GPR148 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): 0.34 docs)

VERSION

2018-07-10

MAIN TEMPLATE

M4 receptor (sequence similarity: 35%) PDB: 5DSG

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.8 11.8 12.5
Side-chains 12.5 51.6 36.0

Number of backbone templates: 7
Number of rotamer templates: 43

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5DSG
4IAQ
4XES
3V2Y
3SN6
6D9H
5ZKP
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 40 - - - -
N-term 41 - - - -
N-term 42 - - - -
N-term 43 M4 receptor 5DSG M4 receptor 5DSG
N-term 44 M4 receptor 5DSG M4 receptor 5DSG
TM1 45 1.28x28 M4 receptor 5DSG A2A receptor 5IU4
TM1 46 1.29x29 M4 receptor 5DSG A1 receptor 5UEN
TM1 47 1.30x30 M4 receptor 5DSG CB1 receptor 5TGZ
TM1 48 1.31x31 M4 receptor 5DSG Y1 receptor 5ZBH
TM1 49 1.32x32 M4 receptor 5DSG - -
TM1 50 1.33x33 M4 receptor 5DSG ETB receptor 5X93
TM1 51 1.34x34 M4 receptor 5DSG - -
TM1 52 1.35x35 M4 receptor 5DSG OX2 receptor 5WS3
TM1 53 1.36x36 M4 receptor 5DSG FFA1 receptor 5TZY
TM1 54 1.37x37 M4 receptor 5DSG D3 receptor 3PBL
TM1 55 1.38x38 M4 receptor 5DSG - -
TM1 56 1.39x39 M4 receptor 5DSG CB1 receptor 5TGZ
TM1 57 1.40x40 M4 receptor 5DSG β2-adrenoceptor 5JQH
TM1 58 1.41x41 M4 receptor 5DSG M1 receptor 5CXV
TM1 59 1.42x42 M4 receptor 5DSG M4 receptor 5DSG
TM1 60 1.43x43 M4 receptor 5DSG M3 receptor 4U15
TM1 61 1.44x44 M4 receptor 5DSG D2 receptor 6CM4
TM1 62 1.45x45 M4 receptor 5DSG M1 receptor 5CXV
TM1 63 1.46x46 M4 receptor 5DSG M4 receptor 5DSG
TM1 64 1.47x47 M4 receptor 5DSG D4 receptor 5WIV
TM1 65 1.48x48 M4 receptor 5DSG D4 receptor 5WIV
TM1 66 1.49x49 M4 receptor 5DSG AT2 receptor 5UNG
TM1 67 1.50x50 M4 receptor 5DSG - -
TM1 68 1.51x51 M4 receptor 5DSG - -
TM1 69 1.52x52 M4 receptor 5DSG M4 receptor 5DSG
TM1 70 1.53x53 M4 receptor 5DSG Y1 receptor 5ZBH
TM1 71 1.54x54 M4 receptor 5DSG M1 receptor 5CXV
TM1 72 1.55x55 M4 receptor 5DSG M3 receptor 4U15
TM1 73 1.56x56 M4 receptor 5DSG S1P1 receptor 3V2Y
TM1 74 1.57x57 M4 receptor 5DSG M4 receptor 5DSG
TM1 75 1.58x58 M4 receptor 5DSG D3 receptor 3PBL
TM1 76 1.59x59 M4 receptor 5DSG D2 receptor 6CM4
TM1 77 1.60x60 M4 receptor 5DSG M4 receptor 5DSG
ICL1 78 12.48x48 - - - -
ICL1 79 12.49x49 5-HT1B receptor 4IAQ β2-adrenoceptor 5JQH
ICL1 80 12.50x50 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ICL1 81 12.51x51 - - - -
TM2 82 2.36x36 NTS1 receptor 4XES NTS1 receptor 4XES
TM2 83 2.37x37 M4 receptor 5DSG - -
TM2 84 2.38x38 M4 receptor 5DSG D4 receptor 5WIV
TM2 85 2.39x39 M4 receptor 5DSG - -
TM2 86 2.40x40 M4 receptor 5DSG S1P1 receptor 3V2Y
TM2 87 2.41x41 M4 receptor 5DSG H1 receptor 3RZE
