G11 - EP4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term T 394 - G.H3 T 257 G.H3.11
Polar TM3 R 117 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 117 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 Y 356 G.H5.23
Polar H8 T 335 8x49 G.H5 N 357 G.H5.24
Hydrophobic H8 T 335 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 T 335 8x49 G.H5 N 357 G.H5.24
Polar ICL2 Y 127 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 125 34x51 G.S3 I 199 G.S3.01
Van-der-waals ICL2 Y 125 34x51 G.S3 I 199 G.S3.01
Hydrophobic ICL2 A 124 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM6 I 263 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 I 263 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL3 H 228 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 H 228 - G.H4 V 314 G.H4.16
Polar ICL2 Y 127 34x53 G.H5 E 355 G.H5.22
Polar TM6 A 266 6x29 G.H5 N 357 G.H5.24
Van-der-waals TM6 A 266 6x29 G.H5 N 357 G.H5.24
Hydrophobic TM5 L 210 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 L 210 5x65 G.H5 L 353 G.H5.20
Polar C-term P 397 - G.H3 Y 261 G.H3.15
Hydrophobic H8 T 335 8x49 G.H5 V 359 G.H5.26
Van-der-waals H8 T 335 8x49 G.H5 V 359 G.H5.26
Hydrophobic C-term L 396 - G.H3 Y 261 G.H3.15
Van-der-waals C-term L 396 - G.H3 Y 261 G.H3.15
Hydrophobic TM2 T 52 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 52 2x37 G.H5 E 355 G.H5.22
Hydrophobic ICL3 R 256 - G.H4 V 314 G.H4.16
Polar ICL2 H 129 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 H 129 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 H 129 34x55 G.hns1 R 38 G.hns1.03
Polar TM6 Q 269 6x32 G.H5 N 357 G.H5.24
Van-der-waals TM6 Q 269 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM6 M 270 6x33 G.H5 Y 356 G.H5.23
Van-der-waals TM6 M 270 6x33 G.H5 Y 356 G.H5.23
Polar TM3 A 120 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 120 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 120 3x53 G.H5 N 352 G.H5.19
Hydrophobic C-term L 399 - G.H2 I 217 G.H2.08
Van-der-waals C-term L 399 - G.H2 I 217 G.H2.08
Hydrophobic ICL2 Y 125 34x51 G.S3 F 201 G.S3.03
Hydrophobic C-term L 396 - G.H2 R 213 G.H2.04
Hydrophobic TM5 M 213 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 M 213 5x68 G.H5 L 349 G.H5.16
Hydrophobic ICL2 Y 127 34x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 I 121 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 121 3x54 G.H5 L 353 G.H5.20
Polar ICL3 H 228 - G.H4 K 311 G.H4.13
Hydrophobic ICL3 H 228 - G.H4 K 311 G.H4.13
Van-der-waals ICL3 H 228 - G.H4 K 311 G.H4.13
Hydrophobic TM6 I 263 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 I 263 6x26 G.H5 Q 350 G.H5.17
Ionic ICL1 E 51 - G.HN K 33 G.HN.51
Polar ICL1 E 51 - G.HN K 33 G.HN.51
Van-der-waals ICL1 E 51 - G.HN K 33 G.HN.51
Aromatic TM2 F 54 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 F 54 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 F 54 2x39 G.H5 Y 356 G.H5.23
Polar ICL1 Q 49 - G.H5 V 359 G.H5.26
Van-der-waals ICL1 Q 49 - G.H5 V 359 G.H5.26
Polar ICL2 Y 125 34x51 G.H5 K 345 G.H5.12
Hydrophobic ICL2 Y 125 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 Y 125 34x51 G.H5 K 345 G.H5.12
Hydrophobic C-term L 396 - G.H3 T 257 G.H3.11
