GPR149 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -0.58 docs)

VERSION

2018-07-10

MAIN TEMPLATE

S1P1 receptor (sequence similarity: 27%) PDB: 3V2Y

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 67.2 12.0 20.9
Side-chains 10.1 38.3 51.5

Number of backbone templates: 7
Number of rotamer templates: 39

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3V2Y
5VBL
6BQH
5XRA
5TGZ
3SN6
5TZY
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 7 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 8 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 9 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 10 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 11 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM1 12 1.29x29 S1P1 receptor 3V2Y - -
TM1 13 1.30x30 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM1 14 1.31x31 S1P1 receptor 3V2Y NTS1 receptor 4BUO
TM1 15 1.32x32 S1P1 receptor 3V2Y - -
TM1 16 1.33x33 S1P1 receptor 3V2Y OX2 receptor 5WS3
TM1 17 1.34x34 S1P1 receptor 3V2Y - -
TM1 18 1.35x35 S1P1 receptor 3V2Y - -
TM1 19 1.36x36 S1P1 receptor 3V2Y - -
TM1 20 1.37x37 S1P1 receptor 3V2Y - -
TM1 21 1.38x38 S1P1 receptor 3V2Y - -
TM1 22 1.39x39 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM1 23 1.40x40 S1P1 receptor 3V2Y D2 receptor 6CM4
TM1 24 1.41x41 S1P1 receptor 3V2Y - -
TM1 25 1.42x42 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM1 26 1.43x43 S1P1 receptor 3V2Y - -
TM1 27 1.44x44 S1P1 receptor 3V2Y - -
TM1 28 1.45x45 S1P1 receptor 3V2Y 5-HT2B receptor 4IB4
TM1 29 1.46x46 S1P1 receptor 3V2Y - -
TM1 30 1.47x47 S1P1 receptor 3V2Y - -
TM1 31 1.48x48 S1P1 receptor 3V2Y M1 receptor 5CXV
TM1 32 1.49x49 S1P1 receptor 3V2Y H1 receptor 3RZE
TM1 33 1.50x50 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM1 34 1.51x51 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM1 35 1.52x52 S1P1 receptor 3V2Y PAF receptor 5ZKP
TM1 36 1.53x53 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM1 37 1.54x54 S1P1 receptor 3V2Y - -
TM1 38 1.55x55 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM1 39 1.56x56 S1P1 receptor 3V2Y AT2 receptor 5UNG
TM1 40 1.57x57 S1P1 receptor 3V2Y C5a1 receptor 5O9H
TM1 41 1.58x58 S1P1 receptor 3V2Y AT2 receptor 5UNG
TM1 42 1.59x59 S1P1 receptor 3V2Y A2A receptor 3VG9
TM1 43 1.60x60 S1P1 receptor 3V2Y - -
ICL1 44 - - - -
ICL1 45 apelin receptor 5VBL - -
ICL1 46 apelin receptor 5VBL - -
ICL1 47 apelin receptor 5VBL - -
ICL1 48 - - - -
TM2 49 2.37x37 S1P1 receptor 3V2Y - -
TM2 50 2.38x38 S1P1 receptor 3V2Y ETB receptor 5X93
TM2 51 2.39x39 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM2 52 2.40x40 S1P1 receptor 3V2Y P2Y12 receptor 4NTJ
TM2 53 2.41x41 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 54 2.42x42 S1P1 receptor 3V2Y - -
TM2 55 2.43x43 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM2 56 2.44x44 S1P1 receptor 3V2Y US28 4XT1
