Refined structure (8HCQ) of Gq - ETA receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 206 from structure (57.4%), 153 from model (42.6%)
Residue sidechains - 41 from structure (11.4%), 318 from model (88.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 Structure AF2
G.HN 9 C G.HN.09 Structure AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure AF2
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure AF2
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure AF2
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure Structure
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure AF2
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure AF2
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure Structure
G.HN 32 D G.HN.50 Structure AF2
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure AF2
G.hns1 38 R G.hns1.03 Structure AF2
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure AF2
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure AF2
G.S1 43 L G.S1.05 Structure AF2
G.S1 44 L G.S1.06 Structure AF2
G.S1 45 L G.S1.07 Structure AF2
G.s1h1 46 G G.s1h1.01 Structure AF2
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 AF2 AF2
G.s1h1 51 G G.s1h1.06 AF2 AF2
G.H1 52 K G.H1.01 AF2 AF2
G.H1 53 S G.H1.02 AF2 AF2
G.H1 54 T G.H1.03 AF2 AF2
G.H1 55 F G.H1.04 AF2 AF2
G.H1 56 I G.H1.05 AF2 AF2
G.H1 57 K G.H1.06 AF2 AF2
G.H1 58 Q G.H1.07 AF2 AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 Structure AF2
G.hfs2 183 R G.hfs2.02 Structure AF2
G.hfs2 184 V G.hfs2.03 Structure AF2
G.hfs2 185 P G.hfs2.04 Structure AF2
G.hfs2 186 T G.hfs2.05 Structure AF2
G.hfs2 187 T G.hfs2.06 Structure AF2
G.hfs2 188 G G.hfs2.07 Structure AF2
G.S2 189 I G.S2.01 Structure AF2
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure AF2
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure AF2
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure AF2
G.S3 206 V G.S3.08 Structure AF2
G.s3h2 207 G G.s3h2.01 Structure AF2
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure AF2
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure AF2
G.H2 213 R G.H2.04 Structure AF2
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure AF2
G.H2 216 W G.H2.07 Structure AF2
G.H2 217 I G.H2.08 Structure AF2
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure AF2
G.h2s4 220 F G.h2s4.01 Structure AF2
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure AF2
G.S4 225 S G.S4.01 Structure Structure
G.S4 226 I G.S4.02 Structure AF2
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure AF2
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure AF2
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure AF2
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure AF2
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 Structure AF2
G.s4h3 238 V G.s4h3.07 Structure AF2
G.s4h3 239 L G.s4h3.08 Structure AF2
G.s4h3 240 V G.s4h3.09 Structure AF2
G.s4h3 241 E G.s4h3.10 Structure AF2
G.s4h3 242 S G.s4h3.11 Structure AF2
G.s4h3 243 D G.s4h3.12 Structure AF2
G.s4h3 244 N G.s4h3.13 Structure Structure
G.s4h3 245 E G.s4h3.14 Structure AF2
G.s4h3 246 N G.s4h3.15 Structure AF2
G.H3 247 R G.H3.01 Structure AF2
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure Structure
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure Structure
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure AF2
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure AF2
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure Structure
G.h3s5 266 N G.h3s5.02 Structure Structure
G.h3s5 267 S G.h3s5.03 Structure Structure
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 AF2 AF2
G.S5 270 I G.S5.03 AF2 AF2
G.S5 271 L G.S5.04 AF2 AF2
G.S5 272 F G.S5.05 AF2 AF2
G.S5 273 L G.S5.06 AF2 AF2
G.S5 274 N G.S5.07 AF2 AF2
G.s5hg 275 K G.s5hg.01 AF2 AF2
