G12 - P2Y6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 237 6x34 G.H5 I 378 G.H5.23
Hydrophobic H8 Q 305 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 M 240 6x37 G.H5 L 380 G.H5.25
Polar TM6 R 233 6x30 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 233 6x30 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 L 132 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 A 237 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 237 6x34 G.H5 L 375 G.H5.20
Polar H8 Q 305 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 Q 305 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 305 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.H5 K 367 G.H5.12
Polar H8 K 306 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 E 227 6x24 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 E 227 6x24 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 I 128 3x54 G.H5 L 375 G.H5.20
Polar TM6 E 227 6x24 G.S6 L 346 G.S6.01
Van-der-waals TM6 E 227 6x24 G.S6 L 346 G.S6.01
Hydrophobic TM3 I 128 3x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 132 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 K 236 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 128 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 A 237 6x34 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 132 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 132 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 R 234 6x31 G.H5 L 371 G.H5.16
Van-der-waals TM6 R 234 6x31 G.H5 L 371 G.H5.16
Hydrophobic TM3 R 124 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 124 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 215 5x61 G.H5 I 378 G.H5.23
Van-der-waals TM5 L 215 5x61 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 R 234 6x31 G.H5 L 375 G.H5.20
Polar TM5 D 223 5x69 G.H5 H 364 G.H5.09
Hydrophobic TM5 D 223 5x69 G.H5 H 364 G.H5.09
Van-der-waals TM5 D 223 5x69 G.H5 H 364 G.H5.09
Hydrophobic ICL3 G 224 - G.H5 H 364 G.H5.09
Hydrophobic TM3 R 124 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM7 T 304 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 T 304 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 128 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 128 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 R 233 6x30 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 131 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 131 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 R 233 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 233 6x30 G.H5 Q 372 G.H5.17
Polar TM2 T 61 2x39 G.H5 D 377 G.H5.22
Polar TM3 G 127 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 G 127 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 127 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 138 34x57 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 138 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 131 34x50 G.H5 K 367 G.H5.12
Polar TM3 R 124 3x50 G.H5 D 377 G.H5.22
Hydrophobic TM3 R 124 3x50 G.H5 D 377 G.H5.22
Van-der-waals TM3 R 124 3x50 G.H5 D 377 G.H5.22
Hydrophobic TM5 L 219 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 219 5x65 G.H5 L 375 G.H5.20
Polar H8 K 307 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 307 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 307 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 134 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 134 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic TM7 F 301 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 301 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 219 5x65 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 218 5x64 G.H5 K 367 G.H5.12
Ionic TM5 D 223 5x69 G.H5 K 367 G.H5.12
Polar TM5 D 223 5x69 G.H5 K 367 G.H5.12
Van-der-waals TM5 D 223 5x69 G.H5 K 367 G.H5.12
Hydrophobic TM6 R 233 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM7 L 300 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 300 7x52 G.H5 L 380 G.H5.25
Hydrophobic H8 K 306 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 306 8x48 G.H5 Q 381 G.H5.26
Polar TM6 A 230 6x27 G.H5 Q 372 G.H5.17
Hydrophobic TM6 A 230 6x27 G.H5 Q 372 G.H5.17
Van-der-waals TM6 A 230 6x27 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 132 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 132 34x51 G.S3 I 221 G.S3.01
Ionic TM6 R 234 6x31 G.H5 D 368 G.H5.13
Polar TM6 R 234 6x31 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 234 6x31 G.H5 D 368 G.H5.13
Hydrophobic TM6 M 240 6x37 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 240 6x37 G.H5 I 378 G.H5.23