Golf - TAS2R16 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 119 34x54 G.H5 R 367 G.H5.12
Van-der-waals ICL2 S 109 34x44 G.H5 Q 371 G.H5.16
Hydrophobic TM4 R 121 4x37 G.HN L 37 G.HN.52
Polar ICL2 H 113 34x48 G.s2s3 D 202 G.s2s3.01
Hydrophobic ICL2 H 113 34x48 G.s2s3 D 202 G.s2s3.01
Hydrophobic TM2 M 43 2x37 G.H5 Q 377 G.H5.22
Van-der-waals TM2 M 43 2x37 G.H5 Q 377 G.H5.22
Polar TM4 R 124 4x40 G.HN Q 33 G.HN.48
Hydrophobic TM4 R 124 4x40 G.HN Q 33 G.HN.48
Van-der-waals TM4 R 124 4x40 G.HN Q 33 G.HN.48
Ionic TM6 R 222 6x31 G.H5 D 368 G.H5.13
Polar TM6 R 222 6x31 G.H5 D 368 G.H5.13
Polar TM3 Y 103 3x50 G.H5 Y 378 G.H5.23
Aromatic TM3 Y 103 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 V 107 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 107 3x54 G.H5 L 375 G.H5.20
Hydrophobic H8 L 283 8x50 G.H5 E 379 G.H5.24
Van-der-waals H8 L 283 8x50 G.H5 E 379 G.H5.24
Hydrophobic TM4 R 124 4x40 G.HN L 37 G.HN.52
Van-der-waals TM4 R 124 4x40 G.HN L 37 G.HN.52
Polar TM3 V 107 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 V 107 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 V 107 3x54 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 L 116 34x51 G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 L 116 34x51 G.s2s3 D 202 G.s2s3.01
Polar ICL2 W 120 34x55 G.hns1 A 41 G.hns1.03
Hydrophobic ICL2 W 120 34x55 G.hns1 A 41 G.hns1.03
Van-der-waals ICL2 W 120 34x55 G.hns1 A 41 G.hns1.03
Hydrophobic TM6 A 221 6x30 G.H5 L 381 G.H5.26
Polar TM6 P 217 6x26 G.H5 R 372 G.H5.17
Hydrophobic TM6 P 217 6x26 G.H5 R 372 G.H5.17
Polar TM7 S 279 7x56 G.H5 E 379 G.H5.24
Hydrophobic TM7 S 279 7x56 G.H5 E 379 G.H5.24
Van-der-waals TM7 S 279 7x56 G.H5 E 379 G.H5.24
Polar ICL2 S 109 34x44 G.H5 R 367 G.H5.12
Hydrophobic ICL2 S 109 34x44 G.H5 R 367 G.H5.12
Van-der-waals ICL2 S 109 34x44 G.H5 R 367 G.H5.12
Polar TM5 H 214 5x76 G.hgh4 D 310 G.hgh4.13
Hydrophobic TM5 H 214 5x76 G.hgh4 D 310 G.hgh4.13
Van-der-waals TM5 H 214 5x76 G.hgh4 D 310 G.hgh4.13
Polar H8 S 280 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 S 280 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 S 280 8x47 G.H5 E 379 G.H5.24
Polar TM7 S 279 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 S 279 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 221 6x30 G.H5 R 372 G.H5.17
Hydrophobic TM6 A 225 6x34 G.H5 L 375 G.H5.20
Hydrophobic TM3 K 106 3x53 G.H5 Q 371 G.H5.16
Hydrophobic H8 P 281 8x48 G.H5 K 376 G.H5.21
Van-der-waals H8 P 281 8x48 G.H5 K 376 G.H5.21
Hydrophobic TM3 Y 103 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 Y 103 3x50 G.H5 L 380 G.H5.25
Hydrophobic H8 P 281 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 R 285 8x52 G.h4s6 K 343 G.h4s6.12
Van-der-waals H8 R 285 8x52 G.h4s6 K 343 G.h4s6.12
Hydrophobic TM2 V 45 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 V 45 2x39 G.H5 Y 378 G.H5.23
