5-HT7 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.81 docs)

VERSION

2018-04-06

MAIN TEMPLATE

D2 receptor (sequence similarity: 57%) PDB: 6CM4

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.7 13.4 7.9
Side-chains 29.5 50.8 19.7

Number of backbone templates: 5
Number of rotamer templates: 38

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4IAQ
6CM4
3SN6
5TVN
4IB4
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone Xtal Rotamer Xtal
N-term 72 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
N-term 73 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
N-term 74 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
N-term 75 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
N-term 76 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
TM1 77 1x28 5-HT1B receptor 4IAQ PAR2 5NDD
TM1 78 1x29 5-HT1B receptor 4IAQ - -
TM1 79 1x30 5-HT1B receptor 4IAQ β2-adrenoceptor 5JQH
TM1 80 1x31 5-HT1B receptor 4IAQ M4 receptor 5DSG
TM1 81 1x32 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
TM1 82 1x33 D2 receptor 6CM4 P2Y12 receptor 4NTJ
TM1 83 1x34 D2 receptor 6CM4 A2A receptor 3VG9
TM1 84 1x35 D2 receptor 6CM4 M3 receptor 4U15
TM1 85 1x36 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM1 86 1x37 D2 receptor 6CM4 PAR1 3VW7
TM1 87 1x38 D2 receptor 6CM4 A1 receptor 5UEN
TM1 88 1x39 D2 receptor 6CM4 D2 receptor 6CM4
TM1 89 1x40 D2 receptor 6CM4 D2 receptor 6CM4
TM1 90 1x41 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM1 91 1x42 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM1 92 1x43 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM1 93 1x44 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM1 94 1x45 D2 receptor 6CM4 A2A receptor 3VG9
TM1 95 1x46 D2 receptor 6CM4 M3 receptor 4U15
TM1 96 1x47 D2 receptor 6CM4 M3 receptor 4U15
TM1 97 1x48 D2 receptor 6CM4 D4 receptor 5WIV
TM1 98 1x49 D2 receptor 6CM4 D2 receptor 6CM4
TM1 99 1x50 D2 receptor 6CM4 D2 receptor 6CM4
TM1 100 1x51 D2 receptor 6CM4 NOP receptor 5DHG
TM1 101 1x52 D2 receptor 6CM4 D2 receptor 6CM4
TM1 102 1x53 D2 receptor 6CM4 D2 receptor 6CM4
TM1 103 1x54 D2 receptor 6CM4 AT1 receptor 4ZUD
TM1 104 1x55 D2 receptor 6CM4 M1 receptor 5CXV
TM1 105 1x56 D2 receptor 6CM4 D4 receptor 5WIV
TM1 106 1x57 D2 receptor 6CM4 D2 receptor 6CM4
TM1 107 1x58 D2 receptor 6CM4 AT2 receptor 5UNG
TM1 108 1x59 D2 receptor 6CM4 AT1 receptor 4ZUD
TM1 109 1x60 D2 receptor 6CM4 - -
ICL1 110 12x48 - - - -
ICL1 111 12x49 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ICL1 112 12x50 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ICL1 113 12x51 - - - -
TM2 114 2x37 D2 receptor 6CM4 - -
TM2 115 2x38 D2 receptor 6CM4 D4 receptor 5WIV
TM2 116 2x39 D2 receptor 6CM4 CB1 receptor 5TGZ
TM2 117 2x40 D2 receptor 6CM4 D2 receptor 6CM4
TM2 118 2x41 D2 receptor 6CM4 D2 receptor 6CM4
TM2 119 2x42 D2 receptor 6CM4 D2 receptor 6CM4
TM2 120 2x43 D2 receptor 6CM4 D2 receptor 6CM4
