GPR146 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.83 docs)

VERSION

2018-07-10

MAIN TEMPLATE

LPA6 receptor (sequence similarity: 33%) PDB: 5XSZ

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.3 13.3 13.3
Side-chains 10.7 55.0 34.3

Number of backbone templates: 7
Number of rotamer templates: 36

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4ZUD
5XSZ
5WIV
5WS3
4N6H
3ODU
5LWE
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 20 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 21 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 22 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 23 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 24 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 25 1.30x30 AT1 receptor 4ZUD NOP receptor 5DHG
TM1 26 1.31x31 LPA6 receptor 5XSZ δ receptor 4N6H
TM1 27 1.32x32 LPA6 receptor 5XSZ CCR9 5LWE
TM1 28 1.33x33 LPA6 receptor 5XSZ CB1 receptor 5XRA
TM1 29 1.34x34 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM1 30 1.35x35 LPA6 receptor 5XSZ FFA1 receptor 5TZY
TM1 31 1.36x36 LPA6 receptor 5XSZ US28 4XT1
TM1 32 1.37x37 LPA6 receptor 5XSZ M2 receptor 4MQT
TM1 33 1.38x38 LPA6 receptor 5XSZ D4 receptor 5WIV
TM1 34 1.39x39 LPA6 receptor 5XSZ 5-HT2B receptor 5TUD
TM1 35 1.40x40 LPA6 receptor 5XSZ 5-HT2C receptor 6BQG
TM1 36 1.41x41 LPA6 receptor 5XSZ κ receptor 6B73
TM1 37 1.42x42 LPA6 receptor 5XSZ - -
TM1 38 1.43x43 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM1 39 1.44x44 LPA6 receptor 5XSZ - -
TM1 40 1.45x45 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM1 41 1.46x46 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM1 42 1.47x47 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM1 43 1.48x48 LPA6 receptor 5XSZ - -
TM1 44 1.49x49 LPA6 receptor 5XSZ - -
TM1 45 1.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM1 46 1.51x51 LPA6 receptor 5XSZ 5-HT1B receptor 6G79
TM1 47 1.52x52 LPA6 receptor 5XSZ κ receptor 6B73
TM1 48 1.53x53 LPA6 receptor 5XSZ Y1 receptor 5ZBH
TM1 49 1.54x54 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM1 50 1.55x55 LPA6 receptor 5XSZ 5-HT2B receptor 5TUD
TM1 51 1.56x56 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM1 52 1.57x57 LPA6 receptor 5XSZ - -
TM1 53 1.58x58 LPA6 receptor 5XSZ CB1 receptor 5XRA
TM1 54 1.59x59 LPA6 receptor 5XSZ CB1 receptor 5XRA
TM1 55 1.60x60 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL1 56 - - - -
ICL1 57 - - - -
ICL1 58 - - - -
ICL1 59 - - - -
ICL1 60 - - - -
ICL1 61 - - - -
ICL1 62 - - - -
ICL1 63 - - - -
ICL1 64 - - - -
TM2 65 2.37x37 LPA6 receptor 5XSZ 5-HT2B receptor 5TUD
TM2 66 2.38x38 LPA6 receptor 5XSZ - -
TM2 67 2.39x39 LPA6 receptor 5XSZ NTS1 receptor 4XES
TM2 68 2.40x40 LPA6 receptor 5XSZ κ receptor 6B73
TM2 69 2.41x41 LPA6 receptor 5XSZ CCR9 5LWE
TM2 70 2.42x42 LPA6 receptor 5XSZ - -
TM2 71 2.43x43 LPA6 receptor 5XSZ A2A receptor 5G53
