NK1 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.72 docs)

VERSION

2018-07-10

MAIN TEMPLATE

κ receptor (sequence similarity: 47%) PDB: 6B73

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.0 14.7 10.3
Side-chains 21.7 52.3 26.0

Number of backbone templates: 6
Number of rotamer templates: 35

NGL is a WebGL based 3D viewer powered by MMTF.

6B73
5WS3
3ODU
3SN6
4UHR
5ZBH
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 26 - - - -
N-term 27 - - - -
N-term 28 κ receptor 6B73 κ receptor 6B73
N-term 29 κ receptor 6B73 κ receptor 6B73
N-term 30 κ receptor 6B73 κ receptor 6B73
TM1 31 1.31x31 κ receptor 6B73 Rhodopsin 5DYS
TM1 32 1.32x32 κ receptor 6B73 Y1 receptor 5ZBH
TM1 33 1.33x33 κ receptor 6B73 κ receptor 6B73
TM1 34 1.34x34 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 35 1.35x35 κ receptor 6B73 5-HT2B receptor 4IB4
TM1 36 1.36x36 κ receptor 6B73 Rhodopsin 5DYS
TM1 37 1.37x37 κ receptor 6B73 κ receptor 6B73
TM1 38 1.38x38 κ receptor 6B73 OX1 receptor 4ZJ8
TM1 39 1.39x39 κ receptor 6B73 κ receptor 6B73
TM1 40 1.40x40 κ receptor 6B73 D2 receptor 6CM4
TM1 41 1.41x41 κ receptor 6B73 κ receptor 6B73
TM1 42 1.42x42 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 43 1.43x43 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 44 1.44x44 κ receptor 6B73 κ receptor 6B73
TM1 45 1.45x45 κ receptor 6B73 CXCR4 3ODU
TM1 46 1.46x46 κ receptor 6B73 A1 receptor 6D9H
TM1 47 1.47x47 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 48 1.48x48 κ receptor 6B73 κ receptor 6B73
TM1 49 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 50 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 51 1.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 52 1.52x52 κ receptor 6B73 AT2 receptor 5UNG
TM1 53 1.53x53 κ receptor 6B73 κ receptor 6B73
TM1 54 1.54x54 κ receptor 6B73 κ receptor 6B73
TM1 55 1.55x55 κ receptor 6B73 A2A receptor 5G53
TM1 56 1.56x56 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 57 1.57x57 κ receptor 6B73 κ receptor 6B73
TM1 58 1.58x58 κ receptor 6B73 CB1 receptor 5XRA
TM1 59 1.59x59 κ receptor 6B73 FFA1 receptor 5TZY
TM1 60 1.60x60 κ receptor 6B73 NOP receptor 5DHG
ICL1 61 12.48x48 - - - -
ICL1 62 12.49x49 OX2 receptor 5WS3 β2-adrenoceptor 4LDE
ICL1 63 12.50x50 OX2 receptor 5WS3 OX2 receptor 5WS3
ICL1 64 12.51x51 - - - -
TM2 65 2.37x37 κ receptor 6B73 κ receptor 6B73
TM2 66 2.38x38 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 67 2.39x39 κ receptor 6B73 κ receptor 6B73
TM2 68 2.40x40 κ receptor 6B73 κ receptor 6B73
TM2 69 2.41x41 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 70 2.42x42 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 71 2.43x43 κ receptor 6B73 Rhodopsin 5DYS
TM2 72 2.44x44 κ receptor 6B73 A2A receptor 5G53
TM2 73 2.45x45 κ receptor 6B73 κ receptor 6B73
TM2 74 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 75 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 76 2.48x48 κ receptor 6B73 Y1 receptor 5ZBH
TM2 77 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 78 2.50x50 κ receptor 6B73 - -
TM2 79 2.51x51 κ receptor 6B73 κ receptor 6B73
TM2 80 2.52x52 κ receptor 6B73 - -
TM2 81 2.53x53 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 82 2.54x54 κ receptor 6B73 Y1 receptor 5ZBH
TM2 83 2.55x55 κ receptor 6B73 AT2 receptor 5UNG
TM2 84 2.56x56 κ receptor 6B73 - -
TM2 85 2.57x57 κ receptor 6B73 - -
TM2 86 2.58x58 κ receptor 6B73 Rhodopsin 5DYS
TM2 87 2.59x59 κ receptor 6B73 NTS1 receptor 5T04
TM2 88 2.60x60 κ receptor 6B73 D2 receptor 6CM4
TM2 89 2.61x61 κ receptor 6B73 - -
