MRGPRF homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.98 docs)

VERSION

2018-07-10

MAIN TEMPLATE

κ receptor (sequence similarity: 36%) PDB: 6B73

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.1 10.9 10.9
Side-chains 13.9 55.5 30.7

Number of backbone templates: 3
Number of rotamer templates: 38

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5O9H
6B73
4DJH
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 36 - - - -
N-term 37 - - - -
N-term 38 - - - -
N-term 39 - - - -
N-term 40 - - - -
TM1 41 1.29x29 C5a1 receptor 5O9H - -
TM1 42 1.30x30 κ receptor 6B73 5-HT1B receptor 6G79
TM1 43 1.31x31 κ receptor 6B73 C5a1 receptor 5O9H
TM1 44 1.32x32 κ receptor 6B73 κ receptor 6B73
TM1 45 1.33x33 κ receptor 6B73 A1 receptor 6D9H
TM1 46 1.34x34 κ receptor 6B73 US28 4XT1
TM1 47 1.35x35 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 48 1.36x36 κ receptor 6B73 - -
TM1 49 1.37x37 κ receptor 6B73 - -
TM1 50 1.38x38 κ receptor 6B73 A1 receptor 6D9H
TM1 51 1.39x39 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 52 1.40x40 κ receptor 6B73 A2A receptor 5G53
TM1 53 1.41x41 κ receptor 6B73 A1 receptor 6D9H
TM1 54 1.42x42 κ receptor 6B73 M2 receptor 4MQT
TM1 55 1.43x43 κ receptor 6B73 μ receptor 5C1M
TM1 56 1.44x44 κ receptor 6B73 US28 4XT1
TM1 57 1.45x45 κ receptor 6B73 - -
TM1 58 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 59 1.47x47 κ receptor 6B73 κ receptor 6B73
TM1 60 1.48x48 κ receptor 6B73 κ receptor 6B73
TM1 61 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 62 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 63 1.51x51 κ receptor 6B73 PAF receptor 5ZKP
TM1 64 1.52x52 κ receptor 6B73 κ receptor 6B73
TM1 65 1.53x53 κ receptor 6B73 κ receptor 6B73
TM1 66 1.54x54 κ receptor 6B73 PAF receptor 5ZKP
TM1 67 1.55x55 κ receptor 6B73 A1 receptor 6D9H
TM1 68 1.56x56 κ receptor 6B73 - -
TM1 69 1.57x57 κ receptor 6B73 AT2 receptor 5UNG
TM1 70 1.58x58 κ receptor 6B73 CXCR4 3ODU
TM1 71 1.59x59 κ receptor 6B73 C5a1 receptor 5O9H
TM1 72 1.60x60 κ receptor 6B73 CB1 receptor 5XRA
ICL1 73 - - - -
ICL1 74 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL1 75 - - - -
TM2 76 2.37x37 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 77 2.38x38 κ receptor 6B73 5-HT1B receptor 6G79
TM2 78 2.39x39 κ receptor 6B73 P2Y12 receptor 4NTJ
TM2 79 2.40x40 κ receptor 6B73 AT2 receptor 5UNG
TM2 80 2.41x41 κ receptor 6B73 κ receptor 6B73
TM2 81 2.42x42 κ receptor 6B73 κ receptor 6B73
TM2 82 2.43x43 κ receptor 6B73 US28 4XT1
TM2 83 2.44x44 κ receptor 6B73 Rhodopsin 5DYS
TM2 84 2.45x45 κ receptor 6B73 CXCR4 3ODU
TM2 85 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 86 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 87 2.48x48 κ receptor 6B73 - -
TM2 88 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 89 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 90 2.51x51 κ receptor 6B73 A1 receptor 6D9H
TM2 91 2.52x52 κ receptor 6B73 - -
TM2 92 2.53x53 κ receptor 6B73 P2Y1 receptor 4XNW
TM2 93 2.54x54 κ receptor 6B73 AT2 receptor 5UNG
TM2 94 2.55x55 κ receptor 6B73 Rhodopsin 5DYS
