Y2 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.62 docs)

VERSION

2018-07-10

MAIN TEMPLATE

κ receptor (sequence similarity: 48%) PDB: 6B73

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.1 14.0 13.0
Side-chains 21.3 57.1 21.6

Number of backbone templates: 5
Number of rotamer templates: 37

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6B73
4ZJ8
3SN6
5DYS
5ZBH
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 45 - - - -
N-term 46 - - - -
N-term 47 κ receptor 6B73 κ receptor 6B73
N-term 48 κ receptor 6B73 κ receptor 6B73
N-term 49 κ receptor 6B73 κ receptor 6B73
TM1 50 1.32x32 κ receptor 6B73 CB1 receptor 5XRA
TM1 51 1.33x33 κ receptor 6B73 κ receptor 6B73
TM1 52 1.34x34 κ receptor 6B73 US28 4XT1
TM1 53 1.35x35 κ receptor 6B73 5-HT1B receptor 6G79
TM1 54 1.36x36 κ receptor 6B73 A1 receptor 6D9H
TM1 55 1.37x37 κ receptor 6B73 M2 receptor 4MQT
TM1 56 1.38x38 κ receptor 6B73 OX1 receptor 4ZJ8
TM1 57 1.39x39 κ receptor 6B73 κ receptor 6B73
TM1 58 1.40x40 κ receptor 6B73 ETB receptor 5X93
TM1 59 1.41x41 κ receptor 6B73 M2 receptor 4MQT
TM1 60 1.42x42 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 61 1.43x43 κ receptor 6B73 Rhodopsin 5DYS
TM1 62 1.44x44 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 63 1.45x45 κ receptor 6B73 Rhodopsin 5DYS
TM1 64 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 65 1.47x47 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 66 1.48x48 κ receptor 6B73 M2 receptor 4MQT
TM1 67 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 68 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 69 1.51x51 κ receptor 6B73 κ receptor 6B73
TM1 70 1.52x52 κ receptor 6B73 κ receptor 6B73
TM1 71 1.53x53 κ receptor 6B73 κ receptor 6B73
TM1 72 1.54x54 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 73 1.55x55 κ receptor 6B73 - -
TM1 74 1.56x56 κ receptor 6B73 κ receptor 6B73
TM1 75 1.57x57 κ receptor 6B73 5-HT1B receptor 6G79
TM1 76 1.58x58 κ receptor 6B73 κ receptor 6B73
TM1 77 1.59x59 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 78 1.60x60 κ receptor 6B73 - -
ICL1 79 12.48x48 - - - -
ICL1 80 12.49x49 OX1 receptor 4ZJ8 CB1 receptor 5TGZ
ICL1 81 12.50x50 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
ICL1 82 12.51x51 - - - -
TM2 83 2.37x37 κ receptor 6B73 κ receptor 6B73
TM2 84 2.38x38 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 85 2.39x39 κ receptor 6B73 κ receptor 6B73
TM2 86 2.40x40 κ receptor 6B73 κ receptor 6B73
TM2 87 2.41x41 κ receptor 6B73 - -
TM2 88 2.42x42 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 89 2.43x43 κ receptor 6B73 κ receptor 6B73
TM2 90 2.44x44 κ receptor 6B73 5-HT1B receptor 6G79
TM2 91 2.45x45 κ receptor 6B73 κ receptor 6B73
TM2 92 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 93 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 94 2.48x48 κ receptor 6B73 5-HT1B receptor 6G79