TM2 90 2.62x62 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 91 2.63x63 κ receptor 6B73 Rhodopsin 5DYS
TM2 92 2.64x64 κ receptor 6B73 κ receptor 6B73
TM2 93 2.65x65 κ receptor 6B73 AT1 receptor 4ZUD
TM2 94 2.66x66 κ receptor 6B73 CB1 receptor 5XRA
TM2 95 2.67x67 κ receptor 6B73 κ receptor 6B73
TM2 96 2.68x68 - - - -
ECL1 97 23.49x49 - - - -
ECL1 98 23.50x50 - - - -
ECL1 99 23.51x51 - - - -
ECL1 100 23.52x52 - - - -
TM3 101 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 102 3.22x22 κ receptor 6B73 5-HT2B receptor 5TUD
TM3 103 3.23x23 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 104 3.24x24 κ receptor 6B73 - -
TM3 105 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 106 3.26x26 κ receptor 6B73 κ receptor 6B73
TM3 107 3.27x27 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 108 3.28x28 κ receptor 6B73 - -
TM3 109 3.29x29 κ receptor 6B73 CCR9 5LWE
TM3 110 3.30x30 κ receptor 6B73 Rhodopsin 5DYS
TM3 111 3.31x31 κ receptor 6B73 Rhodopsin 5DYS
TM3 112 3.32x32 κ receptor 6B73 - -
TM3 113 3.33x33 κ receptor 6B73 5-HT1B receptor 6G79
TM3 114 3.34x34 κ receptor 6B73 NTS1 receptor 5T04
TM3 115 3.35x35 κ receptor 6B73 US28 4XT1
TM3 116 3.36x36 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 117 3.37x37 κ receptor 6B73 κ receptor 6B73
TM3 118 3.38x38 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 119 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 120 3.40x40 κ receptor 6B73 κ receptor 6B73
TM3 121 3.41x41 κ receptor 6B73 - -
TM3 122 3.42x42 κ receptor 6B73 Rhodopsin 5DYS
TM3 123 3.43x43 κ receptor 6B73 PAR1 3VW7
TM3 124 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 125 3.45x45 κ receptor 6B73 5-HT2B receptor 5TUD
TM3 126 3.46x46 κ receptor 6B73 - -
TM3 127 3.47x47 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 128 3.48x48 κ receptor 6B73 M2 receptor 4MQT
TM3 129 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 130 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 131 3.51x51 κ receptor 6B73 κ receptor 6B73
TM3 132 3.52x52 κ receptor 6B73 - -
TM3 133 3.53x53 κ receptor 6B73 κ receptor 6B73
TM3 134 3.54x54 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 135 3.55x55 κ receptor 6B73 AT2 receptor 5UNG
TM3 136 3.56x56 κ receptor 6B73 κ receptor 6B73
ICL2 137 - - - -
ICL2 138 OX2 receptor 5WS3 OX2 receptor 5WS3
ICL2 139 OX2 receptor 5WS3 - -
ICL2 140 OX2 receptor 5WS3 - -
ICL2 141 OX2 receptor 5WS3 - -
ICL2 142 - - - -
TM4 143 4.38x38 κ receptor 6B73 NTS1 receptor 5T04
TM4 144 4.39x39 κ receptor 6B73 OX2 receptor 5WS3
TM4 145 4.40x40 κ receptor 6B73 5-HT2C receptor 6BQG
TM4 146 4.41x41 κ receptor 6B73 CXCR4 3ODU
TM4 147 4.42x42 κ receptor 6B73 NTS1 receptor 5T04
TM4 148 4.43x43 κ receptor 6B73 κ receptor 6B73
TM4 149 4.44x44 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 150 4.45x45 κ receptor 6B73 μ receptor 5C1M
TM4 151 4.46x46 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 152 4.47x47 κ receptor 6B73 CB1 receptor 5XRA
TM4 153 4.48x48 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 154 4.49x49 κ receptor 6B73 κ receptor 6B73
TM4 155 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 156 4.51x51 κ receptor 6B73 Rhodopsin 5DYS
TM4 157 4.52x52 κ receptor 6B73 κ receptor 6B73
TM4 158 4.53x53 κ receptor 6B73 Rhodopsin 5DYS
TM4 159 4.54x54 κ receptor 6B73 Rhodopsin 5DYS
TM4 160 4.55x55 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 161 4.56x56 κ receptor 6B73 NTS1 receptor 5T04
TM4 162 4.57x57 OX2 receptor 5WS3 Rhodopsin 5DYS
TM4 163 4.58x59 OX2 receptor 5WS3 - -