G.HG 276 K G.HG.01 AF2 AF2
G.HG 277 D G.HG.02 AF2 AF2
G.HG 278 L G.HG.03 Structure AF2
G.HG 279 L G.HG.04 Structure AF2
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure AF2
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure AF2
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure AF2
G.hgh4 291 Y G.hgh4.01 Structure AF2
G.hgh4 292 F G.hgh4.02 Structure AF2
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure AF2
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure Structure
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure Structure
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure AF2
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure AF2
G.H4 309 I G.H4.11 Structure AF2
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure AF2
G.H4 314 V G.H4.16 Structure AF2
G.H4 315 D G.H4.17 Structure AF2
G.h4s6 316 L G.h4s6.01 Structure Structure
G.h4s6 317 N G.h4s6.08 AF2 AF2
G.h4s6 318 P G.h4s6.09 AF2 AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 AF2 AF2
G.s6h5 332 T G.s6h5.04 AF2 AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure AF2
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure AF2
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 AF2 AF2

REFINED GPCR RESIDUES

Residue backbones - 303 from structure (76.5%), 93 from model (23.5%)
Residue sidechains - 287 from structure (72.5%), 109 from model (27.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 C - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 R - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 F - AF2 AF2
N-term 11 W - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 V - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 C - AF2 AF2
N-term 18 V - AF2 AF2
N-term 19 I - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 D - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 P - AF2 AF2
N-term 24 E - AF2 AF2
N-term 25 R - AF2 AF2
N-term 26 Y - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 T - AF2 AF2
N-term 29 N - AF2 AF2
N-term 30 L - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 N - AF2 AF2
N-term 33 H - AF2 AF2
N-term 34 V - AF2 AF2
N-term 35 D - AF2 AF2
N-term 36 D - AF2 AF2
N-term 37 F - AF2 AF2
N-term 38 T - AF2 AF2
N-term 39 T - AF2 AF2
N-term 40 F - AF2 AF2
N-term 41 R - AF2 AF2
N-term 42 G - AF2 AF2
N-term 43 T - AF2 AF2
N-term 44 E - AF2 AF2
N-term 45 L - AF2 AF2
N-term 46 S - AF2 AF2
N-term 47 F - AF2 AF2
N-term 48 L - AF2 AF2
N-term 49 V - AF2 AF2
N-term 50 T - AF2 AF2
N-term 51 T - AF2 AF2
N-term 52 H - AF2 AF2
N-term 53 Q - AF2 AF2
N-term 54 P - AF2 AF2
N-term 55 T - AF2 AF2
N-term 56 N - AF2 AF2
N-term 57 L - AF2 AF2
N-term 58 V - AF2 AF2
N-term 59 L - AF2 AF2
N-term 60 P - AF2 AF2
N-term 61 S - AF2 AF2
N-term 62 N - AF2 AF2
N-term 63 G - AF2 AF2
N-term 64 S - AF2 AF2
N-term 65 M - AF2 AF2
N-term 66 H - Structure Structure
N-term 67 N - Structure Structure
N-term 68 Y - Structure Structure
N-term 69 C - Structure Structure
TM1 70 P 1.22x22 Structure Structure
TM1 71 Q 1.23x23 Structure AF2
TM1 72 Q 1.24x24 Structure Structure
TM1 73 T 1.25x25 Structure Structure
TM1 74 K 1.26x26 Structure Structure
TM1 75 I 1.27x27 Structure Structure
TM1 76 T 1.28x28 Structure Structure
TM1 77 S 1.29x29 Structure Structure
TM1 78 A 1.30x30 Structure Structure
TM1 79 F 1.31x31 Structure Structure
TM1 80 K 1.32x32 Structure AF2
TM1 81 Y 1.33x33 Structure Structure
TM1 82 I 1.34x34 Structure Structure
TM1 83 N 1.35x35 Structure Structure
TM1 84 T 1.36x36 Structure Structure
TM1 85 V 1.37x37 Structure Structure
TM1 86 I 1.38x38 Structure Structure
TM1 87 S 1.39x39 Structure Structure
TM1 88 C 1.40x40 Structure Structure
TM1 89 T 1.41x41 Structure Structure
TM1 90 I 1.42x42 Structure Structure
TM1 91 F 1.43x43 Structure Structure
TM1 92 I 1.44x44 Structure Structure
TM1 93 V 1.45x45 Structure Structure