TM2 95 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 96 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 97 2.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 98 2.52x52 κ receptor 6B73 κ receptor 6B73
TM2 99 2.53x53 κ receptor 6B73 κ receptor 6B73
TM2 100 2.54x54 κ receptor 6B73 - -
TM2 101 2.55x55 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
TM2 102 2.56x551 OX1 receptor 4ZJ8 5-HT1B receptor 6G79
TM2 103 2.57x56 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
TM2 104 2.58x57 κ receptor 6B73 μ receptor 5C1M
TM2 105 2.59x58 κ receptor 6B73 κ receptor 6B73
TM2 106 2.60x59 κ receptor 6B73 κ receptor 6B73
TM2 107 2.61x60 κ receptor 6B73 Rhodopsin 4ZWJ
TM2 108 2.62x61 κ receptor 6B73 Rhodopsin 5DYS
TM2 109 2.63x62 κ receptor 6B73 κ receptor 6B73
TM2 110 2.64x63 κ receptor 6B73 M2 receptor 4MQT
TM2 111 2.65x64 κ receptor 6B73 M2 receptor 4MQT
TM2 112 2.66x65 κ receptor 6B73 κ receptor 6B73
TM2 113 2.67x66 κ receptor 6B73 κ receptor 6B73
ECL1 114 - - - -
ECL1 115 23.49x49 OX1 receptor 4ZJ8 CCR2 5T1A
ECL1 116 23.50x50 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
ECL1 117 23.51x51 OX1 receptor 4ZJ8 S1P1 receptor 3V2Y
ECL1 118 23.52x52 - - - -
TM3 119 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 120 3.22x22 κ receptor 6B73 M2 receptor 4MQT
TM3 121 3.23x23 κ receptor 6B73 κ receptor 6B73
TM3 122 3.24x24 κ receptor 6B73 κ receptor 6B73
TM3 123 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 124 3.26x26 κ receptor 6B73 - -
TM3 125 3.27x27 κ receptor 6B73 M2 receptor 4MQT
TM3 126 3.28x28 κ receptor 6B73 κ receptor 6B73
TM3 127 3.29x29 κ receptor 6B73 OX1 receptor 4ZJ8
TM3 128 3.30x30 κ receptor 6B73 OX1 receptor 4ZJ8
TM3 129 3.31x31 κ receptor 6B73 PAR1 3VW7
TM3 130 3.32x32 κ receptor 6B73 OX1 receptor 4ZJ8
TM3 131 3.33x33 κ receptor 6B73 BLT1 receptor 5X33
TM3 132 3.34x34 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 133 3.35x35 κ receptor 6B73 US28 4XT1
TM3 134 3.36x36 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 135 3.37x37 κ receptor 6B73 A1 receptor 6D9H
TM3 136 3.38x38 κ receptor 6B73 OX1 receptor 4ZJ8
TM3 137 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 138 3.40x40 κ receptor 6B73 NOP receptor 5DHG
TM3 139 3.41x41 κ receptor 6B73 - -
TM3 140 3.42x42 κ receptor 6B73 κ receptor 6B73
TM3 141 3.43x43 κ receptor 6B73 κ receptor 6B73
TM3 142 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 143 3.45x45 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 144 3.46x46 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 145 3.47x47 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 146 3.48x48 κ receptor 6B73 5-HT1B receptor 6G79
TM3 147 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 148 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 149 3.51x51 κ receptor 6B73 Y1 receptor 5ZBH
TM3 150 3.52x52 κ receptor 6B73 ETB receptor 5X93
TM3 151 3.53x53 κ receptor 6B73 M2 receptor 4MQT
