5-HT4 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.75 docs)

VERSION

2018-04-06

MAIN TEMPLATE

D2 receptor (sequence similarity: 60%) PDB: 6CM4

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.6 8.9 15.5
Side-chains 28.2 47.5 24.4

Number of backbone templates: 4
Number of rotamer templates: 36

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3SN6
6CM4
4XES
5TVN
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone Xtal Rotamer Xtal
N-term 11 - - - -
N-term 12 - - - -
N-term 13 - - - -
N-term 14 - - - -
N-term 15 - - - -
TM1 16 1x29 β2-adrenoceptor 3SN6 A1 receptor 5UEN
TM1 17 1x30 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM1 18 1x31 β2-adrenoceptor 3SN6 M4 receptor 5DSG
TM1 19 1x32 β2-adrenoceptor 3SN6 NTS1 receptor 4BUO
TM1 20 1x33 D2 receptor 6CM4 P2Y12 receptor 4NTJ
TM1 21 1x34 D2 receptor 6CM4 A2A receptor 3VG9
TM1 22 1x35 D2 receptor 6CM4 OX2 receptor 5WS3
TM1 23 1x36 D2 receptor 6CM4 D4 receptor 5WIV
TM1 24 1x37 D2 receptor 6CM4 D2 receptor 6CM4
TM1 25 1x38 D2 receptor 6CM4 - -
TM1 26 1x39 D2 receptor 6CM4 D2 receptor 6CM4
TM1 27 1x40 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM1 28 1x41 D2 receptor 6CM4 H1 receptor 3RZE
TM1 29 1x42 D2 receptor 6CM4 OX2 receptor 5WS3
TM1 30 1x43 D2 receptor 6CM4 D2 receptor 6CM4
TM1 31 1x44 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM1 32 1x45 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM1 33 1x46 D2 receptor 6CM4 A2A receptor 3VG9
TM1 34 1x47 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM1 35 1x48 D2 receptor 6CM4 A2A receptor 3VG9
TM1 36 1x49 D2 receptor 6CM4 D2 receptor 6CM4
TM1 37 1x50 D2 receptor 6CM4 D2 receptor 6CM4
TM1 38 1x51 D2 receptor 6CM4 H1 receptor 3RZE
TM1 39 1x52 D2 receptor 6CM4 D2 receptor 6CM4
TM1 40 1x53 D2 receptor 6CM4 D2 receptor 6CM4
TM1 41 1x54 D2 receptor 6CM4 M4 receptor 5DSG
TM1 42 1x55 D2 receptor 6CM4 D4 receptor 5WIV
TM1 43 1x56 D2 receptor 6CM4 D2 receptor 6CM4
TM1 44 1x57 D2 receptor 6CM4 D2 receptor 6CM4
TM1 45 1x58 D2 receptor 6CM4 AT2 receptor 5UNG
TM1 46 1x59 D2 receptor 6CM4 US28 4XT1
TM1 47 1x60 D2 receptor 6CM4 - -
ICL1 48 12x48 D2 receptor 6CM4 D3 receptor 3PBL
ICL1 49 12x49 D2 receptor 6CM4 M3 receptor 4U15
ICL1 50 12x50 D2 receptor 6CM4 D2 receptor 6CM4
ICL1 51 12x51 D2 receptor 6CM4 OX2 receptor 5WS3
TM2 52 2x36 NTS1 receptor 4XES - -
TM2 53 2x37 D2 receptor 6CM4 - -
TM2 54 2x38 D2 receptor 6CM4 - -
TM2 55 2x39 D2 receptor 6CM4 D2 receptor 6CM4
TM2 56 2x40 D2 receptor 6CM4 D2 receptor 6CM4
TM2 57 2x41 D2 receptor 6CM4 D2 receptor 6CM4
TM2 58 2x42 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 59 2x43 D2 receptor 6CM4 D2 receptor 6CM4
TM2 60 2x44 D2 receptor 6CM4 D2 receptor 6CM4
TM2 61 2x45 D2 receptor 6CM4 D2 receptor 6CM4
TM2 62 2x46 D2 receptor 6CM4 D2 receptor 6CM4
TM2 63 2x47 D2 receptor 6CM4 D2 receptor 6CM4
TM2 64 2x48 D2 receptor 6CM4 - -
