G11 - PAR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 M 265 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM5 M 265 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM6 K 281 6x30 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 281 6x30 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 269 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM3 V 176 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 V 176 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 M 181 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 R 173 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 173 3x50 G.H5 L 358 G.H5.25
Polar TM3 V 176 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 V 176 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 V 176 3x53 G.H5 N 352 G.H5.19
Polar ICL2 P 180 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 180 34x50 G.H5 N 352 G.H5.19
Hydrophobic TM3 I 177 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 177 3x54 G.H5 L 349 G.H5.16
Aromatic ICL2 H 183 34x53 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 H 183 34x53 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 H 183 34x53 G.hns1 R 38 G.hns1.03
Hydrophobic TM5 L 269 5x65 G.H5 L 358 G.H5.25
Hydrophobic ICL2 M 181 34x51 G.S3 I 199 G.S3.01
Van-der-waals ICL2 M 181 34x51 G.S3 I 199 G.S3.01
Polar TM3 R 173 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM2 A 110 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM7 F 346 7x55 G.H5 N 357 G.H5.24
Van-der-waals TM7 F 346 7x55 G.H5 N 357 G.H5.24
Hydrophobic ICL2 M 181 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 M 181 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM3 I 177 3x54 G.H5 L 358 G.H5.25
Polar H8 R 352 8x51 G.H5 N 357 G.H5.24
Hydrophobic H8 R 352 8x51 G.H5 N 357 G.H5.24
Van-der-waals H8 R 352 8x51 G.H5 N 357 G.H5.24
Polar TM6 R 284 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 R 284 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 R 284 6x33 G.H5 V 359 G.H5.26
Ionic TM2 H 108 2x37 G.H5 E 355 G.H5.22
Polar TM2 H 108 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 H 108 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 H 108 2x37 G.H5 E 355 G.H5.22
Hydrophobic ICL2 P 180 34x50 G.H5 I 348 G.H5.15
Polar TM7 V 347 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 V 347 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 V 347 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 177 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 180 34x50 G.H5 L 349 G.H5.16
Ionic ICL1 K 106 - G.H5 E 355 G.H5.22
Polar ICL1 K 106 - G.H5 E 355 G.H5.22
Hydrophobic ICL1 K 106 - G.H5 E 355 G.H5.22
Van-der-waals ICL1 K 106 - G.H5 E 355 G.H5.22
Hydrophobic H8 H 349 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 H 349 8x48 G.H5 N 357 G.H5.24
Hydrophobic ICL2 M 181 34x51 G.H5 K 345 G.H5.12
Polar TM3 R 173 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 173 3x50 G.H5 Y 356 G.H5.23
Polar TM2 H 108 2x37 G.H5 Y 356 G.H5.23
Aromatic TM2 H 108 2x37 G.H5 Y 356 G.H5.23
Hydrophobic TM2 H 108 2x37 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 180 34x50 G.H5 K 345 G.H5.12