TM3 152 3.54x54 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 153 3.55x55 κ receptor 6B73 US28 4XT1
TM3 154 3.56x56 κ receptor 6B73 AT2 receptor 5UNG
ICL2 155 - - - -
ICL2 156 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
ICL2 157 OX1 receptor 4ZJ8 - -
ICL2 158 OX1 receptor 4ZJ8 - -
ICL2 159 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
ICL2 160 - - - -
TM4 161 4.38x38 κ receptor 6B73 NTS1 receptor 5T04
TM4 162 4.39x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 163 4.40x40 κ receptor 6B73 μ receptor 5C1M
TM4 164 4.41x41 κ receptor 6B73 PAR2 5NDD
TM4 165 4.42x42 κ receptor 6B73 CCR9 5LWE
TM4 166 4.43x43 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 167 4.44x44 κ receptor 6B73 US28 4XT1
TM4 168 4.45x45 κ receptor 6B73 κ receptor 6B73
TM4 169 4.46x46 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 170 4.47x47 κ receptor 6B73 M1 receptor 5CXV
TM4 171 4.48x48 κ receptor 6B73 5-HT1B receptor 6G79
TM4 172 4.49x49 κ receptor 6B73 M2 receptor 4MQT
TM4 173 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 174 4.51x51 κ receptor 6B73 BLT1 receptor 5X33
TM4 175 4.52x52 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 176 4.53x53 κ receptor 6B73 κ receptor 6B73
TM4 177 4.54x54 κ receptor 6B73 NTS1 receptor 5T04
TM4 178 4.55x55 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 179 4.56x56 κ receptor 6B73 M2 receptor 4MQT
TM4 180 4.57x57 OX1 receptor 4ZJ8 Rhodopsin 5DYS
TM4 181 4.58x59 OX1 receptor 4ZJ8 κ receptor 4DJH
TM4 182 4.59x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 183 4.60x61 κ receptor 6B73 Rhodopsin 5DYS
TM4 184 4.61x62 κ receptor 6B73 Rhodopsin 4ZWJ
TM4 185 4.62x63 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 186 4.63x64 κ receptor 6B73 - -
TM4 187 4.64x65 OX1 receptor 4ZJ8 AT2 receptor 5UNG
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
ECL2 192 - - - -
ECL2 193 - - - -
ECL2 194 - - - -
ECL2 195 - - - -
ECL2 196 - - - -
ECL2 197 - - - -
ECL2 198 - - - -
ECL2 199 - - - -
ECL2 200 - - - -
ECL2 201 - - - -
ECL2 202 - - - -
ECL2 203 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 204 45.51x51 κ receptor 6B73 μ receptor 5C1M
ECL2 205 45.52x52 κ receptor 6B73 OX1 receptor 4ZJ8
ECL2 206 - - - -
ECL2 207 - - - -
ECL2 208 - - - -
ECL2 209 - - - -
ECL2 210 - - - -
ECL2 211 - - - -
ECL2 212 - - - -
TM5 213 5.32x33 OX1 receptor 4ZJ8 κ receptor 4DJH
TM5 214 5.33x34 κ receptor 6B73 OX2 receptor 5WS3
TM5 215 5.34x35 κ receptor 6B73 US28 4XT1
TM5 216 5.35x36 κ receptor 6B73 NOP receptor 5DHG
TM5 217 5.36x37 κ receptor 6B73 ETB receptor 5X93
TM5 218 5.37x38 κ receptor 6B73 NTS1 receptor 5T04
TM5 219 5.38x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 220 5.39x40 κ receptor 6B73 PAR1 3VW7
TM5 221 5.40x41 κ receptor 6B73 AT2 receptor 5UNG
TM5 222 5.41x42 κ receptor 6B73 apelin receptor 5VBL
TM5 223 5.42x43 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 224 5.43x44 κ receptor 6B73 Y1 receptor 5ZBH