TM1 94 G 1.46x46 Structure Structure
TM1 95 M 1.47x47 Structure Structure
TM1 96 V 1.48x48 Structure Structure
TM1 97 G 1.49x49 Structure Structure
TM1 98 N 1.50x50 Structure Structure
TM1 99 A 1.51x51 Structure Structure
TM1 100 T 1.52x52 Structure Structure
TM1 101 L 1.53x53 Structure Structure
TM1 102 L 1.54x54 Structure Structure
TM1 103 R 1.55x55 Structure Structure
TM1 104 I 1.56x56 Structure Structure
TM1 105 I 1.57x57 Structure Structure
TM1 106 Y 1.58x58 Structure Structure
TM1 107 Q 1.59x59 Structure Structure
TM1 108 N 1.60x60 Structure Structure
ICL1 109 K 12.48x48 Structure AF2
ICL1 110 C 12.49x49 Structure Structure
ICL1 111 M 12.50x50 Structure Structure
ICL1 112 R 12.51x51 Structure AF2
ICL1 113 N 12.52x52 Structure Structure
TM2 114 G 2.38x38 Structure Structure
TM2 115 P 2.39x39 Structure Structure
TM2 116 N 2.40x40 Structure Structure
TM2 117 A 2.41x41 Structure Structure
TM2 118 L 2.42x42 Structure Structure
TM2 119 I 2.43x43 Structure Structure
TM2 120 A 2.44x44 Structure Structure
TM2 121 S 2.45x45 Structure Structure
TM2 122 L 2.46x46 Structure Structure
TM2 123 A 2.47x47 Structure Structure
TM2 124 L 2.48x48 Structure Structure
TM2 125 G 2.49x49 Structure Structure
TM2 126 D 2.50x50 Structure Structure
TM2 127 L 2.51x51 Structure Structure
TM2 128 I 2.52x52 Structure Structure
TM2 129 Y 2.53x53 Structure Structure
TM2 130 V 2.54x54 Structure Structure
TM2 131 V 2.55x55 Structure Structure
TM2 132 I 2.56x551 Structure Structure
TM2 133 D 2.57x56 Structure Structure
TM2 134 L 2.58x57 Structure Structure
TM2 135 P 2.59x58 Structure Structure
TM2 136 I 2.60x59 Structure Structure
TM2 137 N 2.61x60 Structure Structure
TM2 138 V 2.62x61 Structure Structure
TM2 139 F 2.63x62 Structure Structure
TM2 140 K 2.64x63 Structure Structure
TM2 141 L 2.65x64 Structure Structure
TM2 142 L 2.66x65 Structure Structure
TM2 143 A 2.67x66 Structure Structure
ECL1 144 G - Structure Structure
ECL1 145 R 23.49x49 Structure Structure
ECL1 146 W 23.50x50 Structure Structure
ECL1 147 P 23.51x51 Structure Structure
ECL1 148 F 23.52x52 Structure Structure
ECL1 149 D - Structure Structure
ECL1 150 H - Structure Structure
TM3 151 N 3.18x18 Structure Structure
TM3 152 D 3.19x19 Structure AF2
TM3 153 F 3.20x20 Structure Structure
TM3 154 G 3.21x21 Structure Structure
TM3 155 V 3.22x22 Structure Structure
TM3 156 F 3.23x23 Structure Structure
TM3 157 L 3.24x24 Structure Structure
TM3 158 C 3.25x25 Structure Structure
TM3 159 K 3.26x26 Structure AF2
TM3 160 L 3.27x27 Structure Structure
TM3 161 F 3.28x28 Structure Structure
TM3 162 P 3.29x29 Structure Structure
TM3 163 F 3.30x30 Structure Structure
TM3 164 L 3.31x31 Structure Structure
TM3 165 Q 3.32x32 Structure Structure
TM3 166 K 3.33x33 Structure Structure
TM3 167 S 3.34x34 Structure Structure
TM3 168 S 3.35x35 Structure Structure
TM3 169 V 3.36x36 Structure Structure
TM3 170 G 3.37x37 Structure Structure
TM3 171 I 3.38x38 Structure Structure
TM3 172 T 3.39x39 Structure Structure
TM3 173 V 3.40x40 Structure Structure
TM3 174 L 3.41x41 Structure Structure
TM3 175 N 3.42x42 Structure Structure
TM3 176 L 3.43x43 Structure Structure
TM3 177 C 3.44x44 Structure Structure
TM3 178 A 3.45x45 Structure Structure
TM3 179 L 3.46x46 Structure Structure
TM3 180 S 3.47x47 Structure Structure
TM3 181 V 3.48x48 Structure Structure
TM3 182 D 3.49x49 Structure Structure
TM3 183 R 3.50x50 Structure Structure
TM3 184 Y 3.51x51 Structure Structure
TM3 185 R 3.52x52 Structure Structure
TM3 186 A 3.53x53 Structure Structure
TM3 187 V 3.54x54 Structure Structure
TM3 188 A 3.55x55 Structure Structure
TM3 189 S 3.56x56 Structure Structure
ICL2 190 W 34.50x50 Structure Structure
ICL2 191 S 34.51x51 Structure Structure
ICL2 192 R 34.52x52 Structure AF2
ICL2 193 V 34.53x53 Structure Structure
ICL2 194 Q 34.54x54 Structure Structure
