G12 - EP3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 162 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM5 R 259 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 259 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 S 167 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 167 34x55 G.hns1 R 56 G.hns1.03
Ionic ICL1 R 84 - G.H5 E 373 G.H5.18
Polar ICL1 R 84 - G.H5 E 373 G.H5.18
Hydrophobic ICL1 R 84 - G.H5 E 373 G.H5.18
Van-der-waals ICL1 R 84 - G.H5 E 373 G.H5.18
Hydrophobic TM2 K 85 2x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 155 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM6 Q 283 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 Q 283 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM2 F 88 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 88 2x39 G.H5 I 378 G.H5.23
Ionic TM5 K 263 5x72 G.H5 D 368 G.H5.13
Polar TM5 K 263 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 263 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 263 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM2 I 92 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 92 2x43 G.H5 L 380 G.H5.25
Polar ICL2 P 162 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 162 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM7 L 347 7x54 G.H5 L 380 G.H5.25
Polar TM3 A 158 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 L 256 5x65 G.H5 L 375 G.H5.20
Polar TM2 K 85 2x36 G.H5 K 376 G.H5.21
Hydrophobic TM2 K 85 2x36 G.H5 K 376 G.H5.21
Hydrophobic ICL2 Y 165 34x53 G.H5 I 378 G.H5.23
Van-der-waals ICL2 Y 165 34x53 G.H5 I 378 G.H5.23
Hydrophobic ICL3 Q 268 - G.S6 H 348 G.S6.03
Polar TM6 Q 272 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 W 273 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 W 273 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 T 280 6x33 G.H5 M 379 G.H5.24
Polar H8 R 350 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 R 350 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 R 350 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 H 163 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 H 163 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 H 163 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 163 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 I 159 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 159 3x54 G.H5 L 371 G.H5.16
Ionic ICL1 R 84 - G.H5 D 377 G.H5.22
Hydrophobic ICL1 R 84 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 R 84 - G.H5 D 377 G.H5.22
Hydrophobic TM2 L 89 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 159 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 159 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM4 K 170 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 A 166 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 W 273 6x26 G.H5 L 375 G.H5.20
Hydrophobic TM6 S 269 6x22 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 S 269 6x22 G.h4s6 P 345 G.h4s6.20
Ionic TM5 R 259 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 259 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 259 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 259 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 H 163 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 T 280 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 H 163 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 Y 165 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 W 273 6x26 G.H5 L 371 G.H5.16
Van-der-waals TM6 W 273 6x26 G.H5 L 371 G.H5.16
Hydrophobic TM3 R 155 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 162 34x50 G.H5 K 367 G.H5.12
Hydrophobic H8 R 350 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 350 8x47 G.H5 Q 381 G.H5.26
Polar TM2 K 85 2x36 G.H5 Q 381 G.H5.26
Van-der-waals TM2 K 85 2x36 G.H5 Q 381 G.H5.26
Polar TM5 R 259 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 259 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 259 5x68 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 162 34x50 G.H5 L 371 G.H5.16
Polar H8 R 350 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 R 350 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 R 350 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 158 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 158 3x53 G.H5 I 378 G.H5.23
Polar ICL3 S 267 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 S 267 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 S 267 - G.S6 H 348 G.S6.03
Hydrophobic TM2 K 85 2x36 G.H5 D 377 G.H5.22
Van-der-waals TM2 K 85 2x36 G.H5 D 377 G.H5.22
Hydrophobic TM2 F 88 2x39 G.H5 L 380 G.H5.25
Polar TM6 Q 272 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 Q 272 6x25 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 Q 272 6x25 G.h4s6 S 343 G.h4s6.12
Polar TM6 E 279 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 E 279 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 S 167 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 167 34x55 G.hns1 R 55 G.hns1.02
Polar ICL2 H 168 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 168 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 168 34x56 G.hns1 R 56 G.hns1.03