TM2 95 2.56x56 κ receptor 6B73 M2 receptor 4MQT
TM2 96 2.57x57 κ receptor 6B73 - -
TM2 97 2.58x58 κ receptor 6B73 - -
TM2 98 2.59x59 κ receptor 6B73 NTS1 receptor 5T04
TM2 99 2.60x60 κ receptor 6B73 M3 receptor 4U15
TM2 100 2.61x61 κ receptor 6B73 κ receptor 6B73
TM2 101 2.62x62 κ receptor 6B73 CB1 receptor 5XRA
TM2 102 2.63x63 κ receptor 6B73 S1P1 receptor 3V2Y
TM2 103 2.64x64 κ receptor 6B73 A1 receptor 6D9H
TM2 104 2.65x65 κ receptor 6B73 A2A receptor 5G53
TM2 105 2.66x66 κ receptor 6B73 A1 receptor 6D9H
TM2 106 2.67x67 C5a1 receptor 5O9H μ receptor 6DDF
ECL1 107 - - - -
ECL1 108 C5a1 receptor 5O9H - -
ECL1 109 C5a1 receptor 5O9H - -
ECL1 110 C5a1 receptor 5O9H - -
ECL1 111 - - - -
TM3 112 3.21x21 κ receptor 6B73 US28 5WB1
TM3 113 3.22x22 κ receptor 6B73 κ receptor 6B73
TM3 114 3.23x23 κ receptor 6B73 5-HT2C receptor 6BQG
TM3 115 3.24x24 κ receptor 6B73 - -
TM3 116 3.25x25 κ receptor 6B73 - -
TM3 117 3.26x26 κ receptor 6B73 C5a1 receptor 5O9H
TM3 118 3.27x27 κ receptor 6B73 AT2 receptor 5UNG
TM3 119 3.28x28 κ receptor 6B73 BLT1 receptor 5X33
TM3 120 3.29x29 κ receptor 6B73 P2Y1 receptor 4XNW
TM3 121 3.30x30 κ receptor 6B73 CXCR4 3ODU
TM3 122 3.31x31 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 123 3.32x32 κ receptor 6B73 - -
TM3 124 3.33x33 κ receptor 6B73 A1 receptor 6D9H
TM3 125 3.34x34 κ receptor 6B73 PAR1 3VW7
TM3 126 3.35x35 κ receptor 6B73 D2 receptor 6CM4
TM3 127 3.36x36 κ receptor 6B73 CB1 receptor 5XRA
TM3 128 3.37x37 κ receptor 6B73 - -
TM3 129 3.38x38 κ receptor 6B73 κ receptor 6B73
TM3 130 3.39x39 κ receptor 6B73 CCR5 5UIW
TM3 131 3.40x40 κ receptor 6B73 M2 receptor 4MQT
TM3 132 3.41x41 κ receptor 6B73 P2Y12 receptor 4NTJ
TM3 133 3.42x42 κ receptor 6B73 C5a1 receptor 5O9H
TM3 134 3.43x43 κ receptor 6B73 κ receptor 6B73
TM3 135 3.44x44 κ receptor 6B73 - -
TM3 136 3.45x45 κ receptor 6B73 A1 receptor 6D9H
TM3 137 3.46x46 κ receptor 6B73 - -
TM3 138 3.47x47 κ receptor 6B73 κ receptor 6B73
TM3 139 3.48x48 κ receptor 6B73 C5a1 receptor 5O9H
TM3 140 3.49x49 κ receptor 6B73 Rhodopsin 5DYS
TM3 141 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 142 3.51x51 κ receptor 6B73 - -
TM3 143 3.52x52 κ receptor 6B73 - -
TM3 144 3.53x53 κ receptor 6B73 AT2 receptor 5UNG
TM3 145 3.54x54 κ receptor 6B73 κ receptor 6B73
TM3 146 3.55x55 κ receptor 6B73 AT2 receptor 5UNG
TM3 147 3.56x56 κ receptor 6B73 FFA1 receptor 5TZY
ICL2 148 34.50x50 - - - -
ICL2 149 34.51x51 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 150 34.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 151 34.53x53 C5a1 receptor 5O9H A1 receptor 6D9H
ICL2 152 34.54x54 C5a1 receptor 5O9H - -
ICL2 153 34.55x55 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 154 34.56x56 C5a1 receptor 5O9H P2Y1 receptor 4XNW
ICL2 155 34.57x57 - - - -
TM4 156 4.38x38 κ receptor 6B73 US28 4XT1
TM4 157 4.39x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 158 4.40x40 κ receptor 6B73 μ receptor 5C1M
TM4 159 4.41x41 κ receptor 6B73 C5a1 receptor 5O9H
TM4 160 4.42x42 κ receptor 6B73 CCR9 5LWE
TM4 161 4.43x43 κ receptor 6B73 A1 receptor 6D9H
TM4 162 4.44x44 κ receptor 6B73 A1 receptor 6D9H
