G12 - TP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 235 6x25 G.H5 Q 372 G.H5.17
Ionic TM6 R 237 6x27 G.H5 D 368 G.H5.13
Polar TM6 R 237 6x27 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 237 6x27 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 237 6x27 G.H5 D 368 G.H5.13
Hydrophobic ICL2 F 138 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 138 34x51 G.H5 I 370 G.H5.15
Polar H8 R 312 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 R 312 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 R 312 8x47 G.H5 M 379 G.H5.24
Aromatic ICL2 F 138 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 138 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 138 34x51 G.H5 F 363 G.H5.08
Ionic TM6 R 235 6x25 G.H5 D 368 G.H5.13
Polar TM6 R 235 6x25 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 235 6x25 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 235 6x25 G.H5 D 368 G.H5.13
Polar ICL2 V 143 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 V 143 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 V 143 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic TM1 L 49 1x57 G.H5 L 380 G.H5.25
Van-der-waals TM1 L 49 1x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 L 371 G.H5.16
Hydrophobic H8 A 314 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 R 140 34x53 G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 140 34x53 G.H5 I 378 G.H5.23
Ionic ICL1 H 58 - G.H5 D 377 G.H5.22
Polar ICL1 H 58 - G.H5 D 377 G.H5.22
Hydrophobic ICL1 H 58 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 H 58 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 138 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 138 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 138 34x51 G.S3 F 223 G.S3.03
Polar TM6 E 242 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 E 242 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 S 239 6x29 G.H5 L 375 G.H5.20
Polar H8 R 312 8x47 G.H5 I 378 G.H5.23
Van-der-waals H8 R 312 8x47 G.H5 I 378 G.H5.23
Hydrophobic TM5 V 225 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 235 6x25 G.S6 F 347 G.S6.02
Hydrophobic TM2 L 67 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 138 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 138 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 M 243 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 M 243 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Hydrophobic H8 R 312 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 R 312 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM2 F 63 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 63 2x39 G.H5 I 378 G.H5.23
Polar TM2 S 61 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 61 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 61 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM5 L 222 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM2 L 64 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 64 2x40 G.H5 L 380 G.H5.25
Polar TM6 Q 234 6x24 G.S6 H 348 G.S6.03
Hydrophobic TM6 Q 234 6x24 G.S6 H 348 G.S6.03
Van-der-waals TM6 Q 234 6x24 G.S6 H 348 G.S6.03
Polar ICL2 P 137 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM6 M 243 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 243 6x33 G.H5 I 378 G.H5.23
Polar ICL2 R 140 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 140 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 140 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 Q 234 6x24 G.S6 F 347 G.S6.02
Van-der-waals TM6 Q 234 6x24 G.S6 F 347 G.S6.02
Hydrophobic TM6 E 242 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 235 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 235 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 M 243 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 243 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 138 34x51 G.H5 V 366 G.H5.11
Polar TM3 G 133 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 G 133 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 133 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 I 134 3x54 G.H5 L 375 G.H5.20
Polar ICL1 S 57 - G.h3s5 N 288 G.h3s5.02
Hydrophobic ICL2 F 138 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 138 34x51 G.S1 V 58 G.S1.02
Ionic ICL2 R 140 34x53 G.H5 D 377 G.H5.22
Polar ICL2 R 140 34x53 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 140 34x53 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 140 34x53 G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 137 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 137 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 141 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 141 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 S 139 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 R 130 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 Q 234 6x24 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 234 6x24 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 E 240 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 134 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 134 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 S 239 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 239 6x29 G.H5 M 379 G.H5.24