TM2 57 2.45x45 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM2 58 2.46x46 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 59 2.47x47 S1P1 receptor 3V2Y - -
TM2 60 2.48x48 S1P1 receptor 3V2Y - -
TM2 61 2.49x49 S1P1 receptor 3V2Y - -
TM2 62 2.50x50 S1P1 receptor 3V2Y - -
TM2 63 2.51x51 S1P1 receptor 3V2Y - -
TM2 64 2.52x52 S1P1 receptor 3V2Y - -
TM2 65 2.53x53 S1P1 receptor 3V2Y - -
TM2 66 2.54x54 S1P1 receptor 3V2Y CXCR4 3ODU
TM2 67 2.55x55 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 68 2.56x56 S1P1 receptor 3V2Y M3 receptor 4U15
TM2 69 2.57x57 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM2 70 2.58x58 S1P1 receptor 3V2Y - -
TM2 71 2.59x59 S1P1 receptor 3V2Y NTS1 receptor 4BUO
TM2 72 2.60x60 S1P1 receptor 3V2Y A1 receptor 5UEN
TM2 73 2.61x61 S1P1 receptor 3V2Y κ receptor 4DJH
TM2 74 2.62x62 S1P1 receptor 3V2Y - -
TM2 75 2.63x63 S1P1 receptor 3V2Y D4 receptor 5WIV
TM2 76 2.64x64 5-HT2C receptor 6BQH - -
TM2 77 2.65x65 5-HT2C receptor 6BQH - -
TM2 78 2.66x66 5-HT2C receptor 6BQH US28 4XT1
TM2 79 2.67x67 5-HT2C receptor 6BQH - -
ECL1 80 - - - -
ECL1 81 - - - -
ECL1 82 - - - -
ECL1 83 - - - -
ECL1 84 - - - -
ECL1 85 - - - -
ECL1 86 - - - -
ECL1 87 23.49x49 - - - -
ECL1 88 23.50x50 - - - -
ECL1 89 23.51x51 - - - -
ECL1 90 23.52x52 - - - -
TM3 91 3.10x10 - - - -
TM3 92 3.11x11 - - - -
TM3 93 3.12x12 - - - -
TM3 94 3.13x13 - - - -
TM3 95 3.14x14 - - - -
TM3 96 3.15x15 - - - -
TM3 97 3.16x16 - - - -
TM3 98 3.17x17 - - - -
TM3 99 3.18x18 - - - -
TM3 100 3.19x19 - - - -
TM3 101 3.20x20 - - - -
TM3 102 3.21x21 S1P1 receptor 3V2Y - -
TM3 103 3.22x22 S1P1 receptor 3V2Y A1 receptor 5UEN
TM3 104 3.23x23 S1P1 receptor 3V2Y M3 receptor 4U15
TM3 105 3.24x24 S1P1 receptor 3V2Y D3 receptor 3PBL
TM3 106 3.25x25 S1P1 receptor 3V2Y - -
TM3 107 3.26x26 S1P1 receptor 3V2Y US28 4XT1
TM3 108 3.27x27 S1P1 receptor 3V2Y - -
TM3 109 3.28x28 S1P1 receptor 3V2Y AT1 receptor 4ZUD
TM3 110 3.29x29 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM3 111 3.30x30 S1P1 receptor 3V2Y - -
TM3 112 3.31x31 S1P1 receptor 3V2Y - -
TM3 113 3.32x32 S1P1 receptor 3V2Y AT2 receptor 5UNG
TM3 114 3.33x33 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM3 115 3.34x34 S1P1 receptor 3V2Y - -
TM3 116 3.35x35 S1P1 receptor 3V2Y Rhodopsin 1GZM
TM3 117 3.36x36 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM3 118 3.37x37 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM3 119 3.38x38 S1P1 receptor 3V2Y CXCR4 3ODU
TM3 120 3.39x39 S1P1 receptor 3V2Y - -
TM3 121 3.40x40 S1P1 receptor 3V2Y Rhodopsin 1GZM
TM3 122 3.41x41 S1P1 receptor 3V2Y - -
TM3 123 3.42x42 S1P1 receptor 3V2Y A1 receptor 5UEN
TM3 124 3.43x43 S1P1 receptor 3V2Y - -
TM3 125 3.44x44 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM3 126 3.45x45 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM3 127 3.46x46 S1P1 receptor 3V2Y - -
TM3 128 3.47x47 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM3 129 3.48x48 S1P1 receptor 3V2Y PAF receptor 5ZKP