TM2 72 2.44x44 LPA6 receptor 5XSZ 5-HT1B receptor 6G79
TM2 73 2.45x45 LPA6 receptor 5XSZ - -
TM2 74 2.46x46 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM2 75 2.47x47 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM2 76 2.48x48 LPA6 receptor 5XSZ κ receptor 6B73
TM2 77 2.49x49 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM2 78 2.50x50 LPA6 receptor 5XSZ - -
TM2 79 2.51x51 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM2 80 2.52x52 LPA6 receptor 5XSZ A2A receptor 5G53
TM2 81 2.53x53 LPA6 receptor 5XSZ - -
TM2 82 2.54x54 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM2 83 2.55x55 D4 receptor 5WIV - -
TM2 84 2.56x551 D4 receptor 5WIV D4 receptor 5WIV
TM2 85 2.57x56 D4 receptor 5WIV - -
TM2 86 2.58x57 LPA6 receptor 5XSZ - -
TM2 87 2.59x58 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM2 88 2.60x59 LPA6 receptor 5XSZ - -
TM2 89 2.61x60 LPA6 receptor 5XSZ 5-HT2C receptor 6BQG
TM2 90 2.62x61 LPA6 receptor 5XSZ κ receptor 6B73
TM2 91 2.63x62 LPA6 receptor 5XSZ - -
ECL1 92 - - - -
ECL1 93 AT1 receptor 4ZUD - -
ECL1 94 23.49x49 AT1 receptor 4ZUD - -
ECL1 95 23.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
ECL1 96 23.51x51 AT1 receptor 4ZUD BLT1 receptor 5X33
ECL1 97 23.52x52 - - - -
TM3 98 3.21x21 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM3 99 3.22x22 LPA6 receptor 5XSZ C5a1 receptor 5O9H
TM3 100 3.23x23 LPA6 receptor 5XSZ PAR1 3VW7
TM3 101 3.24x24 LPA6 receptor 5XSZ M2 receptor 4MQT
TM3 102 3.25x25 LPA6 receptor 5XSZ - -
TM3 103 3.26x26 LPA6 receptor 5XSZ - -
TM3 104 3.27x27 LPA6 receptor 5XSZ 5-HT2B receptor 5TUD
TM3 105 3.28x28 LPA6 receptor 5XSZ US28 4XT1
TM3 106 3.29x29 LPA6 receptor 5XSZ LPA1 receptor 4Z35
TM3 107 3.30x30 LPA6 receptor 5XSZ - -
TM3 108 3.31x31 LPA6 receptor 5XSZ A1 receptor 6D9H
TM3 109 3.32x32 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM3 110 3.33x33 LPA6 receptor 5XSZ - -
TM3 111 3.34x34 LPA6 receptor 5XSZ US28 4XT1
TM3 112 3.35x35 LPA6 receptor 5XSZ CB1 receptor 5XRA
TM3 113 3.36x36 LPA6 receptor 5XSZ 5-HT2C receptor 6BQG
TM3 114 3.37x37 LPA6 receptor 5XSZ - -
TM3 115 3.38x38 LPA6 receptor 5XSZ OX2 receptor 5WS3
TM3 116 3.39x39 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM3 117 3.40x40 LPA6 receptor 5XSZ - -
TM3 118 3.41x41 LPA6 receptor 5XSZ - -
TM3 119 3.42x42 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM3 120 3.43x43 LPA6 receptor 5XSZ - -
TM3 121 3.44x44 LPA6 receptor 5XSZ NTS1 receptor 5T04
TM3 122 3.45x45 LPA6 receptor 5XSZ CB1 receptor 5XRA
TM3 123 3.46x46 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM3 124 3.47x47 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM3 125 3.48x48 LPA6 receptor 5XSZ US28 4XT1
TM3 126 3.49x49 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM3 127 3.50x50 LPA6 receptor 5XSZ - -
TM3 128 3.51x51 LPA6 receptor 5XSZ κ receptor 6B73
TM3 129 3.52x52 LPA6 receptor 5XSZ κ receptor 6B73
