GPR12 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 7.98 docs)

VERSION

2018-07-10

MAIN TEMPLATE

CB1 receptor (sequence similarity: 40%) PDB: 5XRA

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.4 9.1 11.5
Side-chains 23.1 53.8 23.1

Number of backbone templates: 5
Number of rotamer templates: 39

NGL is a WebGL based 3D viewer powered by MMTF.

5XRA
4Z35
4NTJ
4UHR
6CM4
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 37 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 38 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 39 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 40 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 41 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 42 1.30x30 CB1 receptor 5XRA PAR2 5NDD
TM1 43 1.31x31 CB1 receptor 5XRA LPA1 receptor 4Z35
TM1 44 1.32x32 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM1 45 1.33x33 CB1 receptor 5XRA - -
TM1 46 1.34x34 CB1 receptor 5XRA - -
TM1 47 1.35x35 CB1 receptor 5XRA 5-HT2B receptor 4IB4
TM1 48 1.36x36 CB1 receptor 5XRA - -
TM1 49 1.37x37 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM1 50 1.38x38 CB1 receptor 5XRA A2A receptor 5G53
TM1 51 1.39x39 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 52 1.40x40 CB1 receptor 5XRA D3 receptor 3PBL
TM1 53 1.41x41 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 54 1.42x42 CB1 receptor 5XRA BLT1 receptor 5X33
TM1 55 1.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 56 1.44x44 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 57 1.45x45 CB1 receptor 5XRA A2A receptor 5G53
TM1 58 1.46x46 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM1 59 1.47x47 CB1 receptor 5XRA US28 4XT1
TM1 60 1.48x48 CB1 receptor 5XRA - -
TM1 61 1.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 62 1.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 63 1.51x51 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 64 1.52x52 CB1 receptor 5XRA - -
TM1 65 1.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 66 1.54x54 CB1 receptor 5XRA AT2 receptor 5UNG
TM1 67 1.55x55 CB1 receptor 5XRA 5-HT2B receptor 5TUD
TM1 68 1.56x56 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM1 69 1.57x57 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 70 1.58x58 CB1 receptor 5XRA apelin receptor 5VBL
TM1 71 1.59x59 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 72 1.60x60 CB1 receptor 5XRA - -
ICL1 73 - - - -
ICL1 74 LPA1 receptor 4Z35 - -
ICL1 75 LPA1 receptor 4Z35 - -
ICL1 76 - - - -
TM2 77 2.37x37 LPA1 receptor 4Z35 PAR2 5NDD
TM2 78 2.38x38 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 79 2.39x39 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM2 80 2.40x40 CB1 receptor 5XRA A1 receptor 6D9H
TM2 81 2.41x41 CB1 receptor 5XRA H1 receptor 3RZE
TM2 82 2.42x42 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM2 83 2.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 84 2.44x44 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 85 2.45x45 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 86 2.46x46 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 87 2.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 88 2.48x48 CB1 receptor 5XRA κ receptor 6B73
TM2 89 2.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 90 2.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 91 2.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 92 2.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 93 2.53x53 CB1 receptor 5XRA μ receptor 5C1M
TM2 94 2.54x54 CB1 receptor 5XRA A2A receptor 5G53
TM2 95 2.55x55 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM2 96 2.56x56 CB1 receptor 5XRA Rhodopsin 5DYS