TM3 130 3.49x49 S1P1 receptor 3V2Y PAF receptor 5ZKP
TM3 131 3.50x50 S1P1 receptor 3V2Y - -
TM3 132 3.51x51 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM3 133 3.52x52 S1P1 receptor 3V2Y D2 receptor 6CM4
TM3 134 3.53x53 S1P1 receptor 3V2Y - -
TM3 135 3.54x54 CB1 receptor 5XRA - -
TM3 136 3.55x55 CB1 receptor 5XRA A2A receptor 3VG9
TM3 137 3.56x56 CB1 receptor 5XRA - -
ICL2 138 - - - -
ICL2 139 CB1 receptor 5XRA - -
ICL2 140 CB1 receptor 5XRA - -
ICL2 141 CB1 receptor 5XRA - -
ICL2 142 CB1 receptor 5XRA - -
ICL2 143 CB1 receptor 5XRA - -
ICL2 144 CB1 receptor 5XRA - -
ICL2 145 - - - -
TM4 146 4.38x38 S1P1 receptor 3V2Y CCR9 5LWE
TM4 147 4.39x39 S1P1 receptor 3V2Y NOP receptor 5DHG
TM4 148 4.40x40 S1P1 receptor 3V2Y C5a1 receptor 5O9H
TM4 149 4.41x41 S1P1 receptor 3V2Y AT2 receptor 5UNG
TM4 150 4.42x42 S1P1 receptor 3V2Y LPA1 receptor 4Z35
TM4 151 4.43x43 S1P1 receptor 3V2Y D4 receptor 5WIV
TM4 152 4.44x44 S1P1 receptor 3V2Y A2A receptor 3VG9
TM4 153 4.45x45 S1P1 receptor 3V2Y LPA1 receptor 4Z35
TM4 154 4.46x46 S1P1 receptor 3V2Y Rhodopsin 1GZM
TM4 155 4.47x47 S1P1 receptor 3V2Y β2-adrenoceptor 5JQH
TM4 156 4.48x48 S1P1 receptor 3V2Y CCR9 5LWE
TM4 157 4.49x49 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM4 158 4.50x50 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM4 159 4.51x51 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM4 160 4.52x52 S1P1 receptor 3V2Y BLT1 receptor 5X33
TM4 161 4.53x53 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM4 162 4.54x54 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM4 163 4.55x55 S1P1 receptor 3V2Y β2-adrenoceptor 5JQH
TM4 164 4.56x56 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM4 165 4.57x57 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM4 166 4.58x58 S1P1 receptor 3V2Y LPA1 receptor 4Z35
TM4 167 4.59x59 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM4 168 4.60x60 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM4 169 4.61x61 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM4 170 4.62x62 S1P1 receptor 3V2Y - -
TM4 171 4.63x63 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
ECL2 172 - - - -
ECL2 173 - - - -
ECL2 174 - - - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
ECL2 192 - - - -
ECL2 193 - - - -
ECL2 194 - - - -
ECL2 195 - - - -
ECL2 196 - - - -
TM5 197 5.36x37 S1P1 receptor 3V2Y CXCR4 3ODU
TM5 198 5.37x38 S1P1 receptor 3V2Y PAR1 3VW7
TM5 199 5.38x39 S1P1 receptor 3V2Y FFA1 receptor 5TZY
TM5 200 5.39x40 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM5 201 5.40x41 S1P1 receptor 3V2Y PAR1 3VW7
TM5 202 5.41x42 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM5 203 5.42x43 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM5 204 5.43x44 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM5 205 5.44x45 S1P1 receptor 3V2Y OX2 receptor 5WS3
