrophobic ICL2 L 130 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 L 130 34x51 G.S3 L 190 G.S3.01
Polar ICL2 H 131 34x52 G.S1 T 29 G.S1.01
Hydrophobic ICL2 H 131 34x52 G.S1 T 29 G.S1.01
Van-der-waals ICL2 H 131 34x52 G.S1 T 29 G.S1.01
Hydrophobic TM3 I 126 3x54 G.H5 L 349 G.H5.25
Hydrophobic TM2 M 59 2x39 G.H5 G 348 G.H5.24
Van-der-waals TM2 M 59 2x39 G.H5 G 348 G.H5.24
Hydrophobic ICL2 L 134 34x55 G.hns1 D 26 G.hns1.01
Van-der-waals ICL2 L 134 34x55 G.hns1 D 26 G.hns1.01
Hydrophobic TM3 A 125 3x53 G.H5 L 344 G.H5.20
Van-der-waals TM3 A 125 3x53 G.H5 L 344 G.H5.20
Hydrophobic ICL2 P 129 34x50 G.H5 I 340 G.H5.16
Van-der-waals ICL2 P 129 34x50 G.H5 I 340 G.H5.16
Polar TM6 T 240 6x36 G.H5 L 349 G.H5.25
Hydrophobic TM6 T 240 6x36 G.H5 L 349 G.H5.25
Van-der-waals TM6 T 240 6x36 G.H5 L 349 G.H5.25
Hydrophobic TM3 A 125 3x53 G.H5 L 349 G.H5.25
Van-der-waals TM3 A 125 3x53 G.H5 L 349 G.H5.25
Polar ICL2 H 131 34x52 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 H 131 34x52 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 H 131 34x52 G.hns1 R 28 G.hns1.03
Polar ICL2 Y 132 34x53 G.H5 D 346 G.H5.22
Hydrophobic ICL2 Y 132 34x53 G.H5 D 346 G.H5.22
Van-der-waals ICL2 Y 132 34x53 G.H5 D 346 G.H5.22
Hydrophobic ICL2 I 133 34x54 G.H5 D 346 G.H5.22
Van-der-waals ICL2 I 133 34x54 G.H5 D 346 G.H5.22
Polar TM2 T 57 2x37 G.H5 D 346 G.H5.22
Hydrophobic TM2 T 57 2x37 G.H5 D 346 G.H5.22
Van-der-waals TM2 T 57 2x37 G.H5 D 346 G.H5.22
Polar ICL2 P 129 34x50 G.H5 N 343 G.H5.19
Hydrophobic ICL2 P 129 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 P 129 34x50 G.H5 N 343 G.H5.19
Hydrophobic ICL1 Q 54 12x49 G.h4s6 V 312 G.h4s6.10
Van-der-waals ICL1 Q 54 12x49 G.h4s6 V 312 G.h4s6.10
Hydrophobic ICL2 I 135 34x56 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 I 135 34x56 G.hns1 A 27 G.hns1.02
Polar TM2 T 57 2x37 G.H5 G 348 G.H5.24