TM2 88 2.42x42 M4 receptor 5DSG D2 receptor 6CM4
TM2 89 2.43x43 M4 receptor 5DSG - -
TM2 90 2.44x44 M4 receptor 5DSG apelin receptor 5VBL
TM2 91 2.45x45 M4 receptor 5DSG S1P1 receptor 3V2Y
TM2 92 2.46x46 M4 receptor 5DSG - -
TM2 93 2.47x47 M4 receptor 5DSG - -
TM2 94 2.48x48 M4 receptor 5DSG S1P1 receptor 3V2Y
TM2 95 2.49x49 M4 receptor 5DSG S1P1 receptor 3V2Y
TM2 96 2.50x50 M4 receptor 5DSG M4 receptor 5DSG
TM2 97 2.51x51 M4 receptor 5DSG M4 receptor 5DSG
TM2 98 2.52x52 M4 receptor 5DSG A1 receptor 5UEN
TM2 99 2.53x53 M4 receptor 5DSG P2Y1 receptor 4XNW
TM2 100 2.54x54 M4 receptor 5DSG ETB receptor 5X93
TM2 101 2.55x55 S1P1 receptor 3V2Y β2-adrenoceptor 5JQH
TM2 102 2.56x56 S1P1 receptor 3V2Y - -
TM2 103 2.57x57 M4 receptor 5DSG - -
TM2 104 2.58x58 M4 receptor 5DSG - -
TM2 105 2.59x59 M4 receptor 5DSG M4 receptor 5DSG
TM2 106 2.60x60 M4 receptor 5DSG Rhodopsin 5DYS
TM2 107 2.61x61 M4 receptor 5DSG κ receptor 4DJH
TM2 108 2.62x62 M4 receptor 5DSG PAR1 3VW7
TM2 109 2.63x63 M4 receptor 5DSG D4 receptor 5WIV
TM2 110 2.64x64 M4 receptor 5DSG A2A receptor 3VG9
TM2 111 2.65x65 M4 receptor 5DSG M1 receptor 5CXV
TM2 112 2.66x66 M4 receptor 5DSG A1 receptor 5N2S
ECL1 113 23.49x49 - - - -
ECL1 114 23.50x50 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ECL1 115 23.51x51 5-HT1B receptor 4IAQ - -
ECL1 116 23.52x52 - - - -
TM3 117 3.21x21 M4 receptor 5DSG M4 receptor 5DSG
TM3 118 3.22x22 M4 receptor 5DSG D2 receptor 6CM4
TM3 119 3.23x23 M4 receptor 5DSG - -
TM3 120 3.24x24 M4 receptor 5DSG M1 receptor 5CXV
TM3 121 3.25x25 M4 receptor 5DSG M4 receptor 5DSG
TM3 122 3.26x26 M4 receptor 5DSG - -
TM3 123 3.27x27 M4 receptor 5DSG D2 receptor 6CM4
TM3 124 3.28x28 M4 receptor 5DSG D4 receptor 5WIV
TM3 125 3.29x29 M4 receptor 5DSG β2-adrenoceptor 5JQH
TM3 126 3.30x30 M4 receptor 5DSG - -
TM3 127 3.31x31 M4 receptor 5DSG PAR1 3VW7
TM3 128 3.32x32 M4 receptor 5DSG A1 receptor 5UEN
TM3 129 3.33x33 M4 receptor 5DSG S1P1 receptor 3V2Y
TM3 130 3.34x34 M4 receptor 5DSG NTS1 receptor 4BUO
TM3 131 3.35x35 M4 receptor 5DSG M1 receptor 5CXV
TM3 132 3.36x36 M4 receptor 5DSG D2 receptor 6CM4
TM3 133 3.37x37 M4 receptor 5DSG D2 receptor 6CM4
TM3 134 3.38x38 M4 receptor 5DSG A1 receptor 5UEN
TM3 135 3.39x39 M4 receptor 5DSG NTS1 receptor 4BUO
TM3 136 3.40x40 M4 receptor 5DSG β2-adrenoceptor 5JQH
TM3 137 3.41x41 M4 receptor 5DSG D2 receptor 6CM4
TM3 138 3.42x42 M4 receptor 5DSG S1P1 receptor 3V2Y
TM3 139 3.43x43 M4 receptor 5DSG - -
TM3 140 3.44x44 M4 receptor 5DSG κ receptor 4DJH
TM3 141 3.45x45 M4 receptor 5DSG D2 receptor 6CM4
TM3 142 3.46x46 M4 receptor 5DSG M4 receptor 5DSG