TM3 130 3.53x53 LPA6 receptor 5XSZ PAR2 5NDD
TM3 131 3.54x54 LPA6 receptor 5XSZ - -
TM3 132 3.55x55 LPA6 receptor 5XSZ CCR9 5LWE
TM3 133 3.56x56 LPA6 receptor 5XSZ - -
ICL2 134 - - - -
ICL2 135 OX2 receptor 5WS3 - -
ICL2 136 OX2 receptor 5WS3 - -
ICL2 137 OX2 receptor 5WS3 - -
ICL2 138 OX2 receptor 5WS3 - -
ICL2 139 - - - -
TM4 140 4.38x38 LPA6 receptor 5XSZ NTS1 receptor 5T04
TM4 141 4.39x39 LPA6 receptor 5XSZ US28 4XT1
TM4 142 4.40x40 LPA6 receptor 5XSZ - -
TM4 143 4.41x41 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 144 4.42x42 LPA6 receptor 5XSZ NTS1 receptor 5T04
TM4 145 4.43x43 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM4 146 4.44x44 LPA6 receptor 5XSZ - -
TM4 147 4.45x45 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 148 4.46x46 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 149 4.47x47 LPA6 receptor 5XSZ D4 receptor 5WIV
TM4 150 4.48x48 LPA6 receptor 5XSZ US28 4XT1
TM4 151 4.49x49 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 152 4.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 153 4.51x51 LPA6 receptor 5XSZ BLT1 receptor 5X33
TM4 154 4.52x52 LPA6 receptor 5XSZ - -
TM4 155 4.53x53 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM4 156 4.54x54 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 157 4.55x55 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM4 158 4.56x56 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM4 159 4.57x57 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 160 4.58x58 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM4 161 4.59x59 LPA6 receptor 5XSZ κ receptor 4DJH
TM4 162 4.60x60 LPA6 receptor 5XSZ - -
TM4 163 4.61x61 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM4 164 4.62x62 LPA6 receptor 5XSZ A2A receptor 5G53
TM4 165 4.63x63 LPA6 receptor 5XSZ M2 receptor 4MQT
TM4 166 4.64x64 LPA6 receptor 5XSZ Y1 receptor 5ZBH
ECL2 167 - - - -
ECL2 168 - - - -
ECL2 169 - - - -
ECL2 170 - - - -
ECL2 171 - - - -
ECL2 172 - - - -
ECL2 173 - - - -
ECL2 174 - - - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
TM5 183 5.34x35 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM5 184 5.35x36 LPA6 receptor 5XSZ PAR1 3VW7
TM5 185 5.36x37 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM5 186 5.37x38 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM5 187 5.38x39 LPA6 receptor 5XSZ FFA1 receptor 5TZY
TM5 188 5.39x40 LPA6 receptor 5XSZ ETB receptor 5X93
TM5 189 5.40x41 LPA6 receptor 5XSZ PAR1 3VW7
TM5 190 5.41x42 LPA6 receptor 5XSZ AT1 receptor 4ZUD
TM5 191 5.42x43 LPA6 receptor 5XSZ US28 4XT1
TM5 192 5.43x44 LPA6 receptor 5XSZ PAF receptor 5ZKP
TM5 193 5.44x45 LPA6 receptor 5XSZ PAF receptor 5ZKP
TM5 194 5.45x46 LPA6 receptor 5XSZ P2Y12 receptor 4NTJ
TM5 195 5.46x461 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM5 196 5.47x47 LPA6 receptor 5XSZ OX2 receptor 5WS3