TM4 164 4.59x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 165 4.60x61 κ receptor 6B73 OX2 receptor 5WS3
TM4 166 4.61x62 κ receptor 6B73 FFA1 receptor 5TZY
TM4 167 4.62x63 κ receptor 6B73 AT2 receptor 5UNG
TM4 168 4.63x64 κ receptor 6B73 - -
TM4 169 4.64x65 OX2 receptor 5WS3 - -
ECL2 170 - - - -
ECL2 171 CXCR4 3ODU - -
ECL2 172 CXCR4 3ODU - -
ECL2 173 CXCR4 3ODU - -
ECL2 174 CXCR4 3ODU - -
ECL2 175 CXCR4 3ODU - -
ECL2 176 CXCR4 3ODU - -
ECL2 177 CXCR4 3ODU CXCR4 3ODU
ECL2 178 CXCR4 3ODU - -
ECL2 179 - - - -
ECL2 180 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 181 45.51x51 κ receptor 6B73 US28 4XT1
ECL2 182 45.52x52 κ receptor 6B73 Rhodopsin 5DYS
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
TM5 191 5.33x34 κ receptor 6B73 OX2 receptor 5WS3
TM5 192 5.34x35 κ receptor 6B73 US28 4XT1
TM5 193 5.35x36 κ receptor 6B73 μ receptor 5C1M
TM5 194 5.36x37 κ receptor 6B73 NTS1 receptor 5T04
TM5 195 5.37x38 κ receptor 6B73 NTS1 receptor 5T04
TM5 196 5.38x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 197 5.39x40 κ receptor 6B73 PAF receptor 5ZKP
TM5 198 5.40x41 κ receptor 6B73 κ receptor 6B73
TM5 199 5.41x42 κ receptor 6B73 κ receptor 6B73
TM5 200 5.42x43 κ receptor 6B73 κ receptor 6B73
TM5 201 5.43x44 κ receptor 6B73 NTS1 receptor 5T04
TM5 202 5.44x45 κ receptor 6B73 Rhodopsin 5DYS
TM5 203 5.45x46 κ receptor 6B73 AT2 receptor 5UNG
TM5 204 5.46x461 κ receptor 6B73 - -
TM5 205 5.47x47 κ receptor 6B73 OX2 receptor 5WS3
TM5 206 5.48x48 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 207 5.49x49 κ receptor 6B73 M2 receptor 4MQT
TM5 208 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 209 5.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 210 5.52x52 κ receptor 6B73 κ receptor 6B73
TM5 211 5.53x53 κ receptor 6B73 Rhodopsin 5DYS
TM5 212 5.54x54 κ receptor 6B73 κ receptor 6B73
TM5 213 5.55x55 κ receptor 6B73 - -
TM5 214 5.56x56 κ receptor 6B73 CB1 receptor 5XRA
TM5 215 5.57x57 κ receptor 6B73 CB1 receptor 5XRA
TM5 216 5.58x58 κ receptor 6B73 κ receptor 6B73
TM5 217 5.59x59 κ receptor 6B73 κ receptor 6B73
TM5 218 5.60x60 κ receptor 6B73 NTS1 receptor 5T04
TM5 219 5.61x61 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 220 5.62x62 κ receptor 6B73 - -
TM5 221 5.63x63 κ receptor 6B73 Y1 receptor 5ZBH
TM5 222 5.64x64 κ receptor 6B73 Rhodopsin 5DYS
TM5 223 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 224 5.66x66 κ receptor 6B73 OX2 receptor 5WS3
TM5 225 5.67x67 κ receptor 6B73 - -
TM5 226 5.68x68 β2-adrenoceptor 3SN6 P2Y12 receptor 4NTJ
TM5 227 5.69x69 β2-adrenoceptor 3SN6 - -
TM5 228 5.70x70 β2-adrenoceptor 3SN6 - -
TM5 229 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 230 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 231 5.73x73 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
ICL3 232 - - - -
ICL3 233 - - - -
ICL3 234 - - - -
TM6 235 6.22x22 A2A receptor 4UHR A2A receptor 4UHR
TM6 236 6.23x23 κ receptor 6B73 - -
TM6 237 6.24x24 κ receptor 6B73 - -
TM6 238 6.25x25 κ receptor 6B73 μ receptor 6DDF
TM6 239 6.26x26 κ receptor 6B73 OX2 receptor 5WS3
TM6 240 6.27x27 κ receptor 6B73 NTS1 receptor 5T04
TM6 241 6.28x28 κ receptor 6B73 5-HT2B receptor 5TUD
TM6 242 6.29x29 κ receptor 6B73 Rhodopsin 5DYS
TM6 243 6.30x30 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 244 6.31x31 κ receptor 6B73 μ receptor 5C1M
TM6 245 6.32x32 κ receptor 6B73 β2-adrenoceptor 3P0G
TM6 246 6.33x33 κ receptor 6B73 Rhodopsin 5DYS
TM6 247 6.34x34 κ receptor 6B73 NTS1 receptor 5T04
TM6 248 6.35x35 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 249 6.36x36 κ receptor 6B73 μ receptor 5C1M
