Gt2 - TAS2R14 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 233 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 233 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 120 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 120 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM4 K 128 4x40 G.HN Q 24 G.HN.48
Polar H8 N 284 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 284 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 284 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 111 3x54 G.H5 C 351 G.H5.23
Van-der-waals ICL3 I 218 - G.H5 D 341 G.H5.13
Hydrophobic TM6 K 225 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 225 6x30 G.H5 F 354 G.H5.26
Polar TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Ionic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 M 212 5x72 G.H5 A 338 G.H5.10
Hydrophobic TM3 I 111 3x54 G.H5 I 344 G.H5.16
Polar TM3 K 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 M 212 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 M 212 5x72 G.H5 D 337 G.H5.09
Hydrophobic ICL2 L 120 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 120 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 M 212 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 212 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 N 113 34x44 G.H5 T 340 G.H5.12
Van-der-waals ICL2 N 113 34x44 G.H5 T 340 G.H5.12
Hydrophobic TM3 Y 107 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 I 218 - G.S6 Y 320 G.S6.02
Ionic TM4 K 128 4x40 G.HN D 28 G.HN.52
Polar TM4 K 128 4x40 G.HN D 28 G.HN.52
Van-der-waals TM4 K 128 4x40 G.HN D 28 G.HN.52
Polar TM7 G 283 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM6 S 232 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 111 3x54 G.H5 L 353 G.H5.25
Polar H8 K 285 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 K 285 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 285 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 G 229 6x34 G.H5 L 348 G.H5.20
Van-der-waals ICL2 S 117 34x48 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 A 222 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 A 222 6x27 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 225 6x30 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 225 6x30 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 V 230 6x35 G.H5 L 348 G.H5.20
Hydrophobic TM3 F 106 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 216 5x76 G.S6 H 322 G.S6.04
Van-der-waals TM5 V 216 5x76 G.S6 H 322 G.S6.04
Polar TM6 G 229 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 G 229 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 G 229 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM5 H 208 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM2 V 44 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 44 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 111 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 S 115 34x46 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 W 124 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 W 124 34x55 G.hns1 K 32 G.hns1.03
Polar ICL2 W 124 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 W 124 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 W 124 34x55 G.s2s3 D 193 G.s2s3.02
Ionic TM5 K 211 5x71 G.H5 D 337 G.H5.09
Polar TM5 K 211 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 K 211 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 211 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM6 A 226 6x31 G.H5 L 348 G.H5.20
Hydrophobic TM3 K 110 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 H 214 5x74 G.H5 F 334 G.H5.06
Van-der-waals TM5 H 214 5x74 G.H5 F 334 G.H5.06
Hydrophobic TM5 H 208 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 208 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM2 V 44 2x39 G.H5 C 351 G.H5.23
Ionic TM3 K 110 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 110 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 110 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM5 T 215 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 T 215 5x75 G.H5 F 334 G.H5.06