TM5 197 5.48x48 LPA6 receptor 5XSZ κ receptor 6B73
TM5 198 5.49x49 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM5 199 5.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM5 200 5.51x51 LPA6 receptor 5XSZ PAR2 5NDD
TM5 201 5.52x52 LPA6 receptor 5XSZ κ receptor 6B73
TM5 202 5.53x53 LPA6 receptor 5XSZ - -
TM5 203 5.54x54 LPA6 receptor 5XSZ PAR2 5NDD
TM5 204 5.55x55 LPA6 receptor 5XSZ PAF receptor 5ZKP
TM5 205 5.56x56 LPA6 receptor 5XSZ US28 4XT1
TM5 206 5.57x57 LPA6 receptor 5XSZ CB1 receptor 5XRA
TM5 207 5.58x58 LPA6 receptor 5XSZ - -
TM5 208 5.59x59 LPA6 receptor 5XSZ PAR2 5NDD
TM5 209 5.60x60 LPA6 receptor 5XSZ κ receptor 6B73
TM5 210 5.61x61 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM5 211 5.62x62 LPA6 receptor 5XSZ US28 4XT1
TM5 212 5.63x63 LPA6 receptor 5XSZ US28 4XT1
TM5 213 5.64x64 LPA6 receptor 5XSZ 5-HT2C receptor 6BQG
TM5 214 5.65x65 LPA6 receptor 5XSZ - -
TM5 215 5.66x66 LPA6 receptor 5XSZ A2A receptor 5G53
TM5 216 5.67x67 LPA6 receptor 5XSZ - -
TM5 217 5.68x68 δ receptor 4N6H - -
ICL3 218 - - - -
ICL3 219 - - - -
ICL3 220 - - - -
ICL3 221 - - - -
TM6 222 6.24x24 δ receptor 4N6H NOP receptor 5DHG
TM6 223 6.25x25 δ receptor 4N6H ETB receptor 5X93
TM6 224 6.26x26 δ receptor 4N6H Rhodopsin 5DYS
TM6 225 6.27x27 δ receptor 4N6H CXCR4 3ODU
TM6 226 6.28x28 δ receptor 4N6H μ receptor 6DDF
TM6 227 6.29x29 LPA6 receptor 5XSZ - -
TM6 228 6.30x30 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM6 229 6.31x31 LPA6 receptor 5XSZ - -
TM6 230 6.32x32 LPA6 receptor 5XSZ LPA1 receptor 4Z35
TM6 231 6.33x33 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM6 232 6.34x34 LPA6 receptor 5XSZ - -
TM6 233 6.35x35 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM6 234 6.36x36 LPA6 receptor 5XSZ κ receptor 6B73
TM6 235 6.37x37 LPA6 receptor 5XSZ US28 4XT1
TM6 236 6.38x38 LPA6 receptor 5XSZ CB1 receptor 5XRA
TM6 237 6.39x39 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM6 238 6.40x40 LPA6 receptor 5XSZ PAF receptor 5ZKP
TM6 239 6.41x41 LPA6 receptor 5XSZ κ receptor 6B73
TM6 240 6.42x42 LPA6 receptor 5XSZ - -
TM6 241 6.43x43 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM6 242 6.44x44 LPA6 receptor 5XSZ - -
TM6 243 6.45x45 LPA6 receptor 5XSZ PAF receptor 5ZKP
TM6 244 6.46x46 LPA6 receptor 5XSZ NOP receptor 5DHG
TM6 245 6.47x47 LPA6 receptor 5XSZ - -
TM6 246 6.48x48 LPA6 receptor 5XSZ κ receptor 6B73
TM6 247 6.49x49 LPA6 receptor 5XSZ κ receptor 6B73
TM6 248 6.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM6 249 6.51x51 LPA6 receptor 5XSZ PAF receptor 5ZKP
TM6 250 6.52x52 LPA6 receptor 5XSZ CXCR4 3ODU
TM6 251 6.53x53 LPA6 receptor 5XSZ US28 4XT1
TM6 252 6.54x54 LPA6 receptor 5XSZ A2A receptor 5G53
TM6 253 6.55x55 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM6 254 6.56x56 LPA6 receptor 5XSZ κ receptor 6B73
TM6 255 6.57x57 LPA6 receptor 5XSZ - -
