G12 - TAS2R10 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 78.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 K 109 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 D 216 6x25 G.S6 F 347 G.S6.02
Van-der-waals TM6 D 216 6x25 G.S6 F 347 G.S6.02
Aromatic TM6 H 222 6x31 G.H5 K 376 G.H5.21
Hydrophobic TM6 H 222 6x31 G.H5 K 376 G.H5.21
Polar TM3 S 85 3x29 G.HN M 1 G.HN.01
Hydrophobic TM3 S 85 3x29 G.HN M 1 G.HN.01
Van-der-waals TM3 S 85 3x29 G.HN M 1 G.HN.01
Polar ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Van-der-waals ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Polar TM4 N 126 4x39 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 N 126 4x39 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 N 126 4x39 G.hns1 R 56 G.hns1.03
Polar ICL2 L 119 34x51 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM6 D 216 6x25 G.h4s6 P 345 G.h4s6.20
Polar ICL1 L 40 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 L 40 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 L 40 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 F 105 3x49 G.H5 I 378 G.H5.23
Polar H8 N 281 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 N 281 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 281 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM4 L 151 4x64 G.HN L 8 G.HN.08
Hydrophobic TM5 L 178 5x44 G.HN V 5 G.HN.05
Van-der-waals TM5 L 178 5x44 G.HN V 5 G.HN.05
Polar TM3 I 84 3x28 G.HN R 6 G.HN.06
Hydrophobic TM3 I 84 3x28 G.HN R 6 G.HN.06
Van-der-waals TM3 I 84 3x28 G.HN R 6 G.HN.06
Polar TM3 Y 106 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 Y 106 3x50 G.H5 I 378 G.H5.23
Hydrophobic ECL2 Y 154 - G.HN M 1 G.HN.01
Van-der-waals ECL2 Y 154 - G.HN M 1 G.HN.01
Hydrophobic TM6 F 250 6x59 G.HN G 3 G.HN.03
Van-der-waals TM6 F 250 6x59 G.HN G 3 G.HN.03
Polar TM6 N 218 6x27 G.H5 Q 372 G.H5.17
Hydrophobic TM6 N 218 6x27 G.H5 Q 372 G.H5.17
Van-der-waals TM6 N 218 6x27 G.H5 Q 372 G.H5.17
Polar ECL2 K 155 - G.HN S 9 G.HN.09
Polar ECL2 Y 171 - G.HN G 3 G.HN.03
Van-der-waals ECL2 Y 171 - G.HN G 3 G.HN.03
Hydrophobic TM2 S 41 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 S 41 2x37 G.hns1 R 55 G.hns1.02
Ionic ICL1 K 39 - G.HN D 44 G.HN.44
Polar ICL1 K 39 - G.HN D 44 G.HN.44
Van-der-waals ICL1 K 39 - G.HN D 44 G.HN.44
Ionic TM5 H 203 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 203 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 203 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 203 5x68 G.H5 D 368 G.H5.13
Polar TM3 S 85 3x29 G.HN S 2 G.HN.02
Hydrophobic TM3 S 85 3x29 G.HN S 2 G.HN.02
Van-der-waals TM3 S 85 3x29 G.HN S 2 G.HN.02
Hydrophobic TM4 I 147 4x60 G.HN T 7 G.HN.07
Polar ICL1 K 39 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 K 39 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 K 39 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 110 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 I 110 3x54 G.H5 M 379 G.H5.24
Hydrophobic H8 N 281 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 281 8x47 G.H5 L 380 G.H5.25
