Gi2 - RXFP3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term Y 455 - G.H2 S 207 G.H2.02
Van-der-waals C-term Y 455 - G.H2 S 207 G.H2.02
Hydrophobic TM6 A 316 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 A 316 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals C-term G 451 - G.H2 E 208 G.H2.03
Hydrophobic TM3 R 180 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 180 3x50 G.H5 L 354 G.H5.25
Polar ICL2 S 190 - G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 S 190 - G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 S 190 - G.s2s3 D 194 G.s2s3.02
Polar C-term V 452 - G.hfs2 T 183 G.hfs2.06
Hydrophobic C-term V 452 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term V 452 - G.hfs2 T 183 G.hfs2.06
Hydrophobic TM5 R 297 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 297 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM5 F 293 5x64 G.H5 I 345 G.H5.16
Ionic H8 K 398 8x52 G.h3s5 D 262 G.h3s5.02
Hydrophobic ICL2 S 205 - G.HN K 21 G.HN.45
Polar C-term G 451 - G.hfs2 T 183 G.hfs2.06
Hydrophobic C-term G 451 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term G 451 - G.hfs2 T 183 G.hfs2.06
Hydrophobic ICL2 K 189 - G.s2s3 D 194 G.s2s3.02
Hydrophobic TM2 I 117 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 I 117 2x39 G.H5 C 352 G.H5.23
Ionic H8 R 394 8x48 G.h3s5 D 262 G.h3s5.02
Hydrophobic TM6 A 316 6x25 G.S6 Y 321 G.S6.02
Polar TM3 S 183 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 S 183 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 S 183 3x53 G.H5 C 352 G.H5.23
Polar C-term G 451 - G.hfs2 G 184 G.hfs2.07
Hydrophobic C-term G 451 - G.hfs2 G 184 G.hfs2.07
Van-der-waals C-term G 451 - G.hfs2 G 184 G.hfs2.07
Hydrophobic ICL2 L 188 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 188 - G.S3 L 195 G.S3.01
Hydrophobic H8 R 393 8x47 G.H5 C 352 G.H5.23
Polar ICL2 H 191 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 191 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 191 - G.hns1 R 32 G.hns1.03
Polar ICL2 G 207 - G.HN E 28 G.HN.52
Hydrophobic ICL2 G 207 - G.HN E 28 G.HN.52
Van-der-waals ICL2 G 207 - G.HN E 28 G.HN.52
Polar C-term V 452 - G.H2 K 211 G.H2.06
Van-der-waals C-term V 452 - G.H2 K 211 G.H2.06
Polar TM4 C 211 4x39 G.HN R 24 G.HN.48
Hydrophobic TM4 C 211 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 C 211 4x39 G.HN R 24 G.HN.48
Hydrophobic TM6 K 323 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 323 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 V 324 6x33 G.H5 F 355 G.H5.26
Hydrophobic ICL2 A 187 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 A 187 - G.H5 N 348 G.H5.19
Ionic TM6 R 320 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 S 327 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 327 6x36 G.H5 L 354 G.H5.25
Hydrophobic C-term V 453 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term V 453 - G.hfs2 T 183 G.hfs2.06
Polar C-term V 454 - G.H2 E 208 G.H2.03
Polar C-term V 453 - G.H2 E 208 G.H2.03
Hydrophobic C-term V 453 - G.H2 E 208 G.H2.03
Van-der-waals C-term V 453 - G.H2 E 208 G.H2.03
Polar TM3 R 180 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 180 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 180 3x50 G.H5 C 352 G.H5.23
Hydrophobic H8 R 393 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 R 393 8x47 G.H5 G 353 G.H5.24