TM5 206 5.45x46 5-HT2C receptor 6BQH 5-HT2C receptor 6BQH
TM5 207 5.46x461 5-HT2C receptor 6BQH CXCR4 3ODU
TM5 208 5.47x47 5-HT2C receptor 6BQH CXCR4 3ODU
TM5 209 5.48x48 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM5 210 5.49x49 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM5 211 5.50x50 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM5 212 5.51x51 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM5 213 5.52x52 S1P1 receptor 3V2Y 5-HT2C receptor 6BQH
TM5 214 5.53x53 S1P1 receptor 3V2Y - -
TM5 215 5.54x54 S1P1 receptor 3V2Y - -
TM5 216 5.55x55 S1P1 receptor 3V2Y D2 receptor 6CM4
TM5 217 5.56x56 S1P1 receptor 3V2Y D2 receptor 6CM4
TM5 218 5.57x57 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM5 219 5.58x58 S1P1 receptor 3V2Y LPA6 receptor 5XSZ
TM5 220 5.59x59 S1P1 receptor 3V2Y - -
TM5 221 5.60x60 S1P1 receptor 3V2Y A1 receptor 5UEN
TM5 222 5.61x61 S1P1 receptor 3V2Y - -
TM5 223 5.62x62 S1P1 receptor 3V2Y - -
TM5 224 5.63x63 S1P1 receptor 3V2Y M2 receptor 3UON
TM5 225 5.64x64 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM5 226 5.65x65 S1P1 receptor 3V2Y - -
TM5 227 5.66x66 S1P1 receptor 3V2Y CXCR4 3OE0
TM5 228 5.67x67 S1P1 receptor 3V2Y - -
TM5 229 5.68x68 S1P1 receptor 3V2Y - -
TM5 230 5.69x69 β2-adrenoceptor 3SN6 - -
TM5 231 5.70x70 β2-adrenoceptor 3SN6 - -
TM5 232 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 233 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 234 5.73x73 β2-adrenoceptor 3SN6 - -
TM5 235 5.74x74 β2-adrenoceptor 3SN6 - -
TM5 236 5.75x75 β2-adrenoceptor 3SN6 - -
TM5 237 5.76x76 β2-adrenoceptor 3SN6 - -
ICL3 238 - - - -
ICL3 239 - - - -
ICL3 240 - - - -
ICL3 241 - - - -
ICL3 242 - - - -
ICL3 294 - - - -
ICL3 295 - - - -
ICL3 296 - - - -
ICL3 297 - - - -
ICL3 298 - - - -
TM6 299 6.24x24 CB1 receptor 5TGZ - -
TM6 300 6.25x25 CB1 receptor 5TGZ LPA1 receptor 4Z35
TM6 301 6.26x26 CB1 receptor 5TGZ - -
TM6 302 6.27x27 CB1 receptor 5TGZ - -
TM6 303 6.28x28 CB1 receptor 5TGZ - -
TM6 304 6.29x29 CB1 receptor 5TGZ - -
TM6 305 6.30x30 S1P1 receptor 3V2Y C5a1 receptor 6C1R
TM6 306 6.31x31 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM6 307 6.32x32 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM6 308 6.33x33 S1P1 receptor 3V2Y - -
TM6 309 6.34x34 S1P1 receptor 3V2Y - -
TM6 310 6.35x35 S1P1 receptor 3V2Y M1 receptor 5CXV
TM6 311 6.36x36 S1P1 receptor 3V2Y PAR1 3VW7
TM6 312 6.37x37 S1P1 receptor 3V2Y D2 receptor 6CM4
TM6 313 6.38x38 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM6 314 6.39x39 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM6 315 6.40x40 S1P1 receptor 3V2Y CXCR4 3ODU
TM6 316 6.41x41 S1P1 receptor 3V2Y D2 receptor 6CM4
TM6 317 6.42x42 S1P1 receptor 3V2Y M3 receptor 4U15
TM6 318 6.43x43 S1P1 receptor 3V2Y β2-adrenoceptor 5JQH
TM6 319 6.44x44 S1P1 receptor 3V2Y - -
TM6 320 6.45x45 S1P1 receptor 3V2Y κ receptor 4DJH
