Go - secretin receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 E 251 4x39 G.HN K 21 G.HN.45
Van-der-waals TM4 E 251 4x39 G.HN K 21 G.HN.45
Polar TM5 T 326 5x67 G.S1 D 33 G.S1.01
Hydrophobic TM5 T 326 5x67 G.S1 D 33 G.S1.01
Van-der-waals TM5 T 326 5x67 G.S1 D 33 G.S1.01
Hydrophobic TM5 I 316 5x57 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 316 5x57 G.H5 L 353 G.H5.25
Hydrophobic TM5 K 323 5x64 G.H5 N 347 G.H5.19
Van-der-waals TM5 K 323 5x64 G.H5 N 347 G.H5.19
Polar TM5 K 323 5x64 G.HN I 28 G.HN.52
Van-der-waals TM5 K 323 5x64 G.HN I 28 G.HN.52
Polar TM2 T 173 2x45 G.HN K 17 G.HN.41
Van-der-waals TM2 T 173 2x45 G.HN K 17 G.HN.41
Hydrophobic C-term N 421 - G.h4s6 R 313 G.h4s6.03
Van-der-waals C-term N 421 - G.h4s6 R 313 G.h4s6.03
Hydrophobic C-term A 425 - G.H3 F 259 G.H3.17
Van-der-waals C-term A 425 - G.H3 F 259 G.H3.17
Polar ICL3 Q 327 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL3 Q 327 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL3 Q 327 - G.hns1 K 32 G.hns1.03
Hydrophobic TM3 L 244 3x58 G.H5 N 347 G.H5.19
Polar ICL2 F 249 - G.HN K 21 G.HN.45
Aromatic ICL2 F 249 - G.HN K 21 G.HN.45
Hydrophobic ICL2 F 249 - G.HN K 21 G.HN.45
Van-der-waals ICL2 F 249 - G.HN K 21 G.HN.45
Polar C-term F 419 - G.h4s6 P 315 G.h4s6.09
Hydrophobic C-term F 419 - G.h4s6 P 315 G.h4s6.09
Van-der-waals C-term F 419 - G.h4s6 P 315 G.h4s6.09
Polar TM5 T 326 5x67 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 T 326 5x67 G.hns1 K 32 G.hns1.03
Van-der-waals TM5 T 326 5x67 G.hns1 K 32 G.hns1.03
Polar ICL3 E 328 - G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL3 E 328 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL3 E 328 - G.s2s3 N 194 G.s2s3.02
Hydrophobic C-term S 422 - G.h4s6 K 317 G.h4s6.11
Hydrophobic TM5 L 320 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 L 320 5x61 G.H5 L 353 G.H5.25
Ionic TM4 R 252 4x40 G.HN E 14 G.HN.38
Hydrophobic TM4 R 252 4x40 G.HN E 14 G.HN.38
Van-der-waals TM4 R 252 4x40 G.HN E 14 G.HN.38
Hydrophobic ICL2 F 248 - G.HN G 27 G.HN.51
Hydrophobic TM5 R 325 5x66 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 L 243 3x57 G.HN K 24 G.HN.48
Polar ICL2 S 247 - G.HN I 28 G.HN.52
Hydrophobic ICL2 S 247 - G.HN I 28 G.HN.52
Van-der-waals ICL2 S 247 - G.HN I 28 G.HN.52
Hydrophobic C-term T 423 - G.h3s5 I 261 G.h3s5.01
Van-der-waals C-term T 423 - G.h3s5 I 261 G.h3s5.01
Hydrophobic TM5 L 320 5x61 G.H5 Y 354 G.H5.26
Hydrophobic TM3 L 240 3x54 G.H5 C 351 G.H5.23
Van-der-waals ICL3 Q 327 - G.H5 I 343 G.H5.15
Polar ICL3 R 330 - G.H1 H 57 G.H1.12
Hydrophobic ICL3 R 330 - G.H1 H 57 G.H1.12
Van-der-waals ICL3 R 330 - G.H1 H 57 G.H1.12
Polar ICL3 T 329 - G.S3 H 196 G.S3.02
Van-der-waals ICL3 T 329 - G.S3 H 196 G.S3.02
Polar ICL2 F 248 - G.HN K 24 G.HN.48
Hydrophobic ICL2 F 248 - G.HN K 24 G.HN.48
Van-der-waals ICL2 F 248 - G.HN K 24 G.HN.48
Hydrophobic C-term K 424 - G.h3s5 I 261 G.h3s5.01
Van-der-waals C-term K 424 - G.h3s5 I 261 G.h3s5.01
Polar TM4 S 250 4x38 G.HN A 18 G.HN.42
Van-der-waals TM4 S 250 4x38 G.HN A 18 G.HN.42
Hydrophobic TM5 K 323 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 323 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 248 - G.HN S 29 G.HN.53
