Gt1 - TAS2R10 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 85.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 N 218 6x27 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 N 218 6x27 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 N 218 6x27 G.h4s6 E 314 G.h4s6.12
Polar TM6 N 218 6x27 G.H5 D 337 G.H5.13
Hydrophobic TM6 N 218 6x27 G.H5 D 337 G.H5.13
Van-der-waals TM6 N 218 6x27 G.H5 D 337 G.H5.13
Hydrophobic TM2 I 43 2x39 G.H5 C 347 G.H5.23
Van-der-waals TM2 I 43 2x39 G.H5 C 347 G.H5.23
Hydrophobic TM7 G 280 7x56 G.H5 L 349 G.H5.25
Hydrophobic TM3 K 109 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 C 347 G.H5.23
Polar TM6 N 218 6x27 G.H5 K 341 G.H5.17
Hydrophobic TM6 N 218 6x27 G.H5 K 341 G.H5.17
Van-der-waals TM6 N 218 6x27 G.H5 K 341 G.H5.17
Hydrophobic TM5 M 207 5x72 G.H5 A 334 G.H5.10
Polar TM5 Q 206 5x71 G.s2s3 K 188 G.s2s3.01
Hydrophobic TM6 A 225 6x34 G.H5 L 344 G.H5.20
Van-der-waals TM6 A 225 6x34 G.H5 L 344 G.H5.20
Hydrophobic TM6 A 225 6x34 G.H5 L 349 G.H5.25
Hydrophobic TM5 N 210 5x75 G.H5 F 330 G.H5.06
Van-der-waals TM5 N 210 5x75 G.H5 F 330 G.H5.06
Hydrophobic ICL3 L 214 - G.S6 Y 316 G.S6.02
Hydrophobic TM3 I 110 3x54 G.H5 C 347 G.H5.23
Van-der-waals TM3 I 110 3x54 G.H5 C 347 G.H5.23
Hydrophobic TM6 A 221 6x30 G.H5 K 341 G.H5.17
Polar TM5 N 210 5x75 G.H5 D 333 G.H5.09
Van-der-waals TM5 N 210 5x75 G.H5 D 333 G.H5.09
Hydrophobic TM3 I 110 3x54 G.H5 L 344 G.H5.20
Hydrophobic TM6 A 221 6x30 G.H5 F 350 G.H5.26
Van-der-waals TM6 A 221 6x30 G.H5 F 350 G.H5.26
Ionic TM6 H 222 6x31 G.H5 D 337 G.H5.13
Polar TM6 H 222 6x31 G.H5 D 337 G.H5.13
Van-der-waals TM6 H 222 6x31 G.H5 D 337 G.H5.13
Polar H8 N 281 8x47 G.H5 G 348 G.H5.24
Hydrophobic H8 N 281 8x47 G.H5 G 348 G.H5.24
Van-der-waals H8 N 281 8x47 G.H5 G 348 G.H5.24
Hydrophobic ICL3 T 212 - G.S6 S 317 G.S6.03
Van-der-waals ICL3 T 212 - G.S6 S 317 G.S6.03
Hydrophobic ICL3 L 214 - G.S6 I 315 G.S6.01
Van-der-waals ICL3 L 214 - G.S6 I 315 G.S6.01
Hydrophobic TM3 Y 106 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM3 I 110 3x54 G.H5 N 343 G.H5.19
Polar TM7 G 280 7x56 G.H5 F 350 G.H5.26
Polar ICL3 T 212 - G.S6 H 318 G.S6.04
Hydrophobic ICL3 T 212 - G.S6 H 318 G.S6.04
Van-der-waals ICL3 T 212 - G.S6 H 318 G.S6.04
Polar TM6 S 217 6x26 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 S 217 6x26 G.h4s6 E 314 G.h4s6.12
Polar TM5 Q 206 5x71 G.H5 D 333 G.H5.09
Hydrophobic TM5 Q 206 5x71 G.H5 D 333 G.H5.09
Van-der-waals TM5 Q 206 5x71 G.H5 D 333 G.H5.09
Hydrophobic TM6 A 221 6x30 G.H5 L 344 G.H5.20
Ionic TM5 H 203 5x68 G.H5 D 337 G.H5.13
Polar TM5 H 203 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 H 203 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 H 203 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 M 207 5x72 G.H5 D 333 G.H5.09