Van-der-waals C-term L 396 - G.H3 T 257 G.H3.11
Hydrophobic ICL3 F 260 - G.h4s6 I 323 G.h4s6.20
Hydrophobic TM3 I 121 3x54 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 125 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 Y 125 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM6 M 270 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM6 M 270 6x33 G.H5 L 353 G.H5.20
Ionic ICL3 H 228 - G.H4 D 315 G.H4.17
Polar ICL3 H 228 - G.H4 D 315 G.H4.17
Hydrophobic ICL3 H 228 - G.H4 D 315 G.H4.17
Van-der-waals ICL3 H 228 - G.H4 D 315 G.H4.17
Hydrophobic C-term L 396 - G.H3 I 258 G.H3.12
Polar ICL2 V 131 34x57 G.hns1 R 37 G.hns1.02
Polar TM6 R 262 6x25 G.h4s6 S 320 G.h4s6.11
Polar ICL1 Q 49 - G.H5 L 358 G.H5.25
Hydrophobic ICL1 Q 49 - G.H5 L 358 G.H5.25
Hydrophobic TM3 A 120 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 120 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 E 267 6x30 G.H5 L 353 G.H5.20
Hydrophobic ICL2 Y 125 34x51 G.H5 V 344 G.H5.11
Hydrophobic C-term L 396 - G.H3 L 254 G.H3.08
Hydrophobic TM3 I 121 3x54 G.H5 L 349 G.H5.16
Polar ICL3 S 259 - G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL3 S 259 - G.h4s6 S 320 G.h4s6.11
Van-der-waals ICL3 S 259 - G.h4s6 S 320 G.h4s6.11
Polar C-term S 392 - G.s4h3 E 245 G.s4h3.14
Hydrophobic C-term S 392 - G.s4h3 E 245 G.s4h3.14
Van-der-waals C-term S 392 - G.s4h3 E 245 G.s4h3.14
Polar ICL3 R 256 - G.S6 I 324 G.S6.01
Van-der-waals ICL3 R 256 - G.S6 I 324 G.S6.01
Hydrophobic C-term L 396 - G.H2 W 216 G.H2.07
Polar ICL3 R 256 - G.S6 S 326 G.S6.03
Hydrophobic ICL3 R 256 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 R 256 - G.S6 S 326 G.S6.03
Polar ICL3 R 255 - G.h4s6 N 317 G.h4s6.08
Van-der-waals ICL3 R 255 - G.h4s6 N 317 G.h4s6.08
Hydrophobic C-term T 394 - G.H3 E 250 G.H3.04
Hydrophobic H8 R 333 8x47 G.H5 L 358 G.H5.25
Van-der-waals H8 R 333 8x47 G.H5 L 358 G.H5.25
Polar ICL2 Y 125 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 Y 125 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 Y 125 34x51 G.H5 F 341 G.H5.08
Polar ICL3 R 255 - G.H4 D 315 G.H4.17
Van-der-waals ICL3 R 255 - G.H4 D 315 G.H4.17
Polar H8 R 333 8x47 G.H5 Y 356 G.H5.23
Van-der-waals H8 R 333 8x47 G.H5 Y 356 G.H5.23
Ionic TM4 D 132 4x38 G.HN R 34 G.HN.52
Polar TM4 D 132 4x38 G.HN R 34 G.HN.52
Hydrophobic TM4 D 132 4x38 G.HN R 34 G.HN.52
Van-der-waals TM4 D 132 4x38 G.HN R 34 G.HN.52
Hydrophobic H8 R 333 8x47 G.H5 N 357 G.H5.24
Ionic TM6 R 262 6x25 G.h4s6 D 321 G.h4s6.12
Polar TM6 R 262 6x25 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 R 262 6x25 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 R 262 6x25 G.h4s6 D 321 G.h4s6.12
Hydrophobic C-term T 394 - G.H3 A 253 G.H3.07
Polar TM3 E 116 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 116 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 116 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 125 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 Y 125 34x51 G.S1 L 40 G.S1.02
Hydrophobic ICL2 S 128 34x54 G.H5 I 348 G.H5.15
Polar H8 T 335 8x49 G.H5 L 358 G.H5.25
Hydrophobic H8 T 335 8x49 G.H5 L 358 G.H5.25
Van-der-waals H8 T 335 8x49 G.H5 L 358 G.H5.25
Hydrophobic C-term T 394 - G.H3 L 254 G.H3.08