TM3 143 3.47x47 M4 receptor 5DSG - -
TM3 144 3.48x48 M4 receptor 5DSG 5-HT2C receptor 6BQH
TM3 145 3.49x49 M4 receptor 5DSG P2Y1 receptor 4XNW
TM3 146 3.50x50 M4 receptor 5DSG - -
TM3 147 3.51x51 M4 receptor 5DSG M4 receptor 5DSG
TM3 148 3.52x52 M4 receptor 5DSG A1 receptor 5UEN
TM3 149 3.53x53 M4 receptor 5DSG D2 receptor 6CM4
TM3 150 3.54x54 M4 receptor 5DSG M4 receptor 5DSG
TM3 151 3.55x55 M4 receptor 5DSG Y1 receptor 5ZBH
TM3 152 3.56x56 M4 receptor 5DSG κ receptor 4DJH
ICL2 153 34.50x50 - - - -
ICL2 154 34.51x51 5-HT1B receptor 4IAQ M4 receptor 5DSG
ICL2 155 34.52x52 5-HT1B receptor 4IAQ A1 receptor 5UEN
ICL2 156 34.53x53 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ICL2 157 34.54x54 5-HT1B receptor 4IAQ μ receptor 4DKL
ICL2 158 34.55x55 5-HT1B receptor 4IAQ β2-adrenoceptor 3SN6
ICL2 159 34.56x56 5-HT1B receptor 4IAQ δ receptor 4N6H
ICL2 160 34.57x57 - - - -
TM4 161 4.38x38 M4 receptor 5DSG NTS1 receptor 4BUO
TM4 162 4.39x39 M4 receptor 5DSG - -
TM4 163 4.40x40 M4 receptor 5DSG C5a1 receptor 5O9H
TM4 164 4.41x41 M4 receptor 5DSG CXCR4 3ODU
TM4 165 4.42x42 M4 receptor 5DSG M4 receptor 5DSG
TM4 166 4.43x43 M4 receptor 5DSG C5a1 receptor 5O9H
TM4 167 4.44x44 M4 receptor 5DSG NTS1 receptor 4BUO
TM4 168 4.45x45 M4 receptor 5DSG A1 receptor 5UEN
TM4 169 4.46x46 M4 receptor 5DSG Rhodopsin 1GZM
TM4 170 4.47x47 M4 receptor 5DSG M4 receptor 5DSG
TM4 171 4.48x48 M4 receptor 5DSG M1 receptor 5CXV
TM4 172 4.49x49 M4 receptor 5DSG κ receptor 4DJH
TM4 173 4.50x50 M4 receptor 5DSG M4 receptor 5DSG
TM4 174 4.51x51 M4 receptor 5DSG M1 receptor 5CXV
TM4 175 4.52x52 M4 receptor 5DSG M1 receptor 5CXV
TM4 176 4.53x53 M4 receptor 5DSG D3 receptor 3PBL
TM4 177 4.54x54 M4 receptor 5DSG OX2 receptor 5WS3
TM4 178 4.55x55 M4 receptor 5DSG FFA1 receptor 5TZY
TM4 179 4.56x56 M4 receptor 5DSG - -
TM4 180 4.57x57 M4 receptor 5DSG - -
TM4 181 4.58x58 M4 receptor 5DSG - -
TM4 182 4.59x59 M4 receptor 5DSG - -
TM4 183 4.60x60 M4 receptor 5DSG - -
TM4 184 4.61x61 M4 receptor 5DSG M4 receptor 5DSG
TM4 185 4.62x62 M4 receptor 5DSG - -
TM4 186 4.63x63 M4 receptor 5DSG κ receptor 4DJH
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
ECL2 192 - - - -
ECL2 193 - - - -
ECL2 194 - - - -
ECL2 195 - - - -
TM5 196 5.35x36 M4 receptor 5DSG M3 receptor 4U15
TM5 197 5.36x37 M4 receptor 5DSG β2-adrenoceptor 5JQH
TM5 198 5.37x38 M4 receptor 5DSG apelin receptor 5VBL
TM5 199 5.38x39 M4 receptor 5DSG FFA1 receptor 5TZY
TM5 200 5.39x40 M4 receptor 5DSG PAR1 3VW7
TM5 201 5.40x41 M4 receptor 5DSG P2Y12 receptor 4NTJ
TM5 202 5.41x42 M4 receptor 5DSG 5-HT2C receptor 6BQH
TM5 203 5.42x43 M4 receptor 5DSG Y1 receptor 5ZBH