Hydrophobic TM4 R 124 4x40 G.HN R 36 G.HN.51
Van-der-waals TM4 R 124 4x40 G.HN R 36 G.HN.51
Hydrophobic TM2 V 45 2x39 G.H5 Q 377 G.H5.22
Van-der-waals TM2 V 45 2x39 G.H5 Q 377 G.H5.22
Polar ICL2 H 113 34x48 G.s2s3 K 203 G.s2s3.02
Aromatic ICL2 H 113 34x48 G.s2s3 K 203 G.s2s3.02
Hydrophobic ICL2 H 113 34x48 G.s2s3 K 203 G.s2s3.02
Van-der-waals ICL2 H 113 34x48 G.s2s3 K 203 G.s2s3.02
Polar TM3 K 106 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM3 K 106 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 K 106 3x53 G.H5 Y 378 G.H5.23
Polar TM5 H 214 5x76 G.hgh4 T 312 G.hgh4.15
Hydrophobic TM5 H 214 5x76 G.hgh4 T 312 G.hgh4.15
Van-der-waals TM5 H 214 5x76 G.hgh4 T 312 G.hgh4.15
Hydrophobic TM2 L 49 2x43 G.H5 E 379 G.H5.24
Van-der-waals TM2 L 49 2x43 G.H5 E 379 G.H5.24
Polar TM3 K 106 3x53 G.H5 Q 377 G.H5.22
Ionic H8 R 285 8x52 G.h4s6 D 341 G.h4s6.10
Polar H8 R 285 8x52 G.h4s6 D 341 G.h4s6.10
Hydrophobic H8 R 285 8x52 G.h4s6 D 341 G.h4s6.10
Van-der-waals H8 R 285 8x52 G.h4s6 D 341 G.h4s6.10
Aromatic TM3 F 102 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 F 102 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 F 102 3x49 G.H5 Y 378 G.H5.23
Polar ICL2 W 120 34x55 G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 W 120 34x55 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 W 120 34x55 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 R 119 34x54 G.H5 Q 371 G.H5.16
Polar TM5 H 214 5x76 G.hgh4 A 311 G.hgh4.14
Hydrophobic TM5 H 214 5x76 G.hgh4 A 311 G.hgh4.14
Van-der-waals TM5 H 214 5x76 G.hgh4 A 311 G.hgh4.14
Hydrophobic TM6 S 218 6x27 G.H5 R 372 G.H5.17
Van-der-waals TM6 S 218 6x27 G.H5 R 372 G.H5.17
Polar ICL2 R 119 34x54 G.H5 H 374 G.H5.19
Hydrophobic ICL2 R 119 34x54 G.H5 H 374 G.H5.19
Hydrophobic TM6 L 229 6x38 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 116 34x51 G.S3 V 204 G.S3.01
Van-der-waals ICL2 L 116 34x51 G.S3 V 204 G.S3.01
Hydrophobic TM5 G 213 5x75 G.hgh4 T 312 G.hgh4.15
Polar TM6 S 228 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 228 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 228 6x37 G.H5 L 380 G.H5.25
Ionic ICL1 R 41 - G.h2s4 D 227 G.h2s4.03
Polar ICL1 R 41 - G.h2s4 D 227 G.h2s4.03
Hydrophobic ICL1 R 41 - G.h2s4 D 227 G.h2s4.03
Van-der-waals ICL1 R 41 - G.h2s4 D 227 G.h2s4.03
Polar H8 T 282 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 T 282 8x49 G.H5 E 379 G.H5.24
Van-der-waals TM5 Q 206 5x68 G.H5 Q 371 G.H5.16
Polar TM3 K 106 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 H 374 G.H5.19
Hydrophobic ICL2 R 119 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 119 34x54 G.H5 I 370 G.H5.15
Polar TM7 S 279 7x56 G.H5 L 381 G.H5.26
Polar TM5 H 214 5x76 G.hgh4 E 309 G.hgh4.12
Van-der-waals TM5 H 214 5x76 G.hgh4 E 309 G.hgh4.12
Hydrophobic ICL2 W 120 34x55 G.HN L 37 G.HN.52
Van-der-waals ICL2 W 120 34x55 G.HN L 37 G.HN.52