Gq - RXFP1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 522 34x55 G.H5 N 352 G.H5.19
Van-der-waals ICL2 R 522 34x55 G.H5 N 352 G.H5.19
Hydrophobic ICL2 F 518 34x51 G.H5 V 344 G.H5.11
Polar TM2 Y 440 2x39 G.H5 Y 356 G.H5.23
Aromatic TM2 Y 440 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 Y 440 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 Y 440 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 F 518 34x51 G.s2s3 S 198 G.s2s3.02
Hydrophobic H8 P 687 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 P 687 8x49 G.H5 N 357 G.H5.24
Polar ICL1 N 437 12x51 G.H5 E 355 G.H5.22
Hydrophobic ICL1 N 437 12x51 G.H5 E 355 G.H5.22
Van-der-waals ICL1 N 437 12x51 G.H5 E 355 G.H5.22
Hydrophobic TM6 I 616 6x23 G.S6 Y 325 G.S6.02
Van-der-waals TM6 I 616 6x23 G.S6 Y 325 G.S6.02
Polar TM6 R 629 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM6 R 629 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 R 629 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 518 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM5 S 609 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM6 K 622 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM6 L 626 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM6 L 626 6x33 G.H5 L 353 G.H5.20
Ionic TM6 K 622 6x29 G.h4s6 D 321 G.h4s6.12
Polar TM6 K 622 6x29 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 K 622 6x29 G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL2 P 517 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 517 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM6 I 616 6x23 G.H5 A 342 G.H5.09
Hydrophobic TM6 I 616 6x23 G.H5 F 339 G.H5.06
Van-der-waals TM6 I 616 6x23 G.H5 F 339 G.H5.06
Hydrophobic C-term M 722 - G.H3 Y 261 G.H3.15
Hydrophobic TM3 I 514 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 514 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 F 518 34x51 G.H5 I 348 G.H5.15
Aromatic ICL2 F 518 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 F 518 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 F 518 34x51 G.H5 F 341 G.H5.08
Polar ICL2 R 522 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 522 34x55 G.hns1 R 37 G.hns1.02
Polar TM6 I 616 6x23 G.S6 S 326 G.S6.03
Polar TM6 R 629 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 R 629 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 R 629 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM5 V 606 5x65 G.H5 L 349 G.H5.16
Hydrophobic H8 T 685 8x47 G.H5 N 357 G.H5.24
Polar ICL1 E 436 12x50 G.H5 N 357 G.H5.24
Hydrophobic ICL1 E 436 12x50 G.H5 N 357 G.H5.24
Van-der-waals ICL1 E 436 12x50 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 626 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 518 34x51 G.S3 V 199 G.S3.01
Polar TM3 E 509 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 509 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 509 3x49 G.H5 Y 356 G.H5.23
Ionic ICL2 R 522 34x55 G.H5 E 355 G.H5.22
Polar ICL2 R 522 34x55 G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 522 34x55 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 522 34x55 G.H5 E 355 G.H5.22
Hydrophobic TM6 R 617 6x24 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 R 617 6x24 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM3 K 510 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 K 510 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM5 A 613 5x72 G.H5 D 346 G.H5.13
Hydrophobic TM3 I 514 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 514 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 518 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 F 518 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM6 L 626 6x33 G.H5 V 359 G.H5.26
Hydrophobic C-term W 723 - G.H2 R 214 G.H2.05
Hydrophobic H8 R 686 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM6 F 630 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 514 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 514 3x54 G.H5 L 349 G.H5.16
Ionic H8 R 686 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 R 686 8x48 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 R 686 8x48 G.h4s6 D 321 G.h4s6.12
Polar TM6 Q 619 6x26 G.h4s6 S 320 G.h4s6.11
Polar TM3 C 513 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 C 513 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 C 513 3x53 G.H5 Y 356 G.H5.23
Polar TM3 C 513 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 C 513 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 C 513 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 F 518 34x51 G.S3 F 201 G.S3.03
Hydrophobic ICL2 P 517 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 517 34x50 G.H5 K 345 G.H5.12