ICL2 195 G 34.55x55 Structure Structure
ICL2 196 I 34.56x56 Structure Structure
ICL2 197 G 34.57x57 Structure Structure
TM4 198 I 4.38x38 Structure Structure
TM4 199 P 4.39x39 Structure Structure
TM4 200 L 4.40x40 Structure Structure
TM4 201 V 4.41x41 Structure Structure
TM4 202 T 4.42x42 Structure Structure
TM4 203 A 4.43x43 Structure Structure
TM4 204 I 4.44x44 Structure Structure
TM4 205 E 4.45x45 Structure Structure
TM4 206 I 4.46x46 Structure Structure
TM4 207 V 4.47x47 Structure Structure
TM4 208 S 4.48x48 Structure Structure
TM4 209 I 4.49x49 Structure Structure
TM4 210 W 4.50x50 Structure Structure
TM4 211 I 4.51x51 Structure Structure
TM4 212 L 4.52x52 Structure Structure
TM4 213 S 4.53x53 Structure Structure
TM4 214 F 4.54x54 Structure Structure
TM4 215 I 4.55x55 Structure Structure
TM4 216 L 4.56x56 Structure Structure
TM4 217 A 4.57x57 Structure Structure
TM4 218 I 4.58x59 Structure Structure
TM4 219 P 4.59x60 Structure Structure
TM4 220 E 4.60x61 Structure Structure
TM4 221 A 4.61x62 Structure Structure
TM4 222 I 4.62x63 Structure Structure
TM4 223 G 4.63x64 Structure Structure
TM4 224 F 4.64x65 Structure Structure
ECL2 225 V - Structure Structure
ECL2 226 M - Structure Structure
ECL2 227 V - Structure Structure
ECL2 228 P - Structure Structure
ECL2 229 F - Structure Structure
ECL2 230 E - Structure Structure
ECL2 231 Y - Structure Structure
ECL2 232 R - Structure AF2
ECL2 233 G - Structure Structure
ECL2 234 E - Structure AF2
ECL2 235 Q - Structure Structure
ECL2 236 H - Structure Structure
ECL2 237 K - Structure AF2
ECL2 238 T - Structure Structure
ECL2 239 C 45.50x50 Structure Structure
ECL2 240 M 45.51x51 Structure Structure
ECL2 241 L 45.52x52 Structure Structure
ECL2 242 N - Structure Structure
ECL2 243 A - Structure Structure
ECL2 244 T - Structure Structure
TM5 245 S 5.28x29 Structure Structure
TM5 246 K 5.29x30 Structure AF2
TM5 247 F 5.30x31 Structure Structure
TM5 248 M 5.31x32 Structure Structure
TM5 249 E 5.32x33 Structure AF2
TM5 250 F 5.33x34 Structure Structure
TM5 251 Y 5.34x35 Structure Structure
TM5 252 Q 5.35x36 Structure Structure
TM5 253 D 5.36x37 Structure AF2
TM5 254 V 5.37x38 Structure Structure
TM5 255 K 5.38x39 Structure Structure
TM5 256 D 5.39x40 Structure Structure
TM5 257 W 5.40x41 Structure Structure
TM5 258 W 5.41x42 Structure Structure
TM5 259 L 5.42x43 Structure Structure
TM5 260 F 5.43x44 Structure Structure
TM5 261 G 5.44x45 Structure Structure
TM5 262 F 5.45x46 Structure Structure
TM5 263 Y 5.46x461 Structure Structure
TM5 264 F 5.47x47 Structure Structure
TM5 265 C 5.48x48 Structure Structure
TM5 266 M 5.49x49 Structure Structure
TM5 267 P 5.50x50 Structure Structure
TM5 268 L 5.51x51 Structure Structure
TM5 269 V 5.52x52 Structure Structure
TM5 270 C 5.53x53 Structure Structure
TM5 271 T 5.54x54 Structure Structure
TM5 272 A 5.55x55 Structure Structure
TM5 273 I 5.56x56 Structure Structure
TM5 274 F 5.57x57 Structure Structure
TM5 275 Y 5.58x58 Structure Structure
TM5 276 T 5.59x59 Structure Structure
TM5 277 L 5.60x60 Structure Structure
TM5 278 M 5.61x61 Structure Structure
TM5 279 T 5.62x62 Structure Structure
TM5 280 C 5.63x63 Structure Structure
TM5 281 E 5.64x64 Structure AF2
TM5 282 M 5.65x65 Structure Structure
TM5 283 L 5.66x66 Structure Structure
TM5 284 N 5.67x67 Structure Structure
TM5 285 R 5.68x68 AF2 AF2
TM5 286 R 5.69x69 AF2 AF2
TM5 287 N 5.70x70 AF2 AF2
TM5 288 G 5.71x71 AF2 AF2
TM5 289 S 5.72x72 AF2 AF2
ICL3 290 L - AF2 AF2
ICL3 291 R - AF2 AF2
ICL3 292 I - AF2 AF2
ICL3 293 A - AF2 AF2
ICL3 294 L - Structure Structure
TM6 295 S 6.24x24 Structure Structure
TM6 296 E 6.25x25 Structure Structure
TM6 297 H 6.26x26 Structure Structure
TM6 298 L 6.27x27 Structure Structure
TM6 299 K 6.28x28 Structure Structure
TM6 300 Q 6.29x29 Structure Structure
