H4 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 8.78 docs)

VERSION

2018-07-10

MAIN TEMPLATE

M2 receptor (sequence similarity: 51%) PDB: 4MQT

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.9 10.6 9.6
Side-chains 22.1 51.2 26.7

Number of backbone templates: 7
Number of rotamer templates: 38

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4MQT
4U15
6CM4
6BQH
3SN6
5TVN
3VG9
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 7 - - - -
N-term 8 - - - -
N-term 9 - - - -
N-term 10 - - - -
N-term 11 - - - -
TM1 12 1.29x29 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 13 1.30x30 M2 receptor 4MQT CB1 receptor 5XRA
TM1 14 1.31x31 M2 receptor 4MQT μ receptor 5C1M
TM1 15 1.32x32 M2 receptor 4MQT - -
TM1 16 1.33x33 M2 receptor 4MQT M2 receptor 4MQT
TM1 17 1.34x34 M2 receptor 4MQT μ receptor 5C1M
TM1 18 1.35x35 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 19 1.36x36 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM1 20 1.37x37 M2 receptor 4MQT US28 4XT1
TM1 21 1.38x38 M2 receptor 4MQT - -
TM1 22 1.39x39 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM1 23 1.40x40 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM1 24 1.41x41 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 25 1.42x42 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM1 26 1.43x43 M2 receptor 4MQT A1 receptor 6D9H
TM1 27 1.44x44 M2 receptor 4MQT P2Y12 receptor 4NTJ
TM1 28 1.45x45 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 29 1.46x46 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM1 30 1.47x47 M2 receptor 4MQT LPA1 receptor 4Z35
TM1 31 1.48x48 M2 receptor 4MQT A2A receptor 5G53
TM1 32 1.49x49 M2 receptor 4MQT M2 receptor 4MQT
TM1 33 1.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM1 34 1.51x51 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 35 1.52x52 M2 receptor 4MQT M2 receptor 4MQT
TM1 36 1.53x53 M2 receptor 4MQT M2 receptor 4MQT
TM1 37 1.54x54 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 38 1.55x55 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM1 39 1.56x56 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM1 40 1.57x57 M2 receptor 4MQT LPA6 receptor 5XSZ
TM1 41 1.58x58 M2 receptor 4MQT μ receptor 5C1M
TM1 42 1.59x59 M2 receptor 4MQT M2 receptor 4MQT
TM1 43 1.60x60 M2 receptor 4MQT - -
ICL1 44 12.48x48 - - - -
ICL1 45 12.49x49 M3 receptor 4U15 A2A receptor 5G53
ICL1 46 12.50x50 M3 receptor 4U15 M3 receptor 4U15
ICL1 47 12.51x51 - - - -
TM2 48 2.37x37 M2 receptor 4MQT - -
TM2 49 2.38x38 M2 receptor 4MQT - -
TM2 50 2.39x39 M2 receptor 4MQT AT2 receptor 5UNG
TM2 51 2.40x40 M2 receptor 4MQT AT2 receptor 5UNG
TM2 52 2.41x41 M2 receptor 4MQT M2 receptor 4MQT
TM2 53 2.42x42 M2 receptor 4MQT M2 receptor 4MQT
TM2 54 2.43x43 M2 receptor 4MQT US28 4XT1
TM2 55 2.44x44 M2 receptor 4MQT Rhodopsin 5DYS
TM2 56 2.45x45 M2 receptor 4MQT κ receptor 6B73
TM2 57 2.46x46 M2 receptor 4MQT M2 receptor 4MQT
TM2 58 2.47x47 M2 receptor 4MQT M2 receptor 4MQT