Polar TM3 E 82 3x26 G.HN L 8 G.HN.08
Hydrophobic TM3 E 82 3x26 G.HN L 8 G.HN.08
Van-der-waals TM3 E 82 3x26 G.HN L 8 G.HN.08
Polar ECL1 Y 75 - G.HN G 3 G.HN.03
Van-der-waals ECL1 Y 75 - G.HN G 3 G.HN.03
Hydrophobic TM3 I 81 3x25 G.HN M 1 G.HN.01
Van-der-waals TM3 I 81 3x25 G.HN M 1 G.HN.01
Hydrophobic TM6 A 221 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 A 221 6x30 G.H5 K 376 G.H5.21
Hydrophobic TM6 S 217 6x26 G.S6 F 347 G.S6.02
Van-der-waals TM6 S 217 6x26 G.S6 F 347 G.S6.02
Polar TM3 E 82 3x26 G.HN S 9 G.HN.09
Van-der-waals TM3 E 82 3x26 G.HN S 9 G.HN.09
Hydrophobic TM4 I 150 4x63 G.HN M 1 G.HN.01
Van-der-waals TM4 I 150 4x63 G.HN M 1 G.HN.01
Hydrophobic TM3 Y 83 3x27 G.HN L 8 G.HN.08
Van-der-waals TM3 Y 83 3x27 G.HN L 8 G.HN.08
Polar ICL2 S 123 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 L 214 - G.H4 V 332 G.H4.12
Hydrophobic H8 K 283 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 283 8x49 G.H5 Q 381 G.H5.26
Polar H8 K 283 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 283 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM5 Q 175 5x41 G.HN V 4 G.HN.04
Van-der-waals TM5 Q 175 5x41 G.HN V 4 G.HN.04
Hydrophobic TM5 M 207 5x72 G.H5 A 365 G.H5.10
Polar TM6 N 218 6x27 G.H5 T 369 G.H5.14
Hydrophobic TM6 N 218 6x27 G.H5 T 369 G.H5.14
Van-der-waals TM6 N 218 6x27 G.H5 T 369 G.H5.14
Polar TM3 I 84 3x28 G.HN S 2 G.HN.02
Hydrophobic TM3 I 84 3x28 G.HN S 2 G.HN.02
Van-der-waals TM3 I 84 3x28 G.HN S 2 G.HN.02
Hydrophobic ICL1 K 39 - G.HN R 51 G.HN.51
Van-der-waals ICL1 K 39 - G.HN R 51 G.HN.51
Polar H8 Q 286 8x52 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 Q 286 8x52 G.h3s5 N 288 G.h3s5.02
Hydrophobic ICL3 L 214 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 L 214 - G.S6 H 348 G.S6.03
Polar TM6 H 222 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 222 6x31 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 222 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM3 V 89 3x33 G.HN V 5 G.HN.05
Van-der-waals TM3 V 89 3x33 G.HN V 5 G.HN.05
Hydrophobic TM6 A 225 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 225 6x34 G.H5 M 379 G.H5.24
Polar TM3 S 85 3x29 G.HN R 6 G.HN.06
Hydrophobic TM3 S 85 3x29 G.HN R 6 G.HN.06
Van-der-waals TM3 S 85 3x29 G.HN R 6 G.HN.06
Hydrophobic TM2 L 47 2x43 G.H5 Q 381 G.H5.26
Van-der-waals TM2 L 47 2x43 G.H5 Q 381 G.H5.26
Hydrophobic TM3 K 109 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 K 109 3x53 G.H5 L 375 G.H5.20
Polar ICL1 K 39 - G.HN L 47 G.HN.47
Hydrophobic TM5 N 210 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM5 N 210 5x75 G.H5 F 361 G.H5.06
Polar ICL2 S 123 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 S 123 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 S 123 34x55 G.s2s3 K 220 G.s2s3.02
Aromatic TM3 F 87 3x31 G.HN R 6 G.HN.06
Hydrophobic TM3 F 87 3x31 G.HN R 6 G.HN.06
Van-der-waals TM3 F 87 3x31 G.HN R 6 G.HN.06