TM5 204 5.43x44 M4 receptor 5DSG - -
TM5 205 5.44x45 M4 receptor 5DSG - -
TM5 206 5.45x46 M4 receptor 5DSG PAF receptor 5ZKP
TM5 207 5.46x461 M4 receptor 5DSG P2Y1 receptor 4XNW
TM5 208 5.47x47 M4 receptor 5DSG - -
TM5 209 5.48x48 M4 receptor 5DSG S1P1 receptor 3V2Y
TM5 210 5.49x49 M4 receptor 5DSG - -
TM5 211 5.50x50 M4 receptor 5DSG M4 receptor 5DSG
TM5 212 5.51x51 M4 receptor 5DSG CXCR4 3ODU
TM5 213 5.52x52 M4 receptor 5DSG OX2 receptor 5WS3
TM5 214 5.53x53 M4 receptor 5DSG - -
TM5 215 5.54x54 M4 receptor 5DSG C5a1 receptor 5O9H
TM5 216 5.55x55 M4 receptor 5DSG D2 receptor 6CM4
TM5 217 5.56x56 M4 receptor 5DSG M4 receptor 5DSG
TM5 218 5.57x57 M4 receptor 5DSG A1 receptor 5UEN
TM5 219 5.58x58 M4 receptor 5DSG - -
TM5 220 5.59x59 M4 receptor 5DSG κ receptor 4DJH
TM5 221 5.60x60 M4 receptor 5DSG CB1 receptor 5TGZ
TM5 222 5.61x61 M4 receptor 5DSG D4 receptor 5WIV
TM5 223 5.62x62 M4 receptor 5DSG M4 receptor 5DSG
TM5 224 5.63x63 M4 receptor 5DSG D2 receptor 6CM4
TM5 225 5.64x64 β2-adrenoceptor 3SN6 A1 receptor 5UEN
TM5 226 5.65x65 β2-adrenoceptor 3SN6 - -
TM5 227 5.66x66 β2-adrenoceptor 3SN6 - -
TM5 228 5.67x67 β2-adrenoceptor 3SN6 - -
TM5 229 5.68x68 β2-adrenoceptor 3SN6 - -
TM5 230 5.69x69 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 231 5.70x70 β2-adrenoceptor 3SN6 - -
TM5 232 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 233 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 234 5.73x73 β2-adrenoceptor 3SN6 - -
TM5 235 5.74x74 β2-adrenoceptor 3SN6 - -
TM5 236 5.75x75 β2-adrenoceptor 3SN6 - -
TM5 237 5.76x76 β2-adrenoceptor 3SN6 - -
ICL3 238 - - - -
ICL3 239 - - - -
ICL3 240 - - - -
ICL3 241 - - - -
ICL3 242 - - - -
ICL3 248 - - - -
ICL3 249 - - - -
ICL3 250 - - - -
ICL3 251 - - - -
ICL3 252 - - - -
TM6 253 6.24x24 A1 receptor 6D9H AT2 receptor 5UNG
TM6 254 6.25x25 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM6 255 6.26x26 A1 receptor 6D9H - -
TM6 256 6.27x27 A1 receptor 6D9H A1 receptor 6D9H
TM6 257 6.28x28 A1 receptor 6D9H Y1 receptor 5ZBH
TM6 258 6.29x29 A1 receptor 6D9H D3 receptor 3PBL
TM6 259 6.30x30 A1 receptor 6D9H - -
TM6 260 6.31x31 M4 receptor 5DSG M4 receptor 5DSG
TM6 261 6.32x32 M4 receptor 5DSG - -
TM6 262 6.33x33 M4 receptor 5DSG OX2 receptor 5WS3
TM6 263 6.34x34 M4 receptor 5DSG β2-adrenoceptor 5JQH
TM6 264 6.35x35 M4 receptor 5DSG NTS1 receptor 4BUO
TM6 265 6.36x36 M4 receptor 5DSG apelin receptor 5VBL
TM6 266 6.37x37 M4 receptor 5DSG - -
TM6 267 6.38x38 M4 receptor 5DSG M1 receptor 5CXV
TM6 268 6.39x39 M4 receptor 5DSG D4 receptor 5WIV
TM6 269 6.40x40 M4 receptor 5DSG apelin receptor 5VBL