Polar H8 R 394 8x48 G.h4s6 T 317 G.h4s6.10
Hydrophobic H8 R 394 8x48 G.h4s6 T 317 G.h4s6.10
Van-der-waals H8 R 394 8x48 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM3 V 184 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 184 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 A 187 - G.H5 I 344 G.H5.15
Hydrophobic TM5 Y 287 5x58 G.H5 L 354 G.H5.25
Hydrophobic TM6 R 320 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 R 320 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM3 V 184 3x54 G.H5 N 348 G.H5.19
Ionic ICL2 D 208 - G.HN R 24 G.HN.48
Polar ICL2 D 208 - G.HN R 24 G.HN.48
Hydrophobic ICL2 D 208 - G.HN R 24 G.HN.48
Van-der-waals ICL2 D 208 - G.HN R 24 G.HN.48
Polar C-term Y 455 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic C-term Y 455 - G.s3h2 Q 205 G.s3h2.03
Van-der-waals C-term Y 455 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic TM6 V 328 6x37 G.H5 L 354 G.H5.25
Polar C-term Y 455 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term Y 455 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term Y 455 - G.hfs2 K 181 G.hfs2.04
Hydrophobic ICL2 L 188 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 188 - G.H5 T 341 G.H5.12
Ionic TM6 R 320 6x29 G.H5 D 342 G.H5.13
Polar TM6 R 320 6x29 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 320 6x29 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 320 6x29 G.H5 D 342 G.H5.13
Polar C-term P 450 - G.hfs2 T 183 G.hfs2.06
Hydrophobic C-term P 450 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term P 450 - G.hfs2 T 183 G.hfs2.06
Hydrophobic TM3 V 184 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM6 R 320 6x29 G.H5 I 345 G.H5.16
Van-der-waals TM6 R 320 6x29 G.H5 I 345 G.H5.16
Hydrophobic C-term V 453 - G.s3h2 Q 205 G.s3h2.03
Van-der-waals C-term V 453 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic TM5 R 297 5x68 G.H5 T 341 G.H5.12
Van-der-waals TM5 R 297 5x68 G.H5 T 341 G.H5.12
Hydrophobic TM6 R 320 6x29 G.H5 K 346 G.H5.17
Van-der-waals TM6 R 320 6x29 G.H5 K 346 G.H5.17
Polar TM6 K 323 6x32 G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL3 G 311 - G.H4 Q 305 G.H4.12
Polar ICL2 D 208 - G.HN E 28 G.HN.52
Hydrophobic TM5 L 290 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 L 290 5x61 G.H5 L 354 G.H5.25
Hydrophobic C-term V 453 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term V 453 - G.hfs2 K 181 G.hfs2.04
Hydrophobic TM5 G 305 5x76 G.H5 F 335 G.H5.06
Polar H8 R 393 8x47 G.H5 D 351 G.H5.22
Van-der-waals ICL2 L 188 - G.s2s3 K 193 G.s2s3.01
Hydrophobic TM5 V 308 5x79 G.H4 Y 297 G.H4.03
Polar TM3 R 180 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM6 V 324 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 V 324 6x33 G.H5 L 349 G.H5.20
Aromatic TM6 R 320 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 320 6x29 G.H5 F 355 G.H5.26
Hydrophobic C-term V 453 - G.H2 S 207 G.H2.02
Van-der-waals C-term V 453 - G.H2 S 207 G.H2.02
Hydrophobic TM5 I 294 5x65 G.H5 L 349 G.H5.20
Polar TM6 R 320 6x29 G.S6 Y 321 G.S6.02
Van-der-waals TM6 R 320 6x29 G.S6 Y 321 G.S6.02
Polar ICL2 S 205 - G.HN E 25 G.HN.49
Hydrophobic C-term V 452 - G.H2 E 208 G.H2.03
Van-der-waals C-term V 452 - G.H2 E 208 G.H2.03
Polar C-term G 451 - G.H2 K 211 G.H2.06
Van-der-waals C-term G 451 - G.H2 K 211 G.H2.06
Hydrophobic C-term V 454 - G.H2 S 207 G.H2.02
Van-der-waals C-term V 454 - G.H2 S 207 G.H2.02