TM2 121 2x44 D2 receptor 6CM4 D2 receptor 6CM4
TM2 122 2x45 D2 receptor 6CM4 D2 receptor 6CM4
TM2 123 2x46 D2 receptor 6CM4 D2 receptor 6CM4
TM2 124 2x47 D2 receptor 6CM4 D2 receptor 6CM4
TM2 125 2x48 D2 receptor 6CM4 μ receptor 4DKL
TM2 126 2x49 D2 receptor 6CM4 D2 receptor 6CM4
TM2 127 2x50 D2 receptor 6CM4 D2 receptor 6CM4
TM2 128 2x51 D2 receptor 6CM4 D2 receptor 6CM4
TM2 129 2x52 D2 receptor 6CM4 - -
TM2 130 2x53 D2 receptor 6CM4 D2 receptor 6CM4
TM2 131 2x54 D2 receptor 6CM4 D2 receptor 6CM4
TM2 132 2x55 D2 receptor 6CM4 M3 receptor 4U15
TM2 133 2x551 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 134 2x56 D2 receptor 6CM4 D2 receptor 6CM4
TM2 135 2x57 D2 receptor 6CM4 D2 receptor 6CM4
TM2 136 2x58 D2 receptor 6CM4 D2 receptor 6CM4
TM2 137 2x59 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 138 2x60 D2 receptor 6CM4 D2 receptor 6CM4
TM2 139 2x61 D2 receptor 6CM4 μ receptor 4DKL
TM2 140 2x62 D2 receptor 6CM4 M4 receptor 5DSG
TM2 141 2x63 D2 receptor 6CM4 Rhodopsin 1GZM
TM2 142 2x64 D2 receptor 6CM4 OX2 receptor 5WS3
TM2 143 2x65 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 144 2x66 D2 receptor 6CM4 M2 receptor 3UON
TM2 145 2x67 D2 receptor 6CM4 D2 receptor 6CM4
ECL1 146 - - - -
ECL1 147 23x49 5-HT1B receptor 4IAQ H1 receptor 3RZE
ECL1 148 23x50 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ECL1 149 23x51 5-HT1B receptor 4IAQ PAR2 5NDD
ECL1 150 23x52 - - - -
TM3 151 3x21 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 152 3x22 D2 receptor 6CM4 OX1 receptor 4ZJ8
TM3 153 3x23 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 154 3x24 D2 receptor 6CM4 apelin receptor 5VBL
TM3 155 3x25 D2 receptor 6CM4 D2 receptor 6CM4
TM3 156 3x26 D2 receptor 6CM4 Rhodopsin 1GZM
TM3 157 3x27 D2 receptor 6CM4 D3 receptor 3PBL
TM3 158 3x28 D2 receptor 6CM4 D2 receptor 6CM4
TM3 159 3x29 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM3 160 3x30 D2 receptor 6CM4 D4 receptor 5WIV
TM3 161 3x31 D2 receptor 6CM4 D4 receptor 5WIV
TM3 162 3x32 D2 receptor 6CM4 D2 receptor 6CM4
TM3 163 3x33 D2 receptor 6CM4 D2 receptor 6CM4
TM3 164 3x34 D2 receptor 6CM4 D2 receptor 6CM4
TM3 165 3x35 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 166 3x36 D2 receptor 6CM4 D2 receptor 6CM4
TM3 167 3x37 D2 receptor 6CM4 D2 receptor 6CM4
TM3 168 3x38 D2 receptor 6CM4 D2 receptor 6CM4
TM3 169 3x39 D2 receptor 6CM4 D2 receptor 6CM4
TM3 170 3x40 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 171 3x41 D2 receptor 6CM4 M3 receptor 4U15
TM3 172 3x42 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 173 3x43 D2 receptor 6CM4 D2 receptor 6CM4
TM3 174 3x44 D2 receptor 6CM4 D2 receptor 6CM4
TM3 175 3x45 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 176 3x46 D2 receptor 6CM4 D2 receptor 6CM4
TM3 177 3x47 D2 receptor 6CM4 D2 receptor 6CM4
TM3 178 3x48 D2 receptor 6CM4 D2 receptor 6CM4
TM3 179 3x49 D2 receptor 6CM4 D2 receptor 6CM4