TM6 270 6.41x41 M4 receptor 5DSG CXCR4 3ODU
TM6 271 6.42x42 M4 receptor 5DSG CCR9 5LWE
TM6 272 6.43x43 M4 receptor 5DSG A1 receptor 5UEN
TM6 273 6.44x44 M4 receptor 5DSG CCR5 5UIW
TM6 274 6.45x45 M4 receptor 5DSG κ receptor 4DJH
TM6 275 6.46x46 M4 receptor 5DSG - -
TM6 276 6.47x47 M4 receptor 5DSG M4 receptor 5DSG
TM6 277 6.48x48 M4 receptor 5DSG FFA1 receptor 5KW2
TM6 278 6.49x49 M4 receptor 5DSG Rhodopsin 4ZWJ
TM6 279 6.50x50 M4 receptor 5DSG - -
TM6 280 6.51x51 M4 receptor 5DSG D2 receptor 6CM4
TM6 281 6.52x52 M4 receptor 5DSG OX2 receptor 5WS3
TM6 282 6.53x53 M4 receptor 5DSG D3 receptor 3PBL
TM6 283 6.54x54 M4 receptor 5DSG - -
TM6 284 6.55x55 M4 receptor 5DSG CB1 receptor 5TGZ
TM6 285 6.56x56 M4 receptor 5DSG D3 receptor 3PBL
TM6 286 6.57x57 M4 receptor 5DSG D2 receptor 6CM4
TM6 287 6.58x58 M4 receptor 5DSG A1 receptor 5UEN
ECL3 288 - - - -
ECL3 289 - - - -
ECL3 290 - - - -
ECL3 291 - - - -
ECL3 292 - - - -
ECL3 293 - - - -
ECL3 294 - - - -
TM7 295 7.36x35 M4 receptor 5DSG - -
TM7 296 7.37x36 M4 receptor 5DSG - -
TM7 297 7.38x37 M4 receptor 5DSG - -
TM7 298 7.39x38 M4 receptor 5DSG D2 receptor 6CM4
TM7 299 7.40x39 M4 receptor 5DSG M4 receptor 5DSG
TM7 300 7.41x40 M4 receptor 5DSG M4 receptor 5DSG
TM7 301 7.42x41 M4 receptor 5DSG PAF receptor 5ZKP
TM7 302 7.43x42 M4 receptor 5DSG FFA1 receptor 5TZY
TM7 303 7.44x43 M4 receptor 5DSG δ receptor 4N6H
TM7 304 7.45x45 M4 receptor 5DSG M4 receptor 5DSG
TM7 305 7.46x46 M4 receptor 5DSG M4 receptor 5DSG
TM7 306 7.47x47 M4 receptor 5DSG - -
TM7 307 7.48x48 M4 receptor 5DSG M3 receptor 4U15
TM7 308 7.49x49 M4 receptor 5DSG - -
TM7 309 7.50x50 M4 receptor 5DSG - -
TM7 310 7.51x51 M4 receptor 5DSG M1 receptor 5CXV
TM7 311 7.52x52 M4 receptor 5DSG κ receptor 4DJH
TM7 312 7.53x53 M4 receptor 5DSG - -
TM7 313 7.54x54 M4 receptor 5DSG - -
TM7 314 7.55x55 M4 receptor 5DSG - -
TM7 315 7.56x56 M4 receptor 5DSG Rhodopsin 1GZM
TM7 316 7.57x57 PAF receptor 5ZKP - -
H8 317 8.47x47 M4 receptor 5DSG - -
H8 318 8.48x48 M4 receptor 5DSG - -
H8 319 8.49x49 M4 receptor 5DSG - -
H8 320 8.50x50 M4 receptor 5DSG 5-HT2C receptor 6BQH
H8 321 8.51x51 M4 receptor 5DSG - -
H8 322 8.52x52 M4 receptor 5DSG - -
H8 323 8.53x53 M4 receptor 5DSG - -
H8 324 8.54x54 M4 receptor 5DSG - -
H8 325 8.55x55 M4 receptor 5DSG M4 receptor 5DSG
H8 326 8.56x56 M4 receptor 5DSG LPA1 receptor 4Z36
H8 327 8.57x57 M4 receptor 5DSG M4 receptor 5DSG
H8 328 8.58x58 M4 receptor 5DSG M4 receptor 5DSG
C-term 329 M4 receptor 5DSG M4 receptor 5DSG
C-term 330 M4 receptor 5DSG M4 receptor 5DSG
C-term 331 M4 receptor 5DSG M4 receptor 5DSG
C-term 332 M4 receptor 5DSG M4 receptor 5DSG
C-term 333 - - - -