TM2 65 2x49 D2 receptor 6CM4 D2 receptor 6CM4
TM2 66 2x50 D2 receptor 6CM4 D2 receptor 6CM4
TM2 67 2x51 D2 receptor 6CM4 D2 receptor 6CM4
TM2 68 2x52 D2 receptor 6CM4 D2 receptor 6CM4
TM2 69 2x53 D2 receptor 6CM4 D2 receptor 6CM4
TM2 70 2x54 D2 receptor 6CM4 CB1 receptor 5TGZ
TM2 71 2x55 D2 receptor 6CM4 M3 receptor 4U15
TM2 72 2x551 D2 receptor 6CM4 D2 receptor 6CM4
TM2 73 2x56 D2 receptor 6CM4 D2 receptor 6CM4
TM2 74 2x57 D2 receptor 6CM4 D2 receptor 6CM4
TM2 75 2x58 D2 receptor 6CM4 D2 receptor 6CM4
TM2 76 2x59 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 77 2x60 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 78 2x61 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 79 2x62 D2 receptor 6CM4 CB1 receptor 5TGZ
TM2 80 2x63 D2 receptor 6CM4 FFA1 receptor 5TZY
TM2 81 2x64 D2 receptor 6CM4 H1 receptor 3RZE
TM2 82 2x65 D2 receptor 6CM4 D3 receptor 3PBL
TM2 83 2x66 D2 receptor 6CM4 D4 receptor 5WIV
TM2 84 2x67 D2 receptor 6CM4 5-HT2C receptor 6BQH
ECL1 85 23x49 D2 receptor 6CM4 - -
ECL1 86 23x50 D2 receptor 6CM4 D2 receptor 6CM4
ECL1 87 23x51 D2 receptor 6CM4 PAR2 5NDD
ECL1 88 23x52 D2 receptor 6CM4 - -
TM3 89 3x21 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 90 3x22 D2 receptor 6CM4 δ receptor 4N6H
TM3 91 3x23 D2 receptor 6CM4 M4 receptor 5DSG
TM3 92 3x24 D2 receptor 6CM4 apelin receptor 5VBL
TM3 93 3x25 D2 receptor 6CM4 D2 receptor 6CM4
TM3 94 3x26 D2 receptor 6CM4 H1 receptor 3RZE
TM3 95 3x27 D2 receptor 6CM4 D3 receptor 3PBL
TM3 96 3x28 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM3 97 3x29 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 98 3x30 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 99 3x31 D2 receptor 6CM4 D2 receptor 6CM4
TM3 100 3x32 D2 receptor 6CM4 D2 receptor 6CM4
TM3 101 3x33 D2 receptor 6CM4 D2 receptor 6CM4
TM3 102 3x34 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 103 3x35 D2 receptor 6CM4 D4 receptor 5WIV
TM3 104 3x36 D2 receptor 6CM4 A2A receptor 3VG9
TM3 105 3x37 D2 receptor 6CM4 D2 receptor 6CM4
TM3 106 3x38 D2 receptor 6CM4 D2 receptor 6CM4
TM3 107 3x39 D2 receptor 6CM4 D2 receptor 6CM4
TM3 108 3x40 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 109 3x41 D2 receptor 6CM4 D4 receptor 5WIV
TM3 110 3x42 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM3 111 3x43 D2 receptor 6CM4 D2 receptor 6CM4
TM3 112 3x44 D2 receptor 6CM4 D2 receptor 6CM4
TM3 113 3x45 D2 receptor 6CM4 OX2 receptor 5WS3
TM3 114 3x46 D2 receptor 6CM4 D2 receptor 6CM4
TM3 115 3x47 D2 receptor 6CM4 D2 receptor 6CM4
TM3 116 3x48 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM3 117 3x49 D2 receptor 6CM4 D2 receptor 6CM4
TM3 118 3x50 D2 receptor 6CM4 D2 receptor 6CM4
TM3 119 3x51 D2 receptor 6CM4 D2 receptor 6CM4
TM3 120 3x52 D2 receptor 6CM4 OX2 receptor 5WS3
TM3 121 3x53 D2 receptor 6CM4 D2 receptor 6CM4
