Gi1 - TAS2R39 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 148 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 148 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 P 252 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 F 134 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 N 141 34x44 G.H5 I 344 G.H5.16
Hydrophobic ICL2 W 152 34x55 G.HN G 27 G.HN.51
Ionic TM6 H 257 6x31 G.H5 D 341 G.H5.13
Polar TM6 H 257 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 H 257 6x31 G.H5 D 341 G.H5.13
Hydrophobic ICL2 W 152 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 W 152 34x55 G.HN E 28 G.HN.52
Polar H8 N 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 315 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 315 8x47 G.H5 G 352 G.H5.24
Polar H8 R 319 8x51 G.H5 F 354 G.H5.26
Hydrophobic TM6 D 251 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 I 139 3x54 G.H5 I 344 G.H5.16
Polar TM4 R 153 4x37 G.HN R 24 G.HN.48
Hydrophobic TM4 R 153 4x37 G.HN R 24 G.HN.48
Van-der-waals TM4 R 153 4x37 G.HN R 24 G.HN.48
Hydrophobic TM5 H 238 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 238 5x68 G.H5 I 344 G.H5.16
Polar TM6 S 253 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 253 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 253 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 N 141 34x44 G.H5 T 340 G.H5.12
Van-der-waals ICL2 N 141 34x44 G.H5 T 340 G.H5.12
Polar TM3 Y 135 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 135 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 135 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 135 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 263 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 K 138 3x53 G.H5 C 351 G.H5.23
Polar ICL2 W 152 34x55 G.HN R 24 G.HN.48
Aromatic ICL2 W 152 34x55 G.HN R 24 G.HN.48
Hydrophobic ICL2 W 152 34x55 G.HN R 24 G.HN.48
Van-der-waals ICL2 W 152 34x55 G.HN R 24 G.HN.48
Polar ICL3 T 247 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 T 247 - G.H4 Q 304 G.H4.12
Hydrophobic ICL2 L 148 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 H 257 6x31 G.H5 I 344 G.H5.16
Van-der-waals TM6 H 257 6x31 G.H5 I 344 G.H5.16
Hydrophobic TM7 D 314 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 D 314 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 W 152 34x55 G.HN E 25 G.HN.49
Van-der-waals ICL2 W 152 34x55 G.HN E 25 G.HN.49
Hydrophobic TM6 A 256 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 256 6x30 G.H5 F 354 G.H5.26
Polar TM6 P 252 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 P 252 6x26 G.H5 K 345 G.H5.17
Polar TM6 S 253 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 253 6x27 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 253 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 260 6x34 G.H5 L 353 G.H5.25
Ionic TM5 H 238 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 238 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 238 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 238 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 H 257 6x31 G.H5 L 348 G.H5.20
Polar TM7 D 314 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 D 314 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM5 M 242 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 H 238 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 P 252 6x26 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 A 256 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 139 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 267 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM5 N 245 5x75 G.S6 H 322 G.S6.04
Polar H8 P 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 P 316 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 M 242 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 P 252 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM2 S 72 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 72 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 I 264 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 139 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 260 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 260 6x34 G.H5 L 348 G.H5.20
Hydrophobic H8 P 316 8x48 G.H5 G 352 G.H5.24
Ionic TM5 H 241 5x71 G.H5 D 337 G.H5.09
Polar TM5 H 241 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 H 241 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 H 241 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 139 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 M 242 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 M 242 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 139 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 139 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 235 5x65 G.H5 I 344 G.H5.16
Polar TM5 H 241 5x71 G.H5 Q 333 G.H5.05
Polar TM5 N 245 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 N 245 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM6 S 253 6x27 G.H5 K 345 G.H5.17
Polar TM3 K 138 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 138 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 138 3x53 G.H5 N 347 G.H5.19