Golf - TAS2R38 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 123 34x44 G.S1 H 43 G.S1.02
Polar ICL3 R 232 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL3 R 232 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 R 232 - G.hgh4 D 310 G.hgh4.13
Hydrophobic TM6 H 242 6x31 G.H5 Q 371 G.H5.16
Van-der-waals TM6 H 242 6x31 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 R 123 34x44 G.H5 R 367 G.H5.12
Van-der-waals ICL2 R 123 34x44 G.H5 R 367 G.H5.12
Ionic TM6 H 242 6x31 G.H5 D 368 G.H5.13
Polar TM6 H 242 6x31 G.H5 D 368 G.H5.13
Van-der-waals TM6 H 242 6x31 G.H5 D 368 G.H5.13
Hydrophobic TM6 H 242 6x31 G.H5 L 375 G.H5.20
Van-der-waals TM6 H 242 6x31 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 220 5x65 G.H5 L 375 G.H5.20
Polar TM4 R 138 4x40 G.HN R 36 G.HN.51
Van-der-waals TM4 R 138 4x40 G.HN R 36 G.HN.51
Polar TM4 R 138 4x40 G.HN Q 33 G.HN.48
Hydrophobic TM5 M 227 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 M 227 5x72 G.H5 D 368 G.H5.13
Polar TM6 S 238 6x27 G.H5 R 372 G.H5.17
Hydrophobic TM6 S 238 6x27 G.H5 R 372 G.H5.17
Van-der-waals TM6 S 238 6x27 G.H5 R 372 G.H5.17
Hydrophobic TM3 L 121 3x54 G.H5 H 374 G.H5.19
Van-der-waals TM3 L 121 3x54 G.H5 H 374 G.H5.19
Hydrophobic TM4 R 138 4x40 G.HN L 37 G.HN.52
Van-der-waals TM4 R 138 4x40 G.HN L 37 G.HN.52
Hydrophobic TM3 Y 117 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 116 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 L 116 3x49 G.H5 Y 378 G.H5.23
Polar TM3 K 120 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 K 120 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 K 120 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM6 A 245 6x34 G.H5 L 380 G.H5.25
Polar TM5 Y 230 5x75 G.H5 R 360 G.H5.05
Van-der-waals TM5 Y 230 5x75 G.H5 R 360 G.H5.05
Hydrophobic TM6 S 238 6x27 G.H5 D 368 G.H5.13
Hydrophobic ICL2 S 134 34x55 G.HN L 37 G.HN.52
Hydrophobic TM5 M 227 5x72 G.S6 Y 347 G.S6.02
Hydrophobic TM2 S 53 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 S 53 2x39 G.H5 Y 378 G.H5.23
Polar ICL3 R 232 - G.hgh4 T 312 G.hgh4.15
Hydrophobic ICL3 R 232 - G.hgh4 T 312 G.hgh4.15
Van-der-waals ICL3 R 232 - G.hgh4 T 312 G.hgh4.15
Polar ICL3 N 233 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL3 N 233 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 N 233 - G.hgh4 D 310 G.hgh4.13
Polar TM7 G 300 7x56 G.H5 L 381 G.H5.26
Hydrophobic H8 K 303 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 K 303 8x49 G.H5 E 379 G.H5.24
Polar ICL2 R 123 34x44 G.H5 F 363 G.H5.08
Aromatic ICL2 R 123 34x44 G.H5 F 363 G.H5.08
Van-der-waals ICL2 R 123 34x44 G.H5 F 363 G.H5.08
Hydrophobic TM6 A 241 6x30 G.H5 L 381 G.H5.26
Van-der-waals TM6 A 241 6x30 G.H5 L 381 G.H5.26
Hydrophobic TM6 A 245 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 245 6x34 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 123 34x44 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 123 34x44 G.H5 I 370 G.H5.15
Polar TM2 S 53 2x39 G.H5 Q 377 G.H5.22
Ionic TM5 H 223 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 368 G.H5.13
Polar TM5 Y 230 5x75 G.H5 N 364 G.H5.09
Hydrophobic TM5 Y 230 5x75 G.H5 N 364 G.H5.09
Van-der-waals TM5 Y 230 5x75 G.H5 N 364 G.H5.09
Hydrophobic TM3 L 121 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 121 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 L 121 3x54 G.H5 L 380 G.H5.25
Polar TM6 P 237 6x26 G.H5 R 372 G.H5.17
Hydrophobic TM6 P 237 6x26 G.H5 R 372 G.H5.17
Van-der-waals TM6 P 237 6x26 G.H5 R 372 G.H5.17
Hydrophobic ICL3 R 232 - G.hgh4 P 313 G.hgh4.16
Ionic TM6 D 236 6x25 G.H5 R 372 G.H5.17
Polar TM6 D 236 6x25 G.H5 R 372 G.H5.17
Polar ICL2 R 123 34x44 G.H5 C 366 G.H5.11
Hydrophobic ICL2 R 123 34x44 G.H5 C 366 G.H5.11
Van-der-waals ICL2 R 123 34x44 G.H5 C 366 G.H5.11
Hydrophobic TM6 P 237 6x26 G.h4s6 Y 345 G.h4s6.20
Polar TM3 L 121 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 L 121 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 L 121 3x54 G.H5 Q 371 G.H5.16
Polar TM5 H 223 5x68 G.H5 R 367 G.H5.12
Hydrophobic TM5 H 223 5x68 G.H5 R 367 G.H5.12
Van-der-waals TM5 H 223 5x68 G.H5 R 367 G.H5.12
Hydrophobic TM7 G 300 7x56 G.H5 L 380 G.H5.25
Polar H8 N 301 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 N 301 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 N 301 8x47 G.H5 E 379 G.H5.24
Polar H8 A 302 8x48 G.H5 L 381 G.H5.26
Hydrophobic H8 A 302 8x48 G.H5 L 381 G.H5.26
Van-der-waals H8 A 302 8x48 G.H5 L 381 G.H5.26
Polar TM3 K 120 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM3 K 120 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 K 120 3x53 G.H5 Y 378 G.H5.23
Polar TM5 H 223 5x68 G.H5 Q 371 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 Q 371 G.H5.16
Van-der-waals TM5 H 223 5x68 G.H5 Q 371 G.H5.16
Polar ICL3 R 232 - G.hgh4 A 311 G.hgh4.14
Hydrophobic ICL3 R 232 - G.hgh4 A 311 G.hgh4.14
Van-der-waals ICL3 R 232 - G.hgh4 A 311 G.hgh4.14
Polar TM3 Y 117 3x50 G.H5 Y 378 G.H5.23
Aromatic TM3 Y 117 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 Y 117 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 Y 117 3x50 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 T 127 34x48 G.s2s3 K 203 G.s2s3.02