TM6 301 R 6.30x30 Structure Structure
TM6 302 R 6.31x31 Structure Structure
TM6 303 E 6.32x32 Structure Structure
TM6 304 V 6.33x33 Structure Structure
TM6 305 A 6.34x34 Structure Structure
TM6 306 K 6.35x35 Structure Structure
TM6 307 T 6.36x36 Structure Structure
TM6 308 V 6.37x37 Structure Structure
TM6 309 F 6.38x38 Structure Structure
TM6 310 C 6.39x39 Structure Structure
TM6 311 L 6.40x40 Structure Structure
TM6 312 V 6.41x41 Structure Structure
TM6 313 V 6.42x42 Structure Structure
TM6 314 I 6.43x43 Structure Structure
TM6 315 F 6.44x44 Structure Structure
TM6 316 A 6.45x45 Structure Structure
TM6 317 L 6.46x46 Structure Structure
TM6 318 C 6.47x47 Structure Structure
TM6 319 W 6.48x48 Structure Structure
TM6 320 F 6.49x49 Structure Structure
TM6 321 P 6.50x50 Structure Structure
TM6 322 L 6.51x51 Structure Structure
TM6 323 H 6.52x52 Structure Structure
TM6 324 L 6.53x53 Structure Structure
TM6 325 S 6.54x54 Structure Structure
TM6 326 R 6.55x55 Structure Structure
TM6 327 I 6.56x56 Structure Structure
TM6 328 L 6.57x57 Structure Structure
TM6 329 K 6.58x58 Structure AF2
TM6 330 K 6.59x59 Structure Structure
TM6 331 T 6.60x60 Structure Structure
TM6 332 V 6.61x61 Structure Structure
TM6 333 Y 6.62x62 Structure Structure
ECL3 334 N - AF2 AF2
ECL3 335 E - Structure Structure
ECL3 336 M - Structure Structure
ECL3 337 D - Structure Structure
ECL3 338 K - Structure Structure
ECL3 339 N - Structure Structure
TM7 340 R 7.24x23 Structure AF2
TM7 341 C 7.25x24 Structure Structure
TM7 342 E 7.26x25 Structure Structure
TM7 343 L 7.27x26 Structure Structure
TM7 344 L 7.28x27 Structure Structure
TM7 345 S 7.29x28 Structure Structure
TM7 346 F 7.30x29 Structure Structure
TM7 347 L 7.31x30 Structure Structure
TM7 348 L 7.32x31 Structure Structure
TM7 349 L 7.33x32 Structure Structure
TM7 350 M 7.34x33 Structure Structure
TM7 351 D 7.35x34 Structure Structure
TM7 352 Y 7.36x35 Structure Structure
TM7 353 I 7.37x36 Structure Structure
TM7 354 G 7.38x37 Structure Structure
TM7 355 I 7.39x38 Structure Structure
TM7 356 N 7.40x39 Structure Structure
TM7 357 L 7.41x40 Structure Structure
TM7 358 A 7.42x41 Structure Structure
TM7 359 T 7.43x42 Structure Structure
TM7 360 M 7.44x43 Structure Structure
TM7 361 N 7.45x45 Structure Structure
TM7 362 S 7.46x46 Structure Structure
TM7 363 C 7.47x47 Structure Structure
TM7 364 I 7.48x48 Structure Structure
TM7 365 N 7.49x49 Structure Structure
TM7 366 P 7.50x50 Structure Structure
TM7 367 I 7.51x51 Structure Structure
TM7 368 A 7.52x52 Structure Structure
TM7 369 L 7.53x53 Structure Structure
TM7 370 Y 7.54x54 Structure Structure
TM7 371 F 7.55x55 Structure Structure
TM7 372 V 7.56x56 Structure Structure
H8 373 S 8.47x47 Structure Structure
H8 374 K 8.48x48 Structure Structure
H8 375 K 8.49x49 Structure Structure
H8 376 F 8.50x50 Structure Structure
H8 377 K 8.51x51 Structure Structure
H8 378 N 8.52x52 Structure Structure
H8 379 C 8.53x53 AF2 AF2
H8 380 F 8.54x54 AF2 AF2
H8 381 Q 8.55x55 AF2 AF2
H8 382 S 8.56x56 AF2 AF2
H8 383 C 8.57x57 AF2 AF2
H8 384 L 8.58x58 AF2 AF2
H8 385 C 8.59x59 AF2 AF2
H8 386 C 8.60x60 AF2 AF2
C-term 387 C - AF2 AF2
C-term 388 C - AF2 AF2
C-term 389 Y - AF2 AF2
C-term 390 Q - AF2 AF2
C-term 391 S - AF2 AF2
C-term 392 K - AF2 AF2
C-term 393 S - AF2 AF2
C-term 394 L - AF2 AF2
C-term 395 M - AF2 AF2
C-term 396 T - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 S 373 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 373 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 373 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL3 L 294 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 L 294 - G.H5 D 346 G.H5.13
Polar ICL2 G 197 34x57 H.hahb E 104 H.hahb.09
Hydrophobic ICL2 G 197 34x57 H.hahb E 104 H.hahb.09
Van-der-waals ICL2 G 197 34x57 H.hahb E 104 H.hahb.09
Polar ICL2 S 191 34x51 G.S2 Y 192 G.S2.04