TM2 59 2.48x48 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM2 60 2.49x49 M2 receptor 4MQT NTS1 receptor 5T04
TM2 61 2.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM2 62 2.51x51 M2 receptor 4MQT LPA1 receptor 4Z35
TM2 63 2.52x52 M2 receptor 4MQT Rhodopsin 5DYS
TM2 64 2.53x53 M2 receptor 4MQT 5-HT1B receptor 6G79
TM2 65 2.54x54 M2 receptor 4MQT M2 receptor 4MQT
TM2 66 2.55x55 M2 receptor 4MQT M2 receptor 4MQT
TM2 67 2.56x551 M2 receptor 4MQT M3 receptor 4U15
TM2 68 2.57x56 M2 receptor 4MQT M2 receptor 4MQT
TM2 69 2.58x57 M2 receptor 4MQT A1 receptor 6D9H
TM2 70 2.59x58 M2 receptor 4MQT 5-HT1B receptor 6G79
TM2 71 2.60x59 M2 receptor 4MQT M2 receptor 4MQT
TM2 72 2.61x60 M2 receptor 4MQT M2 receptor 4MQT
TM2 73 2.62x61 M2 receptor 4MQT A1 receptor 6D9H
TM2 74 2.63x62 M2 receptor 4MQT - -
TM2 75 2.64x63 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM2 76 2.65x64 M2 receptor 4MQT M2 receptor 4MQT
TM2 77 2.66x65 M2 receptor 4MQT β2-adrenoceptor 3SN6
ECL1 78 - - - -
ECL1 79 23.49x49 M3 receptor 4U15 CCR2 5T1A
ECL1 80 23.50x50 M3 receptor 4U15 M3 receptor 4U15
ECL1 81 23.51x51 M3 receptor 4U15 CCR5 5UIW
ECL1 82 23.52x52 - - - -
TM3 83 3.21x21 M2 receptor 4MQT M2 receptor 4MQT
TM3 84 3.22x22 M2 receptor 4MQT PAF receptor 5ZKP
TM3 85 3.23x23 M2 receptor 4MQT ETB receptor 5X93
TM3 86 3.24x24 M2 receptor 4MQT - -
TM3 87 3.25x25 M2 receptor 4MQT M2 receptor 4MQT
TM3 88 3.26x26 M2 receptor 4MQT - -
TM3 89 3.27x27 M2 receptor 4MQT 5-HT1B receptor 6G79
TM3 90 3.28x28 M2 receptor 4MQT M2 receptor 4MQT
TM3 91 3.29x29 M2 receptor 4MQT M2 receptor 4MQT
TM3 92 3.30x30 M2 receptor 4MQT D2 receptor 6CM4
TM3 93 3.31x31 M2 receptor 4MQT - -
TM3 94 3.32x32 M2 receptor 4MQT M2 receptor 4MQT
TM3 95 3.33x33 M2 receptor 4MQT M2 receptor 4MQT
TM3 96 3.34x34 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM3 97 3.35x35 M2 receptor 4MQT A1 receptor 6D9H
TM3 98 3.36x36 M2 receptor 4MQT 5-HT1B receptor 6G79
TM3 99 3.37x37 M2 receptor 4MQT 5-HT1B receptor 6G79
TM3 100 3.38x38 M2 receptor 4MQT M2 receptor 4MQT
TM3 101 3.39x39 M2 receptor 4MQT M2 receptor 4MQT
TM3 102 3.40x40 M2 receptor 4MQT M2 receptor 4MQT
TM3 103 3.41x41 M2 receptor 4MQT - -
TM3 104 3.42x42 M2 receptor 4MQT M2 receptor 4MQT
TM3 105 3.43x43 M2 receptor 4MQT AT2 receptor 5UNG
TM3 106 3.44x44 M2 receptor 4MQT Rhodopsin 5DYS
TM3 107 3.45x45 M2 receptor 4MQT CB1 receptor 5XRA
TM3 108 3.46x46 M2 receptor 4MQT M2 receptor 4MQT
TM3 109 3.47x47 M2 receptor 4MQT M2 receptor 4MQT
TM3 110 3.48x48 M2 receptor 4MQT PAF receptor 5ZKP
TM3 111 3.49x49 M2 receptor 4MQT M2 receptor 4MQT
TM3 112 3.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM3 113 3.51x51 M2 receptor 4MQT M2 receptor 4MQT
TM3 114 3.52x52 M2 receptor 4MQT A1 receptor 6D9H
TM3 115 3.53x53 M2 receptor 4MQT CB1 receptor 5XRA
TM3 116 3.54x54 M2 receptor 4MQT M2 receptor 4MQT
TM3 117 3.55x55 M2 receptor 4MQT - -
TM3 118 3.56x56 M2 receptor 4MQT 5-HT2C receptor 6BQG
ICL2 119 34.50x50 M2 receptor 4MQT 5-HT1B receptor 6G79