TM4 163 4.45x45 κ receptor 6B73 μ receptor 5C1M
TM4 164 4.46x46 κ receptor 6B73 LPA6 receptor 5XSZ
TM4 165 4.47x47 κ receptor 6B73 A1 receptor 6D9H
TM4 166 4.48x48 κ receptor 6B73 5-HT1B receptor 6G79
TM4 167 4.49x49 κ receptor 6B73 apelin receptor 5VBL
TM4 168 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 169 4.51x51 κ receptor 6B73 5-HT1B receptor 6G79
TM4 170 4.52x52 κ receptor 6B73 κ receptor 6B73
TM4 171 4.53x53 κ receptor 6B73 κ receptor 6B73
TM4 172 4.54x54 κ receptor 6B73 LPA6 receptor 5XSZ
TM4 173 4.55x55 κ receptor 6B73 AT2 receptor 5UNG
TM4 174 4.56x56 κ receptor 6B73 κ receptor 6B73
TM4 175 4.57x57 κ receptor 6B73 C5a1 receptor 5O9H
TM4 176 4.58x58 κ receptor 6B73 - -
TM4 177 4.59x59 κ receptor 6B73 AT2 receptor 5UNG
TM4 178 4.60x60 κ receptor 6B73 - -
TM4 179 4.61x61 κ receptor 6B73 CCR5 5UIW
TM4 180 4.62x62 κ receptor 6B73 PAR2 5NDD
TM4 181 4.63x63 κ receptor 6B73 M2 receptor 4MQT
TM4 182 4.64x64 κ receptor 6B73 - -
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
TM5 192 5.31x32 C5a1 receptor 5O9H - -
TM5 193 5.32x33 C5a1 receptor 5O9H AT2 receptor 5UNG
TM5 194 5.33x34 κ receptor 6B73 - -
TM5 195 5.34x35 κ receptor 6B73 C5a1 receptor 5O9H
TM5 196 5.35x36 κ receptor 6B73 P2Y12 receptor 4NTJ
TM5 197 5.36x37 κ receptor 6B73 A1 receptor 6D9H
TM5 198 5.37x38 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 199 5.38x39 κ receptor 6B73 AT2 receptor 5UNG
TM5 200 5.39x40 κ receptor 6B73 PAR2 5NDD
TM5 201 5.40x41 κ receptor 6B73 AT2 receptor 5UNG
TM5 202 5.41x42 κ receptor 6B73 M2 receptor 4MQT
TM5 203 5.42x43 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 204 5.43x44 κ receptor 6B73 C5a1 receptor 5O9H
TM5 205 5.44x45 κ receptor 6B73 US28 4XT1
TM5 206 5.45x46 κ receptor 6B73 κ receptor 6B73
TM5 207 5.46x461 κ receptor 6B73 FFA1 receptor 5TZY
TM5 208 5.47x47 κ receptor 6B73 CXCR4 3ODU
TM5 209 5.48x48 κ receptor 6B73 P2Y1 receptor 4XNW
TM5 210 5.49x49 κ receptor 6B73 - -
TM5 211 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 212 5.51x51 κ receptor 6B73 US28 4XT1
TM5 213 5.52x52 κ receptor 6B73 - -
TM5 214 5.53x53 κ receptor 6B73 US28 4XT1
TM5 215 5.54x54 κ receptor 6B73 5-HT1B receptor 6G79
TM5 216 5.55x55 κ receptor 6B73 - -
TM5 217 5.56x56 κ receptor 6B73 - -
TM5 218 5.57x57 κ receptor 6B73 5-HT1B receptor 6G79
TM5 219 5.58x58 κ receptor 6B73 - -
TM5 220 5.59x59 κ receptor 6B73 A1 receptor 6D9H
TM5 221 5.60x60 κ receptor 6B73 CXCR4 3ODU
TM5 222 5.61x61 κ receptor 6B73 Rhodopsin 5DYS
TM5 223 5.62x62 κ receptor 6B73 - -
TM5 224 5.63x63 κ receptor 6B73 5-HT1B receptor 6G79
TM5 225 5.64x64 κ receptor 6B73 5-HT1B receptor 6G79
TM5 226 5.65x65 κ receptor 6B73 - -
TM5 227 5.66x66 κ receptor 6B73 A1 receptor 6D9H
TM5 228 5.67x67 κ receptor 6B73 - -
TM5 229 5.68x68 C5a1 receptor 5O9H C5a1 receptor 6C1R
ICL3 230 - - - -
ICL3 231 - - - -
ICL3 232 - - - -
ICL3 233 - - - -
TM6 234 6.30x30 κ receptor 6B73 C5a1 receptor 6C1R
TM6 235 6.31x31 κ receptor 6B73 - -
TM6 236 6.32x32 κ receptor 6B73 A1 receptor 6D9H
TM6 237 6.33x33 κ receptor 6B73 CB1 receptor 5XRA
TM6 238 6.34x34 κ receptor 6B73 Y1 receptor 5ZBH
