G12 - EP1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 S 284 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 S 284 - G.h4s6 K 344 G.h4s6.19
Polar TM3 T 140 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM3 T 140 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 T 140 3x55 G.H5 K 367 G.H5.12
Ionic TM5 R 236 5x70 G.H5 D 368 G.H5.13
Polar TM5 R 236 5x70 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 236 5x70 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 236 5x70 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 143 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 143 34x51 G.H5 I 370 G.H5.15
Polar C-term W 386 - G.H3 K 284 G.H3.16
Aromatic C-term W 386 - G.H3 K 284 G.H3.16
Hydrophobic C-term W 386 - G.H3 K 284 G.H3.16
Van-der-waals C-term W 386 - G.H3 K 284 G.H3.16
Hydrophobic C-term L 391 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 L 143 34x51 G.S3 I 221 G.S3.01
Polar ICL2 H 145 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM2 L 74 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 74 2x40 G.H5 L 380 G.H5.25
Hydrophobic C-term W 386 - G.H3 N 282 G.H3.14
Van-der-waals C-term W 386 - G.H3 N 282 G.H3.14
Aromatic C-term F 402 - G.s4h3 R 266 G.s4h3.13
Hydrophobic C-term F 402 - G.s4h3 R 266 G.s4h3.13
Van-der-waals C-term F 402 - G.s4h3 R 266 G.s4h3.13
Hydrophobic TM6 H 291 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 H 291 6x29 G.H5 M 379 G.H5.24
Polar TM2 S 69 2x35 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 69 2x35 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 69 2x35 G.H5 D 377 G.H5.22
Hydrophobic TM6 H 291 6x29 G.H5 K 376 G.H5.21
Ionic TM2 R 67 2x33 G.H5 D 377 G.H5.22
Polar TM2 R 67 2x33 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 67 2x33 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 67 2x33 G.H5 D 377 G.H5.22
Polar TM6 E 294 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 E 294 6x32 G.H5 Q 381 G.H5.26
Polar C-term S 394 - G.H2 Q 234 G.H2.03
Van-der-waals C-term S 394 - G.H2 Q 234 G.H2.03
Hydrophobic ICL2 L 143 34x51 G.S1 V 58 G.S1.02
Hydrophobic H8 A 357 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 142 34x50 G.H5 I 370 G.H5.15
Polar TM2 A 70 2x36 G.H5 D 377 G.H5.22
Hydrophobic TM2 A 70 2x36 G.H5 D 377 G.H5.22
Van-der-waals TM2 A 70 2x36 G.H5 D 377 G.H5.22
Hydrophobic TM3 V 139 3x54 G.H5 L 375 G.H5.20
Polar TM2 S 69 2x35 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 142 34x50 G.H5 N 374 G.H5.19
Polar ICL3 S 284 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 S 284 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 S 284 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 P 142 34x50 G.H5 L 371 G.H5.16
Polar TM2 R 67 2x33 G.H5 Q 381 G.H5.26
Hydrophobic TM2 R 67 2x33 G.H5 Q 381 G.H5.26
Van-der-waals TM2 R 67 2x33 G.H5 Q 381 G.H5.26
Polar TM2 R 68 2x34 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 R 68 2x34 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 139 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 139 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 143 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 M 295 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 M 295 6x33 G.H5 L 375 G.H5.20
Polar ICL3 S 284 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 S 284 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 S 284 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 P 142 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 142 34x50 G.H5 K 367 G.H5.12
Polar H8 R 355 8x47 G.H5 I 378 G.H5.23
Hydrophobic H8 R 355 8x47 G.H5 I 378 G.H5.23
Van-der-waals H8 R 355 8x47 G.H5 I 378 G.H5.23
Hydrophobic TM6 M 295 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 295 6x33 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 143 34x51 G.H5 F 363 G.H5.08
Polar TM3 G 138 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 138 3x53 G.H5 N 374 G.H5.19
Polar TM6 H 291 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 H 291 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 H 291 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL1 L 64 12x50 G.H5 L 380 G.H5.25
Van-der-waals ICL1 L 64 12x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 229 5x63 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 229 5x63 G.H5 L 375 G.H5.20
Polar H8 R 355 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 R 355 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 R 355 8x47 G.H5 M 379 G.H5.24
Hydrophobic C-term W 386 - G.H3 N 283 G.H3.15
Hydrophobic TM2 F 73 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 73 2x39 G.H5 I 378 G.H5.23
Polar ICL3 S 281 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 S 281 - G.H4 D 336 G.H4.16
Van-der-waals H8 R 355 8x47 G.H5 L 380 G.H5.25
Polar TM5 R 236 5x70 G.H5 Q 372 G.H5.17
Hydrophobic TM5 R 236 5x70 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 236 5x70 G.H5 Q 372 G.H5.17
Polar C-term S 389 - G.H3 K 284 G.H3.16
Polar C-term S 390 - G.H3 K 284 G.H3.16
Hydrophobic C-term S 390 - G.H3 K 284 G.H3.16
Van-der-waals C-term S 390 - G.H3 K 284 G.H3.16
Polar TM6 D 292 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 D 292 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM2 F 73 2x39 G.H5 L 380 G.H5.25
Polar ICL2 A 147 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 147 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 147 34x55 G.hns1 R 56 G.hns1.03
Polar C-term S 400 - G.s4h3 R 266 G.s4h3.13
Van-der-waals C-term S 400 - G.s4h3 R 266 G.s4h3.13
Hydrophobic TM6 E 294 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 E 294 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 M 295 6x33 G.H5 M 379 G.H5.24
Polar TM5 R 239 5x73 G.H5 H 364 G.H5.09
Hydrophobic TM5 R 239 5x73 G.H5 H 364 G.H5.09
Polar C-term S 390 - G.H2 Q 236 G.H2.05