TM6 256 6.58x58 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM6 257 6.59x59 LPA6 receptor 5XSZ US28 4XT1
TM6 258 6.60x60 LPA6 receptor 5XSZ OX2 receptor 5WS3
TM6 259 6.61x61 LPA6 receptor 5XSZ AT1 receptor 4ZUD
TM6 260 6.62x62 LPA6 receptor 5XSZ PAR2 5NDD
TM6 261 6.63x63 LPA6 receptor 5XSZ - -
TM6 262 6.64x64 LPA6 receptor 5XSZ - -
ECL3 263 - - - -
ECL3 264 CXCR4 3ODU - -
ECL3 265 CXCR4 3ODU - -
ECL3 266 - - - -
TM7 267 7.24x23 LPA6 receptor 5XSZ AT1 receptor 4ZUD
TM7 268 7.25x24 LPA6 receptor 5XSZ - -
TM7 269 7.26x25 LPA6 receptor 5XSZ - -
TM7 270 7.27x26 LPA6 receptor 5XSZ - -
TM7 271 7.28x27 LPA6 receptor 5XSZ ETB receptor 5X93
TM7 272 7.29x28 LPA6 receptor 5XSZ - -
TM7 273 7.30x29 LPA6 receptor 5XSZ 5-HT2C receptor 6BQG
TM7 274 7.31x30 LPA6 receptor 5XSZ US28 4XT1
TM7 275 7.32x31 LPA6 receptor 5XSZ NTS1 receptor 5T04
TM7 276 7.33x32 LPA6 receptor 5XSZ PAR1 3VW7
TM7 277 7.34x33 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM7 278 7.35x34 LPA6 receptor 5XSZ P2Y12 receptor 4NTJ
TM7 279 7.36x35 LPA6 receptor 5XSZ 5-HT1B receptor 4IAQ
TM7 280 7.37x36 LPA6 receptor 5XSZ κ receptor 6B73
TM7 281 7.38x37 LPA6 receptor 5XSZ OX2 receptor 5WS3
TM7 282 7.39x38 LPA6 receptor 5XSZ FFA1 receptor 5KW2
TM7 283 7.40x39 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM7 284 7.41x40 LPA6 receptor 5XSZ κ receptor 6B73
TM7 285 7.42x41 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 286 7.43x42 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM7 287 7.44x43 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 288 7.45x45 LPA6 receptor 5XSZ Rhodopsin 5DYS
TM7 289 7.46x46 LPA6 receptor 5XSZ κ receptor 6B73
TM7 290 7.47x47 LPA6 receptor 5XSZ - -
TM7 291 7.48x48 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM7 292 7.49x49 LPA6 receptor 5XSZ - -
TM7 293 7.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 294 7.51x51 LPA6 receptor 5XSZ US28 4XT1
TM7 295 7.52x52 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM7 296 7.53x53 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 297 7.54x54 LPA6 receptor 5XSZ - -
TM7 298 7.55x55 LPA6 receptor 5XSZ A2A receptor 5G53
TM7 299 7.56x56 LPA6 receptor 5XSZ Rhodopsin 5DYS
H8 300 8.47x47 δ receptor 4N6H Rhodopsin 5DYS
H8 301 8.48x48 δ receptor 4N6H δ receptor 4N6H
H8 302 8.49x49 δ receptor 4N6H P2Y12 receptor 4NTJ
H8 303 8.50x50 δ receptor 4N6H δ receptor 4N6H
H8 304 8.51x51 δ receptor 4N6H - -
H8 305 8.52x52 δ receptor 4N6H - -
H8 306 8.53x53 δ receptor 4N6H AT2 receptor 5UNG
H8 307 8.54x54 δ receptor 4N6H AT2 receptor 5UNG
H8 308 8.55x55 δ receptor 4N6H β2-adrenoceptor 3SN6
H8 309 8.56x56 δ receptor 4N6H 5-HT2B receptor 5TUD
H8 310 8.57x57 δ receptor 4N6H US28 4XT1
H8 311 8.58x58 δ receptor 4N6H - -
H8 312 8.59x59 δ receptor 4N6H CCR9 5LWE
H8 313 8.60x60 δ receptor 4N6H - -
H8 314 8.61x61 CCR9 5LWE CCR9 5LWE
C-term 315 - - - -
C-term 316 - - - -
C-term 317 - - - -
C-term 318 - - - -
C-term 319 - - - -