TM3 180 3x50 D2 receptor 6CM4 D2 receptor 6CM4
TM3 181 3x51 D2 receptor 6CM4 D2 receptor 6CM4
TM3 182 3x52 D2 receptor 6CM4 A1 receptor 5UEN
TM3 183 3x53 D2 receptor 6CM4 P2Y1 receptor 4XNW
TM3 184 3x54 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 185 3x55 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 186 3x56 D2 receptor 6CM4 M3 receptor 4U15
ICL2 187 34x50 - - - -
ICL2 188 34x51 5-HT1B receptor 4IAQ M3 receptor 4U15
ICL2 189 34x52 5-HT1B receptor 4IAQ M3 receptor 4U15
ICL2 190 34x53 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ICL2 191 34x54 5-HT1B receptor 4IAQ M4 receptor 5DSG
ICL2 192 34x55 5-HT1B receptor 4IAQ M2 receptor 3UON
ICL2 193 34x56 5-HT1B receptor 4IAQ P2Y1 receptor 4XNW
ICL2 194 34x57 - - - -
TM4 195 4x38 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM4 196 4x39 D2 receptor 6CM4 A2A receptor 3VG9
TM4 197 4x40 D2 receptor 6CM4 M4 receptor 5DSG
TM4 198 4x41 D2 receptor 6CM4 - -
TM4 199 4x42 D2 receptor 6CM4 - -
TM4 200 4x43 D2 receptor 6CM4 D3 receptor 3PBL
TM4 201 4x44 D2 receptor 6CM4 NTS1 receptor 4BUO
TM4 202 4x45 D2 receptor 6CM4 D2 receptor 6CM4
TM4 203 4x46 D2 receptor 6CM4 D2 receptor 6CM4
TM4 204 4x47 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM4 205 4x48 D2 receptor 6CM4 - -
TM4 206 4x49 D2 receptor 6CM4 D2 receptor 6CM4
TM4 207 4x50 D2 receptor 6CM4 D2 receptor 6CM4
TM4 208 4x51 D2 receptor 6CM4 D4 receptor 5WIV
TM4 209 4x52 D2 receptor 6CM4 D2 receptor 6CM4
TM4 210 4x53 D2 receptor 6CM4 D2 receptor 6CM4
TM4 211 4x54 D2 receptor 6CM4 D4 receptor 5WIV
TM4 212 4x55 D2 receptor 6CM4 κ receptor 4DJH
TM4 213 4x56 D2 receptor 6CM4 D2 receptor 6CM4
TM4 214 4x57 5-HT1B receptor 4IAQ CXCR4 3ODU
TM4 215 4x58 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
TM4 216 4x59 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
TM4 217 4x60 D2 receptor 6CM4 D2 receptor 6CM4
TM4 218 4x61 D2 receptor 6CM4 D2 receptor 6CM4
TM4 219 4x62 D2 receptor 6CM4 A1 receptor 5UEN
TM4 220 4x63 D2 receptor 6CM4 H1 receptor 3RZE
ECL2 221 D2 receptor 6CM4 - -
ECL2 222 D2 receptor 6CM4 - -
ECL2 223 D2 receptor 6CM4 - -
ECL2 224 D2 receptor 6CM4 - -
ECL2 225 D2 receptor 6CM4 - -
ECL2 226 D2 receptor 6CM4 - -
ECL2 227 D2 receptor 6CM4 - -
ECL2 228 D2 receptor 6CM4 - -
ECL2 229 D2 receptor 6CM4 - -
ECL2 230 - - - -
ECL2 231 45x50 D2 receptor 6CM4 D2 receptor 6CM4
ECL2 232 45x51 D2 receptor 6CM4 A2A receptor 5UIG
ECL2 233 45x52 D2 receptor 6CM4 D2 receptor 6CM4
ECL2 234 - - - -
ECL2 235 - - - -
TM5 236 5x36 5-HT1B receptor 4IAQ D4 receptor 5WIV
TM5 237 5x37 5-HT1B receptor 4IAQ PAR2 5NDD
TM5 238 5x38 D2 receptor 6CM4 apelin receptor 5VBL
TM5 239 5x39 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 240 5x40 D2 receptor 6CM4 M3 receptor 4U15
TM5 241 5x41 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 242 5x42 D2 receptor 6CM4 D2 receptor 6CM4
TM5 243 5x43 D2 receptor 6CM4 D2 receptor 6CM4
TM5 244 5x44 D2 receptor 6CM4 apelin receptor 5VBL
