Gt2 - TAS2R9 complex model

GPCR CLASS (FAMILY)

T (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 N 113 34x44 G.H5 I 344 G.H5.16
Van-der-waals ICL2 N 113 34x44 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 226 6x30 G.H5 K 345 G.H5.17
Polar TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 124 34x55 G.HN D 28 G.HN.52
Van-der-waals ICL2 L 124 34x55 G.HN D 28 G.HN.52
Polar TM4 K 125 4x37 G.HN Q 24 G.HN.48
Hydrophobic TM4 K 125 4x37 G.HN Q 24 G.HN.48
Van-der-waals TM4 K 125 4x37 G.HN Q 24 G.HN.48
Polar TM4 K 125 4x37 G.HN L 23 G.HN.47
Hydrophobic TM5 L 205 5x65 G.H5 L 348 G.H5.20
Polar TM7 G 285 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM7 G 285 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 G 285 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 111 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 111 3x54 G.H5 L 353 G.H5.25
Polar ICL2 N 113 34x44 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 N 113 34x44 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 N 113 34x44 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 N 113 34x44 G.S3 L 194 G.S3.01
Van-der-waals ICL2 N 113 34x44 G.S3 L 194 G.S3.01
Hydrophobic TM5 L 201 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 124 34x55 G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 L 124 34x55 G.hns1 E 30 G.hns1.01
Polar ICL2 W 121 34x52 G.HN D 28 G.HN.52
Hydrophobic ICL2 W 121 34x52 G.HN D 28 G.HN.52
Van-der-waals ICL2 W 121 34x52 G.HN D 28 G.HN.52
Hydrophobic TM3 I 111 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 Y 107 3x50 G.H5 L 353 G.H5.25
Polar H8 N 286 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 286 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 286 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 N 113 34x44 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 113 34x44 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 F 106 3x49 G.H5 D 350 G.H5.22
Hydrophobic TM4 I 126 4x38 G.hns1 A 31 G.hns1.02
Polar ICL2 S 115 34x46 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 S 115 34x46 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 S 115 34x46 G.s2s3 D 193 G.s2s3.02
Polar TM3 F 106 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 F 106 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 F 106 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM2 I 44 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 I 44 2x39 G.H5 G 352 G.H5.24
Polar TM6 A 230 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 230 6x34 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 124 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 124 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 124 34x55 G.HN K 29 G.HN.53
Van-der-waals ICL2 L 124 34x55 G.HN K 29 G.HN.53
Hydrophobic TM3 K 110 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 120 34x51 G.S3 N 195 G.S3.02
Van-der-waals ICL2 F 120 34x51 G.S3 N 195 G.S3.02
Polar ICL2 L 124 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 124 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 124 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 124 34x55 G.S1 T 33 G.S1.01
Van-der-waals ICL2 L 124 34x55 G.S1 T 33 G.S1.01
Polar ICL2 K 123 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 K 123 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 K 123 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 I 111 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 111 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 111 3x54 G.H5 N 347 G.H5.19
Polar H8 S 287 8x48 G.H5 F 354 G.H5.26
Polar ICL2 W 121 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 W 121 34x52 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 W 121 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 122 34x53 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 122 34x53 G.hns1 K 32 G.hns1.03
Polar ICL2 I 114 34x45 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 I 114 34x45 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 I 114 34x45 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 123 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 123 34x54 G.S3 L 194 G.S3.01
Polar ICL2 F 119 34x50 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 F 119 34x50 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 F 119 34x50 G.hns1 K 32 G.hns1.03
Hydrophobic TM6 V 234 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 227 6x31 G.H5 L 348 G.H5.20
Hydrophobic TM7 G 285 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 G 285 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 W 121 34x52 G.HN E 25 G.HN.49
Polar ICL2 F 120 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 F 120 34x51 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 F 120 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic TM2 I 44 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 I 44 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 K 123 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 123 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 W 121 34x52 G.HN Q 24 G.HN.48
Hydrophobic TM6 A 233 6x37 G.H5 L 353 G.H5.25
Aromatic TM6 R 229 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM4 K 125 4x37 G.hns1 A 31 G.hns1.02
Polar H8 R 290 8x51 G.H5 F 354 G.H5.26
Hydrophobic H8 R 290 8x51 G.H5 F 354 G.H5.26
Van-der-waals H8 R 290 8x51 G.H5 F 354 G.H5.26
Ionic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 124 34x55 G.HN A 27 G.HN.51
Van-der-waals ICL2 L 124 34x55 G.HN A 27 G.HN.51
Polar TM3 K 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 347 G.H5.19
Polar TM7 G 285 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM7 G 285 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 G 285 7x56 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 120 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 F 120 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 I 212 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 212 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 230 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 230 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 226 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 226 6x30 G.H5 F 354 G.H5.26
Ionic TM4 K 125 4x37 G.HN D 28 G.HN.52
Polar TM4 K 125 4x37 G.HN D 28 G.HN.52
Hydrophobic TM4 K 125 4x37 G.HN D 28 G.HN.52
Van-der-waals TM4 K 125 4x37 G.HN D 28 G.HN.52
Hydrophobic TM4 K 125 4x37 G.HN A 27 G.HN.51
Van-der-waals TM4 K 125 4x37 G.HN A 27 G.HN.51
Hydrophobic TM3 I 111 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 F 120 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 120 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 H 208 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM2 I 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 I 44 2x39 G.H5 C 351 G.H5.23
Ionic TM3 K 110 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 110 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 K 110 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 110 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM5 H 215 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 H 215 5x75 G.H5 F 334 G.H5.06