TM2 97 2.57x57 CB1 receptor 5XRA μ receptor 5C1M
TM2 98 2.58x58 CB1 receptor 5XRA - -
TM2 99 2.59x59 CB1 receptor 5XRA Rhodopsin 5DYS
TM2 100 2.60x60 CB1 receptor 5XRA S1P1 receptor 3V2Y
TM2 101 2.61x61 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 102 2.62x62 CB1 receptor 5XRA μ receptor 5C1M
ECL1 103 - - - -
ECL1 104 23.49x49 LPA1 receptor 4Z35 - -
ECL1 105 23.50x50 LPA1 receptor 4Z35 - -
ECL1 106 23.51x51 LPA1 receptor 4Z35 AT2 receptor 5UNG
ECL1 107 23.52x52 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 108 3.20x20 P2Y12 receptor 4NTJ - -
TM3 109 3.21x21 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 110 3.22x22 CB1 receptor 5XRA Y1 receptor 5ZBH
TM3 111 3.23x23 CB1 receptor 5XRA NTS1 receptor 5T04
TM3 112 3.24x24 CB1 receptor 5XRA A1 receptor 6D9H
TM3 113 3.25x25 CB1 receptor 5XRA - -
TM3 114 3.26x26 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 115 3.27x27 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM3 116 3.28x28 CB1 receptor 5XRA P2Y12 receptor 4NTJ
TM3 117 3.29x29 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM3 118 3.30x30 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 119 3.31x31 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM3 120 3.32x32 CB1 receptor 5XRA LPA1 receptor 4Z35
TM3 121 3.33x33 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM3 122 3.34x34 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 123 3.35x35 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 124 3.36x36 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 125 3.37x37 CB1 receptor 5XRA S1P1 receptor 3V2Y
TM3 126 3.38x38 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 127 3.39x39 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 128 3.40x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 129 3.41x41 CB1 receptor 5XRA US28 4XT1
TM3 130 3.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 131 3.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 132 3.44x44 CB1 receptor 5XRA A2A receptor 5G53
TM3 133 3.45x45 CB1 receptor 5XRA A2A receptor 5G53
TM3 134 3.46x46 CB1 receptor 5XRA A2A receptor 5G53
TM3 135 3.47x47 CB1 receptor 5XRA PAF receptor 5ZKP
TM3 136 3.48x48 CB1 receptor 5XRA A1 receptor 6D9H
TM3 137 3.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 138 3.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 139 3.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 140 3.52x52 CB1 receptor 5XRA A1 receptor 6D9H
TM3 141 3.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 142 3.54x54 CB1 receptor 5XRA - -
TM3 143 3.55x55 CB1 receptor 5XRA - -
TM3 144 3.56x56 CB1 receptor 5XRA AT2 receptor 5UNG
ICL2 145 34.50x50 CB1 receptor 5XRA 5-HT1B receptor 6G79
ICL2 146 34.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 147 34.52x52 CB1 receptor 5XRA M2 receptor 4MQT
ICL2 148 34.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 149 34.54x54 CB1 receptor 5XRA CCR9 5LWE
ICL2 150 34.55x55 CB1 receptor 5XRA β2-adrenoceptor 3SN6
ICL2 151 34.56x56 CB1 receptor 5XRA - -
ICL2 152 34.57x57 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 153 4.38x38 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 154 4.39x39 CB1 receptor 5XRA US28 4XT1
TM4 155 4.40x40 CB1 receptor 5XRA A2A receptor 5G53
TM4 156 4.41x41 CB1 receptor 5XRA CCR2 5T1A
TM4 157 4.42x42 CB1 receptor 5XRA NTS1 receptor 5T04
TM4 158 4.43x43 CB1 receptor 5XRA Y1 receptor 5ZBH
TM4 159 4.44x44 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 160 4.45x45 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 161 4.46x46 CB1 receptor 5XRA BLT1 receptor 5X33
TM4 162 4.47x47 CB1 receptor 5XRA μ receptor 5C1M