TM5 245 5x45 D2 receptor 6CM4 - -
TM5 246 5x46 D2 receptor 6CM4 D2 receptor 6CM4
TM5 247 5x461 D2 receptor 6CM4 M3 receptor 4U15
TM5 248 5x47 D2 receptor 6CM4 D2 receptor 6CM4
TM5 249 5x48 D2 receptor 6CM4 D2 receptor 6CM4
TM5 250 5x49 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 251 5x50 D2 receptor 6CM4 D2 receptor 6CM4
TM5 252 5x51 D2 receptor 6CM4 NTS1 receptor 4BUO
TM5 253 5x52 D2 receptor 6CM4 US28 4XT1
TM5 254 5x53 D2 receptor 6CM4 D2 receptor 6CM4
TM5 255 5x54 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 256 5x55 D2 receptor 6CM4 D2 receptor 6CM4
TM5 257 5x56 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 258 5x57 D2 receptor 6CM4 - -
TM5 259 5x58 D2 receptor 6CM4 D2 receptor 6CM4
TM5 260 5x59 D2 receptor 6CM4 US28 4XT1
TM5 261 5x60 D2 receptor 6CM4 Rhodopsin 1GZM
TM5 262 5x61 D2 receptor 6CM4 D2 receptor 6CM4
TM5 263 5x62 D2 receptor 6CM4 D2 receptor 6CM4
TM5 264 5x63 D2 receptor 6CM4 H1 receptor 3RZE
TM5 265 5x64 D2 receptor 6CM4 M2 receptor 3UON
TM5 266 5x65 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 267 5x66 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 268 5x67 D2 receptor 6CM4 A1 receptor 5UEN
TM5 269 5x68 D2 receptor 6CM4 P2Y12 receptor 4NTJ
TM5 270 5x69 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 271 5x70 D2 receptor 6CM4 Rhodopsin 5DYS
TM5 272 5x71 D2 receptor 6CM4 β2-adrenoceptor 3SN6
TM5 273 5x72 β2-adrenoceptor 3SN6 - -
TM5 274 5x73 β2-adrenoceptor 3SN6 - -
TM5 275 5x74 β2-adrenoceptor 3SN6 - -
TM5 276 5x75 β2-adrenoceptor 3SN6 - -
TM5 277 5x76 β2-adrenoceptor 3SN6 - -
ICL3 278 - - - -
ICL3 279 - - - -
ICL3 280 - - - -
ICL3 281 - - - -
ICL3 282 - - - -
ICL3 311 - - - -
ICL3 312 - - - -
ICL3 313 - - - -
ICL3 314 - - - -
ICL3 315 - - - -
TM6 316 6x24 5-HT2B receptor 5TVN - -
TM6 317 6x25 5-HT2B receptor 5TVN A2A receptor 3VG9
TM6 318 6x26 5-HT2B receptor 5TVN - -
TM6 319 6x27 5-HT2B receptor 5TVN - -
TM6 320 6x28 5-HT2B receptor 5TVN Rhodopsin 1GZM
TM6 321 6x29 5-HT2B receptor 5TVN D3 receptor 3PBL
TM6 322 6x30 D2 receptor 6CM4 D2 receptor 6CM4
TM6 323 6x31 D2 receptor 6CM4 5-HT2B receptor 4IB4
TM6 324 6x32 D2 receptor 6CM4 β2-adrenoceptor 2RH1
TM6 325 6x33 D2 receptor 6CM4 D2 receptor 6CM4
TM6 326 6x34 D2 receptor 6CM4 M3 receptor 4U15
TM6 327 6x35 D2 receptor 6CM4 - -
TM6 328 6x36 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 329 6x37 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 330 6x38 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 331 6x39 D2 receptor 6CM4 D2 receptor 6CM4
TM6 332 6x40 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 333 6x41 D2 receptor 6CM4 D4 receptor 5WIV
TM6 334 6x42 D2 receptor 6CM4 D2 receptor 6CM4
TM6 335 6x43 D2 receptor 6CM4 D4 receptor 5WIV
TM6 336 6x44 D2 receptor 6CM4 D2 receptor 6CM4
TM6 337 6x45 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 338 6x46 D2 receptor 6CM4 D3 receptor 3PBL
TM6 339 6x47 D2 receptor 6CM4 D2 receptor 6CM4
