GPCRdb

Residue number
Subdomain Segment Sequence-based (CGN) Structure-based (GproteinDb)
[Green monkey] G protein subunit alpha i1
[Dog] G protein subunit alpha i1
[Gray short-tailed opossum] G protein subunit alpha i1
[Horse] G protein subunit alpha i1
[White-tufted-ear marmoset] G protein subunit alpha i1
[Giant panda] G protein subunit alpha i1
[Little brown bat] G protein subunit alpha i1
[Northern white-cheeked gibbon] G protein subunit alpha i1
[Rabbit] G protein subunit alpha i1
[Western lowland gorilla] G protein subunit alpha i1
[African elephant] G protein subunit alpha i1
[Tasmanian devil] Uncharacterized protein
[Bovine] G(i) subunit alpha-1
[Human] G(i) subunit alpha-1
[Mouse] G(i) subunit alpha-1
[Rat] G(i) subunit alpha-1
[Small-eared galago] G protein subunit alpha i1
[Sumatran orangutan] G(i) subunit alpha-1
[Chimpanzee] G protein subunit alpha i1
[Thirteen-lined ground squirrel] G protein subunit alpha i1
[Cat] G protein subunit alpha i1
[European domestic ferret] G protein subunit alpha i1
[Sheep] G protein subunit alpha i1
Subdomain Segment Sequence-based (CGN) Structure-based (GproteinDb)
Seq consensus
Prop consensus
Length
RESIDUE PROPERTIES & LENGTH
Hydrophobic	HY	any
Hydrophobic	HY	4-5
Hydrophobic aliphatic	HA	any
Hydrophobic aliphatic	HA	1-2
Hydrophobic aliphatic	HA	2-3
Hydrophobic aliphatic	HA	3
Hydrophobic aliphatic	HA	3-4
Hydrophobic aliphatic [M]	M	4
Hydrophob al / α-H prop - very high [A]	A	1
Hydrophobic aliphatic [I]	I
Hydrophobic aliphatic [L]	L
Hydrophobic aliphatic [V]	V
Hydrophobic aromatic	HR	any
Hydrophobic aromatic	HR	4-5
Hydrophobic aromatic	HR	5
Hydrophobic aromatic	HR	5-6
Hydrophobic aromatic [W]	W	6
Hydropob ar / H-bonding [Y]	Y
Hydrophobic aromatic [F]	F
Hydrogen bonding (polar)	Hb	any
Hydrogen bonding	Hb	2
Hydrogen bonding	Hb	3
Hydrogen bonding [N]	N
Hydrogen bonding [Q]	Q
Hydrogen bonding [S]	S
Hydrogen bonding [T]	T
Hydrogen bonding uncharged	Hu	2-3
Hydrogen bonding uncharged	Hu	3-4
Hydrogen bond acceptor	Ha	2-3
Hydrogen bond acceptor	Ha	3
Hydrogen bond acceptor	Ha	3-4
Hydrogen bond acceptor	Ha	4
Hydrogen bond donor	Hd	4
Hydrogen bond donor	Hd	4-5
Hydrogen bond donor	Hd	5-6
Hydrogen bond donor	Hd	6
Charged	+-	any
Charged	+-	3-4
Charged	+-	4-5
Charged positive	+	any
Charged pos / H bond / Hphob ar [H]	H	4
Charged positive	+	4-5
Charged positive [K]	K	5
Charged positive	+	5-6
Charged positive [R]	R	6
Charged negative	-	any
Charged negative [D]	D	3
Charged negative [E]	E	4
Small	Sm	any
Small	Sm	0-1
Small	Sm	1-2
α-Helix propensity - high	αH	Hig
α-Helix propensity - low	αH	Min
α-Helix flexibility [G]	G	0
α-Helix kink [P]	P	2
Disulfide-forming (S-S) [C]	C	2
Gap (no amino acid)	-
RESIDUE Z-SCALES
Z1 (Lipophilicity)
Z2 (Steric properties)
Z3 (Electronic properties)
Z4 (PC1 several properties)
Z5 (PC2 several properties)
Subdomain Segment Sequence-based (CGN) Structure-based (GproteinDb)