Hydrophobic ICL2 S 191 34x51 G.S2 Y 192 G.S2.04
Van-der-waals ICL2 S 191 34x51 G.S2 Y 192 G.S2.04
Polar TM2 N 116 2x40 H.hahb E 104 H.hahb.09
Hydrophobic TM2 N 116 2x40 H.hahb E 104 H.hahb.09
Van-der-waals TM2 N 116 2x40 H.hahb E 104 H.hahb.09
Polar ICL2 G 197 34x57 H.HB A 108 H.HB.04
Hydrophobic ICL2 G 197 34x57 H.HB A 108 H.HB.04
Van-der-waals ICL2 G 197 34x57 H.HB A 108 H.HB.04
Hydrophobic TM7 V 372 7x56 G.H5 L 358 G.H5.25
Aromatic ICL2 W 190 34x50 G.H5 F 341 G.H5.08
Hydrophobic ICL2 W 190 34x50 G.H5 F 341 G.H5.08
Van-der-waals ICL2 W 190 34x50 G.H5 F 341 G.H5.08
Polar ICL2 G 197 34x57 H.HB H 105 H.HB.01
Hydrophobic ICL2 G 197 34x57 H.HB H 105 H.HB.01
Van-der-waals ICL2 G 197 34x57 H.HB H 105 H.HB.01
Hydrophobic H8 F 376 8x50 G.H5 N 357 G.H5.24
Van-der-waals H8 F 376 8x50 G.H5 N 357 G.H5.24
Hydrophobic ICL2 V 193 34x53 H.HA R 92 H.HA.24
Van-der-waals ICL2 V 193 34x53 H.HA R 92 H.HA.24
Hydrophobic ICL2 W 190 34x50 H.HA R 92 H.HA.24
Van-der-waals ICL2 W 190 34x50 H.HA R 92 H.HA.24
Hydrophobic ICL3 L 294 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 L 294 - G.S6 Y 325 G.S6.02
Polar ICL1 N 113 12x52 H.HB K 107 H.HB.03
Hydrophobic ICL1 N 113 12x52 H.HB K 107 H.HB.03
Van-der-waals ICL1 N 113 12x52 H.HB K 107 H.HB.03
Polar ICL1 N 113 12x52 H.hahb E 104 H.hahb.09
Hydrophobic ICL1 N 113 12x52 H.hahb E 104 H.hahb.09
Van-der-waals ICL1 N 113 12x52 H.hahb E 104 H.hahb.09
Hydrophobic TM5 S 289 5x72 G.H5 F 339 G.H5.06
Van-der-waals TM5 S 289 5x72 G.H5 F 339 G.H5.06
Hydrophobic ICL2 V 193 34x53 H.HB A 110 H.HB.06
Van-der-waals ICL2 V 193 34x53 H.HB A 110 H.HB.06
Hydrophobic TM6 H 297 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 H 297 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic H8 S 373 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 S 373 8x47 G.H5 V 359 G.H5.26
Polar TM2 N 116 2x40 H.HB K 107 H.HB.03
Hydrophobic ICL2 Q 194 34x54 H.HB K 107 H.HB.03
Van-der-waals ICL2 Q 194 34x54 H.HB K 107 H.HB.03
Polar TM6 H 297 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 H 297 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 H 297 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 H 297 6x26 H.HA L 97 H.HA.29
Van-der-waals TM6 H 297 6x26 H.HA L 97 H.HA.29
Hydrophobic ICL2 G 195 34x55 H.HB A 110 H.HB.06
Van-der-waals ICL2 G 195 34x55 H.HB A 110 H.HB.06
Hydrophobic H8 K 375 8x49 H.hahb K 102 H.hahb.07
Ionic TM6 H 297 6x26 G.H5 D 346 G.H5.13
Polar TM6 H 297 6x26 G.H5 D 346 G.H5.13
Hydrophobic TM6 H 297 6x26 G.H5 D 346 G.H5.13
Van-der-waals TM6 H 297 6x26 G.H5 D 346 G.H5.13
Polar ICL2 G 195 34x55 H.HB N 106 H.HB.02
Hydrophobic ICL2 G 195 34x55 H.HB N 106 H.HB.02
Van-der-waals ICL2 G 195 34x55 H.HB N 106 H.HB.02
Hydrophobic ICL3 L 290 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 L 290 - G.S6 Y 325 G.S6.02
Hydrophobic ICL1 M 111 12x50 H.hahb E 104 H.hahb.09
Van-der-waals ICL1 M 111 12x50 H.hahb E 104 H.hahb.09
Hydrophobic TM7 L 369 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 369 7x53 G.H5 N 357 G.H5.24
Polar ICL2 V 193 34x53 H.HA I 91 H.HA.23
Hydrophobic ICL2 V 193 34x53 H.HA I 91 H.HA.23
Van-der-waals ICL2 V 193 34x53 H.HA I 91 H.HA.23
Polar ICL2 Q 194 34x54 H.HA D 95 H.HA.27
Van-der-waals ICL2 Q 194 34x54 H.HA D 95 H.HA.27
Hydrophobic ICL2 W 190 34x50 G.HN R 34 G.HN.52
Van-der-waals ICL2 W 190 34x50 G.HN R 34 G.HN.52
Aromatic TM3 R 183 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 183 3x50 G.H5 Y 356 G.H5.23
Polar ICL2 W 190 34x50 H.HA T 96 H.HA.28
Hydrophobic ICL2 W 190 34x50 H.HA T 96 H.HA.28
Van-der-waals ICL2 W 190 34x50 H.HA T 96 H.HA.28
Polar ICL2 I 196 34x56 H.HB K 107 H.HB.03
Hydrophobic ICL2 I 196 34x56 H.HB K 107 H.HB.03
Van-der-waals ICL2 I 196 34x56 H.HB K 107 H.HB.03
Polar TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Polar TM6 H 297 6x26 G.S6 Y 325 G.S6.02