Van-der-waals ICL2 F 248 - G.HN S 29 G.HN.53
Polar C-term S 420 - G.h4s6 K 317 G.h4s6.11
Hydrophobic C-term S 420 - G.h4s6 K 317 G.h4s6.11
Van-der-waals C-term S 420 - G.h4s6 K 317 G.h4s6.11
Polar C-term S 418 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term S 418 - G.h4s6 E 318 G.h4s6.12
Van-der-waals C-term S 418 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 329 - G.S2 T 191 G.S2.07
Van-der-waals ICL3 T 329 - G.S2 T 191 G.S2.07
Polar ICL3 R 330 - G.S2 T 191 G.S2.07
Hydrophobic ICL3 R 330 - G.S2 T 191 G.S2.07
Van-der-waals ICL3 R 330 - G.S2 T 191 G.S2.07
Hydrophobic ICL2 F 248 - G.HN E 25 G.HN.49
Van-der-waals ICL2 F 248 - G.HN E 25 G.HN.49
Hydrophobic TM3 L 244 3x58 G.HN I 28 G.HN.52
Polar C-term N 421 - G.h4s6 N 312 G.h4s6.02
Van-der-waals C-term N 421 - G.h4s6 N 312 G.h4s6.02
Polar TM4 R 252 4x40 G.HN L 13 G.HN.37
Hydrophobic TM4 R 252 4x40 G.HN L 13 G.HN.37
Van-der-waals TM4 R 252 4x40 G.HN L 13 G.HN.37
Hydrophobic TM3 L 244 3x58 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 244 3x58 G.H5 L 353 G.H5.25
Hydrophobic C-term A 425 - G.H3 K 258 G.H3.16
Van-der-waals C-term A 425 - G.H3 K 258 G.H3.16
Polar ICL2 S 247 - G.HN S 29 G.HN.53
Hydrophobic ICL2 S 247 - G.HN S 29 G.HN.53
Van-der-waals ICL2 S 247 - G.HN S 29 G.HN.53
Hydrophobic TM3 L 244 3x58 G.H5 C 351 G.H5.23
Polar TM4 S 250 4x38 G.HN N 22 G.HN.46
Hydrophobic TM4 S 250 4x38 G.HN N 22 G.HN.46
Van-der-waals TM4 S 250 4x38 G.HN N 22 G.HN.46
Polar C-term S 420 - G.h4s6 R 313 G.h4s6.03
Hydrophobic C-term S 420 - G.h4s6 R 313 G.h4s6.03
Van-der-waals C-term S 420 - G.h4s6 R 313 G.h4s6.03
Hydrophobic TM3 L 240 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 240 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 243 3x57 G.HN I 28 G.HN.52
Polar TM5 K 323 5x64 G.HN S 29 G.HN.53
Van-der-waals TM5 K 323 5x64 G.HN S 29 G.HN.53
Hydrophobic ICL3 Q 327 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL3 Q 327 - G.s2s3 N 194 G.s2s3.02
Polar ICL3 Q 327 - G.S3 L 195 G.S3.01
Hydrophobic ICL3 Q 327 - G.S3 L 195 G.S3.01
Van-der-waals ICL3 Q 327 - G.S3 L 195 G.S3.01
Polar C-term S 420 - G.h4s6 S 314 G.h4s6.08
Hydrophobic C-term S 420 - G.h4s6 S 314 G.h4s6.08
Van-der-waals C-term S 420 - G.h4s6 S 314 G.h4s6.08
Polar C-term N 421 - G.h4s6 K 317 G.h4s6.11
Hydrophobic C-term N 421 - G.h4s6 K 317 G.h4s6.11
Van-der-waals C-term N 421 - G.h4s6 K 317 G.h4s6.11
Polar TM5 K 323 5x64 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 K 323 5x64 G.hns1 A 31 G.hns1.02
Van-der-waals TM5 K 323 5x64 G.hns1 A 31 G.hns1.02
Polar TM5 L 324 5x65 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 L 324 5x65 G.hns1 K 32 G.hns1.03
Van-der-waals TM5 L 324 5x65 G.hns1 K 32 G.hns1.03
Polar C-term T 423 - G.H3 K 258 G.H3.16
Hydrophobic C-term T 423 - G.H3 K 258 G.H3.16
Van-der-waals C-term T 423 - G.H3 K 258 G.H3.16
Polar C-term S 420 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term S 420 - G.h4s6 E 318 G.h4s6.12
Van-der-waals C-term S 420 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 Q 327 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 Q 327 - G.H5 I 344 G.H5.16
Ionic C-term K 424 - G.h2s4 E 217 G.h2s4.02
Polar C-term K 424 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term K 424 - G.h2s4 E 217 G.h2s4.02
