Gs - succinate receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 120 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM7 L 298 7x56 G.H5 Q 390 G.H5.22
Van-der-waals TM7 L 298 7x56 G.H5 Q 390 G.H5.22
Polar ICL2 P 127 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 127 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 H 387 G.H5.19
Polar TM3 I 124 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 124 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 124 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 217 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 R 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM7 L 298 7x56 G.H5 Y 391 G.H5.23
Van-der-waals TM7 L 298 7x56 G.H5 Y 391 G.H5.23
Hydrophobic TM5 R 217 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 R 217 5x68 G.H5 L 388 G.H5.20
Polar TM6 P 230 6x33 G.H5 E 392 G.H5.24
Hydrophobic TM6 P 230 6x33 G.H5 E 392 G.H5.24
Van-der-waals TM6 P 230 6x33 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 127 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 128 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 128 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 128 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 128 34x51 G.S3 V 217 G.S3.01
Polar ICL1 N 54 - G.HN K 34 G.HN.51
Hydrophobic TM6 L 227 6x30 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 227 6x30 G.H5 L 394 G.H5.26
Hydrophobic TM6 P 230 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 P 230 6x33 G.H5 L 394 G.H5.26
Polar H8 G 299 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 G 299 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 G 299 8x47 G.H5 Q 390 G.H5.22
Ionic TM5 R 217 5x68 G.H5 D 381 G.H5.13
Polar TM5 R 217 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 217 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 217 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM6 L 225 6x28 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 L 225 6x28 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM5 L 214 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 128 34x51 G.S3 F 219 G.S3.03
Van-der-waals TM4 K 136 4x39 G.HN Q 35 G.HN.52
Polar TM3 R 120 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 127 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 127 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM6 L 227 6x30 G.H5 L 388 G.H5.20
Polar TM7 L 297 7x55 G.H5 E 392 G.H5.24
Hydrophobic TM7 L 297 7x55 G.H5 E 392 G.H5.24
Van-der-waals TM7 L 297 7x55 G.H5 E 392 G.H5.24
Hydrophobic TM7 L 297 7x55 G.H5 Y 391 G.H5.23
Van-der-waals TM7 L 297 7x55 G.H5 Y 391 G.H5.23
Hydrophobic TM6 V 221 6x24 G.H5 R 385 G.H5.17
Van-der-waals TM6 V 221 6x24 G.H5 R 385 G.H5.17
Aromatic ICL2 F 128 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 128 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 128 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 128 34x51 G.H5 C 379 G.H5.11
Polar ICL1 N 54 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 N 54 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 N 54 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 F 213 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 F 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 P 230 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 P 230 6x33 G.H5 L 393 G.H5.25
Hydrophobic H8 G 299 8x47 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 127 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 124 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 388 G.H5.20
Aromatic ICL2 F 128 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 128 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 128 34x51 G.H5 F 376 G.H5.08
Polar ICL2 R 129 34x52 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 129 34x52 G.H5 Y 391 G.H5.23
Hydrophobic TM6 A 224 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 A 224 6x27 G.H5 R 385 G.H5.17
Hydrophobic H8 G 299 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 G 299 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 128 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 128 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM6 V 234 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 234 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 123 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 123 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 124 3x54 G.H5 L 393 G.H5.25
Polar ICL2 R 129 34x52 G.H5 H 387 G.H5.19
Polar TM5 R 217 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 217 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 217 5x68 G.H5 Q 384 G.H5.16
Polar H8 D 300 8x48 G.H5 Q 390 G.H5.22
Hydrophobic H8 D 300 8x48 G.H5 Q 390 G.H5.22
Van-der-waals H8 D 300 8x48 G.H5 Q 390 G.H5.22
Polar TM2 N 56 2x37 G.H5 Y 391 G.H5.23
Van-der-waals TM2 N 56 2x37 G.H5 Y 391 G.H5.23
Polar TM3 I 123 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 123 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 123 3x53 G.H5 H 387 G.H5.19