TM3 122 3x54 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 123 3x55 D2 receptor 6CM4 OX2 receptor 5WS3
TM3 124 3x56 D2 receptor 6CM4 - -
ICL2 125 - - - -
ICL2 126 34x50 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
ICL2 127 34x51 β2-adrenoceptor 3SN6 M3 receptor 4U15
ICL2 128 34x52 β2-adrenoceptor 3SN6 - -
ICL2 129 34x53 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
ICL2 130 34x54 β2-adrenoceptor 3SN6 M3 receptor 4U15
ICL2 131 34x55 β2-adrenoceptor 3SN6 - -
ICL2 132 34x56 β2-adrenoceptor 3SN6 M3 receptor 4U15
ICL2 133 34x57 - - - -
TM4 134 4x38 D2 receptor 6CM4 OX2 receptor 5WS3
TM4 135 4x39 D2 receptor 6CM4 M1 receptor 5CXV
TM4 136 4x40 D2 receptor 6CM4 κ receptor 4DJH
TM4 137 4x41 D2 receptor 6CM4 D2 receptor 6CM4
TM4 138 4x42 D2 receptor 6CM4 - -
TM4 139 4x43 D2 receptor 6CM4 D3 receptor 3PBL
TM4 140 4x44 D2 receptor 6CM4 D3 receptor 3PBL
TM4 141 4x45 D2 receptor 6CM4 D2 receptor 6CM4
TM4 142 4x46 D2 receptor 6CM4 BLT1 receptor 5X33
TM4 143 4x47 D2 receptor 6CM4 D4 receptor 5WIV
TM4 144 4x48 D2 receptor 6CM4 H1 receptor 3RZE
TM4 145 4x49 D2 receptor 6CM4 A2A receptor 3VG9
TM4 146 4x50 D2 receptor 6CM4 D2 receptor 6CM4
TM4 147 4x51 D2 receptor 6CM4 D2 receptor 6CM4
TM4 148 4x52 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM4 149 4x53 D2 receptor 6CM4 - -
TM4 150 4x54 D2 receptor 6CM4 - -
TM4 151 4x55 D2 receptor 6CM4 CCR2 5T1A
TM4 152 4x56 D2 receptor 6CM4 D2 receptor 6CM4
TM4 153 4x57 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM4 154 4x58 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM4 155 4x59 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM4 156 4x60 D2 receptor 6CM4 D2 receptor 6CM4
TM4 157 4x61 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM4 158 4x62 D2 receptor 6CM4 S1P1 receptor 3V2Y
ECL2 159 - - - -
ECL2 160 - - - -
ECL2 161 - - - -
ECL2 162 - - - -
ECL2 163 - - - -
ECL2 164 - - - -
ECL2 165 - - - -
ECL2 166 - - - -
ECL2 167 - - - -
ECL2 168 - - - -
ECL2 169 - - - -
ECL2 170 - - - -
ECL2 171 - - - -
ECL2 172 - - - -
ECL2 173 - - - -
ECL2 174 - - - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 45x50 D2 receptor 6CM4 D2 receptor 6CM4
ECL2 185 45x51 D2 receptor 6CM4 - -
ECL2 186 45x52 D2 receptor 6CM4 β2-adrenoceptor 5JQH
ECL2 187 - - - -
ECL2 188 - - - -
TM5 189 5x36 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 190 5x37 β2-adrenoceptor 3SN6 OX2 receptor 5WS3
TM5 191 5x38 D2 receptor 6CM4 FFA1 receptor 5TZY
TM5 192 5x39 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 193 5x40 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 194 5x41 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 195 5x42 D2 receptor 6CM4 AT1 receptor 4ZUD
TM5 196 5x43 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM5 197 5x44 D2 receptor 6CM4 D2 receptor 6CM4
TM5 198 5x45 D2 receptor 6CM4 D3 receptor 3PBL
TM5 199 5x46 D2 receptor 6CM4 D2 receptor 6CM4