Aromatic TM6 H 297 6x26 G.S6 Y 325 G.S6.02
Hydrophobic TM6 H 297 6x26 G.S6 Y 325 G.S6.02
Van-der-waals TM6 H 297 6x26 G.S6 Y 325 G.S6.02
Polar ICL3 L 290 - G.S6 H 327 G.S6.04
Hydrophobic ICL3 L 290 - G.S6 H 327 G.S6.04
Polar ICL1 C 110 12x49 H.hahb K 102 H.hahb.07
Hydrophobic ICL1 C 110 12x49 H.hahb K 102 H.hahb.07
Van-der-waals ICL1 C 110 12x49 H.hahb K 102 H.hahb.07
Hydrophobic ICL2 V 193 34x53 H.HA Q 88 H.HA.20
Van-der-waals ICL2 V 193 34x53 H.HA Q 88 H.HA.20
Hydrophobic ICL2 Q 194 34x54 H.hahb Y 101 H.hahb.06
Van-der-waals ICL2 Q 194 34x54 H.hahb Y 101 H.hahb.06
Polar ICL1 R 112 12x51 H.hahb E 104 H.hahb.09
Hydrophobic ICL1 R 112 12x51 H.hahb E 104 H.hahb.09
Van-der-waals ICL1 R 112 12x51 H.hahb E 104 H.hahb.09
Polar ICL1 N 113 12x52 H.hahb Y 103 H.hahb.08
Hydrophobic TM6 Q 300 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 Q 300 6x29 G.H5 Q 350 G.H5.17
Polar ICL2 I 196 34x56 H.HB H 109 H.HB.05
Polar H8 K 375 8x49 H.hahb Y 101 H.hahb.06
Hydrophobic H8 K 375 8x49 H.hahb Y 101 H.hahb.06
Van-der-waals H8 K 375 8x49 H.hahb Y 101 H.hahb.06
Hydrophobic ICL3 I 292 - G.HG V 289 G.HG.16
Van-der-waals ICL3 I 292 - G.HG V 289 G.HG.16
Polar ICL2 V 193 34x53 H.HB R 114 H.HB.10
Hydrophobic ICL2 V 193 34x53 H.HB R 114 H.HB.10
Van-der-waals ICL2 V 193 34x53 H.HB R 114 H.HB.10
Hydrophobic ICL2 R 192 34x52 H.HA R 92 H.HA.24
Hydrophobic TM6 R 301 6x30 G.H5 L 349 G.H5.16
Van-der-waals TM6 R 301 6x30 G.H5 L 349 G.H5.16
Hydrophobic ICL2 Q 194 34x54 H.HB A 110 H.HB.06
Van-der-waals ICL2 Q 194 34x54 H.HB A 110 H.HB.06
Ionic TM6 H 297 6x26 H.HD E 150 H.HD.12
Polar TM6 H 297 6x26 H.HD E 150 H.HD.12
Hydrophobic TM6 H 297 6x26 H.HD E 150 H.HD.12
Van-der-waals TM6 H 297 6x26 H.HD E 150 H.HD.12
Polar ICL2 I 196 34x56 H.HB H 105 H.HB.01
Hydrophobic ICL2 I 196 34x56 H.HB H 105 H.HB.01
Van-der-waals ICL2 I 196 34x56 H.HB H 105 H.HB.01
Polar ICL1 C 110 12x49 H.hahb E 104 H.hahb.09
Hydrophobic ICL1 C 110 12x49 H.hahb E 104 H.hahb.09
Van-der-waals ICL1 C 110 12x49 H.hahb E 104 H.hahb.09
Polar ICL3 I 292 - G.S6 H 327 G.S6.04
Polar ICL2 S 191 34x51 G.HN R 34 G.HN.52
Van-der-waals ICL2 S 191 34x51 G.HN R 34 G.HN.52
Polar ICL2 I 196 34x56 H.HB N 106 H.HB.02
Hydrophobic ICL2 I 196 34x56 H.HB N 106 H.HB.02
Van-der-waals ICL2 I 196 34x56 H.HB N 106 H.HB.02
Aromatic ICL2 W 190 34x50 G.S2 Y 192 G.S2.04
Hydrophobic ICL2 W 190 34x50 G.S2 Y 192 G.S2.04
Van-der-waals ICL2 W 190 34x50 G.S2 Y 192 G.S2.04
Van-der-waals ICL2 G 195 34x55 H.hahb E 104 H.hahb.09
Hydrophobic ICL3 L 290 - G.H5 A 342 G.H5.09
Hydrophobic ICL2 W 190 34x50 H.HA D 95 H.HA.27
Van-der-waals ICL2 W 190 34x50 H.HA D 95 H.HA.27
Polar ICL1 C 110 12x49 H.hahb Y 103 H.hahb.08
Hydrophobic ICL1 C 110 12x49 H.hahb Y 103 H.hahb.08
Van-der-waals ICL1 C 110 12x49 H.hahb Y 103 H.hahb.08
Hydrophobic ICL3 L 290 - G.H5 F 339 G.H5.06
Hydrophobic TM3 A 186 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 186 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 W 190 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 W 190 34x50 G.H5 I 348 G.H5.15
Polar ICL2 G 195 34x55 H.HB A 108 H.HB.04
Van-der-waals ICL2 G 195 34x55 H.HB A 108 H.HB.04
Polar ICL2 V 193 34x53 H.HA D 95 H.HA.27
Hydrophobic ICL2 V 193 34x53 H.HA D 95 H.HA.27
Van-der-waals ICL2 V 193 34x53 H.HA D 95 H.HA.27
Polar ICL2 I 196 34x56 H.hahb Y 103 H.hahb.08
Hydrophobic ICL2 I 196 34x56 H.hahb Y 103 H.hahb.08
Van-der-waals ICL2 I 196 34x56 H.hahb Y 103 H.hahb.08
Polar H8 K 375 8x49 G.H5 K 354 G.H5.21
Hydrophobic H8 K 375 8x49 G.H5 K 354 G.H5.21
Van-der-waals H8 K 375 8x49 G.H5 K 354 G.H5.21
Hydrophobic ICL2 V 193 34x53 H.HA M 94 H.HA.26
Van-der-waals ICL2 V 193 34x53 H.HA M 94 H.HA.26
Hydrophobic TM3 A 186 3x53 H.HA D 95 H.HA.27
Van-der-waals TM3 A 186 3x53 H.HA D 95 H.HA.27
Hydrophobic TM2 P 115 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 115 2x39 G.H5 Y 356 G.H5.23