Hydrophobic C-term F 419 - G.h4s6 S 314 G.h4s6.08
Polar ICL3 Q 327 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 Q 327 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 Q 327 - G.H5 T 340 G.H5.12
Hydrophobic TM5 L 324 5x65 G.H5 Y 354 G.H5.26
Van-der-waals TM5 L 324 5x65 G.H5 Y 354 G.H5.26
Polar ICL3 E 328 - G.S1 D 33 G.S1.01
Hydrophobic TM3 L 243 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 243 3x57 G.H5 C 351 G.H5.23
Polar TM4 S 250 4x38 G.HN K 21 G.HN.45
Hydrophobic TM4 S 250 4x38 G.HN K 21 G.HN.45
Van-der-waals TM4 S 250 4x38 G.HN K 21 G.HN.45
Hydrophobic ICL3 E 328 - G.S2 T 191 G.S2.07
Van-der-waals ICL3 E 328 - G.S2 T 191 G.S2.07
Polar C-term F 419 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term F 419 - G.h4s6 E 318 G.h4s6.12
Van-der-waals C-term F 419 - G.h4s6 E 318 G.h4s6.12
Polar TM4 S 250 4x38 G.HN E 25 G.HN.49
Van-der-waals TM4 S 250 4x38 G.HN E 25 G.HN.49
Polar TM4 E 251 4x39 G.HN K 17 G.HN.41
Van-der-waals TM4 E 251 4x39 G.HN K 17 G.HN.41
Polar TM6 R 339 6x37 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 339 6x37 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 339 6x37 G.H5 Y 354 G.H5.26
Polar C-term S 420 - G.h4s6 N 312 G.h4s6.02
Hydrophobic C-term S 420 - G.h4s6 N 312 G.h4s6.02
Van-der-waals C-term S 420 - G.h4s6 N 312 G.h4s6.02
Aromatic ICL3 R 330 - G.S2 F 192 G.S2.08
Hydrophobic ICL3 R 330 - G.S2 F 192 G.S2.08
Van-der-waals ICL3 R 330 - G.S2 F 192 G.S2.08
Polar ICL3 Q 327 - G.S1 D 33 G.S1.01
Hydrophobic ICL3 Q 327 - G.S1 D 33 G.S1.01
Van-der-waals ICL3 Q 327 - G.S1 D 33 G.S1.01
Ionic TM4 E 251 4x39 G.HN K 24 G.HN.48
Polar TM4 E 251 4x39 G.HN K 24 G.HN.48
Van-der-waals TM4 E 251 4x39 G.HN K 24 G.HN.48
Polar TM2 R 174 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 174 2x46 G.H5 C 351 G.H5.23
Van-der-waals ICL2 F 248 - G.HN K 21 G.HN.45
Hydrophobic TM6 S 343 6x41 G.H5 L 353 G.H5.25
Polar TM4 R 252 4x40 G.HN K 17 G.HN.41
Hydrophobic TM4 R 252 4x40 G.HN K 17 G.HN.41
Van-der-waals TM4 R 252 4x40 G.HN K 17 G.HN.41
Hydrophobic TM3 L 243 3x57 G.HN K 21 G.HN.45
Polar ICL3 E 328 - G.S2 F 192 G.S2.08
Polar ICL3 E 328 - G.S3 L 195 G.S3.01
Hydrophobic ICL3 E 328 - G.S3 L 195 G.S3.01
Van-der-waals ICL3 E 328 - G.S3 L 195 G.S3.01
Hydrophobic TM5 K 323 5x64 G.hns1 K 32 G.hns1.03
Van-der-waals TM5 K 323 5x64 G.hns1 K 32 G.hns1.03
Polar ICL2 F 249 - G.HN E 25 G.HN.49
Hydrophobic ICL2 F 249 - G.HN E 25 G.HN.49
Van-der-waals ICL2 F 249 - G.HN E 25 G.HN.49
Polar ICL1 H 171 12x51 G.HN K 17 G.HN.41
Polar C-term S 420 - G.h4s6 P 315 G.h4s6.09
Hydrophobic C-term S 420 - G.h4s6 P 315 G.h4s6.09
Van-der-waals C-term S 420 - G.h4s6 P 315 G.h4s6.09
Hydrophobic C-term N 421 - G.h4s6 P 315 G.h4s6.09
Van-der-waals C-term N 421 - G.h4s6 P 315 G.h4s6.09
Hydrophobic C-term N 421 - G.h4s6 S 314 G.h4s6.08
Van-der-waals C-term N 421 - G.h4s6 S 314 G.h4s6.08
Polar ICL3 E 328 - G.S3 H 196 G.S3.02
Van-der-waals ICL3 E 328 - G.S3 H 196 G.S3.02
Polar C-term S 422 - G.h3s5 I 261 G.h3s5.01
Hydrophobic C-term S 422 - G.h3s5 I 261 G.h3s5.01
Van-der-waals C-term S 422 - G.h3s5 I 261 G.h3s5.01
Hydrophobic C-term K 424 - G.H3 K 258 G.H3.16
Van-der-waals C-term K 424 - G.H3 K 258 G.H3.16