ICL2 120 34.51x51 M2 receptor 4MQT 5-HT1B receptor 6G79
ICL2 121 34.52x52 M2 receptor 4MQT Rhodopsin 4ZWJ
ICL2 122 34.53x53 M2 receptor 4MQT M2 receptor 4MQT
ICL2 123 34.54x54 M2 receptor 4MQT LPA6 receptor 5XSZ
ICL2 124 34.55x55 M2 receptor 4MQT NTS1 receptor 5T04
ICL2 125 34.56x56 M2 receptor 4MQT - -
ICL2 126 34.57x57 M2 receptor 4MQT - -
ICL2 127 34.58x58 - - - -
TM4 128 4.38x38 M2 receptor 4MQT Rhodopsin 5DYS
TM4 129 4.39x39 M2 receptor 4MQT US28 4XT1
TM4 130 4.40x40 M2 receptor 4MQT κ receptor 6B73
TM4 131 4.41x41 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM4 132 4.42x42 M2 receptor 4MQT - -
TM4 133 4.43x43 M2 receptor 4MQT CB1 receptor 5XRA
TM4 134 4.44x44 M2 receptor 4MQT - -
TM4 135 4.45x45 M2 receptor 4MQT D4 receptor 5WIV
TM4 136 4.46x46 M2 receptor 4MQT - -
TM4 137 4.47x47 M2 receptor 4MQT μ receptor 5C1M
TM4 138 4.48x48 M2 receptor 4MQT M2 receptor 4MQT
TM4 139 4.49x49 M2 receptor 4MQT 5-HT1B receptor 6G79
TM4 140 4.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM4 141 4.51x51 M2 receptor 4MQT M2 receptor 4MQT
TM4 142 4.52x52 M2 receptor 4MQT M2 receptor 4MQT
TM4 143 4.53x53 M2 receptor 4MQT Rhodopsin 5DYS
TM4 144 4.54x54 M2 receptor 4MQT M2 receptor 4MQT
TM4 145 4.55x55 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM4 146 4.56x56 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM4 147 4.57x57 D2 receptor 6CM4 - -
TM4 148 4.58x59 D2 receptor 6CM4 - -
TM4 149 4.59x60 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM4 150 4.60x61 M2 receptor 4MQT A1 receptor 6D9H
TM4 151 4.61x62 M2 receptor 4MQT PAF receptor 5ZKP
TM4 152 4.62x63 M2 receptor 4MQT κ receptor 6B73
TM4 153 4.63x64 M2 receptor 4MQT OX2 receptor 5WS3
ECL2 154 - - - -
ECL2 155 5-HT2C receptor 6BQH 5-HT2C receptor 6BQH
ECL2 156 5-HT2C receptor 6BQH - -
ECL2 157 5-HT2C receptor 6BQH - -
ECL2 158 5-HT2C receptor 6BQH - -
ECL2 159 5-HT2C receptor 6BQH - -
ECL2 160 5-HT2C receptor 6BQH - -
ECL2 161 5-HT2C receptor 6BQH - -
ECL2 162 5-HT2C receptor 6BQH - -
ECL2 163 - - - -
ECL2 164 45.50x50 M2 receptor 4MQT M2 receptor 4MQT
ECL2 165 45.51x51 M2 receptor 4MQT A1 receptor 6D9H
ECL2 166 45.52x52 M2 receptor 4MQT NTS1 receptor 5T04
ECL2 167 M2 receptor 4MQT - -
ECL2 168 M2 receptor 4MQT M2 receptor 4MQT
ECL2 169 M2 receptor 4MQT - -
ECL2 170 M2 receptor 4MQT M2 receptor 4MQT
TM5 171 5.35x36 M2 receptor 4MQT M3 receptor 4U15
TM5 172 5.36x37 M2 receptor 4MQT - -
TM5 173 5.37x38 M2 receptor 4MQT PAR1 3VW7
TM5 174 5.38x39 M2 receptor 4MQT AT2 receptor 5UNG
TM5 175 5.39x40 M2 receptor 4MQT CB1 receptor 5XRA
TM5 176 5.40x41 M2 receptor 4MQT PAR1 3VW7
TM5 177 5.41x42 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM5 178 5.42x43 M2 receptor 4MQT M2 receptor 4MQT
TM5 179 5.43x44 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM5 180 5.44x45 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM5 181 5.45x46 M2 receptor 4MQT AT2 receptor 5UNG
TM5 182 5.46x461 M2 receptor 4MQT - -