Polar H8 K 374 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 K 374 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 K 374 8x48 G.H5 V 359 G.H5.26
Polar ICL3 A 293 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 A 293 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 A 293 - G.S6 Y 325 G.S6.02
Hydrophobic TM6 V 308 6x37 G.H5 L 358 G.H5.25
Polar ICL2 R 192 34x52 H.HB R 114 H.HB.10
Hydrophobic ICL2 R 192 34x52 H.HB R 114 H.HB.10
Van-der-waals ICL2 R 192 34x52 H.HB R 114 H.HB.10
Polar ICL2 G 195 34x55 H.HB K 107 H.HB.03
Hydrophobic ICL2 G 195 34x55 H.HB K 107 H.HB.03
Van-der-waals ICL2 G 195 34x55 H.HB K 107 H.HB.03
Ionic TM6 R 301 6x30 G.H5 D 346 G.H5.13
Polar ICL2 V 193 34x53 H.HB Q 111 H.HB.07
Polar ICL2 Q 194 34x54 H.HB R 114 H.HB.10
Hydrophobic ICL2 Q 194 34x54 H.HB R 114 H.HB.10
Van-der-waals ICL2 Q 194 34x54 H.HB R 114 H.HB.10
Hydrophobic TM6 Q 300 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 Q 300 6x29 G.H5 V 359 G.H5.26
Hydrophobic ICL2 I 196 34x56 H.hahb Y 101 H.hahb.06
Van-der-waals ICL2 I 196 34x56 H.hahb Y 101 H.hahb.06
Van-der-waals TM6 R 301 6x30 G.H5 Q 350 G.H5.17
Ionic ICL2 R 192 34x52 H.HB E 115 H.HB.11
Hydrophobic TM3 A 186 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 186 3x53 G.H5 N 352 G.H5.19
Van-der-waals ICL2 I 196 34x56 H.HC S 134 H.HC.09
Hydrophobic TM2 P 115 2x39 H.HB K 107 H.HB.03
Van-der-waals TM2 P 115 2x39 H.HB K 107 H.HB.03
Hydrophobic ICL2 S 191 34x51 H.HA R 92 H.HA.24
Van-der-waals ICL2 S 191 34x51 H.HA R 92 H.HA.24
Hydrophobic ICL3 A 293 - G.S6 H 327 G.S6.04
Van-der-waals ICL3 A 293 - G.S6 H 327 G.S6.04
Hydrophobic TM6 V 304 6x33 G.H5 L 353 G.H5.20
Hydrophobic H8 S 373 8x47 G.H5 L 358 G.H5.25
Polar H8 K 375 8x49 G.H5 V 359 G.H5.26
Van-der-waals H8 K 375 8x49 G.H5 V 359 G.H5.26
Ionic H8 K 375 8x49 G.H5 E 355 G.H5.22
Polar H8 K 375 8x49 G.H5 E 355 G.H5.22
Hydrophobic H8 K 375 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 K 375 8x49 G.H5 E 355 G.H5.22
Polar H8 K 374 8x48 G.h4s6 S 320 G.h4s6.11
Hydrophobic H8 K 374 8x48 G.h4s6 S 320 G.h4s6.11
Van-der-waals H8 K 374 8x48 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM5 M 282 5x65 H.hahb K 98 H.hahb.01
Van-der-waals TM5 M 282 5x65 H.hahb K 98 H.hahb.01
Polar ICL2 I 196 34x56 H.HB A 108 H.HB.04
Hydrophobic ICL2 I 196 34x56 H.HB A 108 H.HB.04
Van-der-waals ICL2 I 196 34x56 H.HB A 108 H.HB.04
Polar ICL2 I 196 34x56 H.hahb E 104 H.hahb.09
Hydrophobic ICL2 I 196 34x56 H.hahb E 104 H.hahb.09
Van-der-waals ICL2 I 196 34x56 H.hahb E 104 H.hahb.09
Hydrophobic TM3 V 187 3x54 G.H5 L 349 G.H5.16
Polar H8 K 375 8x49 G.H5 N 357 G.H5.24
Hydrophobic H8 K 375 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 K 375 8x49 G.H5 N 357 G.H5.24
Hydrophobic ICL2 R 192 34x52 H.HA D 95 H.HA.27
Van-der-waals ICL2 R 192 34x52 H.HA D 95 H.HA.27
Polar TM5 S 289 5x72 G.S6 H 327 G.S6.04
Polar TM6 H 297 6x26 H.HD R 147 H.HD.09
Hydrophobic TM6 H 297 6x26 H.HD R 147 H.HD.09
Van-der-waals TM6 H 297 6x26 H.HD R 147 H.HD.09
Hydrophobic ICL2 I 196 34x56 H.hchd D 138 H.hchd.01
Van-der-waals ICL2 I 196 34x56 H.hchd D 138 H.hchd.01
Hydrophobic H8 K 375 8x49 H.hahb P 100 H.hahb.05
Van-der-waals H8 K 375 8x49 H.hahb P 100 H.hahb.05
Polar ICL1 R 112 12x51 H.HB H 105 H.HB.01
Van-der-waals ICL1 R 112 12x51 H.HB H 105 H.HB.01
Hydrophobic ICL2 Q 194 34x54 H.HA M 94 H.HA.26
Van-der-waals ICL2 Q 194 34x54 H.HA M 94 H.HA.26
Hydrophobic TM6 V 304 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 304 6x33 G.H5 L 358 G.H5.25
Polar ICL2 Q 194 34x54 G.H5 E 355 G.H5.22
Hydrophobic ICL2 Q 194 34x54 G.H5 E 355 G.H5.22
Van-der-waals ICL2 Q 194 34x54 G.H5 E 355 G.H5.22
Hydrophobic ICL2 G 195 34x55 H.hahb Y 101 H.hahb.06
Van-der-waals ICL2 G 195 34x55 H.hahb Y 101 H.hahb.06
Hydrophobic TM5 M 282 5x65 G.H5 L 349 G.H5.16
Hydrophobic ICL2 W 190 34x50 G.H5 K 345 G.H5.12