TM5 225 5.44x45 κ receptor 6B73 US28 4XT1
TM5 226 5.45x46 κ receptor 6B73 H1 receptor 3RZE
TM5 227 5.46x461 κ receptor 6B73 FFA1 receptor 5TZY
TM5 228 5.47x47 κ receptor 6B73 OX1 receptor 4ZJ8
TM5 229 5.48x48 κ receptor 6B73 κ receptor 6B73
TM5 230 5.49x49 κ receptor 6B73 M2 receptor 4MQT
TM5 231 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 232 5.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 233 5.52x52 κ receptor 6B73 OX1 receptor 4ZJ8
TM5 234 5.53x53 κ receptor 6B73 κ receptor 6B73
TM5 235 5.54x54 κ receptor 6B73 κ receptor 6B73
TM5 236 5.55x55 κ receptor 6B73 NTS1 receptor 5T04
TM5 237 5.56x56 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 238 5.57x57 κ receptor 6B73 AT1 receptor 4ZUD
TM5 239 5.58x58 κ receptor 6B73 κ receptor 6B73
TM5 240 5.59x59 κ receptor 6B73 κ receptor 6B73
TM5 241 5.60x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 242 5.61x61 κ receptor 6B73 M2 receptor 4MQT
TM5 243 5.62x62 κ receptor 6B73 AT1 receptor 4YAY
TM5 244 5.63x63 κ receptor 6B73 CXCR4 3ODU
TM5 245 5.64x64 κ receptor 6B73 NTS1 receptor 5T04
TM5 246 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 247 5.66x66 κ receptor 6B73 μ receptor 5C1M
TM5 248 5.67x67 κ receptor 6B73 - -
TM5 249 5.68x68 β2-adrenoceptor 3SN6 CB1 receptor 5XRA
TM5 250 5.69x69 β2-adrenoceptor 3SN6 NTS1 receptor 5T04
TM5 251 5.70x70 β2-adrenoceptor 3SN6 - -
TM5 252 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 253 5.72x72 β2-adrenoceptor 3SN6 - -
ICL3 254 - - - -
ICL3 255 Rhodopsin 5DYS - -
ICL3 256 - - - -
TM6 257 6.24x24 κ receptor 6B73 - -
TM6 258 6.25x25 κ receptor 6B73 - -
TM6 259 6.26x26 κ receptor 6B73 A1 receptor 6D9H
TM6 260 6.27x27 κ receptor 6B73 - -
TM6 261 6.28x28 κ receptor 6B73 NTS1 receptor 5T04
TM6 262 6.29x29 κ receptor 6B73 5-HT1B receptor 6G79
TM6 263 6.30x30 κ receptor 6B73 AT2 receptor 5UNG
TM6 264 6.31x31 κ receptor 6B73 5-HT2B receptor 5TUD
TM6 265 6.32x32 κ receptor 6B73 β2-adrenoceptor 3P0G
TM6 266 6.33x33 κ receptor 6B73 OX1 receptor 4ZJ8
TM6 267 6.34x34 κ receptor 6B73 κ receptor 6B73
TM6 268 6.35x35 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 269 6.36x36 κ receptor 6B73 μ receptor 5C1M
TM6 270 6.37x37 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 271 6.38x38 κ receptor 6B73 CB1 receptor 5XRA
TM6 272 6.39x39 κ receptor 6B73 PAF receptor 5ZKP
TM6 273 6.40x40 κ receptor 6B73 κ receptor 6B73
TM6 274 6.41x41 κ receptor 6B73 κ receptor 6B73
TM6 275 6.42x42 κ receptor 6B73 CB1 receptor 5XRA
TM6 276 6.43x43 κ receptor 6B73 κ receptor 6B73
TM6 277 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 278 6.45x45 κ receptor 6B73 A1 receptor 6D9H
TM6 279 6.46x46 κ receptor 6B73 κ receptor 6B73
TM6 280 6.47x47 κ receptor 6B73 A1 receptor 6D9H
TM6 281 6.48x48 κ receptor 6B73 κ receptor 6B73
TM6 282 6.49x49 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 283 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 284 6.51x51 κ receptor 6B73 CB1 receptor 5XRA