TM6 340 6x48 D2 receptor 6CM4 D2 receptor 6CM4
TM6 341 6x49 D2 receptor 6CM4 D2 receptor 6CM4
TM6 342 6x50 D2 receptor 6CM4 D2 receptor 6CM4
TM6 343 6x51 D2 receptor 6CM4 D2 receptor 6CM4
TM6 344 6x52 D2 receptor 6CM4 D2 receptor 6CM4
TM6 345 6x53 D2 receptor 6CM4 D3 receptor 3PBL
TM6 346 6x54 D2 receptor 6CM4 A1 receptor 5UEN
TM6 347 6x55 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM6 348 6x56 D2 receptor 6CM4 apelin receptor 5VBL
TM6 349 6x57 D2 receptor 6CM4 NOP receptor 5DHG
TM6 350 6x58 D2 receptor 6CM4 - -
TM6 351 6x59 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM6 352 6x60 D2 receptor 6CM4 M3 receptor 4U15
TM6 353 6x61 D2 receptor 6CM4 AT1 receptor 4ZUD
ECL3 354 D2 receptor 6CM4 - -
ECL3 355 D2 receptor 6CM4 - -
ECL3 356 D2 receptor 6CM4 - -
ECL3 357 D2 receptor 6CM4 - -
TM7 358 7x26 5-HT2B receptor 4IB4 - -
TM7 359 7x27 5-HT2B receptor 4IB4 CCR5 5UIW
TM7 360 7x28 5-HT2B receptor 4IB4 - -
TM7 361 7x29 5-HT2B receptor 4IB4 AT1 receptor 4ZUD
TM7 362 7x30 D2 receptor 6CM4 D2 receptor 6CM4
TM7 363 7x31 D2 receptor 6CM4 A2A receptor 3VG9
TM7 364 7x32 D2 receptor 6CM4 A2A receptor 3VG9
TM7 365 7x33 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM7 366 7x34 D2 receptor 6CM4 LPA1 receptor 4Z35
TM7 367 7x35 D2 receptor 6CM4 NOP receptor 5DHG
TM7 368 7x36 D2 receptor 6CM4 - -
TM7 369 7x37 D2 receptor 6CM4 D2 receptor 6CM4
TM7 370 7x38 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM7 371 7x39 D2 receptor 6CM4 D2 receptor 6CM4
TM7 372 7x40 D2 receptor 6CM4 D2 receptor 6CM4
TM7 373 7x41 D2 receptor 6CM4 D2 receptor 6CM4
TM7 374 7x42 D2 receptor 6CM4 D2 receptor 6CM4
TM7 375 7x43 D2 receptor 6CM4 OX2 receptor 5WS3
TM7 376 7x45 D2 receptor 6CM4 D2 receptor 6CM4
TM7 377 7x46 D2 receptor 6CM4 D2 receptor 6CM4
TM7 378 7x47 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM7 379 7x48 D2 receptor 6CM4 M4 receptor 5DSG
TM7 380 7x49 D2 receptor 6CM4 D2 receptor 6CM4
TM7 381 7x50 D2 receptor 6CM4 D2 receptor 6CM4
TM7 382 7x51 D2 receptor 6CM4 A2A receptor 3VG9
TM7 383 7x52 D2 receptor 6CM4 D2 receptor 6CM4
TM7 384 7x53 D2 receptor 6CM4 D2 receptor 6CM4
TM7 385 7x54 D2 receptor 6CM4 M3 receptor 4U15
TM7 386 7x55 D2 receptor 6CM4 A1 receptor 5UEN
TM7 387 7x56 D2 receptor 6CM4 D2 receptor 6CM4
H8 388 8x47 D2 receptor 6CM4 D2 receptor 6CM4
H8 389 8x48 D2 receptor 6CM4 A2A receptor 3VG9
H8 390 8x49 D2 receptor 6CM4 β2-adrenoceptor 5JQH
H8 391 8x50 D2 receptor 6CM4 CB1 receptor 5TGZ
H8 392 8x51 D2 receptor 6CM4 β2-adrenoceptor 5JQH
H8 393 8x52 D2 receptor 6CM4 M3 receptor 4U15
H8 394 8x53 D2 receptor 6CM4 M3 receptor 4U15
H8 395 8x54 D2 receptor 6CM4 - -
H8 396 8x55 D2 receptor 6CM4 M4 receptor 5DSG
H8 397 8x56 D2 receptor 6CM4 apelin receptor 5VBL
H8 398 8x57 D2 receptor 6CM4 β2-adrenoceptor 5JQH
H8 399 8x58 D2 receptor 6CM4 D2 receptor 6CM4
C-term 400 - - - -
C-term 401 - - - -
C-term 402 - - - -
C-term 403 - - - -
C-term 404 - - - -