TM4 163 4.48x48 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM4 164 4.49x49 CB1 receptor 5XRA apelin receptor 5VBL
TM4 165 4.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 166 4.51x51 CB1 receptor 5XRA BLT1 receptor 5X33
TM4 167 4.52x52 CB1 receptor 5XRA - -
TM4 168 4.53x53 CB1 receptor 5XRA A2A receptor 5G53
TM4 169 4.54x54 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 170 4.55x55 CB1 receptor 5XRA FFA1 receptor 5TZY
TM4 171 4.56x56 CB1 receptor 5XRA NTS1 receptor 5T04
TM4 172 4.57x57 CB1 receptor 5XRA A2A receptor 5G53
TM4 173 4.58x58 CB1 receptor 5XRA A2A receptor 5G53
TM4 174 4.59x59 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 175 4.60x60 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 176 4.61x61 CB1 receptor 5XRA 5-HT2B receptor 5TUD
TM4 177 4.62x62 CB1 receptor 5XRA S1P1 receptor 3V2Y
TM4 178 4.63x63 CB1 receptor 5XRA CB1 receptor 5XRA
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
ECL2 192 - - - -
ECL2 193 - - - -
ECL2 194 - - - -
TM5 195 5.36x36 CB1 receptor 5XRA - -
TM5 196 5.37x37 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 197 5.38x38 CB1 receptor 5XRA A2A receptor 5G53
TM5 198 5.39x39 CB1 receptor 5XRA - -
TM5 199 5.40x40 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM5 200 5.41x41 CB1 receptor 5XRA PAR1 3VW7
TM5 201 5.42x42 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM5 202 5.43x43 CB1 receptor 5XRA US28 4XT1
TM5 203 5.44x44 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM5 204 5.45x45 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 205 5.46x46 CB1 receptor 5XRA PAF receptor 5ZKP
TM5 206 5.47x47 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 207 5.48x48 CB1 receptor 5XRA A2A receptor 5G53
TM5 208 5.49x49 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 209 5.50x50 CB1 receptor 5XRA - -
TM5 210 5.51x51 CB1 receptor 5XRA PAF receptor 5ZKP
TM5 211 5.52x52 CB1 receptor 5XRA 5-HT2B receptor 5TUD
TM5 212 5.53x53 CB1 receptor 5XRA A2A receptor 5G53
TM5 213 5.54x54 CB1 receptor 5XRA A2A receptor 5G53
TM5 214 5.55x55 CB1 receptor 5XRA A2A receptor 5G53
TM5 215 5.56x56 CB1 receptor 5XRA - -
TM5 216 5.57x57 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 217 5.58x58 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 218 5.59x59 CB1 receptor 5XRA D2 receptor 6CM4
TM5 219 5.60x60 CB1 receptor 5XRA Rhodopsin 5DYS
TM5 220 5.61x61 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 221 5.62x62 CB1 receptor 5XRA - -
TM5 222 5.63x63 CB1 receptor 5XRA AT2 receptor 5UNG
TM5 223 5.64x64 CB1 receptor 5XRA US28 4XT1
TM5 224 5.65x65 CB1 receptor 5XRA Rhodopsin 5DYS
TM5 225 5.66x66 CB1 receptor 5XRA - -
TM5 226 5.67x67 CB1 receptor 5XRA A2A receptor 5G53
TM5 227 5.68x68 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 228 5.69x69 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 229 5.70x70 A2A receptor 4UHR NTS1 receptor 4BUO
TM5 230 5.71x71 A2A receptor 4UHR A2A receptor 4UHR
TM5 231 5.72x72 A2A receptor 4UHR β2-adrenoceptor 3SN6
TM5 232 5.73x73 A2A receptor 4UHR - -
ICL3 233 - - - -
ICL3 234 - - - -
ICL3 235 - - - -
ICL3 236 - - - -
ICL3 237 - - - -
TM6 238 6.22x22 A2A receptor 4UHR - -
TM6 239 6.23x23 A2A receptor 4UHR A2A receptor 4UHR
TM6 240 6.24x24 A2A receptor 4UHR - -
TM6 241 6.25x25 A2A receptor 4UHR A2A receptor 4UHR
TM6 242 6.26x26 A2A receptor 4UHR ETB receptor 5X93
TM6 243 6.27x27 A2A receptor 4UHR A1 receptor 6D9H
TM6 244 6.28x28 A2A receptor 4UHR M1 receptor 5CXV
TM6 245 6.29x29 A2A receptor 4UHR AT2 receptor 5UNG
TM6 246 6.30x30 CB1 receptor 5XRA Y1 receptor 5ZBH
TM6 247 6.31x31 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM6 248 6.32x32 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 249 6.33x33 CB1 receptor 5XRA NTS1 receptor 5T04