Van-der-waals TM5 M 207 5x72 G.H5 D 333 G.H5.09
Hydrophobic TM5 H 203 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 H 203 5x68 G.H5 I 340 G.H5.16
Polar ICL2 N 112 34x44 G.s2s3 K 188 G.s2s3.01
Van-der-waals ICL2 N 112 34x44 G.s2s3 K 188 G.s2s3.01
Hydrophobic TM3 I 110 3x54 G.H5 L 349 G.H5.25
Hydrophobic TM3 I 110 3x54 G.H5 I 340 G.H5.16
Polar TM4 N 126 4x39 G.HN E 24 G.HN.52
Van-der-waals TM4 N 126 4x39 G.HN E 24 G.HN.52
Hydrophobic TM5 H 203 5x68 G.H5 T 336 G.H5.12
Hydrophobic TM5 M 207 5x72 G.H5 D 337 G.H5.13
Van-der-waals TM5 M 207 5x72 G.H5 D 337 G.H5.13
Hydrophobic ICL3 L 214 - G.S6 S 317 G.S6.03
Van-der-waals ICL3 L 214 - G.S6 S 317 G.S6.03
Polar TM6 K 224 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM6 K 224 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 K 224 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM6 V 228 6x37 G.H5 L 349 G.H5.25
Van-der-waals TM6 V 228 6x37 G.H5 L 349 G.H5.25
Hydrophobic TM7 G 280 7x56 G.H5 G 348 G.H5.24
Van-der-waals TM7 G 280 7x56 G.H5 G 348 G.H5.24
Hydrophobic ICL2 L 119 34x51 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 L 119 34x51 G.s2s3 D 189 G.s2s3.02
Hydrophobic TM6 H 222 6x31 G.H5 I 340 G.H5.16
Van-der-waals TM6 H 222 6x31 G.H5 I 340 G.H5.16
Hydrophobic ICL2 S 123 34x55 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 S 123 34x55 G.hns1 R 28 G.hns1.03
Polar TM3 Y 106 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 Y 106 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 Y 106 3x50 G.H5 C 347 G.H5.23
Ionic TM3 K 109 3x53 G.H5 D 346 G.H5.22
Polar TM3 K 109 3x53 G.H5 D 346 G.H5.22
Hydrophobic TM3 K 109 3x53 G.H5 D 346 G.H5.22
Van-der-waals TM3 K 109 3x53 G.H5 D 346 G.H5.22
Polar ICL2 K 122 34x54 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 K 122 34x54 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 K 122 34x54 G.hns1 R 28 G.hns1.03
Polar TM6 N 218 6x27 G.S6 Y 316 G.S6.02
Hydrophobic TM6 N 218 6x27 G.S6 Y 316 G.S6.02
Van-der-waals TM6 N 218 6x27 G.S6 Y 316 G.S6.02
Hydrophobic TM5 L 200 5x65 G.H5 I 340 G.H5.16
Polar H8 S 282 8x48 G.H5 F 350 G.H5.26
Hydrophobic H8 S 282 8x48 G.H5 F 350 G.H5.26
Van-der-waals H8 S 282 8x48 G.H5 F 350 G.H5.26
Van-der-waals ICL2 S 114 34x46 G.s2s3 D 189 G.s2s3.02
Hydrophobic TM6 H 222 6x31 G.H5 L 344 G.H5.20
Polar ICL2 L 119 34x51 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 L 119 34x51 G.hns1 R 28 G.hns1.03
Hydrophobic TM3 F 105 3x49 G.H5 C 347 G.H5.23
Polar TM3 K 109 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 K 109 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM6 K 224 6x33 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 224 6x33 G.H5 F 350 G.H5.26
Hydrophobic TM4 N 126 4x39 G.HN K 20 G.HN.48