hns1

s1h1

h1ha

hahb

hbhc

hchd

hdhe

hehf

hfs2

s2s3

s3h2

h2s4

s4h3

h3s5

s5hg

hgh4

h4s6

s6h5

G
HN
.1
-

G
HN
.2
-

G
HN
.9
-

G
HN
.10
-

G
HN
.11
-

G
HN
.30
-

G
HN
.31
-

G
HN
.32
-

G
HN
.33
-

G
HN
.34
-

G
HN
.35
-

G
HN
.36
-

G
HN
.37
-

G
HN
.38
-

G
HN
.39
-

G
HN
.40
-

G
HN
.41
-

G
HN
.42
-

G
HN
.43
-

G
HN
.44
-

G
HN
.45
-

G
HN
.46
-

G
HN
.47
-

G
HN
.48
-

G
HN
.49
-

G
HN
.50
-

G
HN
.51
-

G
HN
.52
-

G
HN
.53
-

G
hns1
.1
-

G
hns1
.2
-

G
hns1
.3
-

G
S1
.1
-

G
S1
.2
-

G
S1
.3
-

G
S1
.4
-

G
S1
.5
-

G
S1
.6
-

G
S1
.7
-

G
s1h1
.1
-

G
s1h1
.2
-

G
s1h1
.3
-

G
s1h1
.4
-

G
s1h1
.5
-

G
s1h1
.6
-

G
H1
.1
-

G
H1
.2
-

G
H1
.3
-

G
H1
.4
-

G
H1
.5
-

G
H1
.6
-

G
H1
.7
-

G
H1
.8
-

G
H1
.9
-

G
H1
.10
-

G
H1
.11
-

G
H1
.12
-

G
h1ha
.1
-

G
h1ha
.2
-

G
h1ha
.3
-

G
h1ha
.4
-

G
h1ha
.5
-

H
HA
.1
-

H
HA
.2
-

H
HA
.3
-

H
HA
.4
-

H
HA
.5
-

H
HA
.6
-

H
HA
.7
-

H
HA
.8
-

H
HA
.9
-

H
HA
.10
-

H
HA
.11
-

H
HA
.12
-

H
HA
.13
-

H
HA
.14
-

H
HA
.15
-

H
HA
.16
-

H
HA
.17
-

H
HA
.18
-

H
HA
.19
-

H
HA
.20
-

H
HA
.21
-

H
HA
.22
-

H
HA
.23
-

H
HA
.24
-

H
HA
.25
-

H
HA
.26
-

H
HA
.27
-

H
HA
.28
-

H
HA
.29
-

H
hahb
.1
-

H
hahb
.4
-

H
hahb
.5
-

H
hahb
.6
-

H
hahb
.7
-

H
hahb
.8
-

H
hahb
.9
-

H
HB
.1
-

H
HB
.2
-

H
HB
.3
-

H
HB
.4
-

H
HB
.5
-

H
HB
.6
-

H
HB
.7
-

H
HB
.8
-

H
HB
.9
-

H
HB
.10
-

H
HB
.11
-

H
HB
.12
-

H
HB
.13
-

H
HB
.14
-

H
hbhc
.1
-

H
hbhc
.2
-

H
hbhc
.3
-

H
hbhc
.4
-

H
hbhc
.12
-

H
hbhc
.13
-

H
hbhc
.14
-

H
hbhc
.15
-

H
HC
.1
-

H
HC
.2
-

H
HC
.3
-

H
HC
.4
-

H
HC
.5
-

H
HC
.6
-

H
HC
.7
-

H
HC
.8
-

H
HC
.9
-

H
HC
.10
-

H
HC
.11
-

H
HC
.12
-

H
hchd
.1
-

H
HD
.1
-

H
HD
.2
-

H
HD
.3
-

H
HD
.4
-

H
HD
.5
-

H
HD
.6
-

H
HD
.7
-

H
HD
.8
-

H
HD
.9
-

H
HD
.10
-

H
HD
.11
-

H
HD
.12
-

H
hdhe
.1
-

H
hdhe
.2
-

H
hdhe
.3
-

H
hdhe
.4
-

H
hdhe
.5
-

H
HE
.1
-

H
HE
.2
-

H
HE
.3
-

H
HE
.4
-

H
HE
.5
-

H
HE
.6
-

H
HE
.7
-

H
HE
.8
-

H
HE
.9
-

H
HE
.10
-

H
HE
.11
-

H
HE
.12
-

H
HE
.13
-

H
hehf
.1
-

H
hehf
.2
-

H
hehf
.3
-

H
hehf
.4
-

H
hehf
.5
-

H
hehf
.6
-

H
hehf
.7
-

H
HF
.1
-

H
HF
.2
-

H
HF
.3
-

H
HF
.4
-

H
HF
.5
-

H
