G15 - TAS2R20 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 19.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 A 44 2x39 G.H5 I 371 G.H5.23
Van-der-waals TM2 A 44 2x39 G.H5 I 371 G.H5.23
Hydrophobic TM6 I 223 6x30 G.H5 L 374 G.H5.26
Van-der-waals TM6 I 223 6x30 G.H5 L 374 G.H5.26
Hydrophobic TM3 K 109 3x53 G.H5 I 371 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 I 371 G.H5.23
Polar TM2 S 42 2x37 G.H5 D 369 G.H5.21
Hydrophobic TM2 S 42 2x37 G.H5 D 369 G.H5.21
Van-der-waals TM2 S 42 2x37 G.H5 D 369 G.H5.21
Hydrophobic TM3 I 110 3x54 G.H5 I 371 G.H5.23
Polar H8 N 283 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 N 283 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 N 283 8x47 G.H5 N 372 G.H5.24
Polar TM3 I 110 3x54 G.H5 Y 367 G.H5.19
Hydrophobic TM3 I 110 3x54 G.H5 Y 367 G.H5.19
Van-der-waals TM3 I 110 3x54 G.H5 Y 367 G.H5.19
Polar TM2 D 45 2x40 G.H5 N 372 G.H5.24
Hydrophobic TM2 D 45 2x40 G.H5 N 372 G.H5.24
Van-der-waals TM2 D 45 2x40 G.H5 N 372 G.H5.24
Hydrophobic TM3 I 110 3x54 G.H5 L 373 G.H5.25
Polar TM3 K 109 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 K 109 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 R 123 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 R 123 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic TM7 G 282 7x56 G.H5 L 373 G.H5.25
Van-der-waals TM7 G 282 7x56 G.H5 L 373 G.H5.25
Polar TM1 R 38 1x64 G.h4s6 G 333 G.h4s6.15
Polar ICL2 R 123 34x55 G.HN K 37 G.HN.52
Hydrophobic ICL2 R 123 34x55 G.HN K 37 G.HN.52
Van-der-waals ICL2 R 123 34x55 G.HN K 37 G.HN.52
Polar TM3 Y 106 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 Y 106 3x50 G.H5 I 371 G.H5.23
Polar TM1 R 38 1x64 G.h4s6 K 332 G.h4s6.14
Hydrophobic TM1 R 38 1x64 G.h4s6 K 332 G.h4s6.14
Van-der-waals TM1 R 38 1x64 G.h4s6 K 332 G.h4s6.14
Hydrophobic TM6 A 227 6x34 G.H5 L 373 G.H5.25
Van-der-waals TM6 A 227 6x34 G.H5 L 373 G.H5.25
Hydrophobic H8 K 284 8x48 G.H5 L 373 G.H5.25
Polar TM6 K 226 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 K 226 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 K 226 6x33 G.H5 L 373 G.H5.25
Polar H8 K 284 8x48 G.H5 L 374 G.H5.26
Hydrophobic H8 K 284 8x48 G.H5 L 374 G.H5.26
Van-der-waals H8 K 284 8x48 G.H5 L 374 G.H5.26
Polar TM2 A 44 2x39 G.H5 E 370 G.H5.22
Hydrophobic TM2 A 44 2x39 G.H5 E 370 G.H5.22
Van-der-waals TM2 A 44 2x39 G.H5 E 370 G.H5.22
Hydrophobic TM6 I 223 6x30 G.H5 L 368 G.H5.20
Van-der-waals TM6 I 223 6x30 G.H5 L 368 G.H5.20
Hydrophobic H8 K 284 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 K 284 8x48 G.h4s6 R 335 G.h4s6.17
Polar ICL2 R 123 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 R 123 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 R 123 34x55 G.hns1 R 40 G.hns1.02
Ionic TM3 K 109 3x53 G.H5 E 370 G.H5.22
Polar TM3 K 109 3x53 G.H5 E 370 G.H5.22
Hydrophobic TM3 K 109 3x53 G.H5 E 370 G.H5.22
Van-der-waals TM3 K 109 3x53 G.H5 E 370 G.H5.22
Hydrophobic TM6 K 226 6x33 G.H5 L 374 G.H5.26
Hydrophobic TM3 Y 106 3x50 G.H5 L 373 G.H5.25
Hydrophobic TM6 P 219 6x26 G.H5 L 368 G.H5.20
Hydrophobic TM6 K 222 6x29 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 222 6x29 G.H5 L 374 G.H5.26
Polar TM2 S 42 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM2 S 42 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM6 I 223 6x30 G.H5 Y 367 G.H5.19
Hydrophobic TM6 P 219 6x26 G.H5 L 364 G.H5.16
Hydrophobic TM4 K 124 4x37 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 K 124 4x37 G.hns1 R 40 G.hns1.02
Polar H8 T 285 8x49 G.H5 N 372 G.H5.24
Hydrophobic H8 T 285 8x49 G.H5 N 372 G.H5.24
Van-der-waals H8 T 285 8x49 G.H5 N 372 G.H5.24
Polar H8 K 284 8x48 G.H5 N 372 G.H5.24
Van-der-waals H8 K 284 8x48 G.H5 N 372 G.H5.24
Hydrophobic TM6 I 223 6x30 G.H5 I 371 G.H5.23
Polar TM2 S 43 2x38 G.H5 E 370 G.H5.22
Polar H8 Q 288 8x52 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 Q 288 8x52 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 Q 288 8x52 G.h4s6 R 335 G.h4s6.17
Hydrophobic ICL2 H 120 34x52 G.HN K 37 G.HN.52
Van-der-waals ICL2 H 120 34x52 G.HN K 37 G.HN.52