TM6 321 6.46x46 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM6 322 6.47x47 S1P1 receptor 3V2Y - -
TM6 323 6.48x48 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM6 324 6.49x49 S1P1 receptor 3V2Y D2 receptor 6CM4
TM6 325 6.50x50 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM6 326 6.51x51 S1P1 receptor 3V2Y - -
TM6 327 6.52x52 S1P1 receptor 3V2Y - -
TM6 328 6.53x53 S1P1 receptor 3V2Y - -
TM6 329 6.54x54 S1P1 receptor 3V2Y - -
TM6 330 6.55x55 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM6 331 6.56x56 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM6 332 6.57x57 S1P1 receptor 3V2Y M3 receptor 4U15
TM6 333 6.58x58 S1P1 receptor 3V2Y D4 receptor 5WIV
TM6 334 6.59x59 S1P1 receptor 3V2Y - -
TM6 335 6.60x60 S1P1 receptor 3V2Y OX2 receptor 5WS3
TM6 336 6.61x61 S1P1 receptor 3V2Y δ receptor 4N6H
ECL3 337 - - - -
ECL3 338 FFA1 receptor 5TZY - -
ECL3 339 FFA1 receptor 5TZY - -
ECL3 340 - - - -
TM7 341 7.32x31 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM7 342 7.33x32 S1P1 receptor 3V2Y - -
TM7 343 7.34x33 S1P1 receptor 3V2Y D4 receptor 5WIV
TM7 344 7.35x34 S1P1 receptor 3V2Y LPA1 receptor 4Z35
TM7 345 7.36x35 S1P1 receptor 3V2Y M2 receptor 3UON
TM7 346 7.37x36 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM7 347 7.38x37 S1P1 receptor 3V2Y OX2 receptor 5WS3
TM7 348 7.39x38 S1P1 receptor 3V2Y - -
TM7 349 7.40x39 S1P1 receptor 3V2Y LPA1 receptor 4Z35
TM7 350 7.41x40 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM7 351 7.42x41 S1P1 receptor 3V2Y A1 receptor 5UEN
TM7 352 7.43x42 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM7 353 7.44x43 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM7 354 7.45x45 S1P1 receptor 3V2Y Rhodopsin 4ZWJ
TM7 355 7.46x46 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM7 356 7.47x47 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM7 357 7.48x48 S1P1 receptor 3V2Y CB1 receptor 5TGZ
TM7 358 7.49x49 S1P1 receptor 3V2Y - -
TM7 359 7.50x50 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM7 360 7.51x51 S1P1 receptor 3V2Y M3 receptor 4U15
TM7 361 7.52x52 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM7 362 7.53x53 S1P1 receptor 3V2Y - -
TM7 363 7.54x54 S1P1 receptor 3V2Y - -
TM7 364 7.55x55 S1P1 receptor 3V2Y - -
TM7 365 7.56x56 S1P1 receptor 3V2Y - -
H8 366 8.47x47 S1P1 receptor 3V2Y - -
H8 367 8.48x48 S1P1 receptor 3V2Y - -
H8 368 8.49x49 S1P1 receptor 3V2Y M3 receptor 4U15
H8 369 8.50x50 S1P1 receptor 3V2Y - -
H8 370 8.51x51 S1P1 receptor 3V2Y - -
H8 371 8.52x52 S1P1 receptor 3V2Y - -
H8 372 8.53x53 S1P1 receptor 3V2Y κ receptor 4DJH
H8 373 8.54x54 S1P1 receptor 3V2Y - -
H8 374 8.55x55 S1P1 receptor 3V2Y - -
H8 375 8.56x56 5-HT2C receptor 6BQH - -
H8 376 8.57x57 5-HT2C receptor 6BQH LPA1 receptor 4Z36
H8 377 8.58x58 5-HT2C receptor 6BQH - -
H8 378 8.59x59 5-HT2C receptor 6BQH β2-adrenoceptor 5JQH
C-term 379 - - - -
C-term 380 - - - -
C-term 381 - - - -
C-term 382 - - - -
C-term 383 - - - -