G12 - TAS2R4 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 K 109 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 I 378 G.H5.23
Polar TM6 A 224 6x30 G.H5 K 376 G.H5.21
Hydrophobic TM6 A 224 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 A 224 6x30 G.H5 K 376 G.H5.21
Aromatic TM5 K 209 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM3 I 110 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 375 G.H5.20
Polar TM5 H 206 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 206 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 206 5x68 G.H5 Q 372 G.H5.17
Polar TM2 S 42 2x37 G.H5 I 378 G.H5.23
Hydrophobic TM2 S 42 2x37 G.H5 I 378 G.H5.23
Hydrophobic TM3 K 109 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 K 109 3x53 G.H5 L 375 G.H5.20
Ionic TM5 H 206 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 206 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 206 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 206 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 N 219 6x25 G.h4s6 P 345 G.h4s6.20
Polar H8 H 284 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 H 284 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 H 284 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 K 286 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 286 8x49 G.H5 Q 381 G.H5.26
Polar TM6 Q 221 6x27 G.H5 K 376 G.H5.21
Van-der-waals TM6 Q 221 6x27 G.H5 K 376 G.H5.21
Polar TM6 H 225 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 225 6x31 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 225 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM6 P 220 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 P 220 6x26 G.h4s6 P 345 G.h4s6.20
Polar H8 K 286 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 K 286 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 286 8x49 G.H5 L 380 G.H5.25
Polar ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Van-der-waals ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Hydrophobic TM2 D 45 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 D 45 2x40 G.H5 Q 381 G.H5.26
Polar TM6 H 225 6x31 G.H5 K 376 G.H5.21
Aromatic TM6 H 225 6x31 G.H5 K 376 G.H5.21
Hydrophobic TM6 H 225 6x31 G.H5 K 376 G.H5.21
Van-der-waals TM6 H 225 6x31 G.H5 K 376 G.H5.21
Polar ICL1 R 40 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 R 40 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 R 40 - G.hns1 R 55 G.hns1.02
Hydrophobic TM6 P 220 6x26 G.S6 F 347 G.S6.02
Van-der-waals TM6 P 220 6x26 G.S6 F 347 G.S6.02
Polar TM6 N 219 6x25 G.S6 H 348 G.S6.03
Hydrophobic TM5 M 210 5x72 G.H5 A 365 G.H5.10
Hydrophobic TM5 N 213 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM5 N 213 5x75 G.H5 F 361 G.H5.06
Polar TM3 Y 106 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 Y 106 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 Y 106 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM4 P 127 4x40 G.HN R 52 G.HN.52
Hydrophobic TM6 P 220 6x26 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM2 S 42 2x37 G.hns1 R 55 G.hns1.02
Polar ICL1 R 40 - G.HN R 51 G.HN.51
Hydrophobic ICL1 R 40 - G.HN R 51 G.HN.51
Van-der-waals ICL1 R 40 - G.HN R 51 G.HN.51
Polar TM2 S 42 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 S 42 2x37 G.H5 Q 381 G.H5.26
Polar ICL2 R 123 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 123 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 123 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 M 210 5x72 G.H5 T 369 G.H5.14
Van-der-waals TM5 M 210 5x72 G.H5 T 369 G.H5.14
Hydrophobic TM6 P 220 6x26 G.S6 L 346 G.S6.01
Polar H8 P 285 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 P 285 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 P 285 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM7 T 283 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 T 283 7x56 G.H5 L 380 G.H5.25
Polar H8 H 284 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 H 284 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 H 284 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL3 F 217 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 F 217 - G.S6 H 348 G.S6.03
Polar TM6 Q 221 6x27 G.H5 E 373 G.H5.18
Hydrophobic TM6 Q 221 6x27 G.H5 E 373 G.H5.18
Van-der-waals TM6 Q 221 6x27 G.H5 E 373 G.H5.18
Polar TM2 S 44 2x39 G.H5 M 379 G.H5.24
Hydrophobic TM2 S 44 2x39 G.H5 M 379 G.H5.24
Polar ICL1 I 41 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 I 41 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 I 41 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 W 218 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 W 218 - G.h4s6 P 345 G.h4s6.20
Polar TM6 Q 221 6x27 G.H5 T 369 G.H5.14
Hydrophobic TM6 Q 221 6x27 G.H5 T 369 G.H5.14
Van-der-waals TM6 Q 221 6x27 G.H5 T 369 G.H5.14
Polar H8 H 284 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 H 284 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 H 284 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 N 219 6x25 G.S6 F 347 G.S6.02
Van-der-waals TM6 N 219 6x25 G.S6 F 347 G.S6.02
Polar TM2 S 44 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM2 S 44 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 S 44 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 110 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 I 110 3x54 G.H5 M 379 G.H5.24
Hydrophobic TM6 Q 221 6x27 G.S6 F 347 G.S6.02
Van-der-waals TM6 Q 221 6x27 G.S6 F 347 G.S6.02