TM6 285 6.52x52 κ receptor 6B73 κ receptor 6B73
TM6 286 6.53x53 κ receptor 6B73 CB1 receptor 5XRA
TM6 287 6.54x54 κ receptor 6B73 κ receptor 6B73
TM6 288 6.55x55 κ receptor 6B73 PAF receptor 5ZKP
TM6 289 6.56x56 κ receptor 6B73 κ receptor 6B73
TM6 290 6.57x57 κ receptor 6B73 NOP receptor 5DHG
TM6 291 6.58x58 κ receptor 6B73 - -
TM6 292 6.59x59 κ receptor 6B73 Y1 receptor 5ZBH
TM6 293 6.60x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 294 6.61x61 κ receptor 6B73 - -
ECL3 295 - - - -
ECL3 296 Y1 receptor 5ZBH Y1 receptor 5ZBH
ECL3 297 Y1 receptor 5ZBH - -
ECL3 298 Y1 receptor 5ZBH - -
ECL3 299 - - - -
TM7 300 7.28x27 κ receptor 6B73 - -
TM7 301 7.29x28 κ receptor 6B73 CB1 receptor 5XRA
TM7 302 7.30x29 κ receptor 6B73 - -
TM7 303 7.31x30 κ receptor 6B73 NTS1 receptor 5T04
TM7 304 7.32x31 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 305 7.33x32 κ receptor 6B73 AT2 receptor 5UNG
TM7 306 7.34x33 κ receptor 6B73 5-HT1B receptor 6G79
TM7 307 7.35x34 κ receptor 6B73 5-HT1B receptor 6G79
TM7 308 7.36x35 κ receptor 6B73 M2 receptor 4MQT
TM7 309 7.37x36 κ receptor 6B73 5-HT2C receptor 6BQG
TM7 310 7.38x37 κ receptor 6B73 5-HT1B receptor 6G79
TM7 311 7.39x38 κ receptor 6B73 OX1 receptor 4ZJ8
TM7 312 7.40x39 κ receptor 6B73 FFA1 receptor 5TZY
TM7 313 7.41x40 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 314 7.42x41 κ receptor 6B73 Rhodopsin 5DYS
TM7 315 7.43x42 κ receptor 6B73 Y1 receptor 5ZBH
TM7 316 7.44x43 κ receptor 6B73 US28 4XT1
TM7 317 7.45x45 κ receptor 6B73 Rhodopsin 5DYS
TM7 318 7.46x46 κ receptor 6B73 Y1 receptor 5ZBH
TM7 319 7.47x47 κ receptor 6B73 - -
TM7 320 7.48x48 κ receptor 6B73 OX1 receptor 4ZJ8
TM7 321 7.49x49 κ receptor 6B73 κ receptor 6B73
TM7 322 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 323 7.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 324 7.52x52 OX1 receptor 4ZJ8 μ receptor 6DDF
TM7 325 7.53x53 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
TM7 326 7.54x54 OX1 receptor 4ZJ8 Y1 receptor 5ZBH
TM7 327 7.55x55 OX1 receptor 4ZJ8 - -
TM7 328 7.56x56 OX1 receptor 4ZJ8 Rhodopsin 5DYS
H8 329 8.47x47 OX1 receptor 4ZJ8 M2 receptor 4MQT
H8 330 8.48x48 OX1 receptor 4ZJ8 - -
H8 331 8.49x49 OX1 receptor 4ZJ8 Y1 receptor 5ZBH
H8 332 8.50x50 OX1 receptor 4ZJ8 5-HT2C receptor 6BQG
H8 333 8.51x51 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
H8 334 8.52x52 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
H8 335 8.53x53 OX1 receptor 4ZJ8 β2-adrenoceptor 3SN6
H8 336 8.54x54 OX1 receptor 4ZJ8 β2-adrenoceptor 3SN6
H8 337 8.55x55 OX1 receptor 4ZJ8 Rhodopsin 4ZWJ
H8 338 8.56x56 OX1 receptor 4ZJ8 AT2 receptor 5UNG
H8 339 8.57x57 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
H8 340 8.58x58 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
C-term 341 - - - -
C-term 342 - - - -
C-term 343 - - - -
C-term 344 - - - -
C-term 345 - - - -