TM5 183 5.47x47 M2 receptor 4MQT M2 receptor 4MQT
TM5 184 5.48x48 M2 receptor 4MQT κ receptor 6B73
TM5 185 5.49x49 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM5 186 5.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM5 187 5.51x51 M2 receptor 4MQT M2 receptor 4MQT
TM5 188 5.52x52 M2 receptor 4MQT M2 receptor 4MQT
TM5 189 5.53x53 M2 receptor 4MQT 5-HT1B receptor 6G79
TM5 190 5.54x54 M2 receptor 4MQT BLT1 receptor 5X33
TM5 191 5.55x55 M2 receptor 4MQT AT2 receptor 5UNG
TM5 192 5.56x56 M2 receptor 4MQT CB1 receptor 5XRA
TM5 193 5.57x57 M2 receptor 4MQT H1 receptor 3RZE
TM5 194 5.58x58 M2 receptor 4MQT NTS1 receptor 5T04
TM5 195 5.59x59 M2 receptor 4MQT CB1 receptor 5XRA
TM5 196 5.60x60 M2 receptor 4MQT - -
TM5 197 5.61x61 M2 receptor 4MQT M2 receptor 4MQT
TM5 198 5.62x62 M2 receptor 4MQT 5-HT1B receptor 6G79
TM5 199 5.63x63 M2 receptor 4MQT CB1 receptor 5XRA
TM5 200 5.64x64 M2 receptor 4MQT - -
TM5 201 5.65x65 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM5 202 5.66x66 M2 receptor 4MQT OX2 receptor 5WS3
TM5 203 5.67x67 β2-adrenoceptor 3SN6 5-HT2B receptor 5TUD
TM5 204 5.68x68 β2-adrenoceptor 3SN6 5-HT1B receptor 6G79
TM5 205 5.69x69 β2-adrenoceptor 3SN6 - -
TM5 206 5.70x70 β2-adrenoceptor 3SN6 NTS1 receptor 4BUO
TM5 207 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 208 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 209 5.73x73 β2-adrenoceptor 3SN6 - -
TM5 210 5.74x74 β2-adrenoceptor 3SN6 - -
TM5 211 5.75x75 β2-adrenoceptor 3SN6 - -
TM5 212 5.76x76 β2-adrenoceptor 3SN6 - -
ICL3 213 - - - -
ICL3 214 - - - -
ICL3 215 - - - -
ICL3 216 - - - -
ICL3 217 - - - -
ICL3 287 - - - -
ICL3 288 - - - -
ICL3 289 - - - -
ICL3 290 - - - -
ICL3 291 - - - -
TM6 292 6.24x24 5-HT2B receptor 5TVN - -
TM6 293 6.25x25 5-HT2B receptor 5TVN - -
TM6 294 6.26x26 5-HT2B receptor 5TVN - -
TM6 295 6.27x27 M2 receptor 4MQT M1 receptor 5CXV
TM6 296 6.28x28 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM6 297 6.29x29 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 298 6.30x30 M2 receptor 4MQT - -
TM6 299 6.31x31 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM6 300 6.32x32 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM6 301 6.33x33 M2 receptor 4MQT CB1 receptor 5XRA
TM6 302 6.34x34 M2 receptor 4MQT A1 receptor 6D9H
TM6 303 6.35x35 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 304 6.36x36 M2 receptor 4MQT A1 receptor 6D9H
TM6 305 6.37x37 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 306 6.38x38 M2 receptor 4MQT A1 receptor 6D9H
TM6 307 6.39x39 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 308 6.40x40 M2 receptor 4MQT apelin receptor 5VBL
TM6 309 6.41x41 M2 receptor 4MQT M2 receptor 4MQT
TM6 310 6.42x42 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 311 6.43x43 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM6 312 6.44x44 M2 receptor 4MQT M2 receptor 4MQT
TM6 313 6.45x45 M2 receptor 4MQT A1 receptor 6D9H
