G13 - RXFP4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ECL1 H 106 23x49 G.HN K 42 G.HN.51
Polar ECL2 C 186 - G.h2s4 T 241 G.h2s4.05
Hydrophobic ECL2 C 186 - G.h2s4 T 241 G.h2s4.05
Van-der-waals ECL2 C 186 - G.h2s4 T 241 G.h2s4.05
Hydrophobic ECL2 L 190 - G.H5 L 374 G.H5.23
Van-der-waals ECL2 L 190 - G.H5 L 374 G.H5.23
Hydrophobic N-term F 14 - G.H4 R 320 G.H4.05
Van-der-waals N-term F 14 - G.H4 R 320 G.H4.05
Hydrophobic ECL2 V 188 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 V 188 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL3 W 279 - G.H5 M 375 G.H5.24
Polar ECL3 W 279 - G.H5 H 368 G.H5.17
Aromatic ECL3 W 279 - G.H5 H 368 G.H5.17
Hydrophobic ECL3 W 279 - G.H5 H 368 G.H5.17
Van-der-waals ECL3 W 279 - G.H5 H 368 G.H5.17
Hydrophobic TM2 D 104 2x67 G.HN T 43 G.HN.52
Van-der-waals TM2 D 104 2x67 G.HN T 43 G.HN.52
Hydrophobic ECL1 F 105 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL1 F 105 - G.hns1 R 47 G.hns1.03
Polar ECL2 C 186 - G.S1 L 48 G.S1.01
Hydrophobic ECL2 C 186 - G.S1 L 48 G.S1.01
Van-der-waals ECL2 C 186 - G.S1 L 48 G.S1.01
Hydrophobic N-term V 23 - G.H5 R 360 G.H5.09
Van-der-waals N-term V 23 - G.H5 R 360 G.H5.09
Hydrophobic N-term P 32 - G.s2s3 K 214 G.s2s3.01
Polar N-term S 25 - G.s2s3 K 214 G.s2s3.01
Polar N-term A 29 - G.s2s3 K 214 G.s2s3.01
Hydrophobic N-term A 29 - G.s2s3 K 214 G.s2s3.01
Van-der-waals N-term A 29 - G.s2s3 K 214 G.s2s3.01
Hydrophobic N-term L 24 - G.H5 R 360 G.H5.09
Van-der-waals N-term L 24 - G.H5 R 360 G.H5.09
Hydrophobic TM1 F 35 1x28 G.hns1 R 47 G.hns1.03
Van-der-waals TM1 F 35 1x28 G.hns1 R 47 G.hns1.03
Hydrophobic TM6 K 273 6x62 G.H5 L 376 G.H5.25
Van-der-waals TM6 K 273 6x62 G.H5 L 376 G.H5.25
Hydrophobic ECL2 L 193 45x52 G.H5 Q 377 G.H5.26
Van-der-waals ECL2 L 193 45x52 G.H5 Q 377 G.H5.26
Hydrophobic TM7 Q 287 7x30 G.H5 M 375 G.H5.24
Van-der-waals TM7 Q 287 7x30 G.H5 M 375 G.H5.24
Polar TM6 K 273 6x62 G.H5 M 375 G.H5.24
Hydrophobic TM6 K 273 6x62 G.H5 M 375 G.H5.24
Van-der-waals TM6 K 273 6x62 G.H5 M 375 G.H5.24
Hydrophobic TM5 L 201 5x36 G.H5 L 376 G.H5.25
Van-der-waals TM5 L 201 5x36 G.H5 L 376 G.H5.25
Hydrophobic TM5 L 201 5x36 G.H5 Q 377 G.H5.26
Van-der-waals TM5 L 201 5x36 G.H5 Q 377 G.H5.26
Polar ECL1 H 106 23x49 G.hns1 K 46 G.hns1.02
Hydrophobic ECL1 H 106 23x49 G.hns1 K 46 G.hns1.02
Van-der-waals ECL1 H 106 23x49 G.hns1 K 46 G.hns1.02
Hydrophobic TM5 L 201 5x36 G.H5 M 375 G.H5.24
Polar ECL2 R 189 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 R 189 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 R 189 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 R 194 - G.H5 Q 377 G.H5.26
Van-der-waals ECL2 R 194 - G.H5 Q 377 G.H5.26
Hydrophobic TM7 Y 284 7x27 G.H5 L 371 G.H5.20
Van-der-waals TM7 Y 284 7x27 G.H5 L 371 G.H5.20
Hydrophobic N-term L 24 - G.H5 D 364 G.H5.13
Van-der-waals N-term L 24 - G.H5 D 364 G.H5.13
Polar N-term P 32 - G.s2s3 N 215 G.s2s3.02
Hydrophobic N-term P 32 - G.s2s3 N 215 G.s2s3.02
Van-der-waals N-term P 32 - G.s2s3 N 215 G.s2s3.02
Ionic TM2 D 104 2x67 G.hns1 R 47 G.hns1.03
Polar TM2 D 104 2x67 G.hns1 R 47 G.hns1.03
Hydrophobic TM2 D 104 2x67 G.hns1 R 47 G.hns1.03
Van-der-waals TM2 D 104 2x67 G.hns1 R 47 G.hns1.03
Polar N-term A 26 - G.s2s3 K 214 G.s2s3.01
Hydrophobic N-term A 26 - G.s2s3 K 214 G.s2s3.01
Van-der-waals N-term A 26 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ECL2 C 186 - G.hns1 V 45 G.hns1.01
Hydrophobic TM2 L 103 2x66 G.HN T 43 G.HN.52
Van-der-waals TM2 L 103 2x66 G.HN T 43 G.HN.52
Hydrophobic ECL2 G 187 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 G 187 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 R 198 - G.H5 L 376 G.H5.25
Hydrophobic ECL2 L 192 45x51 G.H5 L 374 G.H5.23
Hydrophobic ECL3 W 279 - G.H5 K 372 G.H5.21
Van-der-waals ECL3 W 279 - G.H5 K 372 G.H5.21
Hydrophobic ECL1 H 106 23x49 G.HN T 43 G.HN.52
Van-der-waals ECL1 H 106 23x49 G.HN T 43 G.HN.52
Hydrophobic ECL2 L 192 45x51 G.H5 Q 377 G.H5.26
Polar ECL2 C 186 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 C 186 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 C 186 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL3 W 279 - G.H5 L 371 G.H5.20
Van-der-waals ECL3 W 279 - G.H5 L 371 G.H5.20