Gs - S1P2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 130 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM5 Y 209 5x58 G.H5 L 393 G.H5.25
Hydrophobic TM2 M 68 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 68 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 139 34x52 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 139 34x52 G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 139 34x52 G.h2s4 T 242 G.h2s4.05
Hydrophobic TM3 I 134 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 134 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 V 216 5x65 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 216 5x65 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 M 223 - G.S6 P 361 G.S6.03
Hydrophobic ICL2 L 139 34x52 G.S1 T 40 G.S1.01
Polar H8 S 292 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 292 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 292 8x47 G.H5 E 392 G.H5.24
Ionic ICL3 H 220 - G.H5 D 381 G.H5.13
Polar ICL3 H 220 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 H 220 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 H 220 - G.H5 D 381 G.H5.13
Polar TM2 S 66 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 V 137 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 137 34x50 G.H5 R 380 G.H5.12
Polar ICL2 Y 140 34x53 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 140 34x53 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 140 34x53 G.hns1 R 38 G.hns1.02
Polar TM4 K 144 4x38 G.H5 H 387 G.H5.19
Van-der-waals TM4 K 144 4x38 G.H5 H 387 G.H5.19
Hydrophobic TM6 A 230 6x32 G.H5 L 394 G.H5.26
Polar TM3 R 130 3x50 G.H5 E 392 G.H5.24
Polar TM6 Q 227 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 Q 227 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 Q 227 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM7 R 291 7x56 G.H5 L 394 G.H5.26
Van-der-waals TM7 R 291 7x56 G.H5 L 394 G.H5.26
Polar TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Polar TM5 V 215 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 215 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 134 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 134 3x54 G.H5 L 393 G.H5.25
Polar ICL2 S 142 34x55 G.HN Q 35 G.HN.52
Hydrophobic ICL2 S 142 34x55 G.HN Q 35 G.HN.52
Van-der-waals ICL2 S 142 34x55 G.HN Q 35 G.HN.52
Hydrophobic ICL2 V 137 34x50 G.H5 I 383 G.H5.15
Polar TM2 Y 69 2x40 G.H5 E 392 G.H5.24
Polar ICL3 H 220 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 H 220 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 H 220 - G.H5 R 385 G.H5.17
Hydrophobic TM5 V 216 5x65 G.H5 L 388 G.H5.20
Polar ICL2 L 139 34x52 G.H5 H 387 G.H5.19
Hydrophobic ICL2 K 138 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM2 L 72 2x43 G.H5 E 392 G.H5.24
Polar TM5 S 219 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 S 219 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 S 219 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM7 R 291 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 291 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 139 34x52 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 139 34x52 G.S1 H 41 G.S1.02
Hydrophobic ICL2 V 137 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM6 A 224 6x26 G.H5 R 385 G.H5.17
Polar TM3 E 129 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 129 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 129 3x49 G.H5 Y 391 G.H5.23
Polar ICL2 K 138 34x51 G.H5 H 387 G.H5.19
Hydrophobic ICL2 K 138 34x51 G.H5 H 387 G.H5.19
Van-der-waals ICL2 K 138 34x51 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 212 5x61 G.H5 L 393 G.H5.25
Polar ICL3 H 220 - G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 231 6x33 G.H5 L 388 G.H5.20
Polar TM6 T 234 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 234 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 234 6x36 G.H5 L 393 G.H5.25
Polar TM6 L 231 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 231 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 231 6x33 G.H5 L 393 G.H5.25
Van-der-waals ICL2 L 139 34x52 G.hns1 R 38 G.hns1.02
Polar TM7 R 291 7x56 G.H5 L 393 G.H5.25
Polar TM6 Q 227 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM6 Q 227 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 Q 227 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM6 Q 227 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 Q 227 6x29 G.H5 L 394 G.H5.26
Polar TM3 A 133 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 133 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 134 3x54 G.H5 Q 384 G.H5.16