Gs - TAS2R4 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL1 R 40 - G.h2s4 D 240 G.h2s4.03
Polar ICL1 R 40 - G.h2s4 D 240 G.h2s4.03
Van-der-waals ICL1 R 40 - G.h2s4 D 240 G.h2s4.03
Hydrophobic ICL2 L 119 34x51 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 L 119 34x51 G.s2s3 D 215 G.s2s3.01
Hydrophobic H8 P 285 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 P 285 8x48 G.H5 R 389 G.H5.21
Hydrophobic TM6 Q 221 6x27 G.S6 Y 360 G.S6.02
Van-der-waals TM6 Q 221 6x27 G.S6 Y 360 G.S6.02
Hydrophobic TM6 P 220 6x26 G.S6 Y 360 G.S6.02
Polar TM2 S 42 2x37 G.H5 Y 391 G.H5.23
Hydrophobic TM2 S 42 2x37 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 42 2x37 G.H5 Y 391 G.H5.23
Polar ICL2 K 122 34x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 K 122 34x54 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 K 122 34x54 G.H5 Q 384 G.H5.16
Polar TM2 S 44 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 S 43 2x38 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 110 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 388 G.H5.20
Polar TM5 N 213 5x75 G.H5 D 378 G.H5.10
Hydrophobic ICL1 R 40 - G.HN K 34 G.HN.51
Van-der-waals ICL1 R 40 - G.HN K 34 G.HN.51
Polar ICL3 T 215 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 T 215 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 T 215 - G.hgh4 T 325 G.hgh4.15
Ionic H8 K 286 8x49 G.H5 E 392 G.H5.24
Polar H8 K 286 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 K 286 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 K 286 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM4 P 127 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM4 P 127 4x40 G.HN Q 35 G.HN.52
Polar ICL2 S 116 34x48 G.s2s3 K 216 G.s2s3.02
Polar TM5 H 206 5x68 G.H5 R 385 G.H5.17
Aromatic TM5 H 206 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 206 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 206 5x68 G.H5 R 385 G.H5.17
Aromatic ICL1 R 40 - G.hns1 Y 37 G.hns1.01
Hydrophobic H8 H 284 8x47 G.H5 L 394 G.H5.26
Polar ICL2 N 112 34x44 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 N 112 34x44 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 N 112 34x44 G.H5 Q 384 G.H5.16
Polar ICL2 Q 114 34x46 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 Q 114 34x46 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM6 P 220 6x26 G.h4s6 Y 358 G.h4s6.20
Polar TM2 S 44 2x39 G.H5 L 393 G.H5.25
Hydrophobic TM2 S 44 2x39 G.H5 L 393 G.H5.25
Van-der-waals TM2 S 44 2x39 G.H5 L 393 G.H5.25
Polar TM2 S 44 2x39 G.H5 E 392 G.H5.24
Hydrophobic TM2 S 44 2x39 G.H5 E 392 G.H5.24
Van-der-waals TM2 S 44 2x39 G.H5 E 392 G.H5.24
Polar ICL2 N 112 34x44 G.H5 D 381 G.H5.13
Hydrophobic ICL2 N 112 34x44 G.H5 D 381 G.H5.13
Van-der-waals ICL2 N 112 34x44 G.H5 D 381 G.H5.13
Polar ICL3 G 216 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 G 216 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 G 216 - G.hgh4 T 325 G.hgh4.15
Polar TM6 Q 221 6x27 G.H5 R 385 G.H5.17
Hydrophobic TM6 Q 221 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 Q 221 6x27 G.H5 R 385 G.H5.17
Hydrophobic H8 P 285 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 P 285 8x48 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 210 5x72 G.H5 D 378 G.H5.10
Van-der-waals TM5 M 210 5x72 G.H5 D 378 G.H5.10
Ionic TM5 H 206 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 206 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 206 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 206 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM2 S 42 2x37 G.H5 E 392 G.H5.24
Hydrophobic TM3 K 109 3x53 G.H5 L 388 G.H5.20
Van-der-waals TM3 K 109 3x53 G.H5 L 388 G.H5.20
Hydrophobic ICL1 R 40 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 40 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 119 34x51 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL3 F 217 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 F 217 - G.hgh4 P 321 G.hgh4.11
Polar TM1 H 39 1x65 G.HN K 34 G.HN.51
Hydrophobic TM3 I 110 3x54 G.H5 L 394 G.H5.26
Polar ICL3 G 216 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 G 216 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 G 216 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 F 217 - G.H4 Y 339 G.H4.08
Polar TM3 Y 106 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM3 Y 106 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 106 3x50 G.H5 L 393 G.H5.25
Polar TM6 H 225 6x31 G.H5 R 385 G.H5.17
Aromatic TM6 H 225 6x31 G.H5 R 385 G.H5.17
Hydrophobic TM6 H 225 6x31 G.H5 R 385 G.H5.17
Van-der-waals TM6 H 225 6x31 G.H5 R 385 G.H5.17
Polar ICL1 I 41 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 I 41 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 I 41 - G.hns1 R 38 G.hns1.02
Aromatic ICL3 F 217 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 F 217 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 F 217 - G.H4 R 342 G.H4.12
Ionic H8 H 284 8x47 G.H5 E 392 G.H5.24
Polar H8 H 284 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 H 284 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 H 284 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 228 6x34 G.H5 L 394 G.H5.26
Hydrophobic TM3 K 109 3x53 G.H5 L 393 G.H5.25
Van-der-waals TM3 K 109 3x53 G.H5 L 393 G.H5.25
Polar ICL3 W 218 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 F 217 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 F 217 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 F 217 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM3 L 105 3x49 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 105 3x49 G.H5 L 393 G.H5.25
Hydrophobic TM2 D 45 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 D 45 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM6 Q 221 6x27 G.H5 I 382 G.H5.14
Van-der-waals TM6 Q 221 6x27 G.H5 I 382 G.H5.14