TM6 250 6.37x37 κ receptor 6B73 PAF receptor 5ZKP
TM6 251 6.38x38 κ receptor 6B73 Rhodopsin 5DYS
TM6 252 6.39x39 κ receptor 6B73 κ receptor 6B73
TM6 253 6.40x40 κ receptor 6B73 κ receptor 6B73
TM6 254 6.41x41 κ receptor 6B73 κ receptor 6B73
TM6 255 6.42x42 κ receptor 6B73 - -
TM6 256 6.43x43 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 257 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 258 6.45x45 κ receptor 6B73 A2A receptor 5G53
TM6 259 6.46x46 κ receptor 6B73 Rhodopsin 5DYS
TM6 260 6.47x47 κ receptor 6B73 κ receptor 6B73
TM6 261 6.48x48 κ receptor 6B73 κ receptor 6B73
TM6 262 6.49x49 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 263 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 264 6.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 265 6.52x52 κ receptor 6B73 κ receptor 6B73
TM6 266 6.53x53 κ receptor 6B73 κ receptor 6B73
TM6 267 6.54x54 κ receptor 6B73 κ receptor 6B73
TM6 268 6.55x55 κ receptor 6B73 H1 receptor 3RZE
TM6 269 6.56x56 κ receptor 6B73 κ receptor 6B73
TM6 270 6.57x57 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 271 6.58x58 κ receptor 6B73 - -
TM6 272 6.59x59 κ receptor 6B73 PAR2 5NDD
TM6 273 6.60x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 274 6.61x61 κ receptor 6B73 Y1 receptor 5ZBH
ECL3 275 - - - -
ECL3 276 Y1 receptor 5ZBH - -
ECL3 277 Y1 receptor 5ZBH - -
ECL3 278 Y1 receptor 5ZBH - -
ECL3 279 - - - -
TM7 280 7.28x27 κ receptor 6B73 - -
TM7 281 7.29x28 κ receptor 6B73 CB1 receptor 5XRA
TM7 282 7.30x29 κ receptor 6B73 μ receptor 5C1M
TM7 283 7.31x30 κ receptor 6B73 AT2 receptor 5UNG
TM7 284 7.32x31 κ receptor 6B73 5-HT2B receptor 5TUD
TM7 285 7.33x32 κ receptor 6B73 CCR5 5UIW
TM7 286 7.34x33 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 287 7.35x34 κ receptor 6B73 κ receptor 6B73
TM7 288 7.36x35 κ receptor 6B73 Y1 receptor 5ZBH
TM7 289 7.37x36 κ receptor 6B73 D2 receptor 6CM4
TM7 290 7.38x37 κ receptor 6B73 - -
TM7 291 7.39x38 κ receptor 6B73 - -
TM7 292 7.40x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 293 7.41x40 κ receptor 6B73 κ receptor 6B73
TM7 294 7.42x41 κ receptor 6B73 Rhodopsin 5DYS
TM7 295 7.43x42 κ receptor 6B73 Y1 receptor 5ZBH
TM7 296 7.44x43 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 297 7.45x45 κ receptor 6B73 Rhodopsin 5DYS
TM7 298 7.46x46 κ receptor 6B73 Y1 receptor 5ZBH
TM7 299 7.47x47 κ receptor 6B73 - -
TM7 300 7.48x48 κ receptor 6B73 Rhodopsin 5DYS
TM7 301 7.49x49 κ receptor 6B73 κ receptor 6B73
TM7 302 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 303 7.51x51 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 304 7.52x52 OX2 receptor 5WS3 OX2 receptor 5WS3
TM7 305 7.53x53 OX2 receptor 5WS3 OX2 receptor 5WS3
TM7 306 7.54x54 OX2 receptor 5WS3 β2-adrenoceptor 3SN6
TM7 307 7.55x55 OX2 receptor 5WS3 - -
TM7 308 7.56x56 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 309 8.47x47 OX2 receptor 5WS3 Rhodopsin 5DYS
H8 310 8.48x48 OX2 receptor 5WS3 - -
H8 311 8.49x49 OX2 receptor 5WS3 AT2 receptor 5UNG
H8 312 8.50x50 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 313 8.51x51 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 314 8.52x52 OX2 receptor 5WS3 - -
H8 315 8.53x53 OX2 receptor 5WS3 - -
H8 316 8.54x54 OX2 receptor 5WS3 β2-adrenoceptor 3SN6
H8 317 8.55x55 OX2 receptor 5WS3 M2 receptor 4MQT
H8 318 8.56x56 OX2 receptor 5WS3 M2 receptor 4MQT
H8 319 8.57x57 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 320 8.58x58 OX2 receptor 5WS3 OX2 receptor 5WS3
C-term 321 - - - -
C-term 322 - - - -
C-term 323 - - - -
C-term 324 - - - -
C-term 325 - - - -