Golf - VPAC2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 234 - G.S3 V 204 G.S3.01
Polar TM4 R 238 4x40 G.HN R 36 G.HN.51
Hydrophobic TM5 K 309 5x64 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 333 6x45 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 332 6x44 G.H5 L 380 G.H5.25
Hydrophobic TM4 R 238 4x40 G.hns1 K 40 G.hns1.02
Van-der-waals TM4 R 238 4x40 G.hns1 K 40 G.hns1.02
Van-der-waals TM3 Y 226 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM3 L 230 3x57 G.H5 H 374 G.H5.19
Polar ICL3 S 312 - G.H5 R 372 G.H5.17
Hydrophobic TM7 Y 375 7x57 G.H5 Y 378 G.H5.23
Hydrophobic TM5 L 306 5x61 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 336 6x48 G.H5 Y 378 G.H5.23
Polar TM3 V 232 3x59 G.H5 R 367 G.H5.12
Van-der-waals TM3 V 232 3x59 G.H5 R 367 G.H5.12
Hydrophobic ICL2 M 234 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 234 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 M 234 - G.H5 F 363 G.H5.08
Hydrophobic TM3 L 231 3x58 G.H5 H 374 G.H5.19
Hydrophobic TM4 R 238 4x40 G.HN L 37 G.HN.52
Van-der-waals TM4 R 238 4x40 G.HN L 37 G.HN.52
Hydrophobic TM5 L 310 5x65 G.H5 L 381 G.H5.26
Van-der-waals TM5 L 310 5x65 G.H5 L 381 G.H5.26
Hydrophobic ICL3 V 315 - G.H5 R 372 G.H5.17
Polar TM3 E 223 3x50 G.H5 Y 378 G.H5.23
Hydrophobic ICL3 V 315 - G.h4s6 Y 345 G.h4s6.20
Van-der-waals ICL3 V 315 - G.h4s6 Y 345 G.h4s6.20
Polar H8 S 380 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 S 380 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 S 380 8x48 G.H5 E 379 G.H5.24
Polar TM2 R 158 2x46 G.H5 Q 377 G.H5.22
Hydrophobic TM2 R 158 2x46 G.H5 Q 377 G.H5.22
Van-der-waals TM2 R 158 2x46 G.H5 Q 377 G.H5.22
Hydrophobic TM3 L 227 3x54 G.H5 Y 378 G.H5.23
Polar TM6 R 325 6x37 G.H5 L 381 G.H5.26
Hydrophobic TM6 R 325 6x37 G.H5 L 381 G.H5.26
Van-der-waals TM6 R 325 6x37 G.H5 L 381 G.H5.26
Hydrophobic TM6 L 332 6x44 G.H5 E 379 G.H5.24
Van-der-waals TM6 L 332 6x44 G.H5 E 379 G.H5.24
Ionic TM5 K 309 5x64 G.H5 D 368 G.H5.13
Polar TM5 K 309 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 309 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 309 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 309 5x64 G.H5 L 381 G.H5.26
Hydrophobic TM2 H 162 2x50 G.H5 Y 378 G.H5.23
Van-der-waals TM2 H 162 2x50 G.H5 Y 378 G.H5.23
Polar TM5 K 309 5x64 G.H5 R 372 G.H5.17
Hydrophobic TM5 K 309 5x64 G.H5 R 372 G.H5.17
Van-der-waals TM5 K 309 5x64 G.H5 R 372 G.H5.17
Hydrophobic ICL2 M 234 - G.H5 R 367 G.H5.12
Van-der-waals ICL2 M 234 - G.H5 R 367 G.H5.12
Hydrophobic TM5 L 306 5x61 G.H5 L 375 G.H5.20
Hydrophobic TM4 P 236 4x38 G.hns1 A 41 G.hns1.03
Van-der-waals TM4 P 236 4x38 G.hns1 A 41 G.hns1.03
Hydrophobic TM3 L 227 3x54 G.H5 L 380 G.H5.25
Aromatic TM2 R 158 2x46 G.H5 Y 378 G.H5.23
Hydrophobic TM2 R 158 2x46 G.H5 Y 378 G.H5.23
Van-der-waals TM2 R 158 2x46 G.H5 Y 378 G.H5.23
Hydrophobic TM5 L 306 5x61 G.H5 L 381 G.H5.26
Polar TM3 L 231 3x58 G.H5 Q 371 G.H5.16
Hydrophobic TM3 L 231 3x58 G.H5 Q 371 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 Q 371 G.H5.16
Polar TM6 S 329 6x41 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 329 6x41 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 329 6x41 G.H5 L 380 G.H5.25
Polar N-term M 1 - G.HN E 29 G.HN.44
Van-der-waals N-term M 1 - G.HN E 29 G.HN.44
Hydrophobic TM3 L 231 3x58 G.H5 L 375 G.H5.20
Polar TM5 K 309 5x64 G.H5 Q 371 G.H5.16
Hydrophobic TM5 K 309 5x64 G.H5 Q 371 G.H5.16
Van-der-waals TM5 K 309 5x64 G.H5 Q 371 G.H5.16