Polar TM6 S 217 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 S 217 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 S 217 6x26 G.h4s6 P 345 G.h4s6.20
Polar TM3 Y 106 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 Y 106 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 Y 106 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM4 I 147 4x60 G.HN R 6 G.HN.06
Van-der-waals TM4 I 147 4x60 G.HN R 6 G.HN.06
Polar TM3 Y 86 3x30 G.HN L 8 G.HN.08
Hydrophobic TM3 Y 86 3x30 G.HN L 8 G.HN.08
Van-der-waals TM3 Y 86 3x30 G.HN L 8 G.HN.08
Polar TM6 N 218 6x27 G.H5 K 376 G.H5.21
Van-der-waals TM6 N 218 6x27 G.H5 K 376 G.H5.21
Hydrophobic ECL2 Y 171 - G.HN V 4 G.HN.04
Van-der-waals ECL2 Y 171 - G.HN V 4 G.HN.04
Polar TM5 H 203 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 203 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 203 5x68 G.H5 Q 372 G.H5.17
Polar H8 N 281 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 281 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 281 8x47 G.H5 Q 381 G.H5.26
Polar TM3 I 81 3x25 G.HN T 7 G.HN.07
Van-der-waals TM3 I 81 3x25 G.HN T 7 G.HN.07
Polar TM3 Y 83 3x27 G.HN R 6 G.HN.06
Hydrophobic TM3 Y 83 3x27 G.HN R 6 G.HN.06
Van-der-waals TM3 Y 83 3x27 G.HN R 6 G.HN.06
Hydrophobic TM3 I 110 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 375 G.H5.20
Polar H8 S 282 8x48 G.H5 D 377 G.H5.22
Polar TM3 E 82 3x26 G.HN T 7 G.HN.07
Hydrophobic TM3 E 82 3x26 G.HN T 7 G.HN.07
Van-der-waals TM3 E 82 3x26 G.HN T 7 G.HN.07
Polar TM3 Y 86 3x30 G.HN T 7 G.HN.07
Hydrophobic TM3 Y 86 3x30 G.HN T 7 G.HN.07
Polar TM2 D 64 2x60 G.HN S 2 G.HN.02
Hydrophobic TM2 D 64 2x60 G.HN S 2 G.HN.02
Van-der-waals TM2 D 64 2x60 G.HN S 2 G.HN.02
Polar TM3 Y 86 3x30 G.HN R 6 G.HN.06
Hydrophobic TM3 Y 86 3x30 G.HN R 6 G.HN.06
Van-der-waals TM3 Y 86 3x30 G.HN R 6 G.HN.06
Hydrophobic TM6 S 217 6x26 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM2 I 43 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 I 43 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM7 G 280 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 G 280 7x56 G.H5 L 380 G.H5.25
Polar TM3 S 85 3x29 G.HN V 5 G.HN.05
Hydrophobic TM3 S 85 3x29 G.HN V 5 G.HN.05
Van-der-waals TM3 S 85 3x29 G.HN V 5 G.HN.05
Polar TM3 E 82 3x26 G.HN R 6 G.HN.06
Hydrophobic TM3 E 82 3x26 G.HN R 6 G.HN.06
Van-der-waals TM3 E 82 3x26 G.HN R 6 G.HN.06
Polar TM4 T 125 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 125 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 N 218 6x27 G.S6 F 347 G.S6.02
Van-der-waals TM6 N 218 6x27 G.S6 F 347 G.S6.02
Hydrophobic TM4 I 147 4x60 G.HN V 5 G.HN.05
Van-der-waals TM4 I 147 4x60 G.HN V 5 G.HN.05
Polar TM2 D 64 2x60 G.HN G 3 G.HN.03
Polar H8 S 282 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 S 282 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 282 8x48 G.H5 L 380 G.H5.25
Polar ECL1 Y 75 - G.HN S 2 G.HN.02
Hydrophobic ECL1 Y 75 - G.HN S 2 G.HN.02
Van-der-waals ECL1 Y 75 - G.HN S 2 G.HN.02
Hydrophobic TM4 L 151 4x64 G.HN T 7 G.HN.07
Van-der-waals TM4 L 151 4x64 G.HN T 7 G.HN.07