TM6 250 6.34x34 CB1 receptor 5XRA NTS1 receptor 5T04
TM6 251 6.35x35 CB1 receptor 5XRA apelin receptor 5VBL
TM6 252 6.36x36 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 253 6.37x37 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 254 6.38x38 CB1 receptor 5XRA A2A receptor 5G53
TM6 255 6.39x39 CB1 receptor 5XRA A2A receptor 5G53
TM6 256 6.40x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 257 6.41x41 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 258 6.42x42 CB1 receptor 5XRA A2A receptor 5G53
TM6 259 6.43x43 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM6 260 6.44x44 CB1 receptor 5XRA A2A receptor 5G53
TM6 261 6.45x45 CB1 receptor 5XRA A2A receptor 5G53
TM6 262 6.46x46 CB1 receptor 5XRA S1P1 receptor 3V2Y
TM6 263 6.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 264 6.48x48 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 265 6.49x49 CB1 receptor 5XRA apelin receptor 5VBL
TM6 266 6.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 267 6.51x51 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 268 6.52x52 CB1 receptor 5XRA Y1 receptor 5ZBH
TM6 269 6.53x53 CB1 receptor 5XRA US28 4XT1
TM6 270 6.54x54 CB1 receptor 5XRA μ receptor 5C1M
TM6 271 6.55x55 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 272 6.56x56 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 273 6.57x57 CB1 receptor 5XRA A1 receptor 6D9H
TM6 274 6.58x58 CB1 receptor 5XRA - -
TM6 275 6.59x59 CB1 receptor 5XRA Y1 receptor 5ZBH
TM6 276 6.60x60 CB1 receptor 5XRA NTS1 receptor 5T04
TM6 277 6.61x61 CB1 receptor 5XRA - -
ECL3 278 - - - -
ECL3 279 - - - -
ECL3 280 - - - -
ECL3 281 - - - -
TM7 282 7.34x33 CB1 receptor 5XRA M3 receptor 4U15
TM7 283 7.35x34 CB1 receptor 5XRA A1 receptor 6D9H
TM7 284 7.36x35 CB1 receptor 5XRA A2A receptor 5G53
TM7 285 7.37x36 CB1 receptor 5XRA D2 receptor 6CM4
TM7 286 7.38x37 CB1 receptor 5XRA NTS1 receptor 5T04
TM7 287 7.39x38 CB1 receptor 5XRA PAF receptor 5ZKP
TM7 288 7.40x39 CB1 receptor 5XRA AT2 receptor 5UNG
TM7 289 7.41x40 CB1 receptor 5XRA - -
TM7 290 7.42x41 CB1 receptor 5XRA Rhodopsin 5DYS
TM7 291 7.43x42 CB1 receptor 5XRA PAR2 5NDD
TM7 292 7.44x43 CB1 receptor 5XRA - -
TM7 293 7.45x45 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 294 7.46x46 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 295 7.47x47 CB1 receptor 5XRA Rhodopsin 4ZWJ
TM7 296 7.48x48 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM7 297 7.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 298 7.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 299 7.51x51 CB1 receptor 5XRA Rhodopsin 5DYS
TM7 300 7.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 301 7.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 302 7.54x54 LPA1 receptor 4Z35 A2A receptor 5G53
TM7 303 7.55x55 LPA1 receptor 4Z35 A1 receptor 6D9H
TM7 304 7.56x56 LPA1 receptor 4Z35 LPA1 receptor 4Z35
H8 305 8.47x47 CB1 receptor 5XRA 5-HT1B receptor 6G79
H8 306 8.48x48 CB1 receptor 5XRA A1 receptor 6D9H
H8 307 8.49x49 CB1 receptor 5XRA LPA1 receptor 4Z35
H8 308 8.50x50 CB1 receptor 5XRA - -
H8 309 8.51x51 CB1 receptor 5XRA AT2 receptor 5UNF
H8 310 8.52x52 CB1 receptor 5XRA H1 receptor 3RZE
H8 311 8.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
H8 312 8.54x54 CB1 receptor 5XRA AT2 receptor 5UNG
H8 313 8.55x55 CB1 receptor 5XRA - -
H8 314 8.56x56 CB1 receptor 5XRA M1 receptor 5CXV
H8 315 8.57x57 CB1 receptor 5XRA A2A receptor 5G53
H8 316 8.58x58 CB1 receptor 5XRA - -
H8 317 8.59x59 D2 receptor 6CM4 β2-adrenoceptor 5JQH
C-term 318 - - - -
C-term 319 - - - -
C-term 320 - - - -
C-term 321 - - - -
C-term 322 - - - -