TM6 314 6.46x46 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 315 6.47x47 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 316 6.48x48 M2 receptor 4MQT M2 receptor 4MQT
TM6 317 6.49x49 M2 receptor 4MQT M2 receptor 4MQT
TM6 318 6.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM6 319 6.51x51 M2 receptor 4MQT M2 receptor 4MQT
TM6 320 6.52x52 M2 receptor 4MQT OX2 receptor 5WS3
TM6 321 6.53x53 M2 receptor 4MQT US28 4XT1
TM6 322 6.54x54 M2 receptor 4MQT κ receptor 6B73
TM6 323 6.55x55 M2 receptor 4MQT AT2 receptor 5UNG
TM6 324 6.56x56 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM6 325 6.57x57 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 326 6.58x58 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM6 327 6.59x59 M2 receptor 4MQT LPA6 receptor 5XSZ
TM6 328 6.60x60 M2 receptor 4MQT M2 receptor 4MQT
TM6 329 6.61x61 M2 receptor 4MQT FFA1 receptor 5TZY
ECL3 330 - - - -
ECL3 331 A2A receptor 3VG9 - -
ECL3 332 A2A receptor 3VG9 - -
ECL3 333 A2A receptor 3VG9 - -
ECL3 334 A2A receptor 3VG9 - -
ECL3 335 - - - -
TM7 336 7.31x30 M2 receptor 4MQT - -
TM7 337 7.32x31 M2 receptor 4MQT A1 receptor 6D9H
TM7 338 7.33x32 M2 receptor 4MQT μ receptor 5C1M
TM7 339 7.34x33 M2 receptor 4MQT OX2 receptor 5WS3
TM7 340 7.35x34 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM7 341 7.36x35 M2 receptor 4MQT NOP receptor 5DHG
TM7 342 7.37x36 M2 receptor 4MQT M2 receptor 4MQT
TM7 343 7.38x37 M2 receptor 4MQT A1 receptor 6D9H
TM7 344 7.39x38 M2 receptor 4MQT - -
TM7 345 7.40x39 M2 receptor 4MQT M2 receptor 4MQT
TM7 346 7.41x40 M2 receptor 4MQT M2 receptor 4MQT
TM7 347 7.42x41 M2 receptor 4MQT - -
TM7 348 7.43x42 M2 receptor 4MQT - -
TM7 349 7.44x43 M2 receptor 4MQT AT1 receptor 4ZUD
TM7 350 7.45x45 M2 receptor 4MQT M2 receptor 4MQT
TM7 351 7.46x46 M2 receptor 4MQT M2 receptor 4MQT
TM7 352 7.47x47 M2 receptor 4MQT - -
TM7 353 7.48x48 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM7 354 7.49x49 M2 receptor 4MQT M2 receptor 4MQT
TM7 355 7.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM7 356 7.51x51 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM7 357 7.52x52 M2 receptor 4MQT μ receptor 6DDF
TM7 358 7.53x53 M2 receptor 4MQT M2 receptor 4MQT
TM7 359 7.54x54 M2 receptor 4MQT H1 receptor 3RZE
TM7 360 7.55x55 M2 receptor 4MQT M2 receptor 4MQT
TM7 361 7.56x56 M2 receptor 4MQT M2 receptor 4MQT
H8 362 8.47x47 M2 receptor 4MQT - -
H8 363 8.48x48 M2 receptor 4MQT 5-HT2C receptor 6BQG
H8 364 8.49x49 M2 receptor 4MQT AT2 receptor 5UNG
H8 365 8.50x50 M2 receptor 4MQT M2 receptor 4MQT
H8 366 8.51x51 M2 receptor 4MQT AT2 receptor 5UNF
H8 367 8.52x52 M2 receptor 4MQT H1 receptor 3RZE
H8 368 8.53x53 M2 receptor 4MQT 5-HT1B receptor 6G79
H8 369 8.54x54 M2 receptor 4MQT M2 receptor 4MQT
H8 370 8.55x55 M2 receptor 4MQT A1 receptor 6D9H
H8 371 8.56x56 M2 receptor 4MQT A1 receptor 6D9H
H8 372 8.57x57 M2 receptor 4MQT A2A receptor 5G53
H8 373 8.58x58 M2 receptor 4MQT PAF receptor 5ZKP
C-term 374 - - - -
C-term 375 - - - -
C-term 376 - - - -
C-term 377 - - - -
C-term 378 - - - -