Gt2 - TAS2R40 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 I 123 3x54 G.H5 L 353 G.H5.25
Polar TM6 P 237 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 P 237 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 P 237 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 F 132 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 132 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM3 I 123 3x54 G.H5 N 347 G.H5.19
Hydrophobic H8 P 301 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 P 301 8x48 G.H5 K 349 G.H5.21
Polar TM5 N 230 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 N 230 5x75 G.H5 D 337 G.H5.09
Polar TM6 S 238 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 238 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 238 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 I 123 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 122 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 122 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 227 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 227 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 F 132 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 F 132 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 N 230 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 N 230 5x75 G.H5 F 334 G.H5.06
Hydrophobic ICL2 N 127 34x46 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 N 127 34x46 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM3 I 123 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 123 3x54 G.H5 C 351 G.H5.23
Polar TM6 A 245 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 245 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 245 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 227 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 M 227 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 L 216 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 242 6x31 G.H5 I 344 G.H5.16
Van-der-waals TM6 H 242 6x31 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 241 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 241 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 220 5x65 G.H5 I 344 G.H5.16
Polar TM6 S 238 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 238 6x27 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 238 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM7 G 299 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 G 299 7x56 G.H5 G 352 G.H5.24
Ionic TM5 H 223 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 248 6x37 G.H5 L 353 G.H5.25
Ionic TM3 R 122 3x53 G.H5 D 350 G.H5.22
Polar TM3 R 122 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 122 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 122 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM6 A 245 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 245 6x34 G.H5 L 348 G.H5.20
Polar TM3 Y 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 119 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 241 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM3 Y 119 3x50 G.H5 L 353 G.H5.25
Ionic TM6 H 242 6x31 G.H5 D 341 G.H5.13
Polar TM6 H 242 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM6 H 242 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 H 242 6x31 G.H5 D 341 G.H5.13
Polar H8 N 300 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 300 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 300 8x47 G.H5 G 352 G.H5.24
Ionic TM5 H 226 5x71 G.H5 D 337 G.H5.09
Polar TM5 H 226 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 H 226 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 H 226 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 123 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 238 6x27 G.S6 Y 320 G.S6.02
Polar TM7 G 299 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 G 299 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM5 H 223 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 223 5x68 G.H5 I 344 G.H5.16
Polar TM3 R 122 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 122 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 122 3x53 G.H5 N 347 G.H5.19
Polar TM7 G 299 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 241 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 220 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 H 242 6x31 G.H5 L 348 G.H5.20
Hydrophobic TM5 H 223 5x68 G.H5 T 340 G.H5.12