G14 - PAC1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 H 182 12x51 G.HN K 30 G.HN.52
Van-der-waals ICL1 H 182 12x51 G.HN K 30 G.HN.52
Polar ICL2 T 258 - G.H5 K 341 G.H5.12
Hydrophobic ICL2 T 258 - G.H5 K 341 G.H5.12
Van-der-waals ICL2 T 258 - G.H5 K 341 G.H5.12
Hydrophobic ICL2 F 259 - G.H5 V 340 G.H5.11
Ionic TM2 R 185 2x46 G.H5 E 351 G.H5.22
Polar TM2 R 185 2x46 G.H5 E 351 G.H5.22
Hydrophobic TM2 R 185 2x46 G.H5 E 351 G.H5.22
Van-der-waals TM2 R 185 2x46 G.H5 E 351 G.H5.22
Ionic ICL2 E 262 - G.hns1 R 34 G.hns1.03
Polar ICL2 E 262 - G.hns1 R 34 G.hns1.03
Polar C-term S 454 - G.H2 H 214 G.H2.09
Hydrophobic C-term S 454 - G.H2 H 214 G.H2.09
Van-der-waals C-term S 454 - G.H2 H 214 G.H2.09
Polar ICL2 R 263 - G.HN K 30 G.HN.52
Hydrophobic ICL2 R 263 - G.HN K 30 G.HN.52
Van-der-waals ICL2 R 263 - G.HN K 30 G.HN.52
Hydrophobic C-term I 456 - G.S2 E 187 G.S2.03
Hydrophobic ICL3 D 339 - G.h4s6 V 319 G.h4s6.20
Polar TM3 L 254 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 254 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM2 H 189 2x50 G.H5 F 352 G.H5.23
Hydrophobic TM5 K 334 5x64 G.H5 L 349 G.H5.20
Aromatic TM2 R 185 2x46 G.H5 F 352 G.H5.23
Hydrophobic TM2 R 185 2x46 G.H5 F 352 G.H5.23
Van-der-waals TM2 R 185 2x46 G.H5 F 352 G.H5.23
Hydrophobic ICL2 F 259 - G.S3 I 195 G.S3.01
Van-der-waals ICL2 F 259 - G.S3 I 195 G.S3.01
Hydrophobic ICL2 F 259 - G.S1 L 36 G.S1.02
Van-der-waals ICL2 F 259 - G.S1 L 36 G.S1.02
Hydrophobic ICL2 F 259 - G.H5 K 341 G.H5.12
Hydrophobic TM3 L 255 3x58 G.H5 L 349 G.H5.20
Van-der-waals TM3 L 255 3x58 G.H5 L 349 G.H5.20
Polar C-term S 452 - G.H2 H 214 G.H2.09
Hydrophobic C-term S 452 - G.H2 H 214 G.H2.09
Van-der-waals C-term S 452 - G.H2 H 214 G.H2.09
Hydrophobic ICL2 F 259 - G.H5 F 337 G.H5.08
Hydrophobic TM5 L 331 5x61 G.H5 L 354 G.H5.25
Polar ICL2 R 263 - G.HN R 26 G.HN.48
Hydrophobic TM3 L 251 3x54 G.H5 F 352 G.H5.23
Ionic TM5 K 334 5x64 G.H5 D 342 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 342 G.H5.13
Polar TM6 S 354 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 354 6x41 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 354 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM3 L 255 3x58 G.H5 L 345 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 L 345 G.H5.16
Hydrophobic TM5 K 334 5x64 G.H5 L 345 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 L 345 G.H5.16
Hydrophobic TM3 L 254 3x57 G.H5 F 352 G.H5.23
Hydrophobic TM6 L 357 6x44 G.H5 N 353 G.H5.24
Van-der-waals TM6 L 357 6x44 G.H5 N 353 G.H5.24
Hydrophobic TM3 L 251 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 331 5x61 G.H5 L 349 G.H5.20
Hydrophobic ICL2 F 259 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 259 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 T 258 - G.H5 I 344 G.H5.15
Ionic ICL2 R 263 - G.HN D 31 G.HN.53
Polar ICL2 R 263 - G.HN D 31 G.HN.53
Hydrophobic ICL2 R 263 - G.HN D 31 G.HN.53
Van-der-waals ICL2 R 263 - G.HN D 31 G.HN.53
Polar TM3 V 256 3x59 G.H5 K 341 G.H5.12
Van-der-waals TM3 V 256 3x59 G.H5 K 341 G.H5.12
Hydrophobic ICL3 M 340 - G.H5 V 355 G.H5.26
Van-der-waals ICL3 M 340 - G.H5 V 355 G.H5.26
Hydrophobic TM5 L 331 5x61 G.H5 V 355 G.H5.26
Hydrophobic C-term L 461 - G.H1 R 56 G.H1.09
Van-der-waals C-term L 461 - G.H1 R 56 G.H1.09
Polar ICL2 T 258 - G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 T 258 - G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 T 258 - G.H5 L 345 G.H5.16
Hydrophobic TM3 Y 250 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM6 L 358 6x45 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 358 6x45 G.H5 L 354 G.H5.25
Polar ICL2 R 263 - G.HN R 27 G.HN.49
Hydrophobic ICL2 R 263 - G.HN R 27 G.HN.49
Van-der-waals ICL2 R 263 - G.HN R 27 G.HN.49
Hydrophobic TM3 L 255 3x58 G.H5 N 348 G.H5.19
Hydrophobic TM5 L 335 5x65 G.H5 V 355 G.H5.26