Gi2 - TAS2R4 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 85.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 Q 221 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 Q 221 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 Q 221 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 110 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM3 Y 106 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM5 H 206 5x68 G.H5 T 341 G.H5.12
Hydrophobic ICL2 L 119 34x51 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM6 H 225 6x31 G.H5 K 346 G.H5.17
Van-der-waals TM6 H 225 6x31 G.H5 K 346 G.H5.17
Ionic TM5 K 209 5x71 G.H5 D 338 G.H5.09
Polar TM5 K 209 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 K 209 5x71 G.H5 D 338 G.H5.09
Van-der-waals TM5 K 209 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM3 I 110 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 110 3x54 G.H5 C 352 G.H5.23
Hydrophobic TM6 A 224 6x30 G.H5 L 349 G.H5.20
Hydrophobic TM5 H 206 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 H 206 5x68 G.H5 I 345 G.H5.16
Aromatic ICL3 F 217 - G.S6 F 324 G.S6.05
Hydrophobic ICL3 F 217 - G.S6 F 324 G.S6.05
Van-der-waals ICL3 F 217 - G.S6 F 324 G.S6.05
Ionic ICL2 R 123 34x55 G.HN E 28 G.HN.52
Polar ICL2 R 123 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 123 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 123 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 Q 114 34x46 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 Q 114 34x46 G.s2s3 D 194 G.s2s3.02
Ionic TM6 H 225 6x31 G.H5 D 342 G.H5.13
Polar TM6 H 225 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM6 H 225 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 H 225 6x31 G.H5 D 342 G.H5.13
Polar TM3 K 109 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 109 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 A 224 6x30 G.H5 F 355 G.H5.26
Van-der-waals TM6 A 224 6x30 G.H5 F 355 G.H5.26
Polar TM4 N 124 4x37 G.HN R 24 G.HN.48
Hydrophobic TM4 N 124 4x37 G.HN R 24 G.HN.48
Van-der-waals TM4 N 124 4x37 G.HN R 24 G.HN.48
Polar ICL3 F 217 - G.H4 Q 305 G.H4.12
Hydrophobic ICL3 F 217 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 F 217 - G.H4 Q 305 G.H4.12
Polar TM5 N 213 5x75 G.H5 D 338 G.H5.09
Van-der-waals TM5 N 213 5x75 G.H5 D 338 G.H5.09
Hydrophobic ICL2 K 122 34x54 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 120 34x52 G.HN E 28 G.HN.52
Van-der-waals ICL2 L 120 34x52 G.HN E 28 G.HN.52
Polar ICL3 W 218 - G.S6 I 320 G.S6.01
Aromatic ICL3 W 218 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 W 218 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 W 218 - G.S6 Y 321 G.S6.02
Hydrophobic ICL2 R 123 34x55 G.HN G 27 G.HN.51
Van-der-waals ICL2 R 123 34x55 G.HN G 27 G.HN.51
Polar TM2 S 44 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM2 S 44 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM5 M 210 5x72 G.S6 Y 321 G.S6.02
Hydrophobic TM3 I 110 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL3 T 215 - G.S6 H 323 G.S6.04
Hydrophobic ICL3 W 218 - G.H5 F 335 G.H5.06
Polar TM6 Q 221 6x27 G.h4s6 K 315 G.h4s6.08
Polar TM3 Y 106 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 Y 106 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 Y 106 3x50 G.H5 C 352 G.H5.23
Polar ICL2 R 123 34x55 G.HN R 24 G.HN.48
Hydrophobic ICL2 R 123 34x55 G.HN R 24 G.HN.48
Van-der-waals ICL2 R 123 34x55 G.HN R 24 G.HN.48
Polar ICL2 N 112 34x44 G.H5 T 341 G.H5.12
Hydrophobic ICL2 N 112 34x44 G.H5 T 341 G.H5.12
Van-der-waals ICL2 N 112 34x44 G.H5 T 341 G.H5.12
Van-der-waals ICL2 R 123 34x55 G.HN E 25 G.HN.49
Polar ICL2 Q 114 34x46 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 Q 114 34x46 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 Q 114 34x46 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 L 119 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 119 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 110 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 M 210 5x72 G.H5 D 342 G.H5.13
Van-der-waals TM5 M 210 5x72 G.H5 D 342 G.H5.13
Polar TM6 Q 221 6x27 G.H5 K 346 G.H5.17
Van-der-waals TM6 Q 221 6x27 G.H5 K 346 G.H5.17
Hydrophobic TM6 A 228 6x34 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 228 6x34 G.H5 L 349 G.H5.20
Hydrophobic ICL2 R 123 34x55 G.hns1 A 31 G.hns1.02
Polar H8 H 284 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 H 284 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 H 284 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL3 F 217 - G.H4 S 302 G.H4.08
Van-der-waals ICL3 F 217 - G.H4 S 302 G.H4.08
Hydrophobic TM5 L 203 5x65 G.H5 I 345 G.H5.16
Hydrophobic TM6 H 225 6x31 G.H5 L 349 G.H5.20
Van-der-waals TM6 H 225 6x31 G.H5 L 349 G.H5.20
Hydrophobic H8 P 285 8x48 G.H5 G 353 G.H5.24
Van-der-waals H8 P 285 8x48 G.H5 G 353 G.H5.24
Hydrophobic TM6 M 232 6x38 G.H5 L 354 G.H5.25
Ionic TM3 K 109 3x53 G.H5 D 351 G.H5.22
Polar TM3 K 109 3x53 G.H5 D 351 G.H5.22
Hydrophobic TM6 A 228 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 H 225 6x31 G.H5 I 345 G.H5.16
Hydrophobic ICL3 W 218 - G.S6 T 322 G.S6.03
Van-der-waals ICL3 W 218 - G.S6 T 322 G.S6.03
Hydrophobic ICL2 N 112 34x44 G.H5 I 345 G.H5.16
Ionic TM5 H 206 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 206 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 206 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 206 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM6 L 231 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 231 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM3 K 109 3x53 G.H5 C 352 G.H5.23
Polar ICL3 W 218 - G.h4s6 E 319 G.h4s6.12
Polar TM2 S 44 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 S 44 2x39 G.H5 D 351 G.H5.22
Hydrophobic ICL3 F 217 - G.H4 A 301 G.H4.07