HF
.6
-

G
hfs2
.1
-

G
hfs2
.2
-

G
hfs2
.3
-

G
hfs2
.4
-

G
hfs2
.5
-

G
hfs2
.6
-

G
hfs2
.7
-

G
S2
.1
-

G
S2
.2
-

G
S2
.3
-

G
S2
.4
-

G
S2
.5
-

G
S2
.6
-

G
S2
.7
-

G
S2
.8
-

G
s2s3
.1
-

G
s2s3
.2
-

G
S3
.1
-

G
S3
.2
-

G
S3
.3
-

G
S3
.4
-

G
S3
.5
-

G
S3
.6
-

G
S3
.7
-

G
S3
.8
-

G
s3h2
.1
-

G
s3h2
.2
-

G
s3h2
.3
-

G
H2
.1
-

G
H2
.2
-

G
H2
.3
-

G
H2
.4
-

G
H2
.5
-

G
H2
.6
-

G
H2
.7
-

G
H2
.8
-

G
H2
.9
-

G
H2
.10
-

G
h2s4
.1
-

G
h2s4
.2
-

G
h2s4
.3
-

G
h2s4
.4
-

G
h2s4
.5
-

G
S4
.1
-

G
S4
.2
-

G
S4
.3
-

G
S4
.4
-

G
S4
.5
-

G
S4
.6
-

G
S4
.7
-

G
s4h3
.1
-

G
s4h3
.2
-

G
s4h3
.3
-

G
s4h3
.4
-

G
s4h3
.5
-

G
s4h3
.6
-

G
s4h3
.7
-

G
s4h3
.8
-

G
s4h3
.9
-

G
s4h3
.10
-

G
s4h3
.11
-

G
s4h3
.12
-

G
s4h3
.13
-

G
s4h3
.14
-

G
s4h3
.15
-

G
H3
.1
-

G
H3
.2
-

G
H3
.3
-

G
H3
.4
-

G
H3
.5
-

G
H3
.6
-

G
H3
.7
-

G
H3
.8
-

G
H3
.9
-

G
H3
.10
-

G
H3
.11
-

G
H3
.12
-

G
H3
.13
-

G
H3
.14
-

G
H3
.15
-

G
H3
.16
-

G
H3
.17
-

G
H3
.18
-

G
h3s5
.1
-

G
h3s5
.2
-

G
h3s5
.3
-

G
S5
.1
-

G
S5
.2
-

G
S5
.3
-

G
S5
.4
-

G
S5
.5
-

G
S5
.6
-

G
S5
.7
-

G
s5hg
.1
-

G
HG
.1
-

G
HG
.2
-

G
HG
.3
-

G
HG
.4
-

G
HG
.5
-

G
HG
.6
-

G
HG
.7
-

G
HG
.8
-

G
HG
.9
-

G
HG
.12
-

G
HG
.13
-

G
HG
.14
-

G
HG
.15
-

G
HG
.16
-

G
HG
.17
-

G
hgh4
.1
-

G
hgh4
.2
-

G
hgh4
.3
-

G
hgh4
.4
-

G
hgh4
.5
-

G
hgh4
.6
-

G
hgh4
.7
-

G
hgh4
.8
-

G
H4
.1
-

G
H4
.2
-

G
H4
.3
-

G
H4
.4
-

G
H4
.5
-

G
H4
.6
-

G
H4
.7
-

G
H4
.8
-

G
H4
.10
-

G
H4
.11
-

G
H4
.12
-

G
H4
.13
-

G
H4
.14
-

G
H4
.15
-

G
H4
.16
-

G
H4
.17
-

G
h4s6
.1
-

G
h4s6
.2
-

G
h4s6
.3
-

G
h4s6
.4
-

G
h4s6
.8
-

G
h4s6
.9
-

G
h4s6
.10
-

G
h4s6
.11
-

G
h4s6
.12
-

G
S6
.1
-

G
S6
.2
-

G
S6
.3
-

G
S6
.4
-

G
S6
.5
-

G
s6h5
.1
-

G
s6h5
.2
-

G
s6h5
.3
-

G
s6h5
.4
-

G
s6h5
.5
-

G
H5
.1
-

G
H5
.2
-

G
H5
.3
-

G
H5
.4
-

G
H5
.5
-

G
H5
.6
-

G
H5
.7
-

G
H5
.8
-

G
H5
.9
-

G
H5
.10
-

G
H5
.11
-

G
H5
.12
-

G
H5
.13
-

G
H5
.14
-

G
H5
.15
-

G
H5
.16
-

G
H5
.17
-

G
H5
.18
-

G
H5
.19
-

G
H5
.20
-

G
H5
.21
-

G
H5
.22
-

G
H5
.23
-

G
H5
.24
-

G
H5
.25
-

G
H5
.26
-

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