TM5 200 5x461 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 201 5x47 D2 receptor 6CM4 D2 receptor 6CM4
TM5 202 5x48 D2 receptor 6CM4 D2 receptor 6CM4
TM5 203 5x49 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 204 5x50 D2 receptor 6CM4 D2 receptor 6CM4
TM5 205 5x51 D2 receptor 6CM4 D2 receptor 6CM4
TM5 206 5x52 D2 receptor 6CM4 H1 receptor 3RZE
TM5 207 5x53 D2 receptor 6CM4 D4 receptor 5WIV
TM5 208 5x54 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 209 5x55 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 210 5x56 D2 receptor 6CM4 D2 receptor 6CM4
TM5 211 5x57 D2 receptor 6CM4 OX2 receptor 5WS3
TM5 212 5x58 D2 receptor 6CM4 D2 receptor 6CM4
TM5 213 5x59 D2 receptor 6CM4 US28 4XT1
TM5 214 5x60 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 215 5x61 D2 receptor 6CM4 D2 receptor 6CM4
TM5 216 5x62 D2 receptor 6CM4 D2 receptor 6CM4
TM5 217 5x63 D2 receptor 6CM4 D3 receptor 3PBL
TM5 218 5x64 D2 receptor 6CM4 apelin receptor 5VBL
TM5 219 5x65 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 220 5x66 D2 receptor 6CM4 β2-adrenoceptor 2RH1
TM5 221 5x67 D2 receptor 6CM4 Rhodopsin 1GZM
TM5 222 5x68 D2 receptor 6CM4 CB1 receptor 5TGZ
TM5 223 5x69 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 224 5x70 D2 receptor 6CM4 NTS1 receptor 4BUO
TM5 225 5x71 D2 receptor 6CM4 A2A receptor 3VG9
TM5 226 5x72 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 227 5x73 β2-adrenoceptor 3SN6 - -
TM5 228 5x74 β2-adrenoceptor 3SN6 - -
TM5 229 5x75 β2-adrenoceptor 3SN6 - -
TM5 230 5x76 β2-adrenoceptor 3SN6 - -
ICL3 231 - - - -
ICL3 232 - - - -
ICL3 233 - - - -
ICL3 234 - - - -
ICL3 235 - - - -
ICL3 243 - - - -
ICL3 244 - - - -
ICL3 245 - - - -
ICL3 246 - - - -
ICL3 247 - - - -
TM6 248 6x24 5-HT2B receptor 5TVN - -
TM6 249 6x25 5-HT2B receptor 5TVN - -
TM6 250 6x26 5-HT2B receptor 5TVN NTS1 receptor 4BUO
TM6 251 6x27 5-HT2B receptor 5TVN OX1 receptor 4ZJ8
TM6 252 6x28 5-HT2B receptor 5TVN OX2 receptor 5WS3
TM6 253 6x29 5-HT2B receptor 5TVN LPA1 receptor 4Z35
TM6 254 6x30 D2 receptor 6CM4 D2 receptor 6CM4
TM6 255 6x31 D2 receptor 6CM4 - -
TM6 256 6x32 D2 receptor 6CM4 β2-adrenoceptor 2RH1
TM6 257 6x33 D2 receptor 6CM4 D2 receptor 6CM4
TM6 258 6x34 D2 receptor 6CM4 H1 receptor 3RZE
TM6 259 6x35 D2 receptor 6CM4 β2-adrenoceptor 2RH1
TM6 260 6x36 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 261 6x37 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 262 6x38 D2 receptor 6CM4 - -
TM6 263 6x39 D2 receptor 6CM4 D2 receptor 6CM4
TM6 264 6x40 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 265 6x41 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 266 6x42 D2 receptor 6CM4 D2 receptor 6CM4
TM6 267 6x43 D2 receptor 6CM4 PAR1 3VW7
TM6 268 6x44 D2 receptor 6CM4 D2 receptor 6CM4
TM6 269 6x45 D2 receptor 6CM4 LPA6 receptor 5XSZ
TM6 270 6x46 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 271 6x47 D2 receptor 6CM4 D2 receptor 6CM4