TM6 239 6.35x35 κ receptor 6B73 - -
TM6 240 6.36x36 κ receptor 6B73 US28 4XT1
TM6 241 6.37x37 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 242 6.38x38 κ receptor 6B73 κ receptor 6B73
TM6 243 6.39x39 κ receptor 6B73 US28 4XT1
TM6 244 6.40x40 κ receptor 6B73 Rhodopsin 5DYS
TM6 245 6.41x41 κ receptor 6B73 κ receptor 6B73
TM6 246 6.42x42 κ receptor 6B73 S1P1 receptor 3V2Y
TM6 247 6.43x43 κ receptor 6B73 κ receptor 6B73
TM6 248 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 249 6.45x45 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 250 6.46x46 κ receptor 6B73 κ receptor 6B73
TM6 251 6.47x47 κ receptor 6B73 A1 receptor 6D9H
TM6 252 6.48x48 κ receptor 6B73 - -
TM6 253 6.49x49 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 254 6.50x50 κ receptor 6B73 - -
TM6 255 6.51x51 κ receptor 6B73 A1 receptor 6D9H
TM6 256 6.52x52 κ receptor 6B73 - -
TM6 257 6.53x53 κ receptor 6B73 κ receptor 6B73
TM6 258 6.54x54 κ receptor 6B73 - -
TM6 259 6.55x55 κ receptor 6B73 - -
TM6 260 6.56x56 κ receptor 6B73 US28 4XT1
TM6 261 6.57x57 κ receptor 6B73 AT2 receptor 5UNG
TM6 262 6.58x58 κ receptor 6B73 NTS1 receptor 5T04
TM6 263 6.59x59 κ receptor 6B73 - -
TM6 264 6.60x60 κ receptor 6B73 OX2 receptor 5WS3
TM6 265 6.61x61 κ receptor 6B73 OX2 receptor 5WQC
ECL3 266 - - - -
ECL3 267 κ receptor 6B73 - -
ECL3 268 κ receptor 6B73 - -
ECL3 269 κ receptor 6B73 - -
TM7 270 7.32x31 κ receptor 6B73 Rhodopsin 5DYS
TM7 271 7.33x32 κ receptor 6B73 S1P1 receptor 3V2Y
TM7 272 7.34x33 κ receptor 6B73 - -
TM7 273 7.35x34 κ receptor 6B73 LPA1 receptor 4Z35
TM7 274 7.36x35 κ receptor 6B73 κ receptor 6B73
TM7 275 7.37x36 κ receptor 6B73 PAF receptor 5ZKP
TM7 276 7.38x37 κ receptor 6B73 US28 4XT1
TM7 277 7.39x38 κ receptor 6B73 - -
TM7 278 7.40x39 κ receptor 6B73 AT2 receptor 5UNG
TM7 279 7.41x40 κ receptor 6B73 - -
TM7 280 7.42x41 κ receptor 6B73 - -
TM7 281 7.43x42 κ receptor 6B73 - -
TM7 282 7.44x43 κ receptor 6B73 M2 receptor 4MQT
TM7 283 7.45x45 κ receptor 6B73 κ receptor 6B73
TM7 284 7.46x46 κ receptor 6B73 κ receptor 6B73
TM7 285 7.47x47 κ receptor 6B73 κ receptor 6B73
TM7 286 7.48x48 κ receptor 6B73 OX2 receptor 5WS3
TM7 287 7.49x49 κ receptor 6B73 - -
TM7 288 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 289 7.51x51 κ receptor 6B73 A1 receptor 6D9H
TM7 290 7.52x52 C5a1 receptor 5O9H A1 receptor 6D9H
TM7 291 7.53x53 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 292 7.54x54 C5a1 receptor 5O9H P2Y1 receptor 4XNW
TM7 293 7.55x55 C5a1 receptor 5O9H M2 receptor 4MQT
TM7 294 7.56x56 C5a1 receptor 5O9H C5a1 receptor 5O9H
H8 295 8.47x47 κ receptor 4DJH US28 4XT1
H8 296 8.48x48 κ receptor 4DJH A2A receptor 4UHR
H8 297 8.49x49 κ receptor 4DJH β2-adrenoceptor 3SN6
H8 298 8.50x50 κ receptor 4DJH - -
H8 299 8.51x51 κ receptor 4DJH LPA1 receptor 4Z35
H8 300 8.52x52 κ receptor 4DJH US28 4XT1
H8 301 8.53x53 κ receptor 4DJH - -
H8 302 8.54x54 κ receptor 4DJH US28 4XT1
H8 303 8.55x55 κ receptor 4DJH - -
H8 304 8.56x56 κ receptor 4DJH β2-adrenoceptor 3SN6
C-term 305 - - - -
C-term 306 - - - -
C-term 307 - - - -
C-term 308 - - - -
C-term 309 - - - -