TM6 272 6x48 D2 receptor 6CM4 D2 receptor 6CM4
TM6 273 6x49 D2 receptor 6CM4 M2 receptor 3UON
TM6 274 6x50 D2 receptor 6CM4 D2 receptor 6CM4
TM6 275 6x51 D2 receptor 6CM4 D2 receptor 6CM4
TM6 276 6x52 D2 receptor 6CM4 D2 receptor 6CM4
TM6 277 6x53 D2 receptor 6CM4 D4 receptor 5WIV
TM6 278 6x54 D2 receptor 6CM4 D2 receptor 6CM4
TM6 279 6x55 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 280 6x56 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 281 6x57 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 282 6x58 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM6 283 6x59 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM6 284 6x60 D2 receptor 6CM4 H1 receptor 3RZE
TM6 285 6x61 D2 receptor 6CM4 AT1 receptor 4ZUD
ECL3 286 D2 receptor 6CM4 - -
ECL3 287 D2 receptor 6CM4 - -
ECL3 288 D2 receptor 6CM4 - -
ECL3 289 D2 receptor 6CM4 - -
TM7 290 7x30 D2 receptor 6CM4 D2 receptor 6CM4
TM7 291 7x31 D2 receptor 6CM4 FFA1 receptor 5TZY
TM7 292 7x32 D2 receptor 6CM4 CCR5 5UIW
TM7 293 7x33 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM7 294 7x34 D2 receptor 6CM4 M3 receptor 4U15
TM7 295 7x35 D2 receptor 6CM4 M2 receptor 3UON
TM7 296 7x36 D2 receptor 6CM4 D2 receptor 6CM4
TM7 297 7x37 D2 receptor 6CM4 D2 receptor 6CM4
TM7 298 7x38 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM7 299 7x39 D2 receptor 6CM4 D2 receptor 6CM4
TM7 300 7x40 D2 receptor 6CM4 D2 receptor 6CM4
TM7 301 7x41 D2 receptor 6CM4 D2 receptor 6CM4
TM7 302 7x42 D2 receptor 6CM4 D2 receptor 6CM4
TM7 303 7x43 D2 receptor 6CM4 H1 receptor 3RZE
TM7 304 7x45 D2 receptor 6CM4 D2 receptor 6CM4
TM7 305 7x46 D2 receptor 6CM4 D2 receptor 6CM4
TM7 306 7x47 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM7 307 7x48 D2 receptor 6CM4 D3 receptor 3PBL
TM7 308 7x49 D2 receptor 6CM4 D2 receptor 6CM4
TM7 309 7x50 D2 receptor 6CM4 D2 receptor 6CM4
TM7 310 7x51 D2 receptor 6CM4 A2A receptor 3VG9
TM7 311 7x52 D2 receptor 6CM4 κ receptor 4DJH
TM7 312 7x53 D2 receptor 6CM4 D2 receptor 6CM4
TM7 313 7x54 D2 receptor 6CM4 M3 receptor 4U15
TM7 314 7x55 D2 receptor 6CM4 OX2 receptor 5WS3
TM7 315 7x56 D2 receptor 6CM4 OX2 receptor 5WS3
H8 316 8x47 D2 receptor 6CM4 D2 receptor 6CM4
H8 317 8x48 D2 receptor 6CM4 5-HT2C receptor 6BQH
H8 318 8x49 D2 receptor 6CM4 P2Y12 receptor 4NTJ
H8 319 8x50 D2 receptor 6CM4 D2 receptor 6CM4
H8 320 8x51 D2 receptor 6CM4 β2-adrenoceptor 5JQH
H8 321 8x52 D2 receptor 6CM4 5-HT2C receptor 6BQH
H8 322 8x53 D2 receptor 6CM4 D2 receptor 6CM4
H8 323 8x54 D2 receptor 6CM4 D2 receptor 6CM4
H8 324 8x55 D2 receptor 6CM4 D3 receptor 3PBL
H8 325 8x56 D2 receptor 6CM4 - -
H8 326 8x57 D2 receptor 6CM4 D2 receptor 6CM4
H8 327 8x58 D2 receptor 6CM4 D2 receptor 6CM4
H8 328 8x59 D2 receptor 6CM4 β2-adrenoceptor 5JQH
C-term 329 - - - -
C-term 330 - - - -
C-term 